Functional analysis of RRD1 [YIL153w) and RRD2 [YPL152w), which encode two putative activators of the phosphotyrosyl phosphatase activity of PP2A in Saccharomyces cerevisiae

Molecular and General Genetics

Volumn 262, Issue 6, 2000, Pages 1081-1092

  Rempola, B ^a   Kaniak, A ^b   Migdalski, A ^a   Rytka, J ^a   Slonimski, P P ^b   Di Rago, J P ^b  

^a INSTITUTE OF BIOCHEMISTRY AND BIOPHYSICS   (Poland)

^b CNRS   (France)

Author keywords

MAP kinases; Phosphotyrosyl phosphatase activator (PTPA); Synthetic lethality suppressors

Indexed keywords

CAFFEINE; CALCIUM ION; CYCLOHEXIMIDE; GLUCOSE; KETOCONAZOLE; PROTEIN TYROSINE PHOSPHATASE; RAPAMYCIN; SORBITOL; VANADIC ACID;

ALLELE; ARTICLE; CONTROLLED STUDY; CULTURE MEDIUM; ENZYME ACTIVITY; ENZYME SUBUNIT; FUNGAL GENETICS; FUNGUS GROWTH; GENE DELETION; GENE FUNCTION; GENE OVEREXPRESSION; GENE SEQUENCE; GENETIC ANALYSIS; NONHUMAN; OPEN READING FRAME; PHENOTYPE; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE; SIGNAL TRANSDUCTION;

FUNGI; MYXOGASTRIA; SACCHAROMYCES CEREVISIAE;

EID: 0033984829     PISSN: 00268925     EISSN: None     Source Type: Journal    
DOI: 10.1007/PL00008651     Document Type: Article

References (51)

