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Volumn 98, Issue 9, 2001, Pages 2664-2672

High-level erythroid-specific gene expression in primary human and murine hematopoietic cells with self-inactivating lentiviral vectors

Author keywords

[No Author keywords available]

Indexed keywords

5 AMINOLEVULINATE SYNTHASE; ANKYRIN; BETA GLOBIN; GAMMA GLOBIN; GREEN FLUORESCENT PROTEIN; HEAT SHOCK PROTEIN 40; TRANSCRIPTION FACTOR GATA 1;

EID: 0035525735     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.V98.9.2664     Document Type: Article
Times cited : (101)

References (54)
  • 1
    • 0029084785 scopus 로고
    • Generation of a high-titer retroviral vector capable of expressing high levels of the human beta-globin gene
    • Sadelain M, Wang CH, Antoniou M, Grosveld F, Mulligan RC. Generation of a high-titer retroviral vector capable of expressing high levels of the human beta-globin gene. Proc Natl Acad Sci U S A. 1995;92:6728-6732.
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 6728-6732
    • Sadelain, M.1    Wang, C.H.2    Antoniou, M.3    Grosveld, F.4    Mulligan, R.C.5
  • 3
    • 0023864651 scopus 로고
    • Lineage-specific expression of a human betaglobin gene in murine bone marrow transplant recipients reconstituted with retrovirus-transduced stem cells
    • Dzierzak EA, Papayannopoulou T, Mulligan RC. Lineage-specific expression of a human betaglobin gene in murine bone marrow transplant recipients reconstituted with retrovirus-transduced stem cells. Nature. 1988;331:35-41.
    • (1988) Nature , vol.331 , pp. 35-41
    • Dzierzak, E.A.1    Papayannopoulou, T.2    Mulligan, R.C.3
  • 4
    • 0021726790 scopus 로고
    • Genes with promoters in retrovirus vectors can be independently suppressed by an epigenetic mechanism
    • Emerman M, Temin HM. Genes with promoters in retrovirus vectors can be independently suppressed by an epigenetic mechanism. Cell. 1984;39:449-467.
    • (1984) Cell , vol.39 , pp. 449-467
    • Emerman, M.1    Temin, H.M.2
  • 5
    • 0022625565 scopus 로고
    • Quantitative analysis of gene suppression in integrated retrovirus vectors
    • Emerman M, Temin HM. Quantitative analysis of gene suppression in integrated retrovirus vectors. Mol Cell Biol. 1986;6:792-800.
    • (1986) Mol Cell Biol , vol.6 , pp. 792-800
    • Emerman, M.1    Temin, H.M.2
  • 6
    • 0023045648 scopus 로고
    • Comparison of promoter suppression in avian and murine retrovirus vectors
    • Emerman M, Temin HM. Comparison of promoter suppression in avian and murine retrovirus vectors. Nucleic Acids Res. 1986;14:9381-9396.
    • (1986) Nucleic Acids Res , vol.14 , pp. 9381-9396
    • Emerman, M.1    Temin, H.M.2
  • 7
    • 0346132122 scopus 로고
    • Self-inactivating retroviral vectors designed for transfer of whole genes into mammalian cells
    • Yu SF, von Ruden T, Kantoff PW, et al. Self-inactivating retroviral vectors designed for transfer of whole genes into mammalian cells. Proc Natl Acad Sci U S A. 1986;83:3194-3198.
    • (1986) Proc Natl Acad Sci U S A , vol.83 , pp. 3194-3198
    • Yu, S.F.1    Von Ruden, T.2    Kantoff, P.W.3
  • 9
    • 0023790358 scopus 로고
    • Comparison of intron-dependent and intron-independent gene expression
    • Buchman AR, Berg P. Comparison of intron-dependent and intron-independent gene expression. Mol Cell Biol. 1988;8:4395-4405.
    • (1988) Mol Cell Biol , vol.8 , pp. 4395-4405
    • Buchman, A.R.1    Berg, P.2
  • 10
    • 0025101148 scopus 로고
    • Definition of the minimal requirements within the human beta-globin gene and the dominant control region for high level expression
    • Collis P, Antoniou M, Grosveld F. Definition of the minimal requirements within the human beta-globin gene and the dominant control region for high level expression. EMBO J. 1990;9:233-240.
