NF-κB activation is required for C5a-induced interleukin-8 gene expression in mononuclear cells

Blood

Volumn 93, Issue 10, 1999, Pages 3241-3249

  Hsu, Matthew H ^b   Wang, Meiying ^b   Browning, Darren D ^b   Mukaida, Naofumi ^b   Ye, Richard D ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENT COMPONENT C5A; DNA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; INTERLEUKIN 6; INTERLEUKIN 8; MESSENGER RNA; PERTUSSIS TOXIN; RECOMBINANT PROTEIN; TRANSCRIPTION FACTOR AP 1;

ADENOSINE DIPHOSPHATE RIBOSYLATION; ANIMAL CELL; ARTICLE; CALCIUM MOBILIZATION; CELL STIMULATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE PRODUCTION; GENE EXPRESSION; GENE INDUCTION; HUMAN; HUMAN CELL; MOLECULAR DYNAMICS; MONONUCLEAR CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DETERMINATION; PROTEIN DNA BINDING; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REPORTER GENE; SITE DIRECTED MUTAGENESIS; ANIMAL; BIOSYNTHESIS; CELL LINE; CELL NUCLEUS; CYTOSOL; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; GENETICS; IMMUNOLOGY; KINETICS; METABOLISM;

ANIMALS; CELL LINE; CELL NUCLEUS; COMPLEMENT C5A; CYTOSOL; GENE EXPRESSION REGULATION; GENES, REPORTER; HUMANS; INTERLEUKIN-8; KINETICS; LEUKOCYTES, MONONUCLEAR; MICE; NF-KAPPA B; RECOMBINANT PROTEINS; TRANSCRIPTION FACTOR AP-1; TRANSCRIPTION, GENETIC; TRANSFECTION;

EID: 0033561796     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v93.10.3241.410k02_3241_3249     Document Type: Article

References (42)

