Immunodiagnosis of pemphigus and mucous membrane pemphigoid

Acta Odontologica Scandinavica

Volumn 59, Issue 4, 2001, Pages 226-234

  Challacombe, Stephen J ^a   Setterfield, Jane ^b   Shirlaw, Pepe ^b   Harman, Karen ^b   Scully, Crispian ^b   Black, Martin M ^b  

^a GUY S HOSPITAL   (United Kingdom)

^b NONE

Author keywords

Autoantibodies; Basement membrane; Desmogleins; Mucous membrane

Indexed keywords

AUTOANTIGEN; BP180 AUTOANTIGEN; CELL ADHESION MOLECULE; CYTOSKELETON PROTEIN; DESMOGLEIN; DESMOGLEIN 1; DESMOPLAKIN; DSG1 PROTEIN, HUMAN;

BASEMENT MEMBRANE; BULLOUS PEMPHIGOID; DESMOSOME; DIFFERENTIAL DIAGNOSIS; HUMAN; IMMUNOLOGICAL PROCEDURES; IMMUNOLOGY; MOUTH DISEASE; PEMPHIGUS; REVIEW;

AUTOANTIGENS; BASEMENT MEMBRANE; CELL ADHESION MOLECULES; CYTOSKELETAL PROTEINS; DESMOGLEIN 1; DESMOGLEINS; DESMOPLAKINS; DESMOSOMES; DIAGNOSIS, DIFFERENTIAL; HUMANS; IMMUNOLOGIC TESTS; MOUTH DISEASES; PEMPHIGOID, BULLOUS; PEMPHIGUS;

EID: 0035434406     PISSN: 00016357     EISSN: None     Source Type: Journal    
DOI: 10.1080/00016350152509256     Document Type: Article

References (78)