    • (1990) EMBO J , vol.9 , pp. 233-240
    • Collis, P.1    Antoniou, M.2    Grosveld, F.3
  • 11
    • 0033559693 scopus 로고    scopus 로고
    • Intronless mRNA transport elements may affect multiple steps of pre-mRNA processing
    • Huang Y, Wimler KM, Carmichael GG. Intronless mRNA transport elements may affect multiple steps of pre-mRNA processing. EMBO J. 1999;18:1642-1652.
    • (1999) EMBO J , vol.18 , pp. 1642-1652
    • Huang, Y.1    Wimler, K.M.2    Carmichael, G.G.3
  • 13
    • 0032004354 scopus 로고    scopus 로고
    • Efficient 3′-end formation of human beta-globin mRNA in vivo requires sequences within the last intron but occurs independently of the splicing reaction
    • Antoniou M, Geraghty F, Hurst J, Grosveld F. Efficient 3′-end formation of human beta-globin mRNA in vivo requires sequences within the last intron but occurs independently of the splicing reaction. Nucleic Acids Res. 1998;26:721-729.
    • (1998) Nucleic Acids Res , vol.26 , pp. 721-729
    • Antoniou, M.1    Geraghty, F.2    Hurst, J.3    Grosveld, F.4
  • 14
    • 0023955979 scopus 로고
    • The human beta-globin gene contains multiple regulatory regions: Identification of one promoter and two downstream enhancers
    • Antoniou M, deBoer E, Habets G, Grosveld F. The human beta-globin gene contains multiple regulatory regions: identification of one promoter and two downstream enhancers. EMBO J. 1988;7:377-384.
    • (1988) EMBO J , vol.7 , pp. 377-384
    • Antoniou, M.1    DeBoer, E.2    Habets, G.3    Grosveld, F.4
  • 15
    • 0029044417 scopus 로고
    • Role of the hepatitis B virus posttranscriptional regulatory element in export of intronless transcripts
    • Huang ZM, Yen TS. Role of the hepatitis B virus posttranscriptional regulatory element in export of intronless transcripts. Mol Cell Biol. 1995;15:3864-3869.
    • (1995) Mol Cell Biol , vol.15 , pp. 3864-3869
    • Huang, Z.M.1    Yen, T.S.2
  • 16
    • 4243525961 scopus 로고    scopus 로고
    • The woodchuck hepatitis virus posttranscriptional regulatory element greatly increases titers from retroviral vectors and improves expression of the beta globin cDNA
    • Jiang G, Perelman N, Xu D, Leboulch P, Pepper KA, Malik P. The woodchuck hepatitis virus posttranscriptional regulatory element greatly increases titers from retroviral vectors and improves expression of the beta globin cDNA. Blood. 1999;94:176a.
    • (1999) Blood , vol.94
    • Jiang, G.1    Perelman, N.2    Xu, D.3    Leboulch, P.4    Pepper, K.A.5    Malik, P.6
  • 17
    • 0029996147 scopus 로고    scopus 로고
    • In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector
    • Naldini L, Blomer U, Gallay P, et al. In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector [see comments]. Science. 1996;272:263-267.
    • (1996) Science , vol.272 , pp. 263-267
    • Naldini, L.1    Blomer, U.2    Gallay, P.3
  • 18
    • 0033613827 scopus 로고    scopus 로고
    • Transduction of human CD34+ cells that mediate long-term engraftment of NOD/SCID mice by HIV vectors
    • Miyoshi H, Smith KA, Mosier DE, Verma IM, Torbett BE. Transduction of human CD34+ cells that mediate long-term engraftment of NOD/SCID mice by HIV vectors. Science. 1999;283:682-686.
    • (1999) Science , vol.283 , pp. 682-686
    • Miyoshi, H.1    Smith, K.A.2    Mosier, D.E.3    Verma, I.M.4    Torbett, B.E.5
  • 19
    • 13044309472 scopus 로고    scopus 로고
    • Stable transduction of quiescent CD34(+)CD38(-) human hematopoietic cells by HIV-1-based lentiviral vectors
    • Case SS, Price MA, Jordan CT, et al. Stable transduction of quiescent CD34(+)CD38(-) human hematopoietic cells by HIV-1-based lentiviral vectors. Proc Natl Acad Sci U S A. 1999;96:2988-2993.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 2988-2993
    • Case, S.S.1    Price, M.A.2    Jordan, C.T.3
  • 20
    • 0031743608 scopus 로고    scopus 로고
    • Self-inactivating lentivirus vector for safe and efficient in vivo gene delivery
    • Zufferey R, Dull T, Mandel RJ, et al. Self-inactivating lentivirus vector for safe and efficient in vivo gene delivery. J Virol. 1998;72:9873-9880.
