Examination of the reduced affinity of the thymidylate synthase G52S mutation for FdUMP by Ab initio and semi-empirical studies

Molecular Medicine

Volumn 7, Issue 3, 2001, Pages 200-204

  Sapse, Anne Marie ^a,b   Capiaux, Gina M ^c,d   Bertino, Joseph R ^c,d  

^a JOHN JAY COLLEGE OF CRIMINAL JUSTICE   (United States)

^b ROCKEFELLER UNIVERSITY   (United States)

^c MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^d Weill Cornell Graduate School of Biomedical Sciences   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; ENZYME INHIBITOR; FLOXURIDINE PHOSPHATE; THYMIDYLATE SYNTHASE;

ANIMAL; ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; GENETICS; METABOLISM; MUTATION; PROTEIN CONFORMATION; RAT;

ANIMALS; ARGININE; ENZYME INHIBITORS; FLUORODEOXYURIDYLATE; MODELS, MOLECULAR; MUTATION; PROTEIN CONFORMATION; RATS; THYMIDYLATE SYNTHASE;

EID: 0035288608     PISSN: 10761551     EISSN: None     Source Type: Journal    
DOI: 10.1007/bf03401954     Document Type: Article

References (10)

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