1. Agostinis P, Donella-Deana A, Van Hoof C, Cesaro L, Brunati AM, Ruzzene M, Merlevede W, Pinna LA, Goris J (1996) A comparative study of the phosphotyrosyl phosphatase specificity of protein phosphatase type 2A and phosphotyrosyl phosphatase type 1B using phosphopeptides and phosphoproteins p50/HSl, c-Fgr and Lyn. Eur J Biochem 236:548-557
2. Albertyn J, Hohmann S, Thevelein JM, Prior BA (1994) GPD1, which encodes glycerol-3-phosphate dehydrogenase, is essential for growth under osmotic stress in Saccharomyces cerevisiae, and its expression is regulated by the high-osmolarity glycerol response pathway. Mol Cell Biol 14:4135-4144
3. Amberg DC, Botstein D, Beasley EM (1995) Precise gene disruption in Saccharomyces cerevisiae by double fusion polymerase chain reaction. Yeast 11:1275-1280
4. 1 progression in yeast. Mol Biol Cell 7:25-42
5. Baudin A, Ozier-Kalogeropoulos O, Denouel A, Lacroute F, Cullin C (1993) A simple and efficient method for direct gene deletion in Saccharomyces cerevisiae. Nucleic Acids Res 21:3329-3330
6. Bonneaud N, Ozier-Kalogeropoulos O, Li G, Labouesse M, Minvielle-Sebastia L, Lacroute F (1991) A family of low and high copy replicative, integrative and single-stranded S. cerevisiae/E. coli shuttle vectors. Yeast 7:609-615
7. Brewster JL, de Valoir T, Dwyer ND, Winter E, Gustin MC (1993) An osmosensing signal transduction pathway in yeast. Science 259:1760-1763
8. Cayla X, Van Hoof C, Bosch M, Waelkens E, Vandekerckhove J, Peeters B, Merlevede W, Goris J (1994) Molecular cloning, expression, and characterization of PTPA, a protein that activates the tyrosyl phosphatase activity of protein phosphatase 2A. J Biol Cell 269:15668-15675
9. Chen D-C, Yang B-C, Tsong-Teh K (1992) One-step transformation of yeast in stationary phase. Curr Genet 21:83-84
10. Cid VJ, Duran A, Del Rey F, Snyder M, Nombela P, Sanchez M (1995) Molecular basis of cell integrity and morphogenesis in Saccharomyces cerevisiae. Microbiol Rev 59:345-386
11. Claisse ML, Pere-Aubert GA, Clavilier LP, Slonimski PP (1970) Method for the determination of cytochrome concentrations in whole yeast cells (in French). Eur J Biochem 16:430-438
12. Costigan C, Snyder M (1994) SLK1, a yeast homolog of MAP kinase activators, has a RAS/cAMP-independent role in nutrient sensing. Mol Gen Genet 243:286-296
13. Costigan C, Kolodrubetz D, Snyder M (1994) NHP6A and NHP6B, which encode HMG1-like proteins, are candidates for downstream components of the yeast SLT2 mitogen-activated protein kinase pathway. Mol Cell Biol 14:2391-2403
14. Di Como CJ, Arndt KT (1996) Nutrients, via the Tor proteins, stimulate the association of Tap42 with type 2A phosphatases. Genes Dev 10:1904-1916
15. Dujardin G, Pajot P, Groudinsky O, Slonimski PP (1980) Long range control within mitochondria and between nucleus and mitochondria. I. Methodology and phenomenology of suppressors. Mol Gen Genet 179:469-482
16. Evans DRH, Stark MJR (1997) Mutations in the Saccharomyces cerevisiae type 2A protein phosphatase catalytic subunit reveal roles in cell wall integrity, actin cytoskeleton organization and mitosis. Genetics 145:227-241
17. Heitman J, Movva NR, Hall MN (1991) Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast. Science 253:905-909
18. Huffman CS, Winston F (1987) A ten-minute DNA preparation from yeast efficiently releases autonomous plasmids for transformation of Escherichia coli. Gene 57:267-272
19. Hohmann S (1997) Shaping up: the response of yeast to osmotic stress. In: Hohmann S, Mager WH (eds) Yeast stress responses. RG Landes, Austin, pp 101-145
20. Hu GZ, Ronne HJ (1994) Overexpression of yeast PAM1 gene permits survival without protein phosphatase 2A and induces a filamentous phenotype. J Biol Chem 269:3429-3435
21. Igual JC, Johnson AL, Johnston LH (1996) Coordinated regulation of gene expression by the cell cycle transcription factor SWI4 and the protein kinase C MAP kinase pathway for yeast cell integrity. EMBO J 15:5001-5013
22. Jiang B, Ram AF, Sheraton J, Klis FM, Bussey H (1995) Regulation of cell wall beta-glucan assembly: PTC1 negatively affects PBS2 action in a pathway that includes modulation of EXG1 transcription. Mol Gen Genet 248:260-269
23. Jones JS, Prakash L (1990) Yeast Saccharomyces cerevisiae selectable markers in pUC18 polylinkers. Yeast 6:363-366
24. Kamada Y, Jung US, Piotrowski J, Levin DE (1995) The protein kinase C-activated MAP kinase pathway of Saccharomyces cerevisiae mediates a novel aspect of the heat shock response. Genes Dev 9:1559-1571
25. Levin DE, Bowers B, Chen C-Y, Kamada Y, Watanabe M (1994) Dissecting the protein kinase C/MAP kinase signalling pathway of Saccharomyces cerevisiae. Cell Mol Biol Res 40:229-239
