N-3 and n-6 fatty acids for the treatment of autoimmune diseases

European Journal of Lipid Science and Technology

Volumn 103, Issue 6, 2001, Pages 399-407

  Belluzzi, Andrea ^a,b  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b NONE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0035533401     PISSN: 14387697     EISSN: None     Source Type: Journal    
DOI: 10.1002/1438-9312(200106)103:6<399::AID-EJLT399>3.0.CO;2-4     Document Type: Article

References (82)

1. K. Lauritsen, L. S. Laursen, K. Bukhave, J. RaskMadsen: Inflammatory intermediaries in inflammatory bowel disease. Int. J. Colorect. Dis. 4 (1989) 75-90.
2. W. Kromann, A. Green: Epidemiological studie in the Upernavik district, Greenland:incidence of some chronic diseases 1950-1974. Acta Med. Scand. 208 (1980) 401-406.
3. A. W. Ford-Hutchinson: Leukotriene B, a potent chemokinetic and aggregating substance released from polymorphonuclear leucocytes. Nature 286 (1980) 264.
4. D. S. Rampton, C. E. Collins: Review article: thromboxanes in inflammatory bowel disease-pathogenic and therapeutic implications. Aliment Pharm. Therap. 7 (1993) 357-367.
5. T. H. Lee, R. L. Hoover, D. Williams, R. I. Sperling, J. Ravalese, B. W. Spur, D. R. Robinson, E. J. Corey, R. A. Lewis, K. F. Austen: Effect of a dietary enrichment with eicosapentaenoic acid and docosahexaenoic acids on in vitro polymorphonuclear and monocyte leukotriene generation and polymorphonuclear leukocyte function. N. Engl. J. Med. 312 (1985) 1217-1224.
6. S. Endres, R. Ghorbani, V. E. Kelly, K. Georgilis, G. Lonnemann, J. W. van der Meer, J. G. Cannon, T. S. Rogers, M. S. Klempner, P. C. Weber: The effect of dietary supplementation with n-3 fatty acids on the synthesis of interleukin-1 and tumor necrosis factor by mononuclear cells. N. Engl. J. Med. 320 (1989) 265-270.
7. P. C. Calder: N-3 polyunsaturated fatty acids and cytokine production in health and disease. Ann. Nutr. Metab. 41 (1997) 203-234.
8. S. Endres, C. von Schacky: N-3 polyunsaturated fatty acids and human cytokine synthesis. Current Opinion in Lipidology 7 (1996) 48-52.
9. D. G. Payan, M. Y. S. Wong, T. Chernov-Rogan, F. H. Valone, W. C. Pickett, V. A. Blake, W. M. Gold, E. J. Goetzl: Alterations in Human Leukocyte function induced by ingestion of eicosapenatenoic acid. J. Clin. Immunol. 6(5) (1986) 402-410.
10. D. F. Horrobin: The regulation of prostaglandin biosynthesis by the manipulation of essential fatty acid metabolism. Rev. Pure Appl. Pharmacol. Sci. 4 (1983) 339-432.
11. V. A. Ziboh, R. S. Chapikin: Biologic significance of polyunsaturated fatty acids in the skin. Arch. Dermatol. 123 (1987) 1686-1690.
12. D. G. Baker, K. A. Krakauer, G. A. Tate, M. Laposata, R. B. Zurier: Suppression of human synovial cell proliferation by dihomo-y-linolenic acid. Arthritis Rheum 32 (1989) 1273-1281.
13. D. Santoli, P. D. Phillips, T. L. Colt, R. B. Zurier: Suppression of interleukin-2 dependent human T cell growth by E-series prostaglandins (PGE) and their precursor fatty acids: evidence for a PGE-independent mechanism of inhibition by the fatty acids. J. Clin. Invest. 35 (1990) 424-432.
14. L. S. Harbige, L. Layward, M. M. Morris-Downes, D. C. Dumonde, S. Amor: The protective effects of omega-6 fatty acids in experimental autoimmune encephalomyelitis (EAE) in relation to transforming growth factor-beta 1 (TGF-β1) up-regulation and increased prostaglandin E2 (PGE2) production. Clin. Exp. Immunol. 122(3) (2000) 445-452.
15. J. H. Millar, K. J. Zilkha, M. J. Langman, H. P. Wright, A. D. Smith, J. Belin, R. H. Thompson: Double-blind trial of linoleate supplementation of the diet in multiple sclerosis. Br. Med. J. 1(856) (1973) 765-768.