    • (1998) J Virol , vol.72 , pp. 9873-9880
    • Zufferey, R.1    Dull, T.2    Mandel, R.J.3
  • 22
    • 0032191380 scopus 로고    scopus 로고
    • Lentiviruses as gene transfer agents for delivery to non-dividing cells
    • Naldini L. Lentiviruses as gene transfer agents for delivery to non-dividing cells. Curr Opin Biotechnol. 1998;9:457-463.
    • (1998) Curr Opin Biotechnol , vol.9 , pp. 457-463
    • Naldini, L.1
  • 23
    • 0033562853 scopus 로고    scopus 로고
    • Transcriptional targeting of retroviral vectors to the erythroblastic progeny of transduced hematopoietic stem cells
    • Grande A, Piovani B, Aiuti A, Ottolenghi S, Mavilio F, Ferrari G. Transcriptional targeting of retroviral vectors to the erythroblastic progeny of transduced hematopoietic stem cells. Blood. 1999;93:3276-3285.
    • (1999) Blood , vol.93 , pp. 3276-3285
    • Grande, A.1    Piovani, B.2    Aiuti, A.3    Ottolenghi, S.4    Mavilio, F.5    Ferrari, G.6
  • 24
    • 0032479292 scopus 로고    scopus 로고
    • Identification and characterization of a conserved erythroid-specific enhancer located in intron 8 of the human 5-aminolevulinate synthase 2 gene
    • Surinya KH, Cox TC, May BK. Identification and characterization of a conserved erythroid-specific enhancer located in intron 8 of the human 5-aminolevulinate synthase 2 gene. J Biol Chem. 1998;273:16798-16809.
    • (1998) J Biol Chem , vol.273 , pp. 16798-16809
    • Surinya, K.H.1    Cox, T.C.2    May, B.K.3
  • 25
    • 0032444352 scopus 로고    scopus 로고
    • Derepression of human embryonic zeta-globin promoter by a locus-control region sequence
    • Huang BL, Fan-Chiang IR, Wen SC, et al. Derepression of human embryonic zeta-globin promoter by a locus-control region sequence. Proc Natl Acad Sci U S A. 1998;95:14669-14674.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 14669-14674
    • Huang, B.L.1    Fan-Chiang, I.R.2    Wen, S.C.3
  • 28
    • 0032978712 scopus 로고    scopus 로고
    • Woodchuck hepatitis virus posttranscriptional regulatory element enhances expression of transgenes delivered by retroviral vectors
    • Zufferey R, Donello JE, Trono D, Hope TJ. Woodchuck hepatitis virus posttranscriptional regulatory element enhances expression of transgenes delivered by retroviral vectors. J Virol. 1999;73:2886-2892.
    • (1999) J Virol , vol.73 , pp. 2886-2892
    • Zufferey, R.1    Donello, J.E.2    Trono, D.3    Hope, T.J.4
  • 29
    • 0034657848 scopus 로고    scopus 로고
    • Locus control region activity by 5′HS3 requires a functional interaction with beta-globin gene regulatory elements: Expression of novel beta/gamma-globin hybrid transgenes
    • Rubin JE, Pasceri P, Wu X, Leboulch P, Ellis J. Locus control region activity by 5′HS3 requires a functional interaction with beta-globin gene regulatory elements: expression of novel beta/gamma-globin hybrid transgenes. Blood. 2000;95:3242-3249.
    • (2000) Blood , vol.95 , pp. 3242-3249
    • Rubin, J.E.1    Pasceri, P.2    Wu, X.3    Leboulch, P.4    Ellis, J.5
  • 30
    • 0032523073 scopus 로고    scopus 로고
    • An in vitro model of human red blood cell production from hematopoietic progenitor cells
    • Malik P, Fisher TC, Barsky LL, et al. An in vitro model of human red blood cell production from hematopoietic progenitor cells. Blood. 1998;91:2664-2671.