1. Nguyen QD, Foster CS. Cicatricial pemphigoid: diagnosis and treatment. Int Ophthalmol Clin 1996;6:41-60.
2. Ahmed AR, Hombal SM. Cicatricial pemphigoid. Int J Dermatol 1986;25:90-6.
3. Setterfield J, Shirlaw PJ, Kerr-Muir M, Bhogal BS. Morgan PR, Tilling K, et al. Mucous membrane pemphigoid: A dual circulating antibody response with IgG and IgA signifies a more severe and persistent disease. Br J Dermatol 1998;138:602 10.
4. Ahmed AR, Graham J, Jordon RE, Provost TT. Pemphigus: current concepts. Ann Intern Med 1980;92:396-405.
5. Ramirez-Amador VA, Esquivel-Pedraza L, Orozco-Topete R. Frequency of oral conditions in a dermatology clinic. Int J Dermatol 2000;39:501-5.
6. Borradori L, Sonnenberg A. Structure and function of hemidesmosomes: more than simple adhesion complexes. J Invest Dermatol 1999;12:411-8.
7. Buxton RS, Cowin P, Franke WW, Yarrod DR, Green KJ, King IA, et al. Nomenclature of the desmosomal cadherins. J Cell Biol 1993;121:481-3.
8. Shirakata Y, Amagai M, Hanakawa Y, Nishikawa T, Hashimoto K. Lack of mucosal involvement in pemphigus foliaceus may be due to low expression of desmoglein 1. J Invest Dermatol 1998; 110:76-8.
9. Champliaud MF, Lunstrum GP, Rousselle P, Nishiyama T, Keene DR, Burgeson RE. Human amnion contains a novel laminin variant, laminin 7, which like laminin 6, covalently associates with laminin 5 to promote stable epithelial-stromal attachment. J Cell Biol 1996;132:1189-98.
10. Hopkinson SB, Baker SE, Jones JC. Molecular genetic studies of a human epidermal autoantigen (the 180-kD bullous pemphigoid antigen/BP180): identification of functionally important sequences within the BP180 molecule and evidence for an interaction between BP180 and alpha 6 integrin. J Cell Biol 1995;130:117-25.
11. Cozzani E, Cacciapuoti M, Parodi A, Ghohestani R, Rebora A. Desmosomes and their autoimmune pathologies. Eur J Dermatol 2000;10:255-61.
12. Jolliffe DS, Sim-Davis D. Cicatricial pemphigoid in a young girl, Clin Exp Dermatol 1977;2:281-4.
13. Laskaris G, Sklavounou A, Stratigos J. Bullous pemphigoid, cicatricial pemphigoid and pemphigus vulgaris: a comparative clinical survey of 278 cases. Oral Surg Oral Med Oral Pathol 1982;54:656-62.
14. Mondino BJ, Linstone FA. Ocular pemphigoid. Clin Dermatol 1987;5:28-35.
15. Foster CS. Cicatricial pemphigoid. Trans Am Ophthalmol 1986; 84:527-663.
16. Lever WF. Commentary on Brunsting LA, Perry HO. Benign pemphigoid? A report of seven cases with chronic, scarring, herpetiform plaques about the head and neck. Arch Dermatol 1957;75:489-501.
17. Hanson RD, Olsen KD, Rogers RS. Upper aerodigestive tract manifestations of cicatricial pemphigoid. Ann Otol Rhinol Laryngol 1988;97:493-9.
18. Hardy KM, Perry HO, Pingree GC, Kirby TJ. Benign mucous membrane pemphigoid. Arch Dermatol 1971;104:467-75.
19. Zaltas MM, Ahmed R, Foster CS. Association of HLA-DR4 with ocular cicatricial pemphigoid. Curr Eye Res 1989;8:189-93.
20. Ahmed AR, Foster S, Zaltas M, Notani G, Awdeh Z, Alper CA, et al. Association of DQw7 (DQB1*0.301) with ocular cicatricial pemphigoid. Proc Natl Acad Sci USA 1991;88:11579-82.
21. Nayar M, Wojnarowska F, Venning V, Taylor CJ. Association of cicatricial pemphigoid and autoimmunity: is there an immunogenetic basis? J Am Acad Dermatol 1991;25:1011-5.
22. Venning VA, Frith PA, Bron AJ, Millard PR, Wojnarowska F. Mucosal involvement in bullous and cicatricial pemphigoid: a clinical and immunopathological study. Br J Dermatol 1988; 118:7-15.
