Ability to undergo apoptosis does not correlate with the intrinsic radiosensitivity (SF2) of human cervix tumor cell lines

International Journal of Radiation Oncology Biology Physics

Volumn 50, Issue 2, 2001, Pages 503-509

  Sheridan, Mary T ^a   West, Catharine M L ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

Apoptosis; Cervix; Clonogenicity; Radiation; Survival

Indexed keywords

ASSAYS; CELLS; DNA; ELECTROPHORESIS; MORPHOLOGY; TUMORS;

RADIOSENSITIVITY;

ONCOLOGY;

LIPOCORTIN 5;

APOPTOSIS; ARTICLE; CELL SURVIVAL; CLONOGENIC ASSAY; CONTROLLED STUDY; DOSE RESPONSE; FLOW CYTOMETRY; GEL ELECTROPHORESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; MICROSCOPY; NICK END LABELING; PRIORITY JOURNAL; RADIATION DOSE; RADIOSENSITIVITY; TUMOR CELL LINE; UTERINE CERVIX CANCER;

APOPTOSIS; CELL DEATH; FEMALE; HELA CELLS; HUMANS; NECROSIS; RADIATION TOLERANCE; TUMOR CELLS, CULTURED; UTERINE CERVICAL NEOPLASMS;

EID: 0035371030     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0360-3016(01)01496-1     Document Type: Article

References (24)

1. Lowe S.W., Bodis S., McClatchey A., et al. p53 status, and the efficacy of cancer therapy in vivo. Science. 266:1994;807-810.
2. Lowe S.W., Ruley H.E., Jacks T., et al. p53-dependent apoptosis modulates the cytotoxicity of anticancer agents. Cell. 74:1993;957-967.
3. Brown J.M., Wouters B.G. Apoptosis, p53, and tumor cell sensitivity to anticancer agents. Cancer Res. 59:1999;1391-1399.
4. Lock R.B., Stribinskiene L. Dual modes of death induced by etoposide in human epithelial tumor cells allow Bcl-2 to inhibit apoptosis without affecting clonogenic survival. Cancer Res. 56:1996;4006-4012.
5. Waldman T., Zhang Y., Dillehay L., et al. Cell-cycle arrest versus cell death in cancer therapy. (see comments) Nat Med. 3:1997;1034-1036.
6. Wouters BG, Giaccia AJ, Denko NC; et al. Loss of p21Waf1/Cip1 sensitizes tumors to radiation by an apoptosis-independent mechanism. Cancer Res 1997;57:4703-4076.
7. Levine E.L., Renehan A., Gossiel R., et al. Apoptosis, intrinsic radiosensitivity, and prediction of radiotherapy response in cervical carcinoma. Radiother Oncol. 37:1995;1-9.
8. Siles E., Villalobos M., Jones L., et al. Apoptosis after gamma irradiation. Is it an important cell death modality? Br J Cancer. 78:1998;1594-1599.
9. Vermes I., Haanen C., Steffens Nakken H., et al. A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V. J Immunol Methods. 184:1995;39-51.
10. Sheridan M.T., Cooper R.A., West C.M. A high ratio of apoptosis to proliferation correlates with improved survival after radiotherapy for cervical adenocarcinoma (see comments). Int J Radiat Oncol Biol Phys. 44:1999;507-512.
11. Nakano H., Shinohara K. Correlation between unirradiated cell TP53 protein levels and radiosensitivity in MOLT-4 cells. Radiat Res. 151:1999;686-693.
12. Muschel R.J., Soto D.E., McKenna W.G., et al. Radiosensitization and apoptosis. Oncogene. 17:1998;3359-3363.
13. Guo G.Z., Sasai K., Oya N., et al. A significant correlation between clonogenic radiosensitivity and the simultaneous assessment of micronucleus and apoptotic cell frequencies. Int J Radiat Oncol Biol Phys. 75:1999;857-864.
14. Liang X.H., Mungal S., Ayscue A., et al. Bcl-2 protooncogene expression in cervical carcinoma cell lines containing inactive p53. J Cell Biochem. 57:1995;509-521.
15. Bernhard E.J., Muschel R.J., Bakanauskas V.J., et al. Reducing the radiation-induced G2 delay causes HeLa cells to undergo apoptosis instead of mitotic death. Int J Radiat Oncol Biol Phys. 69:1996;575-584.
16. Meyn R.E., Stephens L.C., Ang K.K., et al. Heterogeneity in the development of apoptosis in irradiated murine tumours of different histologies. Int J Radiat Oncol Biol Phys. 64:1993;583-591.
17. Olive P.L., Vikse C.M., Vanderbyl S. Increase in the fraction of necrotic, not apoptotic, cells in SiHa xenograft tumours shortly after irradiation. Radiother Oncol. 50:1999;113-119.
18. Hunakova L., Chorvath M., Duraj J., et al. Radiation-induced apoptosis, and cell cycle alterations in human carcinoma cell lines with different radiosensitivities. Neoplasma. 47:2000;25-31.
19. Szumiel I., Jaworska A., Kapiszewska M., et al. Differential induction of apoptosis in x-irradiated L5178Y sublines bearing p53 mutation. Radiat Environ Biophys. 39:2000;33-40.
20. Abend M., Kehe K., Kehe K., et al. Correlation of micronucleus and apoptosis assays with reproductive cell death can be improved by considering other modes of death. Int J Radiat Oncol Biol Phys. 76:2000;249-259.
21. Dewey W.C., Ling C.C., Meyn R.E. Radiation-induced apoptosis Relevance to radiotherapy . Int J Radiat Oncol Biol Phys. 33:1995;781-796.
22. Tsang R.W., Wong C.S., Fyles A.W., et al. Tumour proliferation and apoptosis in human uterine cervix carcinoma II Correlations with clinical outcome . Radiother Oncol. 50:1999;93-101.
23. Wheeler J.A., Stephens L.C., Tornos C., et al. ASTRO Research Fellowship. apoptosis as a predictor of tumor response to radiation in stage IB cervical carcinoma. American Society for Therapeutic Radiology and Oncology. Int J Radiat Oncol Biol Phys. 32:1995;1487-1493.
24. Sheridan M.T., West C.M., Cooper R.A., et al. Pretreatment apoptosis in carcinoma of the cervix correlates with changes in tumour oxygenation during radiotherapy. Br J Cancer. 82:2000;1177-1182.