    • (1998) Blood , vol.91 , pp. 2664-2671
    • Malik, P.1    Fisher, T.C.2    Barsky, L.L.3
  • 31
    • 0030931963 scopus 로고    scopus 로고
    • Stable and efficient gene transfer into the retina using an HIV-based lentiviral vector
    • Miyoshi H, Takahashi M, Gage FH, Verma IM. Stable and efficient gene transfer into the retina using an HIV-based lentiviral vector. Proc Natl Acad Sci U S A. 1997;94:10319-10323.
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 10319-10323
    • Miyoshi, H.1    Takahashi, M.2    Gage, F.H.3    Verma, I.M.4
  • 32
    • 0031949085 scopus 로고    scopus 로고
    • Genetic treatment of severe hemoglobinopathies: The combat against transgene variegation and transgene silencing
    • Rivella S, Sadelain M. Genetic treatment of severe hemoglobinopathies: the combat against transgene variegation and transgene silencing. Semin Hematol. 1998;35:112-125.
    • (1998) Semin Hematol , vol.35 , pp. 112-125
    • Rivella, S.1    Sadelain, M.2
  • 33
    • 0028903814 scopus 로고
    • Identification of a major positive regulatory element located 5′ to the human zeta-globin gene
    • Sabath DE, Koehler KM, Yang WQ, Patton K, Stamatoyannopoulos G. Identification of a major positive regulatory element located 5′ to the human zeta-globin gene. Blood. 1995;85:2587-2597.
    • (1995) Blood , vol.85 , pp. 2587-2597
    • Sabath, D.E.1    Koehler, K.M.2    Yang, W.Q.3    Patton, K.4    Stamatoyannopoulos, G.5
  • 34
    • 0028927084 scopus 로고
    • Functional roles of in vivo footprinted DNA motifs within an alpha-globin enhancer: Erythroid lineage and developmental stage specificities
    • Zhang Q, Rombel I, Reddy GN, Gang JB, Shen CK. Functional roles of in vivo footprinted DNA motifs within an alpha-globin enhancer: erythroid lineage and developmental stage specificities. J Biol Chem. 1995;270:8501-8505.
    • (1995) J Biol Chem , vol.270 , pp. 8501-8505
    • Zhang, Q.1    Rombel, I.2    Reddy, G.N.3    Gang, J.B.4    Shen, C.K.5
  • 35
    • 0032170660 scopus 로고    scopus 로고
    • Development of a condensed locus control region cassette and testing in retrovirus vectors for A gamma-globin
    • Emery DW, Chen H, Li Q, Stamatoyannopoulos G. Development of a condensed locus control region cassette and testing in retrovirus vectors for A gamma-globin. Blood Cells Mol Dis. 1998;24:322-339.
    • (1998) Blood Cells Mol Dis , vol.24 , pp. 322-339
    • Emery, D.W.1    Chen, H.2    Li, Q.3    Stamatoyannopoulos, G.4
  • 36
    • 0033541517 scopus 로고    scopus 로고
    • Analysis of gamma-globin expression cassettes in retrovirus vectors
    • Emery DW, Morrish F, Li Q, Stamatoyannopoulos G. Analysis of gamma-globin expression cassettes in retrovirus vectors. Hum Gene Ther. 1999;10:877-888.
    • (1999) Hum Gene Ther , vol.10 , pp. 877-888
    • Emery, D.W.1    Morrish, F.2    Li, Q.3    Stamatoyannopoulos, G.4
  • 37
    • 0029984381 scopus 로고    scopus 로고
    • Production of genetically stable high-titer retroviral vectors that carry a human gamma-globin gene under the control of the alpha-globin locus control region
    • Ren S, Wong BY, Li J, Luo XN, Wong PM, Atweh GF. Production of genetically stable high-titer retroviral vectors that carry a human gamma-globin gene under the control of the alpha-globin locus control region. Blood. 1996;87:2518-2524.
    • (1996) Blood , vol.87 , pp. 2518-2524
    • Ren, S.1    Wong, B.Y.2    Li, J.3    Luo, X.N.4    Wong, P.M.5    Atweh, G.F.6
  • 40
    • 0027283593 scopus 로고
    • Role of upstream DNase I hypersensitive sites in the regulation of human alpha globin gene expression
    • Sharpe JA, Summerhill RJ, Vyas P, Gourdon G, Higgs DR, Wood WG. Role of upstream DNase I hypersensitive sites in the regulation of human alpha globin gene expression. Blood. 1993;82:1666-1671.
