Recombinant Gram-positive bacteria as vehicles of vaccine antigens

Biotechnology Annual Review

Volumn 3, Issue C, 1997, Pages 297-312

  Medaglini, Donata ^a   Ricci, Susanna ^a   Maggi, Tiziana ^a   Rush, Catherine M ^a   Manganelli, Riccardo ^a   Oggioni, Marco R ^a   Pozzi, Gianni ^a,b  

^a UNIVERSITY OF SIENA   (Italy)

^b UNIVERSITY OF CAGLIARI   (Italy)

Author keywords

Gram positive bacteria; mucosal vaccine delivery; vaccine vectors

Indexed keywords

EID: 0000451123     PISSN: 13872656     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S1387-2656(08)70038-3     Document Type: Article

References (64)

1. McGhee J.R., and Mestecky J. In defence of mucosal surfaces: development of novel vaccines for IgA responses protective at the portals of entry of microbial pathogens. Infect Dis Clinics North Am. 4 (1990) 315-341
2. Gregoriadis G. Engineering liposomes for drug delivery: progress and problems. Trends Biotechnol 13 (1995) 527-537
3. Alving C.R., Koulchin V., Glenn G.M., and Rao M. Liposomes as carriers of peptide antigens: induction of antibodies and cytotoxic T lymphocytes to conjugated and unconjugated peptides. Immunol Rev 145 (1995) 5-31
4. Sjolander A., Lovgren-Bengtsson K., Johansson M., and Morein B. Kinetics, localisation and isotype profile of antibody responses to immune stimulating complexes (ISCOMS) containing human influenza virus envelope glycoproteins. Scand J Immunol. 43 (1996) 164-172
5. Maloy K.J., Donachie A.M., and Mowat A.M. Induction of Th1 and Th2 CD4+ T cell responses by oral or parenteral immunisation with ISCOMS. Eur J Immunol 25 (1995) 2835-2841
6. Jenkins P.G., Coombes A.G., Yeh M.K., Thomas N.W., and Davis S.S. Aspects of the design and delivery of microparticles for vaccine applications. J Drug Target 3 (1995) 79-81
7. Russell-Jones G.J. Oral vaccination with lectin and lectin-like molecules. In: O'Hagan D.T. (Ed). Novel Delivery Systems for Oral Vaccine (1994), CRC Press, New York
8. Lintermans P., and De Greve H. Live bacterial vectors for mucosal immunisatioa. Adv Drug Deliver Rev 18 (1995) 73-89
9. Oggioni M.R., Manganelli R., Contorni M., Tommasino M., and Pozzi G. Immunisation of mice by oral colonization with live recombinant commensal streptococci. Vaccine 13 (1995) 775-780
10. Wells J.M., Robinson K., Chamberlain L.M., Schofield K.M., and Le Page R.W.F. Lactic acid bacteria as vaccine delivery vehicles. Antonie van Leeuwenhoek 70 (1996) 317-330
11. Graheam F.L., and Prevec L. Adenovirus-based expression vectors and recombinant vaccines. Biotechnology 20 (1992) 363-390
12. Alexander L., Lu H.-H., Gromeier M., and Wimmer E. Dicistronic polioviruses expression vectors for foreign genes. AIDS Res Hum Retrovirus 10 Suppl 2 (1994) S57-S60
13. Cox D.S., and Taubman M.A. Oral induction of the secretory antibody response by soluble and particulate antigens. Int Arch Allergy Appl Immunol 74 (1984) 249
14. Dahlgren U.I.H., Wold A.E., Hanson L.A., and Midtvedt T. Expression of a dietary protein in E. coli renders it strongly antigenic to gut lymphoid tissue. Immunology 73 (1991) 394-397
15. Yasutomi Y., Koenig S., and Haun S.S. Immunisation with recombinant BCG-SIV elicits SIV-specific cytotoxic T lymphocytes in rhesus monkeys. J Immunol 150 (1993) 3101-3107
16. Roberts M., Chatfield S.N., and Dougan G. Salmonella as carriers of heterologous antigens. In: O'Hagan (Ed). Novel Delivery Systems for Oral Vaccines (1994), CRC Press, New York 27-58
17. Gicquel B. BCG as a vector for the construction of multivalent recombinant vaccines. Biologicals 23 (1995) 113-118
18. Mekalanos J.J. Live bacterial vaccines: environmental aspects. Curr Opin Biotechnol 5 (1994) 312-319
