Desmosomes and their autoimmune pathologies

European Journal of Dermatology

Volumn 10, Issue 4, 2000, Pages 255-261

  Cozzani, Emanuele ^a   Cacciapuoti, Marco ^a   Parodi, Aurora ^a   Ghohestani, Reza ^b   Rebora, Alfredo ^a  

^a UNIVERSITY OF GENOA   (Italy)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

Autoimmunity; Cadherins; Cell adhesion; Desmosome; Epitope spreading; Pemphigus

Indexed keywords

CADHERIN;

ACANTHOLYSIS; ANTIBODY PRODUCTION; ANTIGEN FUNCTION; AUTOIMMUNITY; BULLOUS SKIN DISEASE; CELL ADHESION; CELL SPREADING; CELL STRUCTURE; DESMOSOME; EPIDERMIS; HUMAN; MOLECULAR INTERACTION; PEMPHIGUS; PROTEIN INTERACTION; PROTEIN LOCALIZATION; PROTEIN STRUCTURE; REVIEW; TISSUE DISTRIBUTION;

AUTOANTIBODIES; AUTOANTIGENS; AUTOIMMUNE DISEASES; AUTOIMMUNITY; BIOLOGICAL TRANSPORT; CELL ADHESION; CELL ADHESION MOLECULES; DESMOSOMES; EPIDERMIS; HUMANS; SKIN DISEASES;

EID: 0034032982     PISSN: 11671122     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (57)