26. Madden K, Sheu YJ, Baetz K, Andrews B, Snyder M (1997) SBF cell cycle regulator as a target of the yeast PKC-MAP kinase pathway. Science 275:1781-1784
27. Maeda T, Wurgler-Murphy SM, Saito H (1994) A two-component system that regulates an osmosensing MAP kinase cascade in yeast. Nature 369:242-245
28. Martin H, Arroyo J, Sanchez M, Molina M, Nombela C (1993) Activity of the yeast MAP kinase homologue Slt2 is critically required for cell integrity at 37° C. Mol Gen Genet 241:177-184
29. Martin H, Castellanos MC, Cenamor R, Sanchez M, Molina M, Nombela C (1996) Molecular and functional characterization of a mutant allele of the mitogen-activated protein-kinase gene SLT2 (MPK1) rescued from yeast autolytic mutants. Curr Genet 29:516-522
30. Mazzoni C, Zarzov P, Rambourg A, Mann C (1993) The SLT2 (MPK1) MAP kinase homolog is involved in polarized cell growth in Saccharomyces cerevisiae. J Cell Biol 123:1821-1833
31. Nakamura T, Ohmoto T, Hirata D, Miyakawa T (1996) Genetic evidence for functional redundancy of calcineurin-and Mpk1-mediated pathways in the regulation of cellular events important for growth in Saccharomyces cerevisiae. Mol Gen Genet 251:211-219
32. Purnelle B, Coster F, Goffeau A (1996) The sequence of 55 kb on the left arm of yeast chromosome XVI identifies a small nuclear RNA, a new putative protein kinase and two new putative regulators. Yeast 12:1483-1492
33. Ram AF, Wolters A, Ten Hoopen R, Klis FM (1994) A new approach for isolating cell wall mutants in Saccharomyces cerevisiae by screening for hypersensitivity to calcofluor white. Yeast 10:1019-1030
34. Ramotar D, Belanger E, Brodeur I, Massen J-Y, Dobretsky EA (1998) A yeast homologue of the human phosphotyrosyl phosphatase activator PTPA is implicated in protection against oxidative DNA damage induced by the model carcinogen 4-Nitroquinoline 1-Oxide. J Biol Chem 273:21489-21496
35. Rieger K-J, Kaniak A, Coppee J-Y, Aljinovic G, Baudin-Baillieu A, Orlowska G, Gromadka R, Groudinsky O, di Rago J-P, Slonimski PP (1997) Large-scale phenotypic analysis - the pilot project on yeast chromosome III. Yeast 13:1547-1562
36. Rose MD, Winston F, Hieter P (1991) Methods in yeast genetics: a laboratory manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY
37. Sambrook J, Fritsch EF, Maniatis T (1989) Molecular cloning: a laboratory manual (2nd edn). Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY
38. Schott EJ, Gardner RC (1997) Aluminium-sensitive mutants of Saccharomyces cerevisiae. Mol Gen Genet 254:63-72
39. Shimizu J, Yoda K, Yamasaki M (1994) The hypo-osmolarity-sensitive phenotype of the Saccharomyces cerevisiae hpo2 mutant is due to a mutation in PKC1, which regulates expression of beta-glucanase. Mol Gen Genet 242:641-648
40. Sneddon AA, Cohen W, Stark MJ (1990) Saccharomyces cerevisiae protein phosphatase 2A performs an essential cellular function and is encoded by two genes. EMBO J 9:4339-4346
41. Stark MJ (1996) Yeast protein serine/threonine phosphatases: multiple roles and diverse regulation. Yeast 12:1647-1675
42. Sutton A, Immanuel D, Arndt KT (1991) The SIT4 protein phosphatase functions in late G1 for progression into S phase. Mol Cell Biol 11:2133-2148
43. Tanaka K, Waxman L, Goldberg AL (1984) Vanadate inhibits the ATP-dependent degradation of proteins in reticulocytes without affecting ubiquitin conjugation. J Biol Chem 259:2803-2809
44. Uesono Y, Toh-e A, Kikuchi Y (1997) Ssd1p of Saccharomyces cerevisiae associates with RNA. J Biol Chem 272:16103-16109
45. Van Hoof C, Cayla X, Bosch M, Merlevede W, Goris J (1994) A phosphotyrosyl phosphatase activator of protein phosphatase 2A. A novel purification method, immunological and enzymatic characterization. Ear J Biochem 226:899-907
46. Van Hoof C, Jansen V, Dinishiotu A, Merlevede W, Goris J (1998) Functional analysis of conserved domains in the phosphotyrosyl phosphatase activator. Molecular cloning of the homologues from Drosophila melanogaster and Saccharomyces cerevisiae. Biochemistry 37:12899-12908
47. Wach A (1996) PCR-synthesis of marker cassettes with long flanking homology regions for gene disruptions in S. cerevisiae. Yeast 12:259-265
48. Watanabe Y, Irie K, Matsumoto K (1995) Yeast RLM1 encodes a serum response factor-like protein that may function downstream of the Mpk1 (Slt2) mitogen-activated protein kinase pathway. Mol Cell Biol 15:5740-5749
49. Wera S, Hemmings BA (1995) Serine/threonine protein phosphatases. Biochem J 311:17-29
50. Wiederrecht GJ, Sabers CJ, Brunn GJ, Martin MM, Dumont FJ, Abraham RT (1995) Mechanism of action of rapamycin: new insights into the regulation of G1-phase progression in eukaryotic cells. Prog Cell Cycle Res 1:53-71
51. Zarzov P, Mazzoni C, Mann C (1996) The SLT2(MPK1) MAP kinase is activated during periods of polarized cell growth in yeast. EMBO J 15:83-91