16. D. Bates, P. R. Fawcett, D. A. Shaw, D. Weightmann: Polyunsaturated fatty acids in treatment of acute remitting multiple sclerosis. Br. Med. J. 2(6149) (1978) 1390-1.
17. M. A. Crawford, P. Budowski, A. G. Hassam: Dietary management in multiple sclerosis. Proc. Nutr. Soc. 38(3) (1979) 373-9.
18. E. J. Field, G. Joyce: Multiple sclerosis: effect of gamma linolenate administration upon membranes and the need for extended clinical trials of unsaturated fatty acids. Eur. Neurol. 22(1) (1983) 78-83.
19. R. H. Dworkin, D. Bates, J. H. Millar, D. W. Paty: Linoleic acid and multiple sclerosis: a reanalysis of three double-blind trials. Neurology 34(11) (1984) 1441-1445.
20. G. Fitzgerald, L. S. Harbige, A. Forti, M. A. Crawford: The effect of nutritional counselling on diet and plasma EFA statusin multiple sclerosis patients over 3 years. Hum. Nutr. Appl. Nutr. 41(5) (1987) 297-310.
21. R. L. Swank, A. Grimsgaard: Multiple sclerosis: the lipid relationship. Am. J. Clin. Nutr. 48(6) (1988) 1387-1393.
22. D. Bates: Dietary lipids and multiple sclerosis. Ups. J. Med. Sci. Suppl. 48 (1990) 173-187.
23. L. S. Harbige, R. Jones, R. Jenkins, G. Fitzgerald, A. Forti, P. Budowski: Nutritional management in multiple sclerosis with reference to experimental models. Ups. J. Med. Sci. Suppl. 48 (1990) 189-207.
24. I. Nordvik, K. M. Myhr, H. Nyland, K. S. Bjerve: Effect of dietary advice and n-3 supplementation in newly diagnosed MS patients. Acta Neurol. Scand. 102 (2000) 143-149.
25. W. F. Clark, A. Parbtani, M. W. Huff, B. Reid, B. J. Holub, P. Falardeau: Omega-3 fatty acid dietary supplementation in systemic lupus erythematosus. Kidney Int. 36(4) (1989) 653-660.
26. G. Westberg, A. Tarkowski: Effect of MaxEPA in patients with SLE. A double-blind, crossover study. Scand. J. Rheumatol. 19(2) (1990) 137-43.
27. A. J. Walton, M. L. Snaith, M. Locniskar, A. G. Cumberland, W. J. Morrow, D. A. Isenberg: Dietary fish oil and the severity of symptoms in patients with systemic lupus erythematosus. Ann. Rheum. Dis. 50(7) (1991) 463-466.
28. UN Das: Beneficial effect of eicosapentaenoic and docosahexaenoic acid in the menagement of systemic lupus erythematosus and its relationship to the cytokine network. Prostaglandins Leukot. Essent. Fatty Acids 51(3) (1994) 207-213.
29. K. V. Hackshaw, Y. Shi, S. R. Brandwein, K. Jones, J. Y. Westcott: A pilot study of zileuton, a novel selective 5-lipoxygenase inhibitor, in patients with systemic lupus erythematosus. J. Rheumatol. 22(3) (1995) 462-468.
30. J. J. Belch, D. Ansell, R. Madhok, A. O'Dowd, R. D. Sturrock: Effects of altering dietary essential fatty acids on requirements for non-steroidal anti-inflammatory drugs in patients with rheumatoid arthritis: a double blind placebo controlled study. Ann. Rheum. Dis. 47(2) (1988) 96-104.
31. M. Brzeski, R. Madhok, H. A. Capell: Evening primrose oil in patients with rheumatoid arthritis and side-effects of non-steroidal antiinflammatory drugs. Br. J. Rheumatol. 30 (1991) 370-372.
32. I. T. Budiarso: Fish oil versus olive oil. Lancet 336 (1990) 1313-1314, Letter.
33. R. F. Grimble: Interaction between nutrient, proinflammatory cytokines and inflammation. Clin. Sci. 91 (1996) 121-129.
34. A. Petroni, M. Blasevich, M. Salami, N. Papini, G. F. Montedoro, C. Galli: Inhibition of platelet aggregation and eicosanoids production by phenolic components of olive oil. Thromb. Res 78 (1995) 151-60.
35. A. Petroni, M. Blasevich, N. Papini, M. Salami, A. Sala, C. Galli: Inhibition of leukocyte leukotriene- B4 production by an olive oil-derived phenol identified by mass-spectrometry. Thromb Res 1997;87(3): 315-322.