1. 1. Kowalczyk AP, Bornslaeger EA, Norvell SM, Palka HL, Green KJ. Desmosomes: intercellular adhesive junctions specialized for attachment of intermediate filaments. Int Rev Cytol 1999; 185: 237-302.
2. 2. Garrod D, Chidgey M, North A. Desmosomes: differentiation, development, dynamics and disease. Curr Opin Cell Biol 1996; 8: 670-8.
3. 3. Burdett ID. Aspects of the structure and assembly of desmosomes. Micron 1998; 29: 309-28.
4. 4. Koch PJ, Mahoney MG, Ishikawa H, Pulkkinen L, Uitto J, Shultz L, Murphy GF, Whitaker-Menezes D, Stanley JR. Targeted disruption of the pemphigus vulgaris antigen (desmoglein 3) gene in mice causes loss of keratinocyte cell adhesion with a phenotype similar to pemphigus vulgaris. J Cell Biol 1997; 137: 1091-102.
5. 5. Anhalt GJ. Making sense of antigens and antibodies in pemphigus. J Am Acad Dermatol 1999; 40: 763-6.
6. 6. Smith EA, Fuchs E. Defining the interactions between intermediate filaments and desmosomes. J Cell Biol 1998; 141: 1229-41.
7. 7. Stanley JR. Pemphigus and pemphigoid as paradigms of organ-specific, autoantibody-mediated diseases. J Clin Invest 1989; 83: 1443-8.
8. 8. Amagai M. Adhesion molecules. I: Keratinocyte-Keratinocyte interactions. Cadherins and pemphigus. J Invest Dermatol 1995; 104: 146-52.
9. 9. Schwarz MA, Owaride K, Kartenbeck J, Franke WW. Desmosomes and hemidesmosomes: constitutive molecular components. Annu Rev Cell Biol 1990; 6: 461-91.
10. 10. North AJ, Bardsley WG, Hyam J, Bornslaeger EA, Cordingley HC, Trinnaman B, Hatzfeld M, Green KJ, Magee AI, Garrod DR. Molecular map of the desmosomal plaque. J Cell Sci 1999; 112: 4325-36.
11. 11. Nilles LA, Parry DA, Powers EE, Angst BD, Wagner M, Green KG. Structural analysis and expression of human desmoglein: a cadherin-like component of the desmosome. J Cell Sci 1991; 99: 809-21.
12. 12. Mechanic S, Raynor K, Hill JE, Cowin P. Desmocollins form a distinct subset of the cadherin family of cell adhesion molecules. Proc Natl Acad Sci USA 1991; 88: 4476-80.
13. 13. Parker AE, Wheeler GN, Arnemann J, Pidsley SC, Ataliotis P, Thomas CL, Rees DA, Magee AI, Buxton RS. Desmosomal glycoproteins II and III. Cadherin-like junctional molecules generated by alternative splicing. J Biol Chem 1991; 266: 10438-45.
14. 14. Emery DJ, Diaz LA, Fairley JA, Lopez A, Taylor AF, Giudice GJ. Pemphigus foliaceus and pemphigus vulgaris autoantibodies react with the extracellular domain of desmoglein-1. J Invest Dermatol 1995; 104: 323-8.
15. 15. Kowalczyk AP, Andersen JE, Borgwardt JE, Hashimoto T, Stanley JR, Green KJ. Pemphigus sera recognize conformationally sensitive epitopes in the amino-terminal region of desmoglein-1 (desmoglein1). J Invest Dermatol 1995; 105: 147-52.
16. 16. Arnemann J, Sullivan KH, Magee AI, King IA, Buxton RS. Stratification-related expression of isoforms of the desmosomal cadherins in human epidermis. J Cell Sci 1993; 104: 741-50.
17. 17. Amagai M, Koch PJ, Nishikawa T, Stanley JR. Pemphigus vulqaris antigen (Desmoglein 3) is localized in the lower epidermis, the site of blister formation in patients. J Invest Dermatol 1996; 106: 351-5.
18. 18. Amagai M, Karpati S, Klaus-Kovtun V, Udey M, Stanley J. Extracellular domain of pemphigus vulgaris antigen (desmoglein 3) mediates weak homophilic adhesion. J Invest Dermatol 1994; 102: 402-8.
19. +-dependent heterophilic interaction between desmosomal cadherins, desmoglein and desmocollin, contributes to cell-cell adhesion. J Cell Biol 1997; 138: 193-201.
20. 20. Amagai M. Autoantibodies against cell adhesion molecules in pemphigus. J Dermatol 1994; 21: 833-7.
21. 21. Ding X, Aoki V, Mascaro JM Jr, Lopez-Swiderski A, Diaz LA, Fairley JA. Mucosal and mucocutaneous (generalized) pemphigus vulgaris show distinct autoantibody profiles. J Invest Dermatol 1997; 109: 592-6.
22. 22. Hashimoto T, Amagai M, Watanabe K, Dmochowski M, Chidgey M, Yue K, Garrod D, Nishikawa T. A case or pemphigus vulgaris showing reactivity with pemphigus antigens (desmoglein1 and desmoglein3) and desmocollins. J Invest Dermatol 1995; 104: 541-4.
