The protective effects of omega-6 fatty acids in experimental autoimmune encephalomyelitis (EAE) in relation to transforming growth factor-beta 1 (TGF-β1) up-regulation and increased prostaglandin E2 (PGE2) production

Clinical and Experimental Immunology

Volumn 122, Issue 3, 2000, Pages 445-452

  Harbige, L S ^a,b   Layward, L ^a   Morris Downes, M M ^a   Dumonde, D C ^a,c   Amor, S ^a,d  

^a ST THOMAS HOSPITAL   (United Kingdom)

^b UNIVERSITY OF GREENWICH   (United Kingdom)

^c ST GEORGE S HOSPITAL   (United Kingdom)

^d IMPERIAL COLLEGE SCHOOL OF MEDICINE   (United Kingdom)

Author keywords

Experimental autoimmune encephalomyelitis; MOG peptide; Omega 6 fatty acids arachidonic acid; Prostaglandin E2; Transforming growth factor beta 1

Indexed keywords

CONCANAVALIN A; GAMMA INTERFERON; INTERLEUKIN 2; INTERLEUKIN 4; MYELIN OLIGODENDROCYTE GLYCOPROTEIN; OMEGA 6 FATTY ACID; POLYUNSATURATED FATTY ACID; PROSTAGLANDIN E2; TRANSFORMING GROWTH FACTOR BETA1;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE COURSE; FATTY ACID SYNTHESIS; IMMUNE RESPONSE; IMMUNOMODULATION; LYMPHOCYTE ACTIVATION; MALE; MOUSE; NONHUMAN; PHYTOTHERAPY; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS;

ALPHA-LINOLENIC ACID; AMINO ACID SEQUENCE; ANIMALS; CELL MEMBRANE; CELLS, CULTURED; CONCANAVALIN A; DIETARY FATS, UNSATURATED; DINOPROSTONE; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; FATTY ACIDS; FATTY ACIDS, OMEGA-6; FATTY ACIDS, UNSATURATED; GAMMA-LINOLENIC ACID; GENE EXPRESSION; INTERFERON TYPE II; INTERLEUKIN-2; INTERLEUKIN-4; MALE; MICE; MITOGENS; MOLECULAR SEQUENCE DATA; MYELIN-ASSOCIATED GLYCOPROTEIN; PLANT OILS; SPLEEN; T-LYMPHOCYTES; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1; UP-REGULATION;

EID: 0034528109     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2249.2000.01399.x     Document Type: Article

References (55)

