Visual field loss in RCS rats and the effect of RPE cell transplantation

Experimental Neurology

Volumn 152, Issue 2, 1998, Pages 243-250

  Sauvé, Yves ^a   Klassen, Henry ^a,b   Whiteley, Simon J O ^a   Lund, Raymond D ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b MOORFIELDS EYE HOSPITAL   (United Kingdom)

Author keywords

Electrophysiology; RCS rat; Retinal degeneration; Retinal pigment epithelium; Retinal transplantation; Superior colliculus; Visual field

Indexed keywords

ADOLESCENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ELECTROPHYSIOLOGY; NONHUMAN; PIGMENT EPITHELIUM; PRIORITY JOURNAL; RAT; RETINA DEGENERATION; SUPERIOR COLLICULUS; TRANSPLANTATION; VISUAL FIELD; VISUAL IMPAIRMENT;

EID: 0032143956     PISSN: 00144886     EISSN: None     Source Type: Journal    
DOI: 10.1006/exnr.1998.6849     Document Type: Article

References (35)

1. Algvere P. V., Berglin L., Gouras P., Sheng Y. Transplantation of fetal retinal pigment epithelium in age-related macular degeneration with subfoveal neovascularization. Graefes Arch. Clin. Exp. Ophthalmol. 232:1994;707-716.
2. Bok D., Hall M. O. The role of pigment epithelium in the etiology of retinal dystrophy in the rat. J. Cell Biol. 49:1971;664-682.
3. Bush R. A., Hawks K. W., Sieving P. A. Preservation of inner retinal responses in the aged Royal College of Surgeons rat: Evidence against glutamate toxicity in photoreceptor degeneration. Invest. Ophthalmol. Vis. Sci. 36:1995;2054-2062.
4. Castillo B. V. Jr., del Cerro M., White R. M., Cox C., Wyatt J., Nadiga G., del Cerro C. Efficacy of nonfetal human RPE for photoreceptor rescue: A study in dystrophic RCS rats. Exp. Neurol. 146:1997;1-9.
5. Chang C. W., Roque R. S., Defoe D. M., Caldwell R. B. An improved method for isolation and culture of pigment epithelial cells. Curr. Eye Res. 10:1991;1081-1086.
6. Cicerone C. M., Green D. G., Fisher L. J. Cone inputs to ganglion cells in hereditary retinal degeneration. Science. 203:1979;1113-1115.
7. Coffey P. J., Hetherington L., Bin L., Whiteley S. J., Litchfield T. M., Lund R. D. Detection of visual patterns and c-fos expression in retina and superior colliculus of dystrophic RCS rats following RPE transplants: ARVO Abstracts. Invest. Ophthalmol. Vis. Sci. 37:1996;S94.
8. Curcio C. A., Medeiros N. E., Millican C. L. Photoreceptor loss in age-related macular degeneration. Invest. Ophthalmol. Vis. Sci. 37:1996;1236-1249.
9. Deshpande S., Thompson M., Parker J. A., Abrahamson E. W. Study of retinal dystrophy in RCS rats: a comparison of Mg-ATP dependent light scattering activity and ERG b-wave. Vis. Res. 32:1992;425-432.
10. Dowling J. E., Sidman R. L. Inherited retinal dystrophy in the rat. J. Cell Biol. 14:1962;73-109.
11. Dräger U. C., Hubel D. H. Studies of visual function and its decay in mice with hereditary retinal degeneration. J. Comp. Neurol. 180:1978;85-114.
12. Faktorovich E. G., Steinberg R. H., Yasumura D., Matthes M. T., LaVail M. M. Photoreceptor degeneration in inherited retinal dystrophy delayed by basic fibroblast growth factor. Nature. 347:1990;83-86.
13. Fulton A. B. Background adaptation in RCS rats. Invest. Ophthalmol. Vis. Sci. 24:1983;72-76.
14. Gilbert C. D., Wiesel T. N. Receptive field dynamics in adult primary visual cortex. Nature. 356:1992;150-152.
15. Green W. R., Enger C. Age-related macular degeneration histopathologic studies. Ophthalmology. 100:1993;1519-1535.
16. Hughes A. The topography of vision in mammals of contrasting life style: comparative optics and retinal organization. Handbook of Sensory Physiology. 1977;Springer Verlag, Berlin. p. 615-756.