23. 23. Cozzani E, Ghohestani R, Claudy A, Nicolas JF. Identification of desmosomal antigens recognized by pemphigus vulgaris and pemphigus foliaceus IgG autoantibodies using protein lysates derived from various epithelial cells and tissues. Eur J Dermatol 1997; 7: 566-9.
24. 24. Ding X, Diaz LA, Fairley JA, Giudice GJ, Liu Z. The anti-desmoglein1 autoantibodies in pemphigus vulgaris sera are pathogenic. J Invest Dermatol 1999; 112: 739-43.
25. 25. Amagai M, Hashimoto T, Green KJ, Shimitsu N, Nishikawa T. Antigen-specific immunoadsorption of pathogenic autoantibodies in pemphigus foliaceus. J Invest Dermatol 1995; 104: 895-901.
26. 26. Ishii K, Amagai M, Komai A, Ebihara T, Chorzelski TP, Nishikawa T, Hashimoto T. Desmoglein 1 and desmoglein 3 are autoimmune target of herpetiform pemphigus [Abstract]. J Invest Dermatol 1998; 110: 510.
27. 27. Hashimoto T, Amagai M, Watanabe K, Chorzelski T, Bhogal B, Black M, Stevens H, Boorsma D, Korman N, Gamou S, Shimizu N, Nishikawa T. Characterization of paraneoplastic pemphigus autoantigens by immunoblot analysis. J Invest Dermatol 1995; 104: 829-34.
28. 28. Wang J, Kwon J, Ding X, Fairley JA, Woodley DT, Chan LS. Nonsecretory IgA1 autoantibodies targeting desmosomal component desmoglein 3 in intraepidermal neutrophilic IgA dermatosis. Am J Pathol 1997; 150: 1901-7.
29. 29. Hashimoto T, Kiyokawa C, Mori O, Miyasato M, Chidgey MA, Garrod DR, Kobayasni Y, Komori K, Ishii K, Amagai M, Nishikawa T. Human desmocollin 1 (desmocollin1) is an autoantigen for the subcorneal pustular dermatosis type of IgA pemphigus. J Invest Dermatol 1997; 109: 127-31.
30. 30. Dmochowski M, Hashimoto T, Garrod DR, Nishikawa T. Desmocollin I and II are recognized by certain sera from patients with various types of pemphigus, particularly Brazilian pemphigus foliaceus. J Invest Dermatol 1993; 100: 380-4.
31. 31. Ruhrberg C, Watt FM. The plakin family: versatile organizers of cytoskeletal architecture. Curr Opin Genet Dev 1997; 7: 392-7.
32. 32. Simon M, Green H. Participation of membrane-associated proteins in the formation of the cross-linked envelope of the keratinocytes. Cell 1984; 36: 827-34.
33. 33. Green KJ, Parry DA, Steiner PM, Virata LA, Wagner RM, Angst BD, Nilles LA. Structure of the human desmoplakins: implications for function in the desmosomal plaque. J Biol Chem 1990; 265: 2603-12.
34. 34. Kowalczyk AP, Bornslaeger EA, Borgwardt JE, Palka HL, Dhaliwal AS, Concoran CM, Denning MF, Green KJ. The amino-terminal domain of desmoplakin binds to plakoglobin and clusters desmosomal cadherin-plakoglobin complexes. J Cell Biol 1997; 139: 773-84.
35. 35. Wiche G, Gromov D, Donovan A, Castanon MJ, Fuchs E. Expression of plectin mutant cDNA in cultured cells indicates a role of COOH-terminal domain in intermediate filament association. J Cell Biol 1993; 121: 607-19.
36. 36. Andrä K, Lassmann H, Bittner R, Shorny S, Fässler R, Propst F, Wiche G. Targeted inactivation of plectin reveals essential function in maintaining the integrity of skin, muscle and heart cytoarchitecture. Genes Dev 1997; 11: 3143-56.
37. 37. Ruhrberg C, Hajibagheri N, Perry DAD, Watt FM. Periplakin, a novel component of cornified envelopes and desmosomes that belongs to the plakin family and forms complexes with Envoplakin. J Cell Biol 1997; 139: 1835-49.
38. 38. Oursler JR, Labid RS, Ariss-Abdo L, Burke T, O'Keefe EJ, Anhalt G. Human autoantibodies against desmoplakins in paraneoplastic pemphigus. J Clin Invest 1992; 89: 1775-82.
39. 39. Proby C, Fujii Y, Owaribe K, Nishikawa T, Amagai M. Human antibodies against HD1/Plectin in paraneoplastic pemphigus. J Invest Dermatol 1999; 112: 153-6.
40. 40. Kiyokawa C, Ruhrberg C, Nie Z, Karashima T, Mori O, Nishikawa T, Green KJ, Anhalt GJ, DiColandrea T, Watt FM, Hashimoto T. Envoplakin and periplakin are components of the paraneoplastic pemphigus antigen complex. J Invest Dermatol 1998; 111: 1236-8.