23. Setterfield J, Theron J, Welsh K, Vaughan R, Shirlaw P, Wojnarowska F, et al. Mucous membrane pemphigoid: HLA DQB1*0301 allele is associated with all clinical sites of involvement and may be linked to anti-basement membrane IgG production. Br J Dermatol 2001;145:406-14.
24. Chan LS, Hammerberg C, Cooper KD. Significantly increased occurrence of HLA-DQB1*0301 allele in patients with ocular cicatricial pemphigoid. J Invest Dermatol 1997;108:129-32.
25. Mondino BJ, Ross AN, Rabin BS, Brown SI. Autoimmune phenomena in ocular cicatricial pemphigoid. Am J Ophthalmol 1983;101:1611-3.
26. Setterfield J, Shirlaw PJ, Bhogal BS, Tilling K, Challacombe SJ, Black MM. Cicatricial pemphigoid: serial titres of circulating IgG and IgA antibasement membrane antibodies correlate with disease activity. Br J Dermatol 1999;140:645-50.
27. Bernard P, Prost C, Aucouturier P, Durepaire N, Denis F, Bonnetblank JM. The subclass distribution of IgG autoantibodies in cicatricial pemphigoid and epidermolysis bullosa acquisita. J Invest Dermatol 1991;97:259-63.
28. Labib RS, Anhalt GJ, Patel HP, Mutasim DF, Diaz LA. Molecular heterogeneity of the bullous pemphigoid antigens as detected by immunoblotting. J Immunol 1986;136:1231-5.
29. Chan LS, Hammerberg C, Cooper KD. Cicatricial pemphigoid: identification of two distinct sets of epidermal antigens by IgA and IgG class circulating antibodies. Arch Dermatol 1990;126: 1466-8.
30. Domloge-Hultsch N, Gammon WR, Briggaman RA, Gil SG, Carter WG, Yancey KB. Epiligrin, the major human keratinocyte integrin ligand, is a target in both an acquired autoimmune and an inherited subepidermal blistering skin disease. J Clin Invest 1992;90:1628-33.
31. Chan LS, Fine JD, Briggaman RA, Woodley DT, Hammerberg C, Drugge RJ, et al. Identification and partial characterization of a novel 105-kDalton lower lamina lucida autoantigen associated with a novel immune-mediated subepidermal blistering disease. J Invest Dermatol 1993;101:262-7.
32. Balding SD, Prost C, Diaz LA, Bernard P, Bedane G, Aberdam D, et al. Cicatricial pemphigoid autoantibodics react with multiple sites on the BP180 extracellular domain. J Invest Dermatol 1996;106:141-6.
33. Bedane C, McMillan JR, Balding SD, Bernard P, Prost C, Bonnetblanc JM, et al. Bullous pemphigoid and cicatricial pemphigoid autoantibodies react with ultrastructurally separable epitopes on the BP180 ectodomain: evidence that BP180 spans the lamina lucida. J Invest Dermatol 1997;108:901-7.
34. Murakami H, Nishioka S, Setterfield J, Bhogal BS, Black MM, Zillikens D, et al. Analysis of antigens targeted by circulating IgG and IgA autoantibodies in 50 patients with cicatricial pemphigoid. J Dermatol Sci 1998;17:39-44.
35. Lish KM, Washenik K, Yancey KB, Yee C, Rico MJ. Antiepiligrin cicatricial pemphigoid in a patient with HIV. J Am Acad Dermatol 1997;36:486-8.
36. Lenz P, Hsu R, Yee C, Yancey K, Volc-Platzer B, Stengl G, et al. Vernarbendesa Pemphigoid mit Autoantikorpern gegen Laminin-5 (Epiligrin) bei einer Patientin mit metastasierendem Endometriumkarzinom. Hautarzt 1998;49:31-5.
37. Fujimoto W, Ishida-Yamamoto A, Hsu R, Nagao Y, Iizuka H, Yancey KB. Anti-epiligrin cicatricial pemphigoid: a case associated with gastric carcinoma and features resembling epidermolysis bullosa acquisita. Br J Dermatol 1998;139:682-7.
38. Setterfield J, Shirlaw PJ, Lazarova Z, Bryant BM, Bhogal BS, Harman K, et al. Paraneoplastic cicatricial pemphigoid. Br J Dermatol 1999;141:127-31.
39. Bhol K, Mohimen A, Neumann R, Yunis J, Foster CS, Yunis EJ, et al. Differences in the anti-basement membrance zone antibodies in ocular and pseudo-ocular cicatricial pemphigoid. Curr Eye Res 1996;15:521-32.
