Bioactive angiotensin peptides: Focus on angiotensin IV

JRAAS - Journal of the Renin-Angiotensin-Aldosterone System

Volumn 2, Issue 4, 2001, Pages 205-210

  Mustafa, Tomris ^a   Lee, Joo Hyung ^a   Chai, Siew Yeen ^a   Albiston, Anthony L ^a   McDowall, Sharon G ^a   Mendelsohn, Frederick A O ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Angiotensin II (1 7); Angiotensin III; Angiotensin IV; Angiotensin metabolites; LVV Hemorphin 7

Indexed keywords

ANGIOTENSIN II; ANGIOTENSIN II, DES ASP(1) DES ARG(2) ILE(5); ANGIOTENSIN II, DES-ASP(1)-DES-ARG(2)-ILE(5)-; DRUG DERIVATIVE; PEPTIDE FRAGMENT;

ANIMAL; HUMAN; PHYSIOLOGY; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; REVIEW;

ANGIOTENSIN II; ANIMALS; HUMANS; PEPTIDE FRAGMENTS; RENIN-ANGIOTENSIN SYSTEM;

EID: 0035528587     PISSN: 14703203     EISSN: None     Source Type: Journal    
DOI: 10.3317/jraas.2001.032     Document Type: Review

References (115)

1. Robertson JTS. Renin Angiotensin:A Historical Review ed. Nicholls MG, Gower medical publishing, London, 1993.
2. Saavedra JM. Brain and pituitary angiotensin. Endocr Rev 1992;13:329-80.
3. Bottari SP, de Gasparo M, Steckelings UM, Levens NR. Angiotensin II receptor subtypes: characterization, signalling mechanisms, and possible physiological implications. Front Neuroendocrinol 1993;14:123-71.
4. Wright JW, Harding JW. Brain angiotensin receptor subtypes in the control of physiological and behavioral responses. Neurosci Biobehav Rev 1994;18:21-53.
5. Semple PF, Boyd AS, Dawes PM, Morton JJ. Angiotensin II and its heptapeptide (2-8), hexapeptide (3-8), and pentapeptide (4-8) metabolites in arterial and venous blood of man. Circ Res 1976;39:671-8.
6. 125I]angiotensins in rat. J Neurochem 1986;46:1292-7.
7. Zini S, Fournie-Zaluski MC, Chauvel E, Roques BP, Corvol P, Llorens-Cortes C. Identification of metabolic pathways of brain angiotensin II and III using specific aminopeptidase inhibitors: predominant role of angiotensin III in the control of vasopressin release. Proc Natl Acad Sci USA 1996;93:11968-73.
8. Tonnaer JA, Wiegant VM, de Jong W, De Wied D. Proteolytic conversion of angiotensins in rat brain tissue. Eur J Biochem 1983;131:415-21.
9. Welches WR, Santos RA, Chappell MC, Brosnihan KB, Greene LJ, Ferrario CM. Evidence that prolyl endopeptidase participates in the processing of brain angiotensin. J Hypertens 1991;9:631-8.
10. Neves LA, Almeida AP, Khosla MC, Santos RA. Metabolism of angiotensin I in isolated rat hearts. Effect of angiotensin converting enzyme inhibitors. Biochem Pharmacol 1995;50:1451-9.
11. Welches WR, Brosnihan KB, Ferrario CM. A comparison of the properties and enzymatic activities of three angiotensin processing enzymes: angiotensin converting enzyme, prolyl endopeptidase and neutral endopeptidase 24.11. Life Sci 1993;52:1461-80.
12. Pendleton RG, Gessner G, Horner E. Studies defining minimal receptor domains for angiotensin II. J Pharmacol Exp Ther 1989;250:31-6.
13. Blair-West JR, Coghlan JP, Denton DA, Funder JW, Scoggins BA, Wright RD. The effect of the heptapeptide (2-8) and hexapeptide (3-8) fragments of angiotensin II on aldosterone secretion. J Clin Endocrinol Metab 1971;32:575-8.
14. Fitzsimons JT. The effect on drinking of peptide precursors and of shorter chain peptide fragments of angiotensin II injected into the rat's diencephalon. J Physiol 1971;214:295-303.
15. Caldicott WJ, Taub KJ, Hollenberg NK. Identical mesenteric, femoral and renal vascular responses to angiotensin II and III in the dog. Life Sci 1977;20:517-21.
