The mouse mammary tumor cell line, MMT060562, produces prostaglandin E2 and leukemia inhibitory factor and supports osteoclast formation in vitro via a stromal cell-dependent pathway

Journal of Bone and Mineral Research

Volumn 13, Issue 3, 1998, Pages 400-408

  Akatsu, Takuhiko ^a   Ono, Katsuhiro ^a   Katayama, Yasuyuki ^a   Tamura, Tatsuya ^b   Nishikawa, Miyuki ^a   Kugai, Nobuo ^a   Yamamoto, Michiko ^a   Nagata, Naokazu ^a  

^a NATIONAL DEFENSE MEDICAL COLLEGE   (Japan)

^b CHUGAI PHARMACEUTICAL CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

LEUKEMIA INHIBITORY FACTOR; PROSTAGLANDIN E2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW CELL; BONE METASTASIS; CELL DIFFERENTIATION; CONTROLLED STUDY; MALE; MOUSE; NONHUMAN; OSTEOCLAST; OSTEOLYSIS; TUMOR CELL LINE;

ACID PHOSPHATASE; ALKALINE PHOSPHATASE; ANIMALS; BONE MARROW CELLS; BONE RESORPTION; CALCITONIN; COCULTURE TECHNIQUES; GROWTH INHIBITORS; INTERLEUKIN-6; ISOENZYMES; LEUKEMIA INHIBITORY FACTOR; LYMPHOKINES; MALE; MAMMARY NEOPLASMS, EXPERIMENTAL; MICE; MICE, INBRED BALB C; OSTEOCLASTS; PROSTAGLANDINS E; STROMAL CELLS; TUMOR CELLS, CULTURED; TUMOR MARKERS, BIOLOGICAL;

EID: 0031945434     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/jbmr.1998.13.3.400     Document Type: Article

References (48)

1. Mundy GR, Yoneda T 1995 Facilitation and suppression of bone metastasis. Clin Orthop 312:34-44.
2. Orr FW, Kostenuik P, Sanchez-Sweatman OH, Singh G 1993 Mechanisms involved in the metastasis of cancer to bone. Breast Cancer Res Treat 25:151-163.
3. Mundy GR 1991 Mechanisms of osteolytic bone destruction. Bone 12 (Suppl 1):S1-S6.
4. Taube T, Elomaa I, Blomqvist C, Beneton MNC, Kanis JA 1994 Histomorphometric evidence for osteoclast-mediated bone resorption in metastatic breast cancer. Bone 15:161-166.
5. Bataille R, Chappard D, Marcelli C, Dessauw P, Baldet P, Sany J, Alexandre C 1991 Recruitment of new osteoblasts and osteoclasts is the earliest critical event in the pathogenesis of human multiple myeloma. J Clin Invest 88:62-66.
6. Hiraga T, Nakajima T, Ozawa H 1995 Bone resorption induced by a metastatic human melanoma cell line. Bone 16:349-356.
7. Ralston SH, Gallacher SJ, Patel U, Campbell J, Boyle IT 1990 Cancer-associated hypercalcemia: Morbidity and mortality. Ann Intern Med 112:499-504.
8. Rosol TJ, Capen CC 1992 Mechanisms of cancer-induced hypercalcemia. Lab Invest 67:680-702.
9. Yoneda T 1993 Cytokines in bone: Local translators in cell-to-cell communications. In: Noda M (ed.) Cellular and Molecular Biology of Bone. Academic Press, New York, NY, U.S.A., pp. 375-412.
10. Wysolmerski JJ, Broadus AE 1994 Hypercalcemia of malignancy: The central role of parathyroid hormone-related protein. Ann Rev Med 45:189-200.
11. Akatsu T, Nagata N, Kugai N, Yasutomo Y, Kinoshita T, Kosano H, Takatani O, Takishima K, Mamiya G 1988 On the activities of parathyroid hormone-like factor and transforming growth factors in extract of pancreatic cancer associated with humoral hypercalcemia of malignancy. Acta Endocrinol 118:232-238.
12. Nagata N, Akatsu T, Kugai N, Yasutomo Y, Kinoshita T, Kosano H, Shimauchi T, Takatani O, Ueyama Y 1989 The tumor cells (FA-6) established from a pancreatic cancer associated with humoral hypercalcemia of malignancy: A simultaneous production of parathyroid hormone-like activity and transforming growth factor activity. Endocrinol Japon 36:75-85.
13. Nowak RA, Morrison NE, Goad DL, Gaffney EV, Tashjian AH 1990 Squamous cell carcinomas often produce more than a single bone resorption-stimulating factor: Role of interleukin-1α. Endocrinology 127:3061-3069.
14. Ibbotson KJ, Harrod J, Gowen M, D'Souza S, Smith DD, Winkler ME, Derynck R, Mundy GR 1986 Human recombinant transforming growth factor α stimulates bone resorption and inhibits formation in vitro. Proc Natl Acad Sci USA 83:2228-2232.
15. Sato K, Fujii Y, Kasono K, Tsushima T, Shizume K 1988 Production of interleukin 1α and PTH-like factor by squamous cell carcinoma of the esophagus (EC-GI) derived from a patient with hypercalcemia. J Clin Endocrinol Metab 67:592-601.
16. Sato K, Fujii Y, Kasono K, Ozawa M, Imamura H, Kanaji Y, Kurosawa H, Tsushima T, Shizume K 1989 Parathyroid hormone-related protein and interleukin 1α synergistically stimulate bone resorption in vitro and increase the serum calcium concentration in mice in vivo. Endocrinology 124:2172-2178.
17. Grill V, Ho P, Body JJ, Johanson N, Lee SC, Kukreja SC, Moseley JM, Martin TJ 1991 Parathyroid hormone-related protein: Elevated levels in both humoral hypercalcemia of malignancy and hypercalcemia complicating metastatic breast cancer. J Clin Endocrinol Metab 73:1309-1315.
18. Mundy GR, Roodman GD 1987 Osteoclast ontogeny and function. In: Peck WA (ed.) Bone and Mineral Research, Vol 5. Elsevier Science Publishers BV, pp. 209-279.
19. Roodman GD, Kurihara N, Ohsaki Y, Kukita A, Hosking D, Demulder A, Smith JF, Singer FR 1992 Interleukin 6: A potential autocrine/paracrine factor in Paget's disease of bone. J Clin Invest 89:46-52.
20. Takahashi N, Yamana H, Yoshiki S, Roodman GD, Mundy GR, Jones SJ, Boyde A, Suda T 1988 Osteoclast-like cell formation and its regulation by osteotropic hormones in mouse bone marrow cultures. Endocrinology 122:1373-1382.
21. Akatsu T, Takahashi N, Udagawa N, Sato K, Nagata N, Moseley JM, Martin TJ, Suda T 1989 Parathyroid hormone (PTH)-related protein is a potent