1. Cochrane CG, Muller-Eberhard HJ: The derivation of two distinct anaphylatoxin activities from the third and fifth components of human complement. J Exp Med 127:368, 1968
2. Goldstein IM: Complement: Biologically active products, in Gallin JI, Goldstein IM, Snyderman R (eds): Inflammation: Basic Principles and Clinical Correlates. New York, NY, Raven, 1988, p 55
3. Hugli TE, Muller-Eberhard HJ: Anaphylatoxins C3a and C5a. Adv Immunol 26:26, 1978
4. Chenoweth DE, Goodman MG, Hugli TE: Demonstration of specific C5a receptors on intact human polymorphonuclear leukocytes. Proc Natl Acad Sci USA 75:3943, 1978
5. Gerard C, Gerard NP: C5a anaphylatoxin and its seven transmembrane-segment receptor. Annu Rev Immunol 12:775, 1994
6. Haviland DL, McCoy RL, Whitehead WT, Akama H, Molmenti EP, Brown A, Haviland JC, Parks WC, Perlmutter DH, Wetsel RA: Cellular expression of the C5a anaphylatoxin receptor (C5aR): Demonstration of C5aR on nonmyeloid cells of the liver and lung. J Immunol 154:1861, 1995
7. Buchner RR, Hugli TE, Ember JA, Morgan EL: Expression of functional receptors for human C5a anaphylatoxin (CD88) on the human hepatocellular carcinoma cell line HepG2. J Immunol 155:308, 1995
8. Gasque P, Fontaine M, Morgan BP: Complement expression in human brain. J Immunol 154:4726, 1995
9. Lacy M, Jones J, Whittemore SR, Haviland DL, Wetsel RA, Barnum SR: Expression of the receptors for the C5a anaphylatoxin, interleukin-8 and FMLP by human astrocytes and microglia. J Neuroimmunol 61:71, 1995
10. Gerard NP, Gerard C: The chemotactic receptor for human C5a anaphylatoxin. Nature 349:614, 1991
11. Boulay F, Mery L, Tardif M, Brauchen L, Vignais P: Expression cloning of a receptor for C5a anaphylatoxin on diffrentiated HL-60 cells. Biochemistry 30:2993, 1991
12. Gerard C, Bao L, Orozco O, Pearson M, Kunz D, Gerard NP: Structural diversity in the extracellular faces of peptidergic G-protein-coupled receptors. Molecular cloning of the mouse C5a anaphylatoxin receptor. J Immunol 149:2600, 1992
13. Perret JJ, Raspe E, Vassart G, Parmentier M: Cloning and functional expression of the canine anaphylatoxin C5a receptor. Evidence for high interspecies variability. Biochem J 288:911, 1992
14. Murphy PM: The molecular biology of leukocyte chemoattractant receptors. Annu Rev Immunol 12:593, 1994
15. Hopken UE, Lu B, Gerard NP, Gerard C: The C5a chemoattractant receptor mediates mucosal defense to infection. Nature 383:86, 1996
16. Schindler R, Gelfand JA, Dinarello CA: Recombinant C5a stimulates transcription rather than translation of interleukin-1 (IL-1) and tumor necrosis factor: Translational signal provided by lipopolysaccharide or IL-1 itself. Blood 76:1631, 1990
17. Gross V, Andus T: Human recombinant C5a enchances lipopolysaccharide-induced synthesis of interleukin-6 by human monocytes. Eur J Clin Invest 22:271, 1992
18. Okusawa S, Dinarello CA, Yancy KB, Endres S, Lawley TJ, Frank MM, Burke JF, Gelfand JA: C5a induction of human interleukin 1. Synergistic effect with endotoxin or interferon gamma. J Immunol 8:2635, 1987
19. Foreman KE, Vaporciyan AA, Bonish BK, Jones ML, Johnson KJ, Glovsky MM, Eddy SM, Ward PA: C5a-induced expression of P-selectin in endothelial cells. J Clin Invest 94:1147, 1994
20. Hopken UE, Lu B, Gerard NP, Gerard C: Impaired inflammatory responses in the reverse Arthus reaction through genetic deletion of the C5a receptor. J Exp Med 186:749, 1997
21. Okusawa S, Yancy KB, van der Meer JWM, Endres S, Lonnemann G, Hefterr K, Frank MM, Burke JF, Dinarello CA, Gelfand JA: C5a stimulates secretion of tumor necrosis factor from human mononuclear cells in vitro. J Exp Med 168:443, 1988
22. Ember JA, Sanderson SD, Hugli TE, Morgan EL: Induction of interleukin-8 synthesis from monocytes by human C5a anaphylatoxin. Am J Pathol 144:393, 1994
23. Holmes WE, Lee J, Kuang W-J, Rice GC, Wood WI: Structure and functional expression of a human interleukin-8 receptor. Science 253:1278, 1991
24. Murphy PM, Tiffany HL: Cloning of complementary DNA encoding a functional human interleukin-8 receptor. Science 253:1280, 1991
25. Koch AE, Polverini PJ, Kunkel SL, Harlow LA, DiPietro LA, Einer VM, Einer SG, Strieter RM: Interleukin-8 as a macrophagederived mediator of angiogenesis. Science 258:1798, 1992
26. Mukaida N, Monta M, Ishikawa Y, Rice N, Okamoto S, Kasahara T, Matsushima K: Novel mechanism of glucocotticoidmediated gene repression. Nuclear factor-kappa B is target for glucocorticoid-mediated interleukin 8 gene repression. J Biol Chem 269:13289, 1994
27. Mukaida N, Shiroo M, Matsushima K: Genomic structure of the human monocyte-derived neutrophil chemotactic factor IL-8. J Immunol 142:1366, 1989
28. Mukaida N, Mahe Y, Matsushima K: Cooperative interaction of nuclear factor-kappaB- and cis-regulatory enhancer binding protein-like factor binding elements in activating the interleukin-8 gene by proinflammatory cytokines. J Biol Chem 265:21128, 1990
29. Baeuerle PA, Henkel T: Function and activation of NF-kB in the immune system. Annu Rev Immunol 32:141, 1994
30. Chiao PJ, Miyamoto S, Verma IM: Autoregulation of IkB-alpha activity. Proc Natl Acad Sci USA 91:28, 1994
31. Baeuerle PA, Baltimore D: IkB: A specific inhibitor of the NF-kB transcription factor. Science 242:540, 1988
32. Ghosh S, Baltimore D: Activation in vitro of NF-kB by phosphorylation of its inhibitor IkB. Nature 344:678, 1990
33. Henkel T, Machleidt T, Alkalay I, Kranke M, Ben-Neriah Y, Baeuerle PA: Rapid proteolysis of IkB-alpha is necessary for activation of transcription factor NF-kB. Nature 365:182, 1993
34. Van Antwerp D, Martin SJ, Kafri T, Green DR, Verma IM: Suppression of TNF-alpha induced apoptosis by NF-kB. Science 274:787, 1996
35. Rollins TE, Siciliano S, Kobayashi S, Cianciarulo DN, Bonilla-Argudo V, Collier K, Springer MS: Purification of the active C5a receptor from human polymorphonuclear leukocytes as a receptor-Gi complex. Proc Natl Acad Sci USA 88:971, 1991
36. Amatruda TT, Steel DA, Slepak VZ, Simon MI: G alpha 16, a G protein alpha subunit specifically expressed in hematopoietic cells. Proc Natl Acad Sci USA 88:5587, 1991
37. Amatruda TT, Gerard NP, Gerard C, Simon MI: Specific interactions of chemoattractant factor receptors with G proteins. J Biol Chem 268:10139, 1993
38. Buhl AM, Eisfelder BJ, Worthen GS, Johnson GL, Russell M: Selective coupling of the human anaphylatoxin C5a receptor and alpha 16 in human kidney 293 cells. FEBS Lett 323:132, 1993
39. Prossnitz ER, Quehenberger O, Cochrane CG, Ye RD: Transmembrane signalling by the N-formyl peptide receptor in stably transfected fibroblasts. Biochem Biophys Res Commun 179:471, 1991
40. Mukaida N, Okamoto S, Ishikawa Y, Matsushima K: Molecular mechanism of interleukin-8 gene expression. J Leukoc Biol 56:554, 1994
41. Mastronarde JG, Monick MM, Mukaida N, Matsushima K, Hunninghake GW: Activator protein-1 is the preferred transcription factor for cooperative interaction with nuclear factor-kappa B in respiratory syncytial virus-induced interleukin-8 gene expression in airway epithelium. J Infect Dis 177:1275, 1998
42. Murayama T, Ohara Y, Obuchi M, Khabar KS, Higashi H, Mukaida N, Matsushima K: Human cytomegalovirus induces interleukin-8 production by a human monocytic cell line, THP-1, through acting concurrently on AP-1- and NF-kappaB-binding sites of the interleukin-8 gene. J Virol 71:5692, 1997