1. Progress in determining the causes and treatment of multiple sclerosis
2. Mechanisms of immune injury in multiple sclerosis
3. Characterisation of a major T cell epitope in SJL/J mice with synthetic oligopeptides of myelin basic protein
4. Identification of major encephalitogenic epitope (residues 56-70) of proteolipid protein for the induction of experimental allergic encephalomyelitis in Biozzi AB/H and non-obese diabetic mice
5. Identification of epitopes of myelin oligodendrocyte glycoprotein for the induction of experimental allergic encephalomyelitis in SJL and Biozzi AB/H mice
6. Linoleic acid and multiple sclerosis: A reanalysis of three double blind trials
7. Reduction by linoleic acid of the severity of experimental allergic encephalomyelitis in the guinea-pig
8. Linoleic acid therapy in severe experimental allergic encephalomyelitis in the guinea pig
9. Essential fatty acids alter the activity of manganese superoxide dismutase in rat heart
10. Prevention of experimental autoimmnne encephalomyelitis in Lewis rats by a novel fungal source of γ-linolenic acid
11. 1 synthesis is altered by dietary gamma-linolenic acid
12. A new view of prostaglandin E regulation of the immune response
13. Specificity of expression and effects of eicosanoid mediators in normal physiology and human disease
14. Cytokine secretion by human T cell clones is differentially regulated by eicosanoids
15. 2 on Th0-type human T cell clones: Modulation of functions of nuclear proteins involved in cytokine production
16. Effect of omega-6 lipid-rich borage oil feeding on immune function in healthy volunteers
17. Suppression by essential fatty acids of experimental allergic encephalomyelitis is abolished by indomethacin
18. The spleen is required for the suppression of experimental allergic encephalomyelitis by prostaglandin precursors
19. A simple method for the isolation and purification of total lipids from animals tissues
20. Addendum: A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity
21. 1 is an early response to wounding in the mouse embryo
22. Modulation of cell growth and expression of early response genes by endogenous arachidonic acid metabolites
23. Immunoregulatory role of prostaglandins and related lipids
24. Immunomodulatory effects of linoleic and gamma-linolenic acid-rich oil in experimental autoimmune encephalomyelitis
25. Specific inhibitory action of polyunsaturated fatty acids on lymphocyte transformation induced by PHA and PPD
26. Fatty acids, dietary lipids and lymphocyte functions
27. Dietary fatty acids and lymphocyte functions
28. Prostaglandin E precursor fatty acids inhibit human IL-2 production by a prostaglandin E-independent mechanism
29. The inhibition of T lymphocyte proliferation by fatty acids is via an eicosanoid independent mechanism
30. Dietary n-6 and n-3 fatty acids in immunity and autoimmune disease
31. Evidence of endogenous regulatory function of transforming growth factor-β1 in experimental allergic encephalomyelitis
32. Prevention and treatment of chronic relapsing experimental allergic encephalomyelitis by transforming growth factor-β1
33. Studies on the mechanisms by which transforming growth factor-β protects against allergic encephalomyelitis
34. Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease
35. Abrogation of TGFβ signalling in T cells leads to spontaneous T cell differentiation and autoimmune disease
36. Effect of indomethecin treatment upon actively induced and transferred experimental allergic encephalomyelitis (EAE) in Lewis rats
37. Nutrition and immunity: The immunoregulatory effect of n-6 essential fatty acids is mediated through prostaglandin E
38. + suppressor cells inhibit the function of effector cells of experimental autoimmune encephalomyelitis through a mechanism involving transforming growth factor-β
39. Interferon gamma, interleukin 4 and transforming growth factor β in experimental autoimmune encephalomyelitis in Lewis rats: Dynamics of cellular mRNA expression in the central nervous system and lymphoid cells
40. Oral tolerance to the myelin basic protein and natural recovery from experimental autoimmune encephalomyelitis are associated with downregulation of inflammatory cytokines and differential upregulation of transforming growth factor β, interleukin 4, and prostaglandin E expression in the brain
41. Transforming growth factor-β suppresses activation and proliferation of microglia in vitro
42. + T cells in the pathogenesis of organ-specific autoimmune diseases
43. Increased TGFβ and decreased oncogene expression by ω-3 fatty acids in the spleen delays onset of autoimmune disease in B/W mice
44. Specific T-cell tolerance may reflect selective activation of lymphokine synthesis
45. Interactions between adipose tissue and the immune system
46. Allergic encephalomyelitis induced by brain antigen after deficiency in polyunsaturated fatty acids during myelination
47. Fat deficiency in rats during development of the central nervous system and susceptibility to experimental allergic encephalomyelitis
48. Fatty acid composition of phospholipids from platelets and erythrocytes in multiple sclerosis
49. Levels of linoleate and arachidonate in red blood cells of healthy individuals and patients with multiple sclerosis
50. Linoleic acid levels in white blood cells, platelets and serum of multiple sclerosis patients
51. Red blood cell fatty acids in multiple sclerosis
52. TGF-β-like activity produced during regression of exacerbations in multiple sclerosis
53. Cytokine mRNA levels in mononuclear blood cells from patients with multiple sclerosis
54. Defective production of antiinflammatory cytokine, TGF-β by T cell lines of patients with active multiple sclerosis
55. 1) mRNA level correlates with magnetic resonance imaging disease activity in multiple sclerosis patients