36. L. J. Leventhal, E. G. Boyce, R. B. Zurier: Treatment of rheumatoid arthritis with gammalinolenic acid. Ann. Intern. Med. 119 (1993) 867-873.
37. R. B. Zurier, R. G. Rossetti, E. J. Jacobson, D. M. De Marco, N. Y. Liu, J. E. Temming, B. M. White, M. Laposata: Gammalinolenic acid treatmentof rheumatoidarthritis: a randomized placebo-controlled trial. Arthritis Rheum. 39 (1996) 1808-1817.
38. D. Rothman, H. Allen, L. Herzog, A. Pilapil, C. M. Seiler, R. B. Zurier: Effects of unsaturated fatty acids on interleukin-1beta production by human monocytes. Cytokine 9(12) (1997) 1008-1012.
39. P. R. Fortin, R. A. Lew, M. H. Liang, E. A. Wright, L. A. Beckett, T. C. Chalmers, R. I. Sperling: Validation of a metaanalysis: the effects of fish oil in rheumatoid arthritis. J. Clin. Epidemiol. 48 (1995) 1379-90.
40. J. A. Shapiro, T. D. Koepsell, L. F. Voigt, C. E. Dugowson, M. Kestin, J. L. Nelson: Diet and rheumatoid arthritis in women: a possible protective effect of fish consumption. Epidemiology 7(3) (1996) 256-263.
41. G. V. Hansen, L. Nielsen, E. Kluger, M. Thysen, H. Emmerstsen, K. Stengaard-Pedersen, E. L. Hansen, B. Unger, P. W. Andersen: Nutritional status of danish rheumatoid patients and effects of a diet adjusted in energy intake, fish meal, and antioxidants. Scan. J. Rheumatol. 25(5) (1996) 325-330.
42. C. S. Lau, K. D. Morley, J. J. Belch: Effects of fish oil supplementation on non-steroidal anti-inflammatory drug requirement in patients with mild rheumatoid arthritis - a double blind placebo controlled study. Br. J. Rheumatol. 32(11) (1993) 982-989.
43. P. Geusens, C. Wouters, J. Nijs, Y. Jiang, J. Dequeker: Long-term effect of omega-3 fatty acid supplementation in active rheumatoid arthritis. A 12-month, double-blind, controlled study. Arthritis Rheum. 37(6) (1994) 824-829.
44. J. M. Kremer, D. A. Lawrence, G. F. Petrillo, L. L. Litts, P. M. Mullaly, R. I. Rynes, P. P. Stocker, N. Parhami, N. S. Greenstein, B. R. Fuchs: Effects of high-dose fish oil on rheumatoid arthritis after stopping nonsteroidal anti-inflammatory drugs. Clinical and immune correlates. Arthritis Rheum. 38(8) (1995) 1107-1114.
45. K. L. Faarvang, G. L. Nielsen, B. S. Thomsen, K. L. Teglbjaerg, H. H. Lervang, E. B. Schmidt, J. Dyerberg, E. Ernst: Fish oils and rheumatoid arthritis. A randomized and double blind study. Ugeskr Laeger 156(23) (1994) 3495-3498.
46. J. M. Kremer, D. A. Lawrence, W. Jubiz, R. DiGiacomo, R. Rynes, L. E. Bartholomew, M. Sherman: Dietary fish oil and olive oil supplementation in patients with rheumatoid arthritis . Clinical and immunologic effects. Arthritis Rheum. 33 (6) (1990) 810-820.
47. J. V. Donadio, E. J. Bergstralh, K. P. Offord, D. C. Spencer, K. E. Holley: A controlled trial of fish oil in IgA nephropathy. N. Engl. J. Med. 331 (1994) 1194-1199.
48. I. J. Cartwright, A. G. Pockley, J. H. Galloway, M. Greaves, F. E. Preston: The effects of dietary omega-3 polyunsaturated fatty acids on erythrocyte membrane phospholipids, erythrocyte deformability, and blood viscosity in healthy volunteers. Atherosclerosis 55 (1985) 267-281.
49. R. De Caterina, R. Caprioli, D. Giannessi, R. Sicari, C. Galli, G. Lazzerini, W. Bernini, L. Carr, P. Rindi: N-3 fatty acids reduce proteinuria in patients with chronic glomerular disease. Kidney Int. 44(4) (1993) 843-850.
