PC18, a specific aminopeptidase N inhibitor, induces vasopressin release by increasing the half-life of brain Angiotensin III

Neuroendocrinology

Volumn 69, Issue 5, 1999, Pages 370-376

  Réaux, Annabelle ^a   De Mota, Nadia ^a   Zini, Sylvie ^a   Cadel, Sandrine ^c   Fournié Zaluski, Marie Claude ^b   Roques, Bernard P ^b   Corvol, Pierre ^a   Llorens Cortès, Catherine ^a  

^a INSERM   (France)

^b Laboratoire de Pharmacochimie   (France)

^c CNRS   (France)

Author keywords

Aminopeptidases; Aminopeptidases inhibitors; Angiotensins; Vasopressin

Indexed keywords

2 AMINO 4 METHYLSULFONYL BUTANE THIOL; AMINOPEPTIDASE B; ANGIOTENSIN III; ENZYME INHIBITOR; GLUTAMYL AMINOPEPTIDASE; METALLOPROTEINASE; MICROSOMAL AMINOPEPTIDASE; PC 18; UNCLASSIFIED DRUG; VASOPRESSIN;

AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN; CONTROLLED STUDY; ENZYME SPECIFICITY; HALF LIFE TIME; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; VASOPRESSIN RELEASE;

AMINOPEPTIDASES; ANGIOTENSIN II; ANGIOTENSIN III; ANIMALS; ANTIGENS, CD13; BRAIN CHEMISTRY; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, ION EXCHANGE; GLUTAMYL AMINOPEPTIDASE; HALF-LIFE; HYPOTHALAMUS; INJECTIONS, INTRAVENTRICULAR; MALE; MICE; PROTEASE INHIBITORS; VASOPRESSINS;

EID: 0345711597     PISSN: 00283835     EISSN: None     Source Type: Journal    
DOI: 10.1159/000054439     Document Type: Article

References (35)