16. Wright JW, Morseth S, Mana MJ, LaCrosse E, Peterson EP, Harding JW. Central angiotensin III-induced dipsogenicity in rats and gerbils. Brain Res 1984;295:121-6.
17. Wright JW, Roberts KA, Cook VI, Murray CE, Sardinia MF, Harding JW. Intracerebroventric-ularly infused [D-Arg1]angiotensin III, is superior to [D-Asp1]angiotensin II, as a pressor agent in rats. Brain Res 1990;514:5-10.
18. Harding JW, Felix D. Angiotensin-sensitive neurons in the rat paraventricular nucleus: relative potencies of angiotensin II and angiotensin III. Brain Res 1987;410:130-4.
19. Reaux A, de Mota N, Zini S et al. PC18, a specific aminopeptidase N inhibitor, induces vasopressin release by increasing the half-life of brain angiotensin III. Neuroendocrinology 1999;69:370-6.
20. Zini S, Demassey Y, Fournie-Zaluski MC, et al. Inhibition of vasopressinergic neurons by central injection of a specific aminopeptidase A inhibitor. Neuroreport 1998;9:825-8.
21. Reaux A, Fournie-Zaluski MC, David C et al. Aminopeptidase A inhibitors as potential central antihypertensive agents. Proc Natl Acad Sci USA 1999;96:13415-20.
22. Reaux A, Iturrioz X, Vazeux G et al. Aminopeptidase A, which generates one of the main effector peptides of the brain renin-angiotensin system, angiotensin III, has a key role in central control of arterial blood pressure. Biochem Soc Trans 2000;28:435-40.
23. Reaux A, Fournie-Zaluski MC, Llorens-Cortes C. Angiotensin III: a central regulator of vasoprcssin release and blood pressure. Trends Endocrinol Metab 2001;12:157-62.
24. Ruiz-Ortega M, Lorenzo O, Egido J. Angiotensin III up-regulates genes involved in kidney damage in mesangial cells and renal interstitial fibroblasts. Kidney Int Suppl 1998;68:S41-5.
25. Ruiz-Ortega M, Lorenzo O, Egido J. Angiotensin III increases MCP-1 and activates NF-κB and AP-1 in cultured mesangial and mononuclear cells. Kidney Int 2000;57:2285-98.
26. Tonnaer JA, Wiegant VM, de Jong W, De Wied D. Central effects of angiotensins on drinking and blood pressure: structure-activity relationships. Brain Res 1982;236:417-28.
27. Porsti I, Bara AT, Busse R, Hecker M. Release of nitric oxide by angiotensin-(1-7) from porcine coronary endothelium: implications for a novel angiotensin receptor. Br J Pharmacol 1994;111:652-4.
28. Brosnihan KB, Li P, Ferrario CM. Angiotensin-(1-7) dilates canine coronary arteries through kinins and nitric oxide. Hypertension 1996;27:523-8.
29. Osei SY, Ahima RS, Minkes RK, Weaver JP, Khosla MC, Kadowitz PJ. Differential responses to angiotensin-(1-7) in the feline mesenteric and hindquarters vascular beds. Eur J Pharmacol 1993;234:35-42.
30. Jaiswal N, Tallant EA, Diz DI, Khosla MC, Ferrario CM. Subtype 2 angiotensin receptors mediate prostaglandin synthesis in human astrocytes. Hypertension 1991;17:1115-20.
31. Jaiswal N, Diz DI, Tallant EA, Khosla MC, Ferrario CM. Characterization of angiotensin receptors mediating prostaglandin synthesis in C6 glioma cells. Am J Physiol 1991;260:R1000-6.
32. Jaiswal N, Diz DI, Chappell MC, Khosla MC, Ferrario CM. Stimulation of endothelial cell prostaglandin production by angiotensin peptides. Characterization of receptors. Hypertension 1992;19:1149-55.
33. Jaiswal N, Jaiswal RK, Tallant EA, Diz DI, Ferrario CM. Alterations in prostaglandin production in spontaneously hypertensive rat smooth muscle cells. Hypertension 1993;21:900-5.
34. Jaiswal N, Tallant EA, Jaiswal RK, Diz DI, Ferrario CM. Differential regulation of prostaglandin synthesis by angiotensin peptides in porcine aortic smooth muscle cells: subtypes of angiotensin receptors involved. J Pharmacol Exp Ther 1993;265:664-73.
