Linkage and association studies of the lipoprotein lipase gene with postheparin plasma lipase activities, body fat, and plasma lipid and lipoprotein concentrations: The HERITAGE Family Study

Metabolism: Clinical and Experimental

Volumn 49, Issue 4, 2000, Pages 432-439

  Garenc, Christophe ^a,b,c,d,e,f   Pérusse, Louis ^a,b,c,d,e,f   Gagnon, Jacques ^a,b,c,d,e,f   Chagnon, Yvon C ^a,b,c,d,e,f   Bergeron, Jean ^a,b,c,d,e,f   Déspres, Jean Pierre ^a,b,c,d,e,f   Province, Michael A ^a,b,c,d,e,f   Leon, Arthur S ^a,b,c,d,e,f   Skinner, James S ^a,b,c,d,e,f   Wilmore, Jack H ^a,b,c,d,e,f   Rao, D C ^a,b,c,d,e,f   Bouchard, Claude ^a,b,c,d,e,f  

^a UNIVERSITÉ LAVAL   (Canada)

^b UNIVERSITY OF MINNESOTA   (United States)

^c INDIANA UNIVERSITY   (United States)

^d TEXAS A AND M UNIVERSITY   (United States)

^e WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f PENNINGTON BIOMEDICAL RESEARCH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN B; CHOLESTEROL; HEPARIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LIPOPROTEIN LIPASE; VERY LOW DENSITY LIPOPROTEIN;

ADULT; ARTICLE; CLINICAL TRIAL; ENZYME MECHANISM; FEMALE; GENE LOCUS; GENETIC LINKAGE; GENETIC POLYMORPHISM; HUMAN; HUMAN CELL; HUMAN TISSUE; HYDROLYSIS; LIPID BLOOD LEVEL; LIPID METABOLISM; MALE; MULTICENTER STUDY; PHENOTYPE; PRIORITY JOURNAL;

EID: 0034076314     PISSN: 00260495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0026-0495(00)80004-9     Document Type: Article

References (42)