    • (1993) Blood , vol.82 , pp. 1666-1671
    • Sharpe, J.A.1    Summerhill, R.J.2    Vyas, P.3    Gourdon, G.4    Higgs, D.R.5    Wood, W.G.6
  • 41
    • 0030758620 scopus 로고    scopus 로고
    • Analysis of enhancer function of the HS-40 core sequence of the human alpha-globin cluster
    • Chen H, Lowrey CH, Stamatoyannopoulos G. Analysis of enhancer function of the HS-40 core sequence of the human alpha-globin cluster. Nucleic Acids Res. 1997;25:2917-2922.
    • (1997) Nucleic Acids Res , vol.25 , pp. 2917-2922
    • Chen, H.1    Lowrey, C.H.2    Stamatoyannopoulos, G.3
  • 42
    • 0026742198 scopus 로고
    • A single beta-globin locus control region element (5′ hypersensitive site 2) is sufficient for developmental regulation of human globin genes in transgenic mice
    • Morley BJ, Abbott CA, Sharpe JA, Lida J, ChanThomas PS, Wood WG. A single beta-globin locus control region element (5′ hypersensitive site 2) is sufficient for developmental regulation of human globin genes in transgenic mice. Mol Cell Biol. 1992;12:2057-2066.
    • (1992) Mol Cell Biol , vol.12 , pp. 2057-2066
    • Morley, B.J.1    Abbott, C.A.2    Sharpe, J.A.3    Lida, J.4    ChanThomas, P.S.5    Wood, W.G.6
  • 43
    • 0026091926 scopus 로고
    • Protein-DNA interactions in vivo of an erythroid-specific, human beta-globin locus enhancer
    • Reddy PM, Shen CK. Protein-DNA interactions in vivo of an erythroid-specific, human beta-globin locus enhancer. Proc Natl Acad Sci U S A. 1991;88:8676-8680.
    • (1991) Proc Natl Acad Sci U S A , vol.88 , pp. 8676-8680
    • Reddy, P.M.1    Shen, C.K.2
  • 44
    • 0027475324 scopus 로고
    • Erythroid differentiation of mouse erythroleukemia cells results in reorganization of protein-DNA complexes in the mouse beta maj globin promoter but not its distal enhancer
    • Reddy PM, Shen CK. Erythroid differentiation of mouse erythroleukemia cells results in reorganization of protein-DNA complexes in the mouse beta maj globin promoter but not its distal enhancer. Mol Cell Biol. 1993;13:1093-1103.
    • (1993) Mol Cell Biol , vol.13 , pp. 1093-1103
    • Reddy, P.M.1    Shen, C.K.2
  • 45
    • 0028303758 scopus 로고
    • Mutagenesis of retroviral vectors transducing human beta-globin gene and beta-globin locus control region derivatives results in stable transmission of an active transcriptional structure
    • Leboulch P, Huang GM, Humphries RK, et al. Mutagenesis of retroviral vectors transducing human beta-globin gene and beta-globin locus control region derivatives results in stable transmission of an active transcriptional structure. EMBO J. 1994;13:3065-3076.
    • (1994) EMBO J , vol.13 , pp. 3065-3076
    • Leboulch, P.1    Huang, G.M.2    Humphries, R.K.3
  • 46
    • 0028949176 scopus 로고
    • Retroviral transfer of a human beta-globin/delta-globin hybrid gene linked to beta locus control region hypersensitive site 2 aimed at the gene therapy of sickle cell disease
    • Takekoshi KJ, Oh YH, Westerman KW, London IM, Leboulch P. Retroviral transfer of a human beta-globin/delta-globin hybrid gene linked to beta locus control region hypersensitive site 2 aimed at the gene therapy of sickle cell disease. Proc Natl Acad Sci U S A. 1995;92:3014-3018.
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 3014-3018
    • Takekoshi, K.J.1    Oh, Y.H.2    Westerman, K.W.3    London, I.M.4    Leboulch, P.5
  • 47
    • 0343628721 scopus 로고    scopus 로고
    • Therapeutic haemoglobin synthesis in beta-thalassaemic mice expressing lentivirus-encoded human betaglobin
    • May C, Rivella S, Callegari J, et al. Therapeutic haemoglobin synthesis in beta-thalassaemic mice expressing lentivirus-encoded human betaglobin. Nature. 2000;406:82-86.