35. Oliveira MA, Fortes ZB, Santos RA, Kosla MC, De Carvalho MH. Synergistic effect of angiotensin-(1-7) on bradykinin arteriolar dilation in vivo. Peptides 1999;20:1195-201.
36. Paula RD et al. Potentiation of the hypotensive effect of bradykinin by angiotensin-(1-7)-related peptides. Peptides 1999;20:493-500.
37. Gorelik G, Carbini LA, Scicli AG. Angiotensin 1-7 induces bradykinin-mediated relaxation in porcine coronary artery. J Pharmacol Exp Ther 1998;286:403-10.
38. Deddish PA et al. N-domain-specific substrate and C-domain inhibitors of angiotensin-converting enzyme: angiotensin-(1-7) and keto-ACE. Hypertension 1998;31:912-7.
39. Yamada K, Iyer SN, Chappell MC, Ganten D, Ferrari, CM. Converting enzyme determines plasma clearance of angiotensin-(1-7). Hypertension 1998;32:496-502.
40. Machado RD, Santos RA, Andrade SP. Opposing actions of angiotensins on angiogenesis. Life Sci 2000;66:67-76.
41. Strawn WB, Ferrario CM, Tallant EA. Angiotensin-(1-7) reduces smooth muscle growth after vascular injury. Hypertension 1999;33:207-11.
42. Freeman EJ, Chisolm GM, Ferrario CM, Tallant EA. Angiotensin-(1-7) inhibits vascular smooth muscle cell growth. Hypertension 1996;28:104-8.
43. Tallant EA, Higson JT. Angiotensin II activates distinct signal transduction pathways in astrocytes isolated from neonatal rat brain. Glia 1997;19:333-42.
44. Freeman EJ, Tallant EA. Vascular smooth-muscle cells contain AT1 angiotensin receptors coupled to phospholipase D activation. Biochem J 1994;304:543-8.
45. Freeman EJ, Ferrario CM, Tallant EA. Angiotensins differentially activate phospholipase D in vascular smooth muscle cells from spontaneously hypertensive and Wistar-Kyoto rats. Am J Hypertens 1995;8:1105-11.
46. Santos RA, Campagnole-Santos MJ, Andrade SP. Angiotensin-(1-7): an update. Regul Pept 2000;91:45-62.
47. Ferrario CM, Chappell MC, Tallant EA, Brosnihan KB, Diz DI. Counterregulatory actions of angiotensin-(1-7). Hypertension 1997;30:535-41.
48. Ferrario CM, Iyer SN. Angiotensin-(1-7): a bioactive fragment of the renin-angiotensin system. Regul Pept 1998;78:13-18.
49. Chappell MC, Diz DI, Yunis C, Ferrario CM. Differential actions of angiotensin-(1-7) in the kidney. Kidney Int Suppl 1998;68:S3-6.
50. Tipnis SR, Hooper NM, Hyde R, Karran E, Christie G, Turner AJ. A human homolog of angiotensin-converting enzyme. Cloning and functional expression as a captopril-insensitive carboxypeptidase. J Biol Chem 2000;275:33238-43.
51. Donoghue M, Hsieh F, Baronas E et al. A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9. Circ Res 2000;87:E1-9.
52. de Gasparo M, Husain A, Alexander W et al. Proposed update of angiotensin receptor nomenclature. Hypertension 1995;25:924-7.
53. Swanson GN, Hanesworth JM, Sardinia MF et al. Discovery of a distinct binding site for angiotensin II (3-8), a putative angiotensin IV receptor. Regul Pept 1992;40:409-19.
54. Harding JW, Cook VI, Miller-Wing AV et al. Identification of an AII(3-8) [AIV] binding site in guinea pig hippocampus. Brain Res 1992;583:340-3.
55. Miller-Wing AV, Hanesworth JM, Sardinia MF et al. Central angiotensin IV binding sites: distribution and specificity in guinea pig brain. J Pharmacol Exp Ther 1993;266:1718-26.
56. Hanesworth JM, Sardinia MF, Krebs LT, Hall KL, Harding JW. Elucidation of a specific binding site for angiotensin II(3-8), angiotensin IV, in mammalian heart membranes. J Pharmacol Exp Ther 1993;266:1036-42.