40. Domloge-Hultsch N, Anhalt GJ, Gammon WR, Lazarova Z, Briggaman R, Welch M, et al. Antiepiligrin cicatricial pemphigoid. A subepithelial bullous disorder. Arch Dermatol 1994;130: 1521-9.
41. Smith EP, Taylor TB, Meyer LJ, Zone JJ. Identification of a basement membrane zone antigen reactive with circulating IgA antibody in ocular cicatricial pemphigoid. J Invest Dermatol 1993;101:619-23.
42. Nishikawa T, Hashimoto T, Shimizu H, Ebihara T, Amagai M. Pemphigus from immunofluorescence to molecular biology. J Dermatol Sci 1996;12:1-9.
43. Amagai M. Towards a better understanding of pemphigus autoimmunity. Br J Dermatol 2000;143:237-8.
44. Harman KE, Gratian MJ, Bhogal BS, Challacombe SJ, Black MM The use of two substrates to improve the sensitivity of indirect immunofluorescence in the diagnosis of pemphigus. Br J Dermatol 2000;142:1135-9.
45. Harman KE, Gratian MJ, Bhogal BS, Challacombe SJ, Black, MM. A study of desmoglein 1 autoantibodies in pemphigus vulgaris: racial differences in frequency and the association with a more severe phenotype. Br J Dermatol 2000;143:343-8.
46. Miyagawa S, Amagai M, Iida T, Yamamoto Y, Nishikawa T, Shirai T. Late development of antidesmoglein 1 antibodies in pemphigus vulgaris: correlation with disease progression. Br J Dermatol. 1999;141:1084-7.
47. Harman KE, Seed PT, Gratian MJ, Bhogal BS, Challacombe SJ, Black MM. The severity of cutaneous and oral pemphigus is related to desmoglein 1 and 3 antibody levels. Br J Dermatol 2001;144:775-80.
48. Harman KE, Gratian MJ, Seed PT, Bhogal BS, Challacombe SJ, Black MM. Diagnosis of pemphigus by ELISA: a critical evaluation of two ELISAs for the detection of antibodies to the major pemphigus antigens, desmoglein 1 and 3. Clin Exp Dermatol 2000;25:236-40.
49. Weinberg MA, Insler MS, Campen RB. Mucocutaneous features of autoimmune blistering diseases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1997;84:517-34.
50. Scully, C, Almeida OPD, Porter SR, Gilkes J. Pemphigus vulgaris: the manifestations and long-term management of 55 patients with oral lesions. Br J Dermatol 1999;140:84-9.
51. Virgili A, Thrombelli L, Calura G. Sudden vegetation of the mouth: pemphigus vegetans of the mouth (Hallopeau type). Arch Dermatol 1992;128:398-9, 401-2.
52. Allen CM, Camisa G. Paraneoplastic pemphigus: a review of the literature. Oral Dis 2000;6:208-14.
53. Wong KC, Ho KK. Pemphigus with pemphigoid-like presentation, associated with squamous cell carcinoma of the tongue. Australas J Dermatol 2000;41:178-80.
54. Laskaris G, Papavasiliou S, Bovopoulou O, Nicolis G. Association of oral pemphigus with chronic lymphocytic leukaemia. Oral Surg Oral Med Oral Pathol 1980;2:211-9.
55. Perniciaro G, Kuechle MK, Colon-Otero G, Solberg LA, Cockerill KJ, Hook CC, et al. Paraneoplastic pemphigus: a case of prolonged survival. Mayo Clin Proc 1994;69:851-5.
56. Bialy-Golan A, Brenner S, Anhalt GJ. Paraneoplastic pemphigus: oral involvement as the sole manifestation. Acta Derm Venereol (Stockh) 1996;76:253-4.
57. Kricheli D, David M, Frusic-Zlotkin M, Goldsmith D, Rabinov M, Sulkes J, et al. The distribution of pemphigus vulgaris-IgG subclasses and their reactivity with desmoglein 3 and 1 in pemphigus patients and their first-degree relatives. Br J Dermatol 2000;143:337-42.
58. Loiseau P, Lecleach L, Prost C, Lepage V, Busson M, Bastuji-Garin S, et al. HLA class II polymorphism contributes to specify desmoglein derived peptides in pemphigus vulgaris and pemphigus foliaceus. J Autoimmun 2000;15:67-73.