41. 41. Peifer M, McCrea PD, Green KJ, Wieschaus E, Gumbiner BM. The vertebrate adhesive junction proteins b-catenin and plakoglobin and the drosophila segment polarity gene armadillo form a multigene family with similar properties. J Cell Biol 1992; 118: 681-91.
42. 42. Marcozzi C, Burdett I, Buxton R, Magee A. Coexpression of both types of desmosomal cadherin and plakoglobin confers strong intercellular adhesion. J Cell Sci 1998; 111: 495-509.
43. 43. Chitaev NA, Leube RE, Troianowsky RB, Eshkind LG, Franke WW, Troianowsky SM. The binding of plakoglobin to desmosomal cadherins: patterns of binding sites and topogenic potential. J Cell Biol 1996; 133: 359-69.
44. 44. Moll I, Kurzen H, Langbein L, Franke WW. The distribution of the desmosomal protein, plakophilin 1, in human skin and skin tumors. J Invest Dermatol 1997; 108: 139-46.
45. 45. Heid HW, Schmidt A, Zimbelmann R, Schäfer S, Winter-Simanowski S, Stumpp S, Keith M, Figge U, Schnölzer M, Franke WW. Cell type-specific desmosomal plaque proteins of the plakoglobin family: plakophilin 1 (band 6 protein). Differentiation 1994; 58: 113-31.
46. 46. Schmidt A, Langbein L, Rode M, Pratzel S, Zimbelmann R, Franke WW. Plakophilins 1a and 1b: widespread nuclear proteins recruited in specific epithelial cells as desmosomal plaque components. Cell Tissue Res 1997; 290: 481-99.
47. 47. Hashimoto K, Shafran KM, Webber PS, Lazarus GS, Singer KH. Anti-cell surface pemphigus autoantibody stimulates plasminogen activator activity of human epidermal cells: a mechanism for the loss of epidermal cohesion and blister formation. J Exp Med 1983; 157: 259-72.
48. 48. Shirakata Y, Amagai M, Hanakawa Y, Nishikawa T, Hashimoto K. Lack of mucosal involvement in pemphigus foliaceus may be due to low expression of desmoglein 1. J Invest Dermatol 1998; 110: 76-8.
49. 49. Mahoney MG, Wang Z, Rothenberger K, Koch PJ, Amagai M, Stanley JR. Explanation for the clinical and microscopic localization of lesions in pemphigus foliaceus and vulgaris. J Clin Invest 1999; 103: 461-8.
50. 50. Anhalt GJ, Hilu J, Takenara K, Lee A, Casciola-Rosen L. Identification of a putative transmembrane autoantigen in paraneoplastic pemphigus [abstract]. Clin Res 1993; 41: 407.
51. 51. Amagai M, Nishikawa T, Nousari HC, Anhalt GJ, Hashimoto T. Antibodies against desmoglein 3 (pemphigus vulgaris antigen) are present in sera from patients with paraneoplastic pemphigus and cause acantholysis in vivo in neonatal mice. J Clin Invest 1998; 102: 775-82.
52. 52. Chan LS, Vanderlugt CJ, Hashimoto T, Nishikawa T, Zone JJ, Black MM, Wojnarowska F, Stevens SR, Chen M, Fairley JA, Woodley DT, Miller SD, Gordon KB. Epitope spreading: lessons from autoimmune skin diseases. J Invest Dermatol 1998; 110: 103-9.
53. 53. Joly P, Gilbert D, Thomine E, Zitouni M, Ghohestani R, Delpech A, Lauret P, Tron F. Identification of a new antibody population direct against a desmosomal plaque antigen in pemphigus vulgaris and pemphigus foliaceus. J Invest Dermatol 1997; 108: 469-75.
54. 54. Joly P, Mokhtar I, Gilbert D, Fazaa B, Bardi R, Lauret P, Ayed K, Tron F, Kamoun M. Analyse des spécificités antigéniques reconnues par les sérums de pemphigus tunisiens. Ann Dermatol Venereol 1997; 124: suppl. 1: 30 (abstr.).
55. 55. Supapannachart N, Mutasim DF. The distribution of IgA pemphigus antigen in human skin and the role of IgA anti-cell surface antibodies in the induction of intraepidermal acantholysis. Arch Dermatol 1993; 129: 605-8.
56. 56. Kim SC, Kwon Y, Lee IJ, Chang S, Lee T. cDNA cloning of the 210 kDa paraneoplastic pemphigus antigen reveals that Envoplakin is a component of the antigen complex. J Invest Dermatol 1997; 109: 365-9.
57. 57. Emilie D, Devergne O, Raphael M, Coumbaras U, Galanaud P. Production of interleukin-6 in high grade B lymphomas. Curr Top Microbiol Immunol 1992; 182: 349-55.