57. Hall KL, Hanesworth JM, Ball AE, Felgenhauer GP, Hosick HL, Harding JW. Identification and characterisation of a novel angiotensin binding site in cultured vascular smooth muscle cells that is specific for the hexapeptide (3-8) fragment of angiotensin II, angiotensin IV. Regul Pept 1993;44:225-32.
58. Hall KL, Venkateswaran S, Hanesworth JM, Schelling ME, Harding JW. Characterization of a functional angiotensin IV receptor on coronary microvascular endothelial cells. Regul Pept 1995;58:107-15.
59. Moeller I, Chai SY, Oldfield BJ, McKinley MJ, Casley D, Mendelsohn FA. Localization of angiotensin IV binding sites to motor and sensory neurons in the sheep spinal cord and hindbrain. Brain Res 1995;701:301-6.
60. Moeller I, Paxinos G, Mendelsohn FA, Aldred GP, Casley D, Chai SY. Distribution of AT4 receptors in the Macaca fascicularis brain. Brain Res 1996;712:307-24.
61. Chai SY, Bastias MA, Clune EF et al. Distribution of angiotensin IV binding sites (AT(4) receptor) in the human forebrain, midbrain and pons as visualised by in vitro receptor autoradiography. J Chem Neuroanat 2000;20:339-48.
62. de Gasparo M, Catt KJ, Inagami, T, Wright JW, Unger T. International union of pharmacology. XXIII. The angiotensin II receptors. Pharmacol Rev 2000;52:415-72.
63. Braszko JJ, Kupryszewski G, Witczuk B, Wisniewski K. Angiotensin II-(3-8)-hexapeptide affects motor activity, performance of passive avoidance and a conditioned avoidance response in rats. Neuroscience 1988;27:777-83.
64. Wright JW, Miller-Wing AV, Shaffer MJ et al. Angiotensin II(3-8) (ANG IV) hippocampal binding: potential role in the facilitation of memory. Brain Res Bull 1993;32:497-502.
65. Tchekalarova J, Kambourova T, Georgiev V. Interaction between angiotensin IV and adenosine A(1) receptor related drugs in passive avoidance conditioning in rats. Behav Brain Res 2001;123:113-16.
66. Delorenzi ALF, Romano A, Nahmod V, Maldonado H. Angiotensin II (3-8) induces long-term memory improvement in the crab Chasmagnathus. Neurosci Lett 1997;226:143-6.
67. Wright JW, Stubley L, Pederson ES, Kramar EA, Hanesworth JM, Harding JW. Contributions of the brain angiotensin IV-AT4 receptor subtype system to spatial learning. J Neurosci 1999;19:3952-61.
68. Roberts KA, Krebs LT, Kramar EA, Shaffer MJ, Harding JW, Wright JW. Autoradiographic identification of brain angiotensin IV binding sites and differential c-Fos expression following intracerebroventricular injection of angiotensin II and IV in rats. Brain Res 1995;682:13-21.
69. Lee JCS, Mendelsohn FA, Morris MJ, Allen AM. Potentiation of cholinergic transmission in the rat hippocampus by angiotensin IV and LVV-hemorphin-7. Neuropharmacology 2001;40:618-23.
70. Kramar EA, Armstrong DL, Ikeda S, Wayner MJ, Harding JW, Wright JW. The effects of angiotensin IV analogs on long-term potentiation within the CA1 region of the hippocampus in vitro. Brain Res 2001;897:114-21.
71. Wayner MJAD, Phelix CF, Wright JW, Harding JW. Angiotensin IV enhances LTP in rat dentate gyrus in vivo. Peptides 2001;22:1403-14.
72. Haberl RL, Decker PJ, Einhaupl KM. Angiotensin degradation products mediate endothelium-dependent dilation of rabbit brain arterioles. Circ Res 1991;68:1621-7.
73. Kramar EA, Krishnan R, Harding JW, Wright JW. Role of nitric oxide in angiotensin IV-induced increases in cerebral blood flow. Regul Pept 1998;74:185-92.
74. Coleman JK, Lee JI, Miller JM, Nuttall AL. Changes in cochlear blood flow due to intra-arterial infusions of angiotensin II (3-8) (angiotensin IV) in guinea pigs. Heart Res 1998;119:61-8.