17. Jiang L. Q., Hamasaki D. Corneal electroretinographic function rescued by normal retinal pigment epithelial grafts in retinal degenerative Royal College of Surgeons rats. Invest. Ophthalmol. Vis. Sci. 35:1994;4300-4309.
18. Kovalevsky G., DiLoreto D. Jr., Wyatt J., del Cerro C., Cox C., del Cerro M. The intensity of the pupillary light reflex does not correlate with the number of retinal photoreceptor cells. Exp. Neurol. 133:1995;43-49.
19. La Vail M. M., Sidman M., Rausin R., Sidman R. L. Discrimination of light intensity by rats with inherited retinal degeneration: a behavioral and cytological study. Vision Res. 14:1974;693-702.
20. La Vail M. M., Battelle B. A. Influence of eye pigmentation and light deprivation on inherited retinal dystrophy in the rat. Exp. Eye Res. 21:1975;167-192.
21. Li L., Turner J. E. Inherited retinal dystrophy in the RCS rat: prevention of photoreceptor degeneration by pigment epithelial cell transplantation. Exp. Eye Res. 47:1988;911-917.
22. Little C. W., Castillo B., DiLoreto D. A., Cox C., Wyatt J., del Cerro C., del Cerro M. Transplantation of human fetal retinal pigment epithelium rescues photoreceptor cells from degeneration in the Royal College of Surgeons rat retina. Invest. Ophthalmol. Vis. Sci. 37:1996;204-211.
23. Little C. W., Cox C., Wyatt J., del Cerro C., del Cerro M. Correlates of photoreceptor rescue by transplantation of human fetal RPE in the RCS rat. Exp. Neurol. 149:1998;151-160.
24. Lopez R., Gouras P., Kjeldbye H., Sullivan B., Reppucci V., Brittis M., Wapner F., Goluboff E. Transplanted retinal pigment epithelium modifies the retinal degeneration in the RCS rat. Invest. Ophthalmol. Vis. Sci. 30:1989;586-588.
25. Lu B., Coffey P. J., Lund R. D. C-Fos expression in retina and superior colliculus of RCS rat following light flashes. ARVO Abstracts. Invest. Ophthalmol. Vis. Sci. 37:1996;S1047.
26. Noell W. K., Salinsky M. C. Preservation of visual evoked cortical responses at advanced state of retinal degeneration in the Rdy rat. LaVail M. M., Hollyfield J. G., Anderson R. E. Retinal Degeneration. 1985;301-320 A. R. Liss, New York.
27. Noell W. K., Pewitt E. B., Cotter J. R. ERG of the pigmented rdy rat at advanced stages of hereditary retinal degeneration. Prog. Clin. Biol. Res. 314:1989;357-375.
28. Perlman I. Dark-adaptation in abnormal (RCS) rats studied electrophysiologically. J. Physiol. 278:1978;161-175.
29. Sauvé Y., Klassen H., Whiteley S. J. O., Litchfield T. M., Lund R. D. Functional preservation following RPE grafting. i. Retinotopic mapping in the superior colliculus. ARVO Abstracts. Invest. Ophthalmol. Vis. Sci. 37:1996;S93.
30. Sauvé Y., Klassen H., Whiteley S. J. O., Litchfield T. M., Lund R. D. Retinotopic analysis of response parameters in the superior colliculus of RCS rats following retinal pigment epithelial cell transplantation. Soc. Neurosci. Abstr. 22:1996;1978.
31. Trejo L. J., Cicerone C. M. Retinal sensitivity measured by the pupillary light reflex in RCS and albino rats. Vision Res. 22:1982;1163-1171.
32. Villegas-Pérez M. P., Lawrence J. M., Vidal-Sanz M., Lund R. D. Ganglion cell loss in RCS rat retina: A result of compression of axons by contracting intraretinal vessels linked to the pigment epithelium. J. Comp. Neurol. 392:1998;58-77.
33. Whiteley S. J. O., Litchfield T. M., Coffey P. J., Lund R. D. Improvement of the pupillary light reflex of Royal College of Surgeons rats following RPE cell grafts. Exp. Neurol. 140:1996;100-104.
34. Yamamoto S., Du J., Gouras P., Kjeldye H. Retinal pigment epithelial transplants and retinal function in RCS rats. Invest. Ophthalmol. Vis. Sci. 34:1993;3068-3075.
35. Young R. W. Pathophysiology of age-related macular degeneration. Surv. Ophthalmol. 31:1987;291-306.