Activity at the GABA transporter contributes to acute cellular swelling produced by metabolic impairment in retina

Vision Research

Volumn 37, Issue 24, 1997, Pages 3463-3470

  Zeevalk, Gail D ^a   Nicklas, William J ^a  

^a RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

Author keywords

Chicken; GABA; Ischemia; Metabolism; Retina; Toxicity

Indexed keywords

1 (4,4 DIPHENYL 3 BUTENYL)NIPECOTIC ACID; 1 [2 (BENZHYDRYLIDENEAMINOOXY)ETHYL] 1,2,5,6 TETRAHYDRO 3 PYRIDINECARBOXYLIC ACID; 4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID CARRIER; 4 AMINOBUTYRIC ACID RECEPTOR STIMULATING AGENT; CARBON 14; CARRIER PROTEIN; MUSCIMOL; NIPECOTIC ACID; UNCLASSIFIED DRUG;

4 AMINOBUTYRIC ACID RELEASE; ACUTE TOXICITY; ANIMAL CELL; ARTICLE; CELL SWELLING; CHICK EMBRYO; CONTROLLED STUDY; GLYCOLYSIS; ISOTOPE LABELING; METABOLIC INHIBITION; NONHUMAN; PRIORITY JOURNAL; RETINA INJURY; RETINA NERVE CELL;

ANIMALS; BIOLOGICAL TRANSPORT; CARBON RADIOISOTOPES; CARRIER PROTEINS; CHICK EMBRYO; CULTURE TECHNIQUES; GABA AGONISTS; GABA ANTAGONISTS; GABA PLASMA MEMBRANE TRANSPORT PROTEINS; GAMMA-AMINOBUTYRIC ACID; GLYCOLYSIS; IODOACETATES; ISCHEMIA; ISOXAZOLES; MEMBRANE PROTEINS; MEMBRANE TRANSPORT PROTEINS; MUSCIMOL; NIPECOTIC ACIDS; ORGANIC ANION TRANSPORTERS; OXIMES; PROLINE; RETINA;

EID: 0030729457     PISSN: 00426989     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0042-6989(97)00184-3     Document Type: Article

References (39)