75. Patel JM, Martens JR, Li YD, Gelband CH, Raizada MR, Block ER. Angiotensin IV receptor-mediated activation of lung endothelial NOS is associated with vasorelaxation. Am J Physiol 1998;275:L1061-8.
76. Gardiner SM, Kemp PA, March JE, Bennett T. Regional haemodynamic effects of angiotensin II (3-8) in conscious rats. Br J Pharmacol 1993;110:159-62.
77. Cheng DY, DeWitt BJ, Dent EL, Nossaman BD, Kadowitz PJ. Analysis of responses to angiotensin IV in the pulmonary vascular bed of the cat. Eur J Pharmacol 1994;261:223-7.
78. Nossaman BD, Feng CJ, Kaye AD, Kadowitz PJ. Analysis of responses to ANG IV: effects of PD-123319 and DuP-753 in the pulmonary circulation of the rat. Am J Physiol 1995;268:L302-8.
79. Garrison EA, Santiago JA, Osei SY, Kadowitz PJ. Analysis of responses to angiotensin peptides in the hindquarters vascular bed of the cat. Am J Physiol 1995;268:H2418-25.
80. Li Q, Feenstra M, Pfaffendorf M, Eijsman L, van Zwieten PA. Comparative vasoconstrictor effects of angiotensin II, III, and IV in human isolated saphenous vein. J Cardiovasc Pharmacol 1997;29:451-6.
81. Moeller I, Small DH, Reed G, Harding JW, Mendelsohn FA, Chai SY. Angiotensin IV inhibits neurite outgrowth in cultured embryonic chicken sympathetic neurones. Brain Res 1996;725:61-6.
82. Mustafa T, Chai SY, Mendelsohn FA, Moeller I, Albiston AL. Characterization of the AT(4) receptor in a human neuroblastoma cell line (SK-N-MC). J Neurochem 2001;76:1679-87.
83. 4 receptor. J Neurochem 1999;73:301-8.
84. Kakinuma Y. Impaired blood-brain barrier function in angiotensinogen-deficient mice. Nature Medicine 1998;4: 1078-80.
85. Kakinuma Y, Hama H, Sugiyama F, Goto K, Murakami K, Fukamizu A. Anti-apoptotic action of angiotensin fragments to neuronal cells from angiotensinogen knock-out mice. Neurosci Lett 1997;232:167-70.
86. Kakinuma Y, Sugiyama F, Taniguchi K et al. Developmental stage-specific involvement of angiotensin in murine nephrogenesis. Pediatr Nephrol 1999;13:792-9.
87. Pawlikowski M, Kunert-Radek J. Angiotensin IV stimulates the proliferation of rat anterior pituitary cells in vitro. Biochem Biophys Res Commun 1997;232:292-3.
88. Wang L, Eberhard M, Erne P. Stimulation of DNA and RNA synthesis in cultured rabbit cardiac fibroblasts by angiotensin IV. Clin Sci (Lond) 1995;88:557-62.
89. Pawlikowski M, Melen-Mucha G, Mucha S. The involvement of the renin-angiotensin system in the regulation of cell proliferation in the rat endometrium. Cell Mol Life Sci 1999;55:506-10.
90. 4 receptor levels in carotid arteries following balloon injury. Regul Pept 1999;83:25-30.
91. Zhang JH, Stobb JW, Hanesworth JM, Sardinia MF, Harding JW. Characterization and purification of the bovine adrenal angiotensin IV receptor (AT4) using [125I]benzoylphenylalanine-angiotensin IV as a specific photolabel. J Pharmacol Exp Ther 1998;287:416-24.
92. Zhang JH, Hanesworth JM, Sardinia MF, Alt JS, Wright JW, Harding JW. Structural analysis of angiotensin IV receptor (AT4) from selected bovine tissues. J Pharmacol Exp Ther 1999;289:1075-83.
93. 4 receptor from bovine aortic endothelium with photosensitive analogues of angiotensin IV. Biochemistry 1998;37:4280-7.
94. 4 receptor agonist [Nle]-angiotensin IV reduces mechanically induced immediate-early gene expression in the isolated rabbit heart. Regul Pept 1997;71:175-83.
95. Kerins DM, Hao Q, Vaughan DE. Angiotensin induction of PAM expression in endothelial cells is mediated by the hexapeptide angiotensin IV. J Clin Invest 1995;96:2515-20.
