Human breast-cancer cells stimulate the fusion, migration and resorptive activity of osteoclasts in bone explants

International Journal of Cancer

Volumn 91, Issue 5, 2001, Pages 665-672

  Hsu, Chih Ping ^a   Yang, Chuan Ching ^a   Yang, Shiaw Der ^a  

^a NATIONAL TSING HUA UNIVERSITY   (Taiwan)

Author keywords

Bone explants; Bone resorption; Breast cancer cells; Osteoclast fusion; Osteoclast migration

Indexed keywords

CALCIUM ION; CYSTEINE PROTEINASE INHIBITOR; INTERLEUKIN 11; INTERLEUKIN 6; LEUKOTRIENE; MATRIX METALLOPROTEINASE INHIBITOR; PARATHYROID HORMONE RELATED PROTEIN; PHOSPHATASE; PROSTAGLANDIN; TARTARIC ACID; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; BONE ATROPHY; BONE MARROW; BONE METASTASIS; BREAST CARCINOMA; CANCER CELL; CELL FUSION; CELL MIGRATION; CONTROLLED STUDY; ENZYME ACTIVITY; EPITHELIUM CELL; EXPLANT; FRACTIONATION; HUMAN; HUMAN CELL; METATARSAL BONE; MORPHOMETRICS; OSTEOCLAST; OSTEOLYSIS; PERIOSTEUM; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS;

ANIMALS; BONE AND BONES; BONE RESORPTION; BREAST; BREAST NEOPLASMS; CELL FUSION; CELL LINE; CELL MOVEMENT; CULTURE MEDIA, CONDITIONED; CYSTEINE PROTEINASE INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; IN SITU HYBRIDIZATION; INTERLEUKIN-1; INTERLEUKIN-11; INTERLEUKIN-6; LEUKOTRIENES; MATRIX METALLOPROTEINASE 9; MATRIX METALLOPROTEINASES; METATARSAL BONES; MICE; NEOPLASM METASTASIS; ORGAN CULTURE TECHNIQUES; OSTEOCLASTS; PARATHYROID HORMONE-RELATED PROTEIN; PROSTAGLANDINS; PROTEINS; TIME FACTORS; TUMOR CELLS, CULTURED; TUMOR NECROSIS FACTOR-ALPHA; ULTRAFILTRATION;

EID: 0035283746     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/1097-0215(200002)9999:9999<::AID-IJC1100>3.0.CO;2-3     Document Type: Article

References (32)

1. Evidence for a causal role of parathyroid hormone-related protein in the pathogenesis of human breast cancer-mediated osteolysis
2. Osteolytic bone metastasis in breast cancer
3. Facilitation and suppression of bone metastasis
4. Localized tumor-associated osteolysis involves the recruitment and activation of osteoclasts
5. Human breast cancer induces osteoclast activation and increases the number of osteoclasts at sites of tumor osteolysis
6. Identification of breast cancer cell line-derived paracrine factors that stimulate osteoclast activity
7. Expression of transcripts of interleukin-6 and related cytokines by human breast tumours, breast cancer cells and adipose stromal cells
8. 2 and leukemia inhibitory factor and supports osteoclast formation in vitro via a stromal dependent pathway
9. TGFβ signalling blockade inhibits PTHrP secretion by breast cancer cells and bone metastases development
10. Modulation of osteoclast differentiation
11. Differentiation kinetics of osteoclasts in the periosteum of embryonic bones in vivo and in vitro
12. Inhibition of bone resorption in vitro by selective inhibitors of gelatinase and collagenase
13. Matrix metalloproteinases are obligatory for migration of preosteoclasts to the developing marrow cavity of primitive long bones
14. Kinetic and cytochemical identification of osteoclast precursors and their differentiation into multinucleated osteoclasts
15. Epidermal growth factor stimulation of stromelysin mRNA in rat fibroblasts requires induction of proto-oncogenes c-fos and c-jun and activation of protein kinase C
16. In vitro formation of osteoclasts from long-term cultures of bone marrow mononuclear phagocytes
17. Increased osteoclast development after estrogen loss: Mediation by interleukin-6
18. Interleukin-11: A new cytokine critical for osteoclast development
19. Parathyroid hormone-related protein and bone metastases
20. Comparison of the effects of various lengths of synthetic human parathyroid hormone-related peptide (hPTHrP) of malignancy on bone resorption and formation in organ culture
21. Effects of a synthetic peptide of a parathyroid hormone-related protein on calcium homeostasis, renal tubular calcium reabsorption, and bone metabolism in vivo and in vitro in rodents
22. Two distinct effects of recombinant human tumour necrosis factor-α on osteoclast development and subsequent resorption of mineralized matrix
23. Structural requirements for the action of parathyroid hormone-related protein (PTHrP) on bone resorption by isolated osteoclasts
24. A carboxyl-terminal peptide from the parathyroid hormone-related protein inhibits bone resorption by osteoclasts
25. Bone matrix stimulates osteoclastic differentiation in cultures of rabbit bone marrow cells
26. 4 stimulates bone resorption both in vitro and in vivo
27. Extracellular matrix degradation
28. Inhibiting and stimulating effects of TGF-β on osteoclastic bone resorption in fetal mouse bone organ cultures
29. Leukemia inhibitory factor inhibits osteoclastic resorption, growth, mineralization and alkaline phosphatase activity in fetal mouse metacarpal bones in culture
30. Parathyroid hormone-induced resorption in fetal rat limb bones is associated with production of the metalloproteinases collagenase and gelatinase B
31. Expression of matrix metalloproteinase-2 and 9 during early human wound healing
32. Matrix metalloproteinase-9 from U937 monoblastoid cells: Correlation with cellular invasion