Daunorubicin inhibits gene expression of cyclooxygenase-2 in vascular smooth muscle cells

Thrombosis Research

Volumn 103, Issue 3, 2001, Pages 233-240

  Yasui, Kenichi ^a   Wakabayashi, Ichiro ^a   Negoro, Munetaka ^a   Suehiro, Akira ^b   Kakishita, Eizo ^b  

^a YAMAGATA UNIVERSITY   (Japan)

^b HYOGO COLLEGE OF MEDICINE   (Japan)

Author keywords

Anthracyclines; Arachidonic acid; Daunorubicin; Prostacyclin; Transcription factors

Indexed keywords

ARACHIDONIC ACID; CYCLOHEXIMIDE; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; DAUNORUBICIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDOMETACIN; INTERLEUKIN 1BETA; MESSENGER RNA; NITRIC OXIDE; PROSTACYCLIN;

ANIMAL CELL; AORTA MEDIA; ARTICLE; ATTENUATION; CELL ISOLATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG INHIBITION; ENZYME ACTIVITY; EVALUATION; GENE EXPRESSION REGULATION; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; RAT; SMOOTH MUSCLE FIBER; STIMULATION; VASCULAR SMOOTH MUSCLE;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; AORTA; CYCLOOXYGENASE 2; DAUNORUBICIN; DOSE-RESPONSE RELATIONSHIP, DRUG; EPOPROSTENOL; GENE EXPRESSION; INTERLEUKIN-1; ISOENZYMES; MUSCLE, SMOOTH, VASCULAR; NF-KAPPA B; NITRIC OXIDE; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; RATS;

EID: 0035424108     PISSN: 00493848     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0049-3848(01)00324-3     Document Type: Article

References (16)

1. Vascular toxicity associated with antineoplastic agents
2. Biological importance of prostacyclin. Eighth Gaddum Memorial Lecture, University of London Institute of Education, December 1980
3. Cyclooxygenase-2: Regulation and relevance in inflammation
4. Cloning two isoforms of rat cyclooxygenase: Differential regulation of their expression
5. Role of nuclear factor-κB activation in cytokine- and sphingomyelinase-stimulated inducible nitric oxide synthase gene expression in vascular smooth muscle cells
6. Effects of antitumor agents on inducible prostacyclin production in vascular smooth muscle
7. The smooth muscle cell: II. Growth of smooth muscle in culture and formation of elastic fibers
8. Induction by staurosporine of nitric oxide synthase expression in vascular smooth muscle cells: Role of NF-κB CREB and C/EBP β
9. Expression and regulation of cyclooxygenase-2 in rat microglia
10. Involvement of NF-κB in silica-induced cyclooxygenase II gene expression in rat alveolar macrophages
11. Doxorubicin cardiotoxicity: Analysis of prevailing hypotheses
12. Assessing oxygen radicals as mediators in activation of inducible eukaryotic transcription factor NF-κB
13. Oxidative damage of cardiomyocytes is limited by extracellular regulated kinases 1/2-mediated induction of cyclooxygenase-2
14. Biophysical chemistry of the daunomycin-DNA interaction
15. Effects of chronic indomethacin therapy on the development and progression of spontaneous mammary tumors in C3H/HEJ mice
16. Chemopreventive effects of NSAIDs against colorectal cancer: Regulation of apoptosis and mitosis by COX-1 and COX-2