1. + and glutamate activates different neurotransmitter release mechanisms in GABAergic neurons: vesicular versus non-vesicular release of GABA. Neuroscience, 54, 1019-1034.
2. Borden, L. A., Murali Dhar, T. G., Smith, K. E., Weinshank, R. L., Branchek, T. A. & Gluchowski, C. (1994). Tiagabine, SK & F 89976-A, CI-966 and NNC-711 are selective for the cloned GABA transporter GAT-1. European Journal of Pharmacology, 269, 219-224.
3. Brecha, N. C. & Weigmann, C. (1994). Expression of GAT-1, a highaffinity gamma-aminobutyric acid plasma membrane transporter in the rat retina. Journal of Comparative Neurology, 345, 602-611.
4. Buckingham, S. D., Hosie, A. M., Roush, R. L. & Sattelle, D. B. (1994). Actions of agonists and convulsant antagonists on a Drosophila melanogaster GABA receptor (Rdl) homo-oligomer expressed in Xenopus oocytes. Neuroscience Letters, 181, 137-140.
5. Cammack, J. N., Rakhilin, S. V. & Schwartz, E. A. (1994). A GABA transporter operates asymmetrically and with variable stoichiometry. Neuron, 13, 949-960.
6. Corey, J. L., Guastella, J., Davidson, N. & Lester, H. A. (1994). GABA uptake and release by a mammalian cell line stably expressing a cloned rat brain GABA transporter. Molecular Membrane Biology, 11, 23030.
7. David, P., Lusky, M. & Teichberg, V. I. (1988). Involvement of excitatory neurotransmitters in the damage produced in chick embryo retinas by anoxia and extracellular high potassium. Experimental Eye Research, 46, 657-662.
8. Dunlop, J., Grieve, A., Schousboe, A. & Griffiths, R. (1991). Stimulation of gamma[3H]aminobutyric acid release from cultured mouse cerebral cortex neurons by sulphur-containing excitatory amino acid transmitter candidates: receptor activation mediates two distinct mechanisms of release. Journal of Neurochemistry, 57, 1388-1397.
9. Gomeza, J., Gimenez, C. & Zafra, F. (1994). Cellular distribution and regulation by cAMP of the GABA transporter (GAT-1) mRNA. Molecular Brain Research, 21, 150-156.
10. Harris, K. M. & Miller, R. J. (1989). Excitatory amino acid-evoked release of [3H]GABA from hippocampal neurons in primary culture. Brain Research, 482, 23-33.
11. Hofmann, H. & Mockel, V. (1991). Release of gamma-amino[3H]butyric acid from cultured amacrine-like neurons mediated by different excitatory amino acid receptors. Journal of Neurochemistry, 56, 923-932.
12. Honda, S., Yamamoto, M. & Saito, N. (1995). Immunocytochemical localization of three subtypes of GABA transporter in rat retina. Molecular Brain Research, 33, 319-325.
13. Johnston, G. A. R., Stephanson, A. L. & Twitchin, B. (1976). Uptake and release of nipecotic acid by rat brain slices. Journal of Neurochemistry, 26, 83-87.
14. Jonsson, U., Lundstrom, M., Sellstrom, A. & Ehinger, B. (1986). Calcium-independent release of gamma-aminobutyrate from nerve processes in the developing rabbit retina. Neuroscience, 17, 1235-1241.
15. Larsson, O. M., Falch, E.. Krogsgaard-Larson, P. & Schousboe, A. (1988). Kinetic characterization of inhibition of garnma-aminobutyric acid uptake into cultured neurons and astrocytes by 4,4-diphenyl-3-butenyl derivatives of nipecotic acid and guvacine. Journal of Neurochemistry, 50, 818-823.
16. Lowry, O. H., Rosebrough, N. J., Fair. A. L. & Randall, R. J. (1951). Protein measurement with the folin phenol reagent. Journal of Biological Chemistry, 193, 265-275.
17. Lyden, P. D. & Lonzo, L. (1994). Combination therapy protects ischemic brain in rats. Stroke, 25. 189-196.
18. Madden, K. P. (1994). Effect of gamma-aminobutyric acid modulation on neuronal ischemia in rabbits. Stroke, 25. 2271-2275.
19. Malchow, R. P. & Ripps, H. ( 1990). Effects of gamma-aminobutyric acid on skate retinal horizontal cells: evidence for an electrogenic uptake mechanism. Proceedings of the National Academy of Sciences USA, 87, 8945-8949.
20. Mosinger, J. L., Price, M. T., Bai, H. Y., Xiao, H., Wozniak, D. F. & Olney, J. W. (1991). Blockade of both NMDA and non-NMDA receptors is required for optimal protection against ischemic neuronal degeneration in the in vivo adult mammalian retina. Experimental Neurology, 113, 10-17.