59. Degaldo JC, Yunis DE, Bozon MV, Salazar M, Deulofeut R, Turbay D, et al. MHC class II alleles and haplotypes in patients with pemphigus vulgaris from India. Tissue Antigens 1996;48: 668-72.
60. Emery DJ, Diaz LA, Fairley JA, Lopez A, Taylor AT, Giudice GJ. Pemphigus foliaceus and pemphigus vulgaris autoantibodies react with the extracellular domain of desmoglein-1. J Invest Dermatol 1995;104:323-8
61. Hertl M. Humoral and cellular autoimmunity in autoimmune bullous skin disorders. Int Arch Allergy Immunol 2000;122:91 100.
62. Seishima M, Iwasaki-Bessho Y, Itoh Y, Nozawa Y, Amagai M, Kitajima Y. Phosphatidylcholine-specific phospholipase C, but not phospholipase D, is involved in pemphigus IgG-induced signal transduction. Arch Dermatol Res 1999;291:606-13.
63. Nguyen VT, Ndoye A, Shultz LD, Pittelkow MR, Grando SA. Antibodies against keratinocyte antigens other than desmogleins 1 and 3 can induce pemphigus vulgaris-like lesions. J Clin Invest 2000;106:1467-79.
64. Hertl M, Riechers R. Analysis of the T cells that are potentially involved in autoantibody production in pemphigus vulgaris. J Dermatol 1999;26:748-52.
65. Toto P, Feliciani C, Amerio P, Suzuki H, Wang B, Shivji GM, et al. Immune modulation in pemphigus vulgaris: role of CD28 and IL-10. J Immunol 2000;164:522-9.
66. Sciubba JJ. Autoimmune aspects of pemphigus vulgaris and mucosal pemphigoid. Adv Dent Res 1996;10:52-6.
67. Zegarelli D, Zegarelli E. Intraoral pemphigus vulgaris. Oral Surg 1977;44:384-93.
68. Orlowski WA, Bressman E, Doyle JL, Chassens AI. Chronic pemphigus vulgaris of the gingiva. J Periodontol 1983;54:685-9.
69. Dobrev H, Popova L, Vlashev D. Proteinase inhibitors and pemphigus vulgaris. An in vitro and in vivo study. Arch Dermatol Res 1996;288:648-55.
70. Proby CM, Ota T, Suzuki H, Koyasu S, Gamou S, Shimizu N, et al. Development of chimeric molecules for recognition and targeting of antigen-specific B cells in pemphigus vulgaris. Br J Dermatol 2000;142:321-30.
71. Grando SA. Autoimmunity to keratinocyte acetylcholine receptors in pemphigus. Dermatology 2000;201:290-5.
72. Sarrett Y, Reano A, Nicolas JF, Su H, Thivolet J. Bullous pemphigoid and cicatricial pemphigoid: immunoblotting detection of involved autoantigens. Autoimmunity 1989;2:145-53.
73. Ghohestani RF, Nicolas JF, Rousselle P, Claudy AL. Identification of a 168-kDa mucosal antigen in a subset of patients with cicatricial pemphigoid. J Invest Dermatol 1996;107:136-9.
74. Haftek M, Zone JJ, Taylor TB, Kowalewski C, Chorzelski TP, Schmitt D. Immunogold localization of the 97-kD antigen of linear IgA bullous dermatosis (LABD) detected with patients' sera. J Invest Dermatol 1994;103:656-9.
75. Anhalt GJ, Kim SC, Stanley JR, Korman NJ, Jabs DA, Kory M, et al. Paraneoplastic pemphigus: an autoimmune mucocutaneous disease associated with neoplasia. N Engl J Med 1990;323:1729-35.
76. Ishii K, Amagai M, Ohata Y, Shimizu H, Hashimoto T, Ohya K, et al. Development of pemphigus vulguris in a patient with pemphigus foliaceus: antidesmoglein antibody profile shift confirmed by enzyme-linked immunosorbent assay. J Am Acad Dermatol 2000;42:859-61.
77. Korman N, Eyre R, Zone J, Stanley J. Induced pemphigus: autoantibodies directed against the pemphigus antigen complexes are present in penicillamine and captopril-induced pemphigus. J Invest Dermatol 1991;96:273-6.
78. Yasuda H, Kobayashi H, Hashimoto T, Itoh K, Yamane M, Nakamura J. Subcorneal pustular dermatosis type of IgA pemphigus: demonstration of autoantibodies to desmocollin-1 and clinical review. Br J Dermatol 2000;143:144-8.