19. Pozzi G, Streptococci as live vectors of recombinant vaccines. XI Lancefield International Symposium on Streptococci and Streptococcal Diseases, Siena, 1990; 33(Abstract L34).
20. Pozzi G., Contorni M., Oggioni M.R., Manganelli R., Tommasino M., Cavalieri F., and Fischetti V.A. Delivery and expression of a heterologous antigen on the surface of streptococci. Infect Immun 60 (1992) 1902-1907
21. Hansson M., Ståhl S., Nguyen T.N., Bachi T., Robert A., Binz H., Sjolander A., and Uhlén M. Expression of recombinant proteins on the surface of the coagulase-negative bacterium Staphylococcus xylosus. J Bacterid 174 (1992) 4239-4245
22. Iwaki M., Okahashi N., Takahashi I., Kanamoto T., Sugita-Konishi Y., Aibara K., and Koga T. Oral immunization with recombinant Streptococcus lactis carrying the Streptococcus mutans surface protein antigen gene. Infect Immun 58 (1990) 2929-2934
23. Wells J.M., Wilson P.W., Norton P.M., Gasson M.J., and Le Page R.W.F. Lactococcus lactis high level expression of tetanus toxin fragment C and protection against lethal challenge. Molec Microbiol 8 (1993) 1155-1162
24. Pozzi G., Oggioni M.R., Manganelli R., and Fischetti V.A. Surface expression of M6 protein in Streptococcus gordonii Challis after transcriptional fusion with chromosomal promoters. Res Microbiol 143 (1992) 449-459
25. Pozzi G., Oggioni M.R., Manganelli R., Medaglini D., Fischetti V.A., Fenoglio D., Valle M.T., Kunkl A., and Manca F. Recognition by human T helper cells of an immunodominant epitope of HIV-1 gp120 expressed on the surface of Streptococcus gordonii. Vaccine 12 (1994) 1071-1076
26. Oggioni M.R., Medaglini D., Contorni M., Cavalieri F., and Pozzi G. Expression of fusion proteins in the naturally transformable Streptococcus gordonii (Streptococcus sanguis) Challis. In: DBalla E., Berencsi G., and Szentirmai A. (Eds). DNA Transfer and Gene Expression in Microorganisms (1993), Intercept Ltd., Andover 235-240
27. Medaglini D., Oggioni M.R., Contorni M., Cavalieri F., and Pozzi G. Secretion of heterologous proteins in Streptococcus gordonii (Streptococcus sanguis) Challis. In: DBalla E., Berencsi G., and Szentirmai A. (Eds). DNA Transfer and Gene Expression in Microorganisms (1993), Intercept Ltd., Andover 263-268
28. Oggioni M.R., and Pozzi G. A host-vector system for heterologous gene expression in Streptococcus gordonii. Gene 169 (1996) 85-90
29. Nguyen T.N., Hansson M., Ståhl S., Bachi T., Robert A., Domzig W., Binz H., and Uhlén M. Cellsurface display of heterologous epitopes on Staphylococcus xylosus as a potential delivery system for oral vaccination. Gene 128 (1993) 89-94
30. Samuelson P., Hansson M., Ahlborg N., Andreoni C., Gotz F., Bachi T., Nguyen T.N., Binz H., Uhlén M., and Ståhl S. Cell surface display of recombinant proteins on Staphylococcus carnosus. J Bacteriol 177 (1995) 1470-1476
31. Wells J.M., Norton P.M., and Le Page R.W.F. Progress in development of mucosal vaccines based on Lactococcus lactis. Int Diary J 5 (1995) 1071-1079
32. Chamberlain L.M., Wells J.M., Robinson K., Schofield K.M., and Le Page R.W.F. Mucosal immunization with recombinant Lactococcus lactis. In: Pozzi G., and Wells J.M. (Eds). Gram-Positive Bacteria as Vaccine Vehicles for Mucosal Immunization (1997), Biotechnology Intelligence Unit, Landes, Austin: RG 83-106
33. Powels P.H., and Leer R.J. Genetic of Lactobacilli: plasmid and gene expression. Antonie van Leeuwenhoek 64 (1993) 85-107
34. Rush CM, Antigen delivery to the female reproductive tract using recombinant Lactobacillus. PhD thesis. Qeensland University of Technology, Brisbane, Australia, 1994.
