Signal transducer gp130: Biochemical characterization of the three membrane-proximal extracellular domains and evaluation of their oligomerization potential

Biochemical Journal

Volumn 356, Issue 2, 2001, Pages 605-612

  Pflanz, S ^a   Kernebeck, T ^a   Giese, B ^a   Herrmann, A ^a   Pachta Nick, M ^a   Stahl, J ^a   Wollmer, A ^a   Heinrich, P C ^a   Muller Newen G ^a   Grotzinger J ^a  

^a RWTH AACHEN UNIVERSITY   (Germany)

Author keywords

Cytokines; Dimerization; Receptors; Signal transduction

Indexed keywords

ANTIBODIES; BIOLOGICAL MEMBRANES; LIGAMENTS; OLIGOMERS; POLYPEPTIDES; PROTEINS;

LIGANDS;

BIOCHEMISTRY;

FIBRONECTIN; GLYCOPROTEIN GP 130; INTERLEUKIN 6; MEMBRANE PROTEIN; RECOMBINANT PROTEIN;

ANIMAL CELL; ARTICLE; CELL INCLUSION; CIRCULAR DICHROISM; CONTROLLED STUDY; GEL PERMEATION CHROMATOGRAPHY; HUMAN; HUMAN CELL; LIGAND BINDING; NONHUMAN; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN INTERACTION; PROTEIN PURIFICATION; PROTEIN TERTIARY STRUCTURE; SIGNAL TRANSDUCTION;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD; CIRCULAR DICHROISM; COS CELLS; CROSS-LINKING REAGENTS; CYTOKINE RECEPTOR GP130; EPITOPE MAPPING; ESCHERICHIA COLI; HUMANS; MEMBRANE GLYCOPROTEINS; PROTEIN FOLDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; PROTEIN SUBUNITS; RECEPTORS, CYTOKINE; RECOMBINANT PROTEINS;

ANIMALIA; BACTERIA (MICROORGANISMS);

EID: 0035367426     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3560605     Document Type: Article

References (27)

1. Hematopoietic receptor complexes
2. Structural design and molecular evolution of a cytokine receptor superfamily
3. Cytokine receptor signaling
4. Molecular cloning and expression of an IL-6 signal transducer, gp130
5. Crystal structure of a cytokine-binding region of gp130
6. The signal transducer gp130: Solution structure of the carboxy-terminal domain of the cytokine receptor homology region
7. IL-6-type cytokine signalling through the gp130/JAK/STAT pathway
8. Novel neurotrophin-1/B cell-stimulating factor-3: A cytokine of the IL-6 family
9. CLF associates with CLC to term a functional heteromeric ligand for the CNTF receptor complex
10. The membrane distal half of gp130 is responsible for the formation of a ternary complex with IL-6 and the IL-6 receptor
11. Activation of the signal transducer gp130 by interleukin-11 and interleukin-6 is mediated by similar molecular interactions
12. Activation of the signal transducer gp130 by both interleukin-6 and interleukin-11 requires two distinct binding epitopes
13. Importance of the membrane-proximal extracellular domains for activation of the signal transducer gp130
14. Ligand-specific utilization of the extracellular membrane-proximal region of the gp130-related signalling receptors
15. Soluble interleukin-6 receptor potentiates the antagonistic activity of soluble gp130 on interleukin-6 responses
16. Use of T7 RNA polymerase to direct expression of cloned genes
17. The signal transducer gp130. Bacterial expression, refolding and properties of the carboxy-terminal domain of the cytokine-binding module
18. Two-point calibration of circular dichrometer with d-10-camphorsulfonic acid
19. Determination of the tryptophan:tyrosine ratio in proteins
20. Molecular modeling-guided mutagenesis of the extracellular part of gp130 leads to the identification of contact sites in the interleukin-6 (IL-6)/IL-6 receptor/gp130 complex
21. Protein secondary structure from circular dichroism spectroscopy. Combining variable selection principle and cluster analysis with neural network, ridge regression and self-consistent methods
22. Interleukin-6 signal transducer gp130 has specific binding sites for different cytokines as determined by antagonistic and agonistic anti-gp130 monoclonal antibodies
23. Reconstitution of two isoforms of the human interleukin-11 receptor and comparison of their functional properties
24. Receptor recognition by gp130 cytokines
25. Functional importance of platelet-derived growth factor (PDGF) receptor extracellular immunoglobulin-like domains. Identification of PDGF binding site and neutralizing monoclonal antibodies
26. Immunoglobulin-like domain 4-mediated receptor-receptor interactions contribute to platelet-derived growth factor-induced receptor dimerization
27. A domain in TNF receptors that mediates ligand-independent receptor assembly and signaling