Synergistic induction of apoptosis in human leukemia cells (U937) exposed to bryostatin 1 and the proteasome inhibitor lactacystin involves dysregulation of the PKC/MAPK cascade

Blood

Volumn 97, Issue 7, 2001, Pages 2105-2114

  Vrana, Julie A ^a,b   Grant, Steven ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b DARTMOUTH MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ALPHA AMANITIN; ANSAMYCIN DERIVATIVE; BISINDOLYLMALEIMIDE; BRYOSTATIN 1; CURCUMIN; CYCLOHEXIMIDE; DACTINOMYCIN; GELDANAMYCIN; LACTACYSTIN; MEZEREIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; PHORBOL 13 ACETATE 12 MYRISTATE; PHOSPHOLIPASE C; PROTEASOME INHIBITOR; PROTEIN INHIBITOR; PROTEIN KINASE C; PROTEIN KINASE C INHIBITOR; RAF PROTEIN; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN;

APOPTOSIS; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; LEUKEMIA CELL; MITOCHONDRION; PRIORITY JOURNAL; PROTEIN STABILITY; SIGNAL TRANSDUCTION; STRESS;

EID: 0035313253     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.V97.7.2105     Document Type: Article

References (81)

1. Regulation of apoptosis by oncogenes
2. Expression and involvement of c-fos and c-jun protooncogenes in programmed cell death induced by growth factor deprivation in lymphoid cell lines
3. Lymphocyte apoptosis - Mechanisms and implications in disease
4. Bcl-2 and Bcl-x: Regulatory switches for lymphoid death and survival
5. Promotion and inhibition of activation-induced apoptosis in T-cell hybridomas by oncogenes and related signals
6. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis
7. Coordinate regulation of stress- and mitogen-activated protein kinases in the apoptotic actions of ceramide and sphingosine
8. Successful treatment of human chronic lymphocytic leukemia xenografts with combination biological agents auristatin PE and bryostatin 1
9. Preclinical evaluation of bryostatin as an anticancer agent against several murine tumor cell lines: In vitro versus in vivo activity
10. Successful treatment of murine melanoma with bryostatin 1
11. Phase 1b trial of bryostatin 1 in patients with refractory malignancies
12. Phase I study of bryostatin 1 in patients with relapsed non-Hodgkin's lymphoma and chronic lymphocytic leukemia
13. Protein kinase C-alpha but not protein kinase C-epsilon is differentially down-regulated by bryostatin 1 and tetradecanoyl phorbol 13-acetate in SH-SY5Y human neuroblastoma cells
14. Differential regulation of protein kinase C isozymes by bryostatin 1 and phorbol 12-myristate 13-acetate in NIH 3T3 fibroblasts
15. Ubiquitination of protein kinase C-alpha and degradation by the proteasome
16. Divergent effects of bryostatin 1 and phorbol myristate acetate on cell cycle arrest and maturation in human myelomonocytic leukemia cells (U937)
17. Comparative effects of polymyxin B, phorbol ester and bryostatin on protein phosphorylation, protein kinase C translocation, phospholipid metabolism and differentiation of HL60 cells
18. KIP1 by deoxycytidine analogs in human leukemia cells: Relationship to apoptosis and differentiation
19. Induction of a common pathway of apoptosis by staurosporine
20. Modulation of 1-[beta-D-arabinofuranosyl] cytosine-induced apoptosis in human myeloid leukemia cells by staurosporine and other pharmacological inhibitors of protein kinase C
21. The proteasome, a novel protease regulated by multiple mechanisms
22. An animal model for antilentiviral therapy: Effect of zidovudine on viral load during acute infection after exposure of macaques to simian immunodeficiency virus
23. p53 dependent induction of apoptosis by proteasome inhibitors
24. Lactacystin, a specific inhibitor of the proteasome, induces apoptosis in human monoblast U937 cells
25. The role of the ubiquitin-proteasome pathway in apoptosis
26. Mitogen-activated protein kinase is involved in the degradation of p53 protein in the bryostatin-1-induced differentiation of the acute promyelocytic leukemia NB4 cell line
27. Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin
28. Establishment and characterization of a human histiocytic lymphoma cell line (U937)
29. Effect of 1-beta-D-arabinofuranosyicytosine on apoptosis and differentiation in human monocytic leukemia cells (U937) expressing a c-Jun dominant-negative mutant protein (TAM67)
30. Evidence of a functional role for the cyclin-dependent kinase inhibitor p21(WAF1/CIP1/MDA6) in the reciprocal regulation of PKC activator-induced apoptosis and differentiation in human myelomonocytic leukemia cells
31. Mechanistic studies on the inactivation of the proteasome by lactacystin in cultured cells
32. Modulation of protein kinase C activity and calcium-sensitive isoform expression in human myeloid leukemia cells by bryostatin 1: Relationship to differentiation and ara-C-induced apoptosis
33. Potentiation of the activity of 1-beta-D-arabinofuranosyl-cytosine by the protein kinase C activator bryostatin 1 in HL-60 cells: Association with enhanced fragmentation of mature DNA