1. Patsh J.R. Prasad S. Gotto A.M. HDL2 relationships of the plasma levels of this lipoprotein species to its composition, to the magnitude of post prandial lipaemia and to the activities of lipoprotein lipase and hepatic lipase J Clin Invest 80 1987 341 347
2. Garfinkel A.S. Schotz M.C. Lipoprotein lipase Gotto A.M. Jr Plasma Lipoproteins 1987 Elsevier Science New York, NY 335 357
3. 3 by lipoprotein lipase Clin Chim Acta 112 1981 325 332
4. Kuusi T. Saarinen P. Nikkilä E.A. Evidence for the role of hepatic endothelial lipase in the metabolism of plasma high density lipoprotein2 in man Atherosclerosis 36 1980 589 593
5. Tikkanen M.J. Nikkilä E.A. Regulation of hepatic lipase and serum lipoproteins by sex steroids Am Heart J 113 1987 562 567
6. Ben-Zeev O. Lusis A.J. Leboeuf R.C. Evidence for independent and genetic regulation of heart and adipose lipoprotein lipase activity J Biol Chem 258 1983 13632 13636
7. Sparkes R.S. Zollman S. Klisak I. Human genes involved in lipolysis of plasma lipoproteins: Mapping of loci for lipoprotein lipase to 8p22 and hepatic lipase to 15g2l Genomics 1 1987 138 144
8. Nickerson D.A. Taylor S.L. Weiss K.M. DNA sequence diversity in a 9.7-kb region of the human lipoprotein lipase gene Nat Genet 19 1998 233 240
9. Humphries S.E. Nicaud V. Margalef J. Lipoprotein lipase gene variation is associated with a paternal history of premature coronary artery disease and fasting and postprandial plasma triglyceride. The European Atherosclerosis Research Study (EARS) Arterioscler Thromb Vasc Biol 18 1998 526 534
10. Jemaa R. Tuzet S. Portos C. Lipoprotein lipase gene polymorphisms: Associations with hypertriglyceridemia and body mass index in obese people Int J Obes Relat Metab Disord 19 1995 270 274
11. Vohl M.-C. Lamarche B. Moorjani S. The lipoprotein lipase Hind III polymorphism modulates plasma triglyceride levels in visceral obesity Arterioscler Thromb Vasc Biol 15 1995 714 720
12. Hata A. Robertson M. Emi M. Direct detection and automated sequencing of individual alleles after electrophoretic strand separation: Identification of a common nonsense mutation in exon 9 of the human lipoprotein lipase gene Nucleic Acids Res 18 1990 5407 5411
13. Kozaki K. Gotoda T. Kawamura M. Mutational analysis of human lipoprotein lipase by carboxy-terminal truncation J Lipid Res 34 1993 1765 1772
14. 447 → Ter) in a Turkish family J Biol Chem 266 1991 14418 14424
15. 447-Stop substitution in the lipoprotein lipase gene Circulation 95 1997 2628 2635
16. Galton D.J. Mattu R. Needham E.W. Identification of putative beneficial mutation for lipid transport Z Gastroenterol 34 suppl 3 1996 56 58
17. Kuivenhoven J.A. Groenemeyer B.E. Boer J.M.A. Ser447Stop mutation in lipoprotein lipase is associated with elevated HDL cholesterol levels in normolipidemic males Arterioscler Thromb Vasc Biol 17 1997 595 599
18. Zhang Q. Cavanna J. Winkelman B.R. Common genetic polymorphisms of lipoprotein lipase that relate to lipid transport in patients with premature coronary artery disease Clin Genet 48 1995 293 298
19. Jemaa R. Fumeron F. Poirier O. Lipoprotein lipase gene polymorphisms : Associations with myocardial infarction and lipoprotein levels. The ECTIM Study J Lipid Res 36 1995 2141 2146
20. 447-Ter mutation of the lipoprotein lipase gene relates to variability of serum lipid and lipoprotein levels in monozygotic twins J Lipid Res 39 1998 437 441
21. Bouchard C. Leon A.S. Rao D.C. The HERITAGE Family Study: Aims, design, and measurement protocol Med Sci Sports Exerc 27 1995 721 729
22. Wilmore J.H. Stanforth P.R. Domenick M.A. Reproducibility of anthropometric and body composition measurements: The HERITAGE Family Study Int J Obes 21 1997 297 303
23. Ferland M. Després J.-P. Tremblay A. Assessment of adipose tissue distribution by computed axial tomography in obese women: Association with body density and anthropometric measurements Br J Nutr 61 1989 139 148
24. Nilsson-Ehle P. Ekman R. Specific assays for lipoprotein lipase and hepatic lipase activities of post-heparin plasma Peeters H. Protides of Biological Fluids vol 25 1978 Pergamon Oxford, UK 243 246
25. St-Amand J. Després J.-P. Lemieux S. Does lipoprotein or hepatic lipase activity explain the protective lipoprotein profile of premenopausal women Metabolism 44 1995 491 498
26. Moorjani S. Dupont A. Labrie F. Increase in plasma high-density lipoprotein concentration following complete androgen blockage in men with prostatic carcinoma Metabolism 36 1987 244 250
27. Burstein M. Samaille J. Sur un dosage rapide du cholesterol lié aux β-lipoprotéins du sérum Clin Chim Acta 5 1960 609 610
28. Gidez L.I. Miller G.J. Burstein M. Separation and quantification of subclass of human plasma high density lipoproteins by a simple precipitation procedure J Lipid Res 23 1982 1206 1223
29. Laurell C.B. Quantitative estimation of proteins by electrophoresis in agarose gel containing antibodies Anal Biochem 5 1960 609 610
30. 2max, and response to endurance training Med Sci Sports Exerc 23 1991 177 185
31. Stocks J. Thom J.A. Galton D.J. Lipoprotein lipase genotype for a common premature termination codon mutation detected by PCR-mediated site-directed mutagenesis and restriction digestion J Lipid Res 33 1992 853 857
32. Zuliani G. Hobbs H.H. Tetranucleotide repeat polymorphism in the LPL gene Nucleic Acids Res 18 1990 4958
33. SAS Institute: Statistical Analysis System, release 6.12. SAS Institute, Cary, NC
34. SAGE: Statistical Analysis for Genetic Epidemiology release 3.1. Computer program package available from the Department of Biometry and Genetics 1997 LSU Medical Center New Orleans, LA
35. Ott J. Analysis of Human Genetic Linkage 1991 The Johns Hopkins University Press Baltimore, MD
36. Mattu R.K. Needham E.W.A. Morgan R. DNA variants at the LPL gene locus associate with angiographically defined severity of atherosclerosis and serum lipoprotein levels in a Welsh population Arterioscler Thromb 14 1994 1090 1097
37. Peacock R.E. Hamsten A. Nilsson-Ehle P. Association between lipoprotein lipase gene polymorphism and plasma correlations of lipids, lipoproteins and lipase activities in young myocardial infarction survivors and age-matched healthy individuals from Sweden Atherosclerosis 97 1992 171 185
38. Kobayashi J. Nishida T. Ameis D. A heterozygous mutation (the codon for Ser447 → a stop codon) in lipoprotein lipase contributes to a defect in lipid interface recognition in a case with type I hyperlipidaemia Biochem Biophys Res Commun 182 1992 70 77
39. Pérusse L. Rice T. Després J.P. Familial resemblance of plasma lipids, lipoproteins and post-heparin lipoprotein and hepatic lipases in the HERITAGE Family Study Arterioscler Thromb Vasc Biol 17 1997 3263 3269
40. Takahashi S. Suzuki J. Kohno M. Enhancement of the binding of triglyceride-rich lipoproteins to the very low density lipoprotein receptor by apolipoprotein E and lipoprotein lipase J Biol Chem 270 1995 15747 15754
41. Beisiegel U. Weber W. Bengtsson-Olivecrona G. Lipoprotein lipase enhances the binding of chylomicrons to low density lipoprotein receptor-related protein Proc Natl Acad Sci USA 88 1991 8342 8346
42. Nykjaer A. Bengtsson-Olivecrona G. Lookene A. The α2-macroglobulin receptor/low density lipoprotein receptor-released protein binds lipoprotein lipase and migrating very low density lipoprotein lipase associated with the lipase J Biol Chem 268 1993 15048 15055