50. T. Hamazaki, S. Tateno, H. Shishido: Eicosapentaenoic acid and IgA nephropathy. Lancet 1 (1984) 1017-1018.
51. W. M. Bennet, R. G. Walker, P. Kincaid-Smith: Treatment of IgA nephropathy with eicosapentaenoic acid (EPA): A two year prospective trial. Clin. Nephrol. 31 (1989) 128-131.
52. E. E. Petterson, S. Rekola, L. Berglund, K. G. Sundqvist, B. Angelin, U. Diczfalusy, I. Bjorkhem, J. Bergstrom: Treatment of IgA nephropathy with omega-3-polyunsaturated fatty acids: a prospective, double-blind, randomized study.
53. I. K. P. Cheng, P. C. K. Chan, M. K. Chan: The effect of fish-oil dietary supplement on the progression of mesangial IgA glomerulonephritis. Nephrol. Dial. Transplant. 5 (1990) 241-246.
54. S. M. Fung, M. J. Ferril, L. L. Norton: Fish oil theraphy in IgA nephropathy. Ann. Pharmacother. 31 (1997) 112-113.
55. J. V. Donadio, R. A. Dart, J. P. Grande, E. J. Bergstralh, D. C. Spencer: Long-term treatment with fish oil reduces renal progression in patients with IgA nephrophaty (IgAN). J. Am. Soc. Nephrol. 8 (1997) 85A.
56. R. J. Hogg: A randomized, placebo controlled, multicenter trial evaluating alternate-day prednisone and fish oil supplements in young patients with IgA nephropathy. Ann. Pharmacother. 26 (1995) 792-796.
57. J. V. Donadio, E. J. Bergstralh, K. P. Offord, J. P. Grande, T. S. Larson, D. C. Spencer A prospective comparative study of two doses of Omacor in the treatment of patients with IgA nephropathy. In progress.
58. R. Shoda, K. Matsueda, S. Yamato, N. Umeda: Epidemiologic analysis of Crohn disease in Japan: increased dietary intake of n-6 polyunsaturated fatty acids and animal protein relates to the increased incidence of Crohn disease in Japan. Am. J. Clin. Nutr. 63(5) (1996) 741-745.
59. A. J. Wakefield, A. M. Sawyerr, A. P. Dhillon, R. M. Pittilo, P. M. Rowles, A. A. Lewis, R. E. Pounder: Pathogenesis of Crohn's disease: multifocal gastrointestinal infarction. Lancet 1 (1989) 1057-1062.
60. K. Jaschoenek, M. R. Clemens, M. Scheurlen: Decreased responsiveness of platelets to a stable prostacyclin analogue in patients with Crohn's disease. Reversal by n-3 polyunsaturated fatty acids. Thromb. Res. 63 (1991) 667-672.
61. J. A. Vanderhoof, J. H. Y. Park, M. K. Herrington, T. E. Adrian: Effects of dietary menhaden oil mucosal adaptation after small bowel resection in rats. Gastroenterology 106 (1994) 94-9.
62. M. A. French, A. M. Parrot, E. S. Kielo, R. V. Rajotte, L. C. Wang, A. B. Thomson, M. T. Clandinin: Polyunsaturated fat in the diet may improve intestinal function in patients with CD. Biochim Biophys Acta 1360(3) (1997) 262-270.
63. T. B. McCall, D. O'Leary, J. Bloomfield, et al.: Therapeutic potential of fish oil in the treatment of ulcerative colitis. Aliment Pharmacol. Therap. 3 (1989) 415-424.
64. P. Salomon, Asher A. Kornbluth, H. D. Janowitz: Treatment of ulcerative colitis with fish oil n-3 fatty acid: an open trial. J. Clin. Gastroenterol. 12 (1990) 157-161.
65. R. Lorenz, P. C. Weber, P. Szimnau, W. Heldwein, T. Strasser, K. Loeschke: Supplementation with n-3 fatty acids from fish oil in chronic inflammatory bowel disease- a randomized, placebo-controlled, double-blind cross-over trial. J. Int. Med. 225(Suppl) (1989): 225-232.
66. W. R. Best, J. M. Becktel, J. W. Singleton, F. Kern: Development of a Crohn's disease activity index. Gastroenterolology 70 (1976) 439-444.
67. A. B. Hawthorne, T. K. Daneshmend, C. J. Hawkey, A. Belluzzi, S. J. Everitt, G. K. Holmes, C. Malkinson, M. Z. Shaheen, J. E. Willars: Treatment of ulcerative colitis with fish oil supplementation: a prospective 12 months randomized controlled trial. Gut 33 (1992) 922-928.