34. Quantitative analysis of dose-effect relationships: The combined effects of multiple drugs or enzyme inhibitors
35. Activation of the cell death program by inhibition of proteasome function
36. Involvement of the proteasome in the programmed cell death of NGF-deprived sympathetic neurons
37. Proteasomes play an essential role in thymocyte apoptosis
38. Enhancement of CPP32-1ike activity in the TNF-treated U937 cells by the proteasome inhibitors
39. Inhibition versus induction of apoptosis by proteasome inhibitors depends on concentration
40. Failure to activate cytosolic phospholipase A2 causes TNF resistance in human leukemic cells
41. Induction of endonucleolytic DNA cleavage in human acute myelogenous leukemia cells by etoposide, camptothecin, and other cytotoxic anticancer drugs: A cautionary note
42. Proteasome inhibitors activate stress kinases and induce Hsp72: Diverse effects on apoptosis
43. Role of c-jun in human myeloid leukemia cell apoptosis induced by pharmacological inhibitors of protein kinase C
44. Inhibition of the c-Jun N-terminal kinase (JNK) signaling pathway by curcumin
45. Bryostatin 1 and phorbol ester down-modulate protein kinase C-alpha and -epsilon via the ubiquitin/Proteasome pathway in human fibroblasts
46. Activation of the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway by conventional, novel, and atypical protein kinase C isotypes
47. Protein kinase C-mediated serine phosphorylation directly activates Raf-1 in murine hematopoietic cells
48. Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: Essential role for stress proteins in oncogenic transformation
49. Raf-1 activates MAP kinase-kinase
50. Growth factor-induced p42/p44 MAPK nuclear translocation and retention requires both MAPK activation and neosynthesis of nuclear anchoring proteins
51. PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo
52. Identification of a novel inhibitor of mitogen-activated protein kinase kinase
53. A necessity for MAP kinase activation in mammalian spatial learning
54. Regulation of p21WAF1/CIP1 expression through mitogen-activated protein kinase signaling pathway
55. Dysregulation of the cyclin-dependent kinase inhibitor p21WAF1/ClP1/MDA6 increases the susceptibility of human leukemia cells (U937) to 1-beta-D-arabinofuranosylcytosine-mediated mitochondrial dysfunction and apoptosis
56. Implication of radical oxygen species in ceramide generation, c-Jun N-terminal kinase activation, and apoptosis induced by daunorubicin
57. Proteasome inhibitors: Valuable new tools for cell biologists
58. The expanded horizon for microbial metabolites - A review
59. Lactacystin and clasto-lactacystin beta-lactone modify multiple proteasome beta-subunits and inhibit intracellular protein degradation and major histocompatibility complex class I antigen presentation
60. Proteasome inhibition circumvents solid tumor resistance to topoisomerase II-directed drugs
61. Proteasome inhibitors: A novel class of potent and effective antitumor agents
62. The role of protein kinase C isoenzymes in the growth inhibition caused by bryostatin 1 in human A549 lung and MCF-7 breast carcinoma cells
63. Dephosphorylation of activated protein kinase C contributes to downregulation by bryostatin
64. Differential down-regulation of protein kinase C subspecies in KM3 cells
65. Differential activation and inhibition of lymphocyte proliferation by phorbol esters, mezerein, teleocidin, and okadaic acid
66. Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C
67. Attenuation of ceramide-induced apoptosis by diglyceride in human myeloid leukemia cells
68. Direction of p21ras-generated signals towards cell growth or apoptosis is determined by protein kinase C and Bcl-2
69. Phosphorylation of BCL-2 after exposure of human leukemia cells to retinoic acid
70. Taxol-induced apoptosis and phosphorylation of Bcl-2 protein involves c-Raf-1 and represents a novel c-Raf-1 signal transduction pathway
71. Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms
72. The extracellular signal-regulated kinase pathway is required for activation-induced cell death of T cells
73. The role of c-Jun N-terminal kinase (JNK) in apoptosis induced by ultraviolet C and gamma radiation: Duration of JNK activation may determine cell death and proliferation
74. The cellular response to oxidative stress: Influences of mitogen-activated protein kinase signalling pathways on cell survival
75. Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis
76. The apoptotic effects and synergistic interaction of sodium butyrate and MG132 in human retinoblastome Y79 cells
77. Sodium butyrate stimulates PKC activation and induces differential expression of certain PKC isoforms during erythroid differentiation
78. Sodium butyrate induces tyrosine phosphorylation and activation of MAP kinase (ERK-1) in human K562 cells
79. Suppression of tumor necrosis factor-induced cell death by inhibitor of apoptosis c-IAP2 is under NF-kappaB control
80. Rel/NF-kappa B transcription factors and the control of apoptosis
81. Suppression of TNF-alpha-induced apoptosis by NF-kappaB