Attenuation of malonate toxicity in primary mesencephalic cultures using the GABA transport blocker, NO-711

Journal of Neuroscience Research

Volumn 64, Issue 1, 2001, Pages 43-52

  Stokes, Alan H ^a   Bernard, Laura P ^a   Nicklas, William J ^a   Zeevalk, Gail D ^a  

^a RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

Author keywords

Energy impairment; Mitochondria; Nipecotic acid; Reactive oxygen species

Indexed keywords

1 [2 (BENZHYDRYLIDENEAMINOOXY)ETHYL] 1,2,5,6 TETRAHYDRO 3 PYRIDINECARBOXYLIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR STIMULATING AGENT; 4 AMINOBUTYRIC ACID RECEPTOR; 4 AMINOBUTYRIC ACID RECEPTOR BLOCKING AGENT; DOPAMINE; GLYCINE; GLYCINE RECEPTOR; MALONIC ACID; MUSCIMOL; NIPECOTIC ACID; REACTIVE OXYGEN METABOLITE; SUCCINATE DEHYDROGENASE;

4 AMINOBUTYRIC ACID RELEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BRAIN MITOCHONDRION; CELL CULTURE; CELL DAMAGE; CHICKEN; CONTROLLED STUDY; DOSE RESPONSE; ENZYME INHIBITION; GABAERGIC SYSTEM; MESENCEPHALON; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT; RETINA CELL;

ANIMALS; CELLS, CULTURED; DOPAMINE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; GABA ANTAGONISTS; GAMMA-AMINOBUTYRIC ACID; MALONATES; MESENCEPHALON; MUSCIMOL; NEURONS; NIPECOTIC ACIDS; OXIMES; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; RECEPTORS, GABA-A;

EID: 0035311326     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/jnr.1052     Document Type: Article

References (39)

1. Age-dependent striatal excitotoxic lesions produced by the endogenous mitochondrial inhibitor malonate
2. Aging, energy, and oxidative stress in neurodegenerative diseases
3. Voltage-dependent block by strychnine of N-methyl-D-aspartic acid-activated cationinc channels in rat cortical neurons in culture
4. GABA transporter heterogeneity: Pharmacology and cellular localization
5. Tiagibine, SK&F 89976A, CI-966, and NNC-711 are selective for the cloned GABA transporter GAT-1
6. - and inhibitory transmitters
7. Excitotoxic cell death dependent on inhibitory receptor activation
8. Selective vulnerability of the CA1 region of the hippocampus to the indirect excitotoxic effects of malonic acid
9. Glycine receptors in the human substantia nigra as defined by [3H]strychnine binding
10. A-like autoreceptor by barbiturates but not by steroids
11. GABA accelerates excitotoxic cell death in cortical cultures: Protection by blockers of GABA-gated chloride channels
12. Excitotoxic index - A biochemical marker of selective vulnerability
13. Characterization of the excitotoxic potential of the reversible succinate dehydrogenase inhibitor malonate
14. Inhibition of succinate dehydrogenase by malonic acid produces an excitotoxic lesion in rat striatum
15. Evaluation of the probe 2', 7'-dichlorofluorescin as an indicator of reactive oxygen species formation and oxidative stress
16. Tweedball mitochondropathy with a unique neurodegenerative disorder
17. Tiagibine: A novel antiepileptic drug
18. Brain, skeletal and platelet homogenate mitochondrial function in Parkinson's disease
19. Neurotransmission in epilepsy
20. Deficiencies in complex I subunits of the respiratory chain in Parkinson's disease
21. Seizure-triggering mechanisms in the kindling model of epilepsy: Collapse of GABA-mediated inhibition and activation of NMDA receptors
22. Antiepileptic effects of Tiagibine, a selective GABA uptake inhibitor, in the rat kindling model of temporal lobe epilepsy
23. Induction of neuronal apoptosis by camptothecin, an inhibitor of DNA topoisomerase-I: Evidence for cell-cycle dependent toxicity
24. A receptor activation attenuates excitotoxicity but exacerbates oxygen-glucose deprivation-induced neuronal injury in vitro
25. Changing properties of GABA(A) receptor-mediated signaling during early neocortical development
26. A receptors in vivo
27. The role of GABA receptors in the control of nigrostriatal dopaminergic neurons: Dual-probe microdialysis study in awake rats
28. Mitochondrial complex I deficiency in Parkinson's disease
29. Involvement of free radicals in excitotoxicity in vivo
30. Postsynaptic action of endogenous GABA released by nipecotic acid in the hippocampus
31. Characterization of the radical trapping activity of a novel series of cyclic nitrone spin traps
32. Glycine stimulates striatal dopamine release in conscious rats
33. Attenuation of excitotoxic cell swelling and GABA release by the GABA transporter inhibitor SKF 89976A
34. Activity at the GABA transporter contributes to acute cellular swelling produced by metabolic impairment in retina
35. Excitatory amino acid-induced toxicity in the chick retina: Amino acid release, histology and effects of chloride channel blockers
36. Relative vulnerability of dopamine and GABA neurons in mesencephalic culture to inhibition of succinate dehydrogenase by malonate and 3-nitropropioninc acid and protection by NMDA receptor blockade
37. Excitotoxicity and oxidative stress during inhibition of energy metabolism
38. Role of oxidative stress and the glutathione system in loss of dopamine neurons due to impairment of energy metabolism
39. Oxidative stress during energy impairment in mesencephalic cultures is not a downstream consequence of a secondary excitotoxicity