21. Nielsen, E. B., Suzdak, P. D., Andersen, K. E., Knutsen, L. J. S., Sonnewald, U. & Braestrup, C. (1991). Characterization of tiagabine *(NO-328), a new potent and selective GABA uptake inhibitor**. European Journal of Pharmacology, 196, 257-266.
22. Olney, J. W., Price, M. T., Samson, L. & Labruyere, J. (1986). The role of specific ions in glutamate neurotoxicity. Neuroscience Letters, 65, 65-71.
23. Pin, J. P. & Bockaert, J. (1989). Two distinct mechanisms, differentially affected by excitatory amino acids, trigger GABA release from fetal mouse striatal neurons in primary culture. Journal of Neuroscience, 9, 648-656.
24. Schousboe, A., Hjeds, H., Krogsgaard-Larsen, P. & Wood, J. D. (1986). Tissue distribution, metabolism, anticonvulsant efficacy, and effect on brain amino acid levels of the glia-selective gammaaminobutyric acid transport inhibitor 4,5,6,7-tetrahydroisoxazolo[4,5-c]pyridin-3-ol in mice and chicks. Journal of Neurochemistry, 47, 758-763.
25. Schousboe, A., Larsson, O. M., Wood, J. D. & Krogsgaard-Larsen, P. (1983). Transport and metabolism of gamma-aminobutyric acid in neurons and glia: implications for epilepsy. Epilepsia, 24, 531-538.
26. Schwartz, E. (1982). Calcium-independent release of GABA from isolated horizontal cells of the toad retina. Journal of Physiology, 323, 211-227.
27. Shuaib, A., Mazagri, R. & Ijaz, S. (1993). GABA agonist muscimol is neuroprotective in repetitive transient forebrain ischemia in gerbils. Experimental Neurology, 123, 284-288.
28. Solis, J. M. & Nicoll, R. A. (1992). Postsynaptic action of endogenous GABA released by nipecotic acid in the hippocampus. Neuroscience Letters, 147, 16-20.
29. Suzdak, P. D., Frederiksen, K., Andersen, K. E., Sorensen, P. O., Knutsen, L. J.S. & Nielsen, E. B. (1992). NNC-711, a novel potent and selective gamma-aminobutyric acid uptake inhibitor: pharmacological characterization. European Journal of Pharmacology, 223, 189-198.
30. Suzdak, P. D. & Jansen, J. A. (1995). A review of the preclinical pharmacology of tiagabine: a potent and selective anticonvulsant GABA uptake inhibitor. Epilepsia, 36, 612-626.
31. Takahashi, K., Miyoshi, S., Kaneko, A. & Copenhagen, D. R. (1995). Actions of nipecotic acid and SKF 89976A on GABA transporter in cone-driven horizontal cells dissociated from the catfish retina. Japanese Journal of Physiology, 45, 457-473.
32. Waldmeier, P. C., Stocklin, K. & Feldtrauer, J. J. (1992). Weak effects of local and systemic administration of the GABA uptake inhibitor, SK and F 89976, on extracellular GABA in the rat striatum. Naunyn-Schmiedeberg's Archives of Pharmacology, 345, 544-547.
33. Weiss, S. (1988). Excitatory amino acid-evoked release of gamma[3H]aminobutyric acid from striatal neurons in primary culture. Journal of Neurochemistry, 51, 435-441.
34. Yazulla, S. & Kleinschmidt, J. (1983). Carrier-mediated release of GABA from retinal horizontal cells. Brain Research, 263, 63-75.
35. Yoon, Y. H. & Marmor, M. F. (1989). Dextromethorphan protects retina against ischemic injury in vivo. Archives of Ophthalmology, 107,409-411.
36. Zeevalk, G. D., Hyndman, A. G. & Nicklas, W. J. (1989). Excitatory amino acid-induced toxicity in chick retina: amino acid release, histology and effects of chloride channel blockers. Journal of Neurochemistry, 53, 1610-1619.
37. Zeevalk, G. D. & Nicklas, W. J. (1990). Chemically induced hypoglycemia and anoxia: relationship to glutamate receptormediated toxicity in retina. Journal of Pharmacology and Experimental Therapeutics, 253, 1285-1292.
38. Zeevalk, G. D. & Nicklas, W. J. (1991). Mechanisms underlying initiation of excitotoxicity associated with metabolic inhibition. Journal of Pharmacology and Experimental Therapeutics, 257, 870-878.
39. Zeevalk, G. D. & Nicklas, W. J. (1996). Attenuation of excitotoxic cell swelling and GABA release by the GABA transport inhibitor SKF 89976A. Molecular and Chemical Neuropathology, 29, 27-36.