1. Phillips MI: Functions of angiotensin in the central nervous system. Annu Rev Physiol 1987;49:412-435.
2. Saavedra JM: Brain and pituitary angiotensin. Endocr Rev 1992;13:329-380.
3. Griendling KK, Lassegue B, Alexander RW: Angiotensin receptors and their therapeutic implications. Annu Rev Pharmacol Toxicol 1996;36:281-306.
4. Wright JW, Harding JW: Regulatory role of brain angiotensins in the control of physiological and behavioral responses. Brain Res Rev 1992;17:227-263.
5. Zini S, Fournié-Zaluski MC, Chauvel E, Roques BP, Corvol P, Llorens-Cortès C: Identification of metabolic pathways of brain angiotensin II and III using specific aminopeptidase inhibitors: Predominant role of angiotensin III in the control of vasopressin release. Proc Natl Acad Sci USA 1996;93:11968-11973.
6. Zini S, Demassey Y, Fournié-Zaluski MC, Bischoff L, Corvol P, Llorens-Cortès C, Sanderson P: Inhibition of vasopressinergic neurons by central injection of a specific aminopeptidase A inhibitor. Neuroreport 1998;9/5:120-124.
7. Watt VM, Yip CC: Amino acid sequence deduced from a rat kidney cDNA suggests it encodes the Zn-peptidase aminopeptidase N. J Biol Chem 1989;264:5480-5487.
8. Malfroy B, Kado-Fong H, Gros C, Giros B, Schwartz JC, Hellmiss R: Molecular cloning and amino acid sequence of rat kidney aminopeptidase M: A member of a super family of zinc-metallohydrolases. Biochem Biophys Res Commun 1989;161:236-241.
9. Wu Q, Lahti JM, Air GM, Burrows PD, Cooper MD: Molecular cloning of the murine BP-1/6C3 antigen: A member of the zinc-dependent metallopeptidase family. Proc Natl Acad Sci USA 1990;87:993-997.
10. Wang JY, Cooper MD: A histidine residue in the zinc-binding motif of aminopeptidase A is critical for enzymatic activity. Proc Natl Acad Sci USA 1993;90:1222-1226.
11. Vazeux G, Wang J, Cooper M, Corvol P, Llorens-Cortès C: Identification of glutamate residues essential for catalytic activity and zinc coordination in aminopeptidase A. J Biol Chem 1996;271:9069-9074.
12. Fukasawa KM, Fukazawa K, Kanai M, Fujii S, Harada M: Molecular cloning and expression of rat liver aminopeptidase B. J Biol Chem 1996;271:30731-30735.
13. Cadel S, Foulon T, Viron A, Balogh A, Midol-Monnet S, Noël N, Cohen P: Aminopeptidase B from the rat testis is a bifunctional enzyme structurally related to leukotriene-A4 hydrolase. Proc Natl Acad Sci USA 1997;94: 2963-2968.
14. Jongeneel CV, Bouvier J, Bairoch A: A unique signature identifies a family of zinc-dependent metallopeptidases. FEBS Lett 1989;242:211-214.
15. Roques BP: Zinc metallopeptidases: Active site structure and design of selective and mixed inhibitors: New approach in the search for analgesics and anti-hypertensives. Biochem Soc Trans 1993;21:678-685.
16. Hopsu VK, Mäkinen KK, Glenner GG: Purification of a mammalian peptidase selective for N-terminal arginine and lysine residues: Aminopeptidase B. Arch Biochem Biophys 1966; 114:557-566.
17. Wilk S, Healy DP: Glutamyl aminopeptidase (aminopeptidase A), the BP-1/6C3 antigen. Adv Neuroimmunol 1993;3:195-207.
18. Cadel S, Pierotti AR, Foulon T, Créminon C, Barré N, Segrétin D, Cohen P: Aminopeptidase-B in the rat testes: Isolation, functional properties and cellular localization in the seminiferous tubules. Mol Cell Biol 1995;110:149-160.
19. McDonald J, Barrett A: Mammalian proteases: A Glossary and Bibliography: Exopeptidases. London, Academic Press, 1986.
20. Kenny AJ, Stephenson SL, Turner AJ: Cell surface peptidases in Mammalian Ectoenzymes; Amsterdam, Kenny AJ & Turner eds, Elsevier Science Publishing 1987, vol 14, pp 169-210.
21. Bausback HH, Churchill L, Ward PE: Angiotensin metabolism by cerebral microvascular aminopeptidase A. Biochem Pharmacol 1988; 37:155-160.
22. Kugler P: Aminopeptidase A is angiotensinase A. II. Biochemical studies on aminopeptidase A and M in rat kidney homogenate. Histochemistry 1982;74:247-261.
23. Soderling E: Substrates specificities of Cl-activated arginine aminopeptidase from human and rat origine. Arch Biochem Biophys 1983; 220:1-10.
24. Chauvel E, Coric P, Llorens-Cortès C, Wilk S, Roques BP, Fournié-Zaluski MC: Investigation of the active site of aminopeptidase A using a series of new thiol-containing inhibitors. J Med Chem 1994;37:1339-1346.
25. Fournié-Zaluski MC, Coric P, Turcaud S, Lucas E, Noble F, Maldonado R, Roques BP: Potent and systemically active aminopeptidase N inhibitors designed from active site investigation. J Med Chem 1992;35:1259-1266.
26. Haley TJ, McCormick WG: Pharmacological effects produced by intracerebral injection of drugs in conscious mouse. Br J Pharmacol 1957;12:12-15.
27. Ledwith BJ, Cahill MK, Losse LS, Satiritz SM, Eydelloth RS, Dallob AL, Tanaka WK, Galloway SM, Nichols WW: Measurement of plasma angiotensin II. Purification by cation-exchange chromatography. Anal Biochem 1993;213: 349-355.
28. Mantle D, Lauffart B, McDermott J, Kidd A, Pennington R: Purification and characterization of two Cl-activated aminopeptidases hydrolysing basic termini from human skeletal muscle. Eur J Biochem 1985;147:307-312.
29. Lalu K, Lampelo S, Vanha-Perttula T: Characterization of three aminopeptidases from maternal serum. Biochim Biophys Acta 1986;873: 190-197.
30. Costa E, Neff NH: In Lajtha A (ed): Handbook of Neurochemistry. New York, Plenum, 1970, vol 4, pp 45-79.
31. Dewey AL, Wright JW, Hanesworth JM, Harding JW: Effects of aminopeptidase inhibition on the half-lives of [125I]angiotensins in the cerebroventricles of the rat. Brain Res 1988; 488:369-372.
32. Wright JW, Quirk W, Hanesworth JM, Harding JW: Influence of aminopeptidase inhibitors on brain angiotensin metabolism and drinking in rat. Brain Res 1988;441:215-220.
33. Song L, Wilk S, Healy DP: Aminopeptidase A antiserum inhibits intracerebroventricular angiotensin II-induced dipsogenic and pressor responses. Brain Res 1997;744:1-6.
34. Wright JW, Mizutani S, Murray CE, Amir HZ, Harding JW: Aminopeptidase-induced elevations and reductions in blood pressure in the spontaneously hypertensive rat. J Hypertens 1990;8:969-974.
35. Jhamandas JH, Lind RW, Renaud LP: Angiotensin II may mediate excitatory neurotransmission from the subfornical organ to the hypothalamic supraoptic nucleus: An anatomical and electrophysiological study in the rat. Brain Res 1989;487:52-61.