68. W. F. Stenson, D. Cort, J. Rodgers, R. Burakoff, K. De-Schryver-Kecskemeti, T. L. Gramlich, W. Beeken: Dietary supplementation with fish oil in ulcerative colitis. Ann. Intern. Med. 116 (1992) 609-614.
69. A. Aslan, G. Triadafilopoulos: Fish oil fatty acid supplementation in active ulcerative colitis: a double-blind, placebo-controlled, crossover study. Am. J. Gastroenterol. 87 (1992) 432-437.
70. J. Matè, J. Castanos, Garcia-Samaniego, J. M. Pajares: Does dietary fish oil maintain the remission of Crohn's disease (CD): a study case control. Gastroenterol. 100 (1993) A-228.
71. K. Loeschke, B. Ueberschaer, A. Pietsch, E. Gruber, K. Ewe, B. Wiebecke, W. Heldwein, R. Lorenz: N-3 fatty acids retard early relapse in ulcerative colitis. Dig. Dis. Sci. 41(10) (1996) 2087-2094.
72. H. Lorenz-Meyer, P. Bauer, C. Nicolay, B. Schulz, J. Purrmann, W. E. Fleig, C. Scheurlen, I. Koop, V. Pudel, L. Carr: Omega-3 fatty acids and carbohydrate diet for maintenance of remission in Crohn's disease. Scan. J. Gastroenterol. 31 (1996) 778-85
73. C. Brignola, G. De Simone, C. Belloli, P. Iannone, A. Belluzzi, P. Gionchetti, M. Campieri, L. Barbara: Steroid treatment in active Crohn's disease: a comparison between two regimens of different duration. Aliment Pharmacol. Ther. 8 (1994) 465-68.
74. L. J. Appel, E. R. Miller, A. J. Seidler, P. K. Whelton: Does supplementation of diet with "fish oil" reduce blood pressure? A meta-analysis of controlled following coronary angioplasty. Am. J. Prev. Med. 8 (1992) 186-192.
75. G. T. O'Connors, D. J. Malenka, E. M. Olmstead, P. S. Johnson, C. H. Hennekens: A meta-analysis of randomized trials of fish oil in prevention of restenosis following coronary angioplasty. Am. J. Prev. Med. 8 (1992) 186-192.
76. U. Kunzel, S. Bertsch: Klinische Erfahrungen mit einem standardisierten Fischölkonzentrat. Feldstudie mit 3.958 hyperlipämischen Patienten in der Praxis des niedergelassenen Arztes. Fortschr. Med. 108 (1990) 437-442.
77. S. El Boustani, C. Colette, L. Monnier, B. Descomps, A. Crastes de Paulet, F. Mendy: Enteral Absorption in man of Eicosapentaenoic acid in different Chemical forms. Lipids 22 (1987) 711-714.
78. L. D. Lawson, B. G. Hughes: Human absorption of fish oil fatty acids as triacylglycerols, free acids, or ethyl esters. Bioch. Bioph. Res. Comm. 152 (1988) 328-335.
79. A. Belluzzi, C. Brignola, M. Campieri, E. P. Camporesi, P. Gionchetti, F. Rizzello, C. Belloli, G. De Simone, S. Boschi, M. Miglioli, L. Barbara: Effects ofa new fish oil derivative on fatty acid phospholipid-membrane pattern in a group of Crohn's disease patients. Dig. Dis. Sci. 39 (1994) 2589-2594.
80. A. Belluzzi, C. Brignola, M. Campieri, A. Pera, S. Boschi, M. Miglioli: Effect of an enteric-coated fish oil preparation on relapses in Crohn's disease. N. Engl. J. Med. 334 (1996) 1557-1616.
81. C. Brignola, P. Iannone, C. Belloli, G. De Simone, L. Bassein, P. Gionchetti, A. Belluzzi, M. Campieri, L. Barbara: Prediction of relapse in patients with Crohn's disease in remission: a simplified index using laboratory tests, enhanced by clinical characteristics. Eur. J. Gastroenterol. Hepatol. 6 (1994) 955-961.
82. S. M. Greenfield, A. T. Green, J. P. Teare, A. P. Jenkins, N. A. Punchard, C. C. Ainley, R. P. Thompson: A randomized controlled study of evening primrose oil and fish oil in ulcerative colitis. Aliment Pharmacol. Ther. 7 (1993) 159-66.