Combinatorial synthesis of heterocycles: Solid-phase synthesis of 6-amino-2,4-dioxo-3,4-dihydro-1,3,5-triazine derivatives

Journal of Combinatorial Chemistry

Volumn 3, Issue 3, 2001, Pages 278-283

  Gopalsamy, Ariamala ^a   Yang, Hui ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINE; AMINO ACID; BENZOIC ACID DERIVATIVE; GUANIDINE DERIVATIVE; THIOUREA; TRIAZINE DERIVATIVE;

ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; COMBINATORIAL CHEMISTRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

AMINES; AMINO ACIDS; BENZOIC ACIDS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COMBINATORIAL CHEMISTRY TECHNIQUES; GUANIDINES; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP; THIOUREA; TRIAZINES;

EID: 0035347036     PISSN: 15204766     EISSN: None     Source Type: Journal    
DOI: 10.1021/cc000091w     Document Type: Article

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30. LC Conditions: HP 1100, 23°C, 10 μL injected; column YMC-ODS-A 4.6 x 50 mm, 5 μm; gradient A, 0.05% TFA/ water; gradient B, 0.05% TFA/acetonitrile; time 0 and 1 min, 98% A and 2% B; 7 min, 10% A and 90% B; 8 min, 10% A and 90% B; 8.9 min, 98% A and 2% B; post time, 1 min; flow rate, 2.5 mL/min; detection, 215 and 254 nm, DAD.
31. Semiprep HPLC: Gilson with Unipoint software; column, Phenomenex C18 Luna 21.6 mm x 60 mm, 5 μM; solvent A, water (0.02% TFA buffer); solvent B, acetonitrile (0.02% TFA buffer); solvent gradient, 0 min, 5% B; 2.5 min, 5% B; 12 min, 95% B; hold, 95% B 3 min; flow rate, 22.5 mL/ min; detection, 215 and 254 nm.