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Volumn 7, Issue 24, 1997, Pages 3091-3094

Synthesis and cell growth inhibitory properties of substituted (E)-1-phenylbut-1-en-3-ones

Author keywords

[No Author keywords available]

Indexed keywords

1 (4 HYDROXYPHENYL 1 BUTEN 3 ONE; 1 (PENTAFLUOROPHENYL) 1 BUTEN 3 ONE; 1 PHENYL 1 BUTEN 3 ONE DERIVATIVE; CYTOTOXIC AGENT; UNCLASSIFIED DRUG;

EID: 0031455796     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(97)10147-0     Document Type: Article
Times cited : (31)

References (17)
  • 1
    • 0002291265 scopus 로고
    • Human medicinal agents from plants
    • eds. Kinghorn, A. D.; Balandrin, M. F., American Chemical Society, Washington, DC
    • 'Human medicinal agents from plants', eds. Kinghorn, A. D.; Balandrin, M. F.; ACS symposium series, 534, American Chemical Society, Washington, DC, 1993.
    • (1993) ACS Symposium Series , vol.534
  • 7
    • 0026767947 scopus 로고
    • Abe, N.; Fujisaki, F.; Sumoto, K.; Miyano, S. Chem. Pharm. Bull., 1991, 39, 1167-1170; Dhawan, D.; Grover, S. K. Synth. Commun., 1992, 22, 2405-2409.
    • (1992) Synth. Commun. , vol.22 , pp. 2405-2409
    • Dhawan, D.1    Grover, S.K.2
  • 8
    • 0344651918 scopus 로고    scopus 로고
    • note
    • Method A: A mixture of the substituted benzaldehyde 5 (10 mmol), acetone (20 ml) and 10% aqueous sodium hydroxide (20 ml) was left to stand at ambient temperature overnight. Water was added and the mixture was extracted with chloroform, dried over anhydrous magnesium sulfate, filtered, evaporated in vacuo and recrystallised to give the trans-phenylbutenone 4.
  • 10
    • 0344220442 scopus 로고    scopus 로고
    • note
    • Method B: Diketene (2 mmol) 6 and bis-(tri-n-butyltin)oxide (2 mmol) were stirred in dry THF (2 ml) under a nitrogen atmosphere at 0 °C for 15 mins. The substituted benzaldehyde 5 (2 mmol) in dry THF (2 ml) and 1,3-dimethyl-3,4,5,6-tetrahydro-2(1)-pyrimidinone (2 mmol) were added and the mixture was stirred for a further 4 hours at 40 °C. Aqueous methanol was added and the mixture was evaporated. The residue was purified by chromatography (silica) and recrystallised from hexane to give the trans-phenylbutenone 4.
  • 11
    • 0344651917 scopus 로고    scopus 로고
    • All compounds were fully characterised and gave the expected spectral and analytical data; Microanalysis confirmed their chemical purity (values for C and H within 0.3%)
    • All compounds were fully characterised and gave the expected spectral and analytical data; Microanalysis confirmed their chemical purity (values for C and H within 0.3%).
  • 12
    • 0345082710 scopus 로고
    • Fluorine in medicine in the 21st century
    • UMIST, UK, April 18-21
    • 'Fluorine in Medicine in the 21st Century', Conference papers, UMIST, UK, April 18-21, 1994.
    • (1994) Conference Papers


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.