35. Mercenier A, Dutot P, Kleinpeter P, Aguirre M, Pris P, Rejmund J, Slos P, Development of lactic acid bacteria as live vectors for oral and local vaccines. Adv Food Sci (In press).
36. Hols P, Slos P, Reymund J, Ferain T, Delplace B, Mercenier A, Delcour J, Evaluation of genetic expression and secretion cartridges suitable for topical delivery of mucosal antigens by Lactobacillus sp. European Commission Conference on Lactic Acid Bacteria, Cork, Ireland, 1995; (Abstract No. pA-7).
37. Dutot P, Evaluation des lactobacilles comme vecteurs de vaccination. PhD thesis, Université Louis Pasteur, Strasbourg, France, 1996.
38. Rush C.M., Mercenier A., and Pozzi G. Expression of vaccine antigens in Lactobacillus. In: Pozzi G., and Wells J.M. (Eds). Gram-Positive Bacteria as Vaccine Vehicles for Mucosal Immunization (1997), Biotechnology Intelligence Unit., Landes, Austin: RG 107-144
39. Shafer R., Portnoy D.A., Brassel S.A., and Paterson Y. Induction of a cellular immune response to a foreign antigen by a recombinant Listeria monocytogenes vaccine. J Immunol 149 (1992) 53-59
40. Ikonomidis G., Paterson Y., Kos F.J., and Portnoy D.A. Delivery of a viral antigen to the class I processing and presentation pathway by Listeria monocytogenes. J Exp Med 180 (1994) 2209-2218
41. Goossens P.L., Milon G., Cossart P., and Saron M.F. Attenuated Listeria monocytogenes as live vector for induction of CD8+ T cells in vivo: a study with the nucleoprotein of the lymphocytic choriomeningitis virus. Int Immunol. 7 (1995) 797-805
42. Shen H., Slifka M.K., Matloubian M., Jansen E.R., Ahmed R., and Miller J.F. Recombinant Listeria monocytogenes as live vaccine vehicle for the induction of protective anti-viral cell-mediated immunity. Proc Natl Acad Sci USA 92 (1995) 3987-3991
43. Guzman C., Weiss S., and Chakraborty T. Listeria monocytogenes a promising vaccine carrier to evoke cellular imune responses. In: Pozzi G., and Wells J.M. (Eds). Gram-Positive Bacteria as Vaccine Vehicles for Mucosal Immunisation (1997), Biotechnology Intelligence Unit., Landes, Austin: RG 145-174
44. Pozzi G., Musmanno R.A., Lievens P.M.J., Oggioni M.R., Plevani P., and Manganelli R. Method and parameters for genetic transformation of Streptococcus sanguis. Res Microbiol 141 (1990) 659-670
45. Medaglini D, Rush CM, Sestini P, Pozzi G, Commensal bacteria as vehicles for mucosa vaccines against sexually transmitted diseases vaginal colonisation with recombinant streptococci induces local and systemic antibodies in mice. Vaccine 1997; (In press).
46. Pozzi G., Oggioni M.R., and Medaglini D. Recombinant Streptococcus gordonii as live vehicle for vaccine antigens. In: Pozzi G., and Wells J.M. (Eds). Gram-Positive Bacteria as Vaccine Vehicles for Mucosal Immunisation (1997), Biotechnology Intelligence Unit., Landes, Austin: RG 35-60
47. Pozzi G., Oggioni M.R., Manganelli R., and Plevani P. Genetic manipulation of streptococci by chromosomal integration of recombinant DNA. In: Dunny G.M., Cleary P.P., and McKay L.L. (Eds). Genetics and Molecular Biology of Streptococci, Lactococci, and Enterococci (1991), American Society for Microbiology, Washington DC 59-61
48. Ricci S, Rush CM, Medaglini D, Marcello A, Palu G, Pozzi G, Expression of the Escherichia coli heat labile toxin subunit B in Streptococcus gordonii. XII European Meeting on Bacterial Gene Transfer and Expression, Siena, Italy, 1996; (Abstract P88).
49. Medaglini D., Pozzi G., King T.P., and Fischetti V.A. Mucosal and systemic immune responses to a recombinant protein expressed on the surface of the oral commensal bacterium Streptococcus gordonii after oral colonisation. Proc Natl Acad Sci USA. 92 (1995) 6868-6872
50. Robert A., Samuelson P., Andreoni C., Bächi T., Uhlén M., Binz H., Nguyen T.N., and Ståhl S. Surface display on staphylococci: a comparative study. FEBS Lett 390 (1996) 327-333
51. Pan Z.K., Ikonomidism G., Pardoll D., and Paterson Y. Regression of established tumors in mice mediated by the oral administration of a recombinant Listeria monocytogenes vaccine. Cancer Res 55 (1995) 4776-4779
52. Pan Z.K., Ikonomidis G., Lazenby A., Pardoll D., and Paterson Y. A recombinant Listeria monocytogenes vaccine expressing a model tumor antigen protects mice against lethal tumor cell challenge and causes regression of established tumors. Nature Med. 1 (1995) 471-477
53. Frankel F.R., Hedge S., Lieberman J., and Paterson Y. Induction of cell-mediated immune responses to human immunodeficiency virus type 1 Gag protein by using Listeria monocytogenes as live vaccine vector. J Immunol. 155 (1995) 4775-4782
54. Wells J.M., Wilson P.W., Norton P.M., and Le Page R.W. A model system for the investigation of heterologous protein secretion pathways in Lactococcus lactis. Appl Environ Microbiol 59 (1993) 3954-3959
55. Nguyen T.N., Gourdon M.-H., Hansson M.A., Robert P., Samuelson C., Libon C., Andreoni P.A., Nygren H., Binz M., Uhlén M., and Ståhl S. Hydrophobicity engineering to facilitate surface display of heterologous gene products on Staphylococcus xylosus. J Biotechnol 47 (1995) 207-219
56. Ståhl S., Samuelson P., Hansson M., Andréoni C., Goetsch L., Libon C., Liljequist S., Guinneriusson E., Binz H., Nguyen T.N., and Uhlén M. Development of non-pathogenic staphylococci as delivery vehicles. In: Pozzi G., and Wells J.M. (Eds). Gram-Positive Bacteria as Vaccine Vehicles for Mucosal Immunization (1997), Biotechnology Intelligence Unit., Landes, Austin: RG 61-81
57. Di Fabio S, Medaglini D, Rush C, Corrias F, Panzini GL, Pace M, Monardo F, Pozzi G, Titti F, Verani P, Recombinant Gram-positive bacteria as delivery system for mucosal vaccines against sexually transmitted diseases (STD) in the primate model. First European Conference on Experimental AIDS Research. Cannes, France, 1996.
58. Robinson K, Chamberlain LM, Schofield KM, Wells JM, Le Page RWF, Oral vaccination of mice with recombinant Lactococcus lactis expressing tetanus toxin fragment C elicits both secretory and protective high-level systemic immune responses. European Commission Conference on Lactic Acid Bacteria, Cork, Ireland, 1995; (Abstract No. pA-6).
59. Pouwels P.H., Leer R.J., and Boersma W.J.A. The potential of Lactobacillus as a carrier for oral immunisation: development and preliminary characterisation of vector systems for targeted delivery of antigens. J Biotechnol. 44 (1996) 183-192
60. Steinman R.M. The dendritic cell system and its role in immunogenicity. Ann Rev Immunol 9 (1991) 271-296
61. Winzler C., Rovere P., Rescigno M., Granucci F., Penna G., Adorini L., Zimmerman V.S., Davoust J., and Ricciardi-Castagnoli P. Maturation stages of mouse dendritic cells in grow-factor dependent long-term cultures. J Exp Med 185 (1997) 1-12
62. Klijn N., Weerkamp A.H., and De Vos W.M. Genetic marking of Lactococcus lactis shows survival in the human gastrointestinal tract. Appl Environ Microbiol 61 (1995) 2771-2774
63. Guzman C.A., Rohde M., Chakraborty T., Domann E., Hudel M., Wehland J., and Timmis K.N. Interaction of Listeria monocytogenes with mouse dendritic cells. Infect Immun 63 (1995) 3665-3673
64. Goossen P.L., and Milon G. Induction of protective CD8+ lymphocytes by an attenuated Listeria monocytogenes act A mutant. Int Immunol 4 (1992) 1415-1421