    • (2000) Nature , vol.406 , pp. 82-86
    • May, C.1    Rivella, S.2    Callegari, J.3
  • 48
    • 0033525852 scopus 로고    scopus 로고
    • A human beta-spectrin gene promoter directs high level expression in erythroid but not muscle or neural cells
    • Gallagher PG, Sabatino DE, Romana M, et al. A human beta-spectrin gene promoter directs high level expression in erythroid but not muscle or neural cells. J Biol Chem. 1999;274:6062-6073.
    • (1999) J Biol Chem , vol.274 , pp. 6062-6073
    • Gallagher, P.G.1    Sabatino, D.E.2    Romana, M.3
  • 49
    • 0031796378 scopus 로고    scopus 로고
    • Substitution of the human beta-spectrin promoter for the human agamma-globin promoter prevents silencing of a linked human beta-globin gene in transgenic mice
    • Sabatino DE, Cline AP, Gallagher PG, et al. Substitution of the human beta-spectrin promoter for the human agamma-globin promoter prevents silencing of a linked human beta-globin gene in transgenic mice. Mol Cell Biol. 1998;18:6634-6640.
    • (1998) Mol Cell Biol , vol.18 , pp. 6634-6640
    • Sabatino, D.E.1    Cline, A.P.2    Gallagher, P.G.3
  • 50
    • 0021605962 scopus 로고
    • Assembly and topogenesis of the spectrin-based membrane skeleton in erythroid development
    • Lazarides E, Moon RT. Assembly and topogenesis of the spectrin-based membrane skeleton in erythroid development. Cell. 1984;37:354-356.
    • (1984) Cell , vol.37 , pp. 354-356
    • Lazarides, E.1    Moon, R.T.2
  • 51
    • 0034665986 scopus 로고    scopus 로고
    • A minimal ankyrin promoter linked to a human gamma-globin gene demonstrates erythroid specific copy number dependent expression with minimal position or enhancer dependence in transgenic mice
    • Sabatino DE, Wong C, Cline AP, et al. A minimal ankyrin promoter linked to a human gamma-globin gene demonstrates erythroid specific copy number dependent expression with minimal position or enhancer dependence in transgenic mice. J Biol Chem. 2000;15:28549-28554.
    • (2000) J Biol Chem , vol.15 , pp. 28549-28554
    • Sabatino, D.E.1    Wong, C.2    Cline, A.P.3
  • 52
    • 0029044417 scopus 로고
    • Role of the hepatitis B virus posttranscriptional regulatory element in export of intronless transcripts
    • Huang ZM, Yen TS. Role of the hepatitis B virus posttranscriptional regulatory element in export of intronless transcripts. Mol Cell Biol. 1995;15:3864-3869.
    • (1995) Mol Cell Biol , vol.15 , pp. 3864-3869
    • Huang, Z.M.1    Yen, T.S.2
  • 53
    • 0034700114 scopus 로고    scopus 로고
    • Long-term expression of gamma-globin mRNA in mouse erythrocytes from retrovirus vectors containing the human gamma-globin gene fused to the ankyrin-1 promoter
    • Sabatino DE, Seidel NE, Aviles-Mendoza GJ, et al. Long-term expression of gamma-globin mRNA in mouse erythrocytes from retrovirus vectors containing the human gamma-globin gene fused to the ankyrin-1 promoter. Proc Natl Acad Sci U S A. 2000;97:13294-13299.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 13294-13299
    • Sabatino, D.E.1    Seidel, N.E.2    Aviles-Mendoza, G.J.3
  • 54
    • 4243488897 scopus 로고    scopus 로고
    • Successful gene therapy in a murine model of erythropoietic protoporphyria with a self inactivating erythroid-specific lentiviral vector
    • Moreau-Gaudry F, Richard E, Xia P, et al. Successful gene therapy in a murine model of erythropoietic protoporphyria with a self inactivating erythroid-specific lentiviral vector [abstract]. Blood. 2000;96:590a.
    • (2000) Blood , vol.96
    • Moreau-Gaudry, F.1    Richard, E.2    Xia, P.3


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