96. Gesualdo L, Ranieri E, Monno R et al. Angiotensin IV stimulates plasminogen activator inhibitor-1 expression in proximal tubular epithelial cells. Kidney Int 1999;56:461-70.
97. Skurk T, Lee YM, Rohrig K, Hauner H. Effect of angiotensin peptides on PAI-1 expression and production in human adipocytes. Horm Metab Res 2001;33:196-200.
98. Skurk T, Lee YM, Hauner H. Angiotensin II and its metabolites stimulate PAI-1 protein release from human adipocytes in primary culture. Hypertension 2001;37:1336-40.
99. Nishimura H, Tsuji H, Masuda H et al. The effects of angiotensin metabolites on the regulation of coagulation and fibrinolysis in cultured rat aortic endothelial cells. Thromb Haemost 1999;82:1516-21.
100. Chen HC, Bouchie JL, Perez AS et al. Role of the angiotensin AT(1) receptor in rat aortic and cardiac PAI-1 gene expression. Arterioscler Thromb Vasc Biol 2000;20:2297-302.
101. 1 Angiotensin Receptors Mobilize Intracellular Calcium in a Subclone of NG 108-15 Neuroblastoma Cells. J Neurochem 1992;58:1883-8.
102. Baker MF, Aceto FJ. Angiotensin II stimulation of protein synthesis and cell growth in chick heart cells. Am J Physiol 1990;259:H610-H618.
103. Dostal DE, Murahashi T, Peach MJ. Regulation of cytosolic calcium by angiotensins in vascular smooth muscle. Hypertension 1990;15:815-22.
104. Dulin N, Madhun ZT, Chang CH, Berti-Mattera L, Dickens D, Douglas JG. Angiotensin IV receptors and signaling in opossum kidney cells. Am J Physiol 1995;269:F644-52.
105. Chansel D, Vandermeersch S, Oko A, Curat C, Ardaillou R. Effects of angiotensin IV and angiotensin-(1-7) on basal and angiotensin II-stimulated cytosolic Ca2+ in mesangial cells. Eur J Pharmacol 2001;414:165-75.
106. Chen JK, Zimpelmann J, Harris RC, Burns KD. Angiotensin IV induces tyrosine phosphorylation of focal adhesion kinase and paxillin in proximal tubule cells. Am J Physiol Renal Physiol 2001;280:F980-8.
107. Handa RK, Harding JW, Simasko SM. Characterization and function of the bovine kidney epithelial angiotensin receptor subtype 4 using angiotensin IV and divalinal angiotensin IV as receptor ligands. J Pharmacol Exp Ther 1999;291:1242-9.
108. Patel JM, Li YD, Zhang J, Gelband CH, Raizada MK, Block ER. Increased expression of calreticulin is linked to ANG IV-mediated activation of lung endothelial NOS. Am J Physiol 1999;277:L794-801.
109. 4 receptor in the brain. J Neurochem 1997;68:2530-7.
110. Chang RC, Huang WY, Redding TW, Arimura A, Coy DH, Serially AV. Isolation and structure of several peptides from porcine hypothalami. Biochim Biophys Acta 1980;625:266-73.
111. Barkhudaryan N, Kellermann J, Galoyan A, Lottspeich F. High molecular weight aspartic endopeptidase generates a coronaro-constrictory peptide from the beta-chain of hemoglobin. FEBS Lett 1993;329:215-18.
112. Glamsta EL, Marklund A, Hellman U, Wernstedt C, Terenius L, Nyberg F. Isolation and characterization of a hemoglobin-derived opioid peptide from the human pituitary gland. Regul Pept 1991;34:169-79.
113. Karelin AA, Philippova MM, Karelina EV, Ivanov VT. Isolation of endogenous hemorphin-related hemoglobin fragments from bovine brain. Biochem Biophys Res Commun 1994;202:410-15.
114. Piot JM, Zhao Q, Guillochon D, Ricart G, Thomas D. Isolation and characterization of two opioid peptides from a bovine hemoglobin peptic hydrolysate. Biochem Biophys Res Commun 1992;189:101-10.
115. Fitzgerald SM, Evans RG, Bergstrom G, Anderson WP. Renal hemodynamic responses to intrarenal infusion of ligands for the putative angiotensin IV receptor in anesthetized rats. J Cardiovasc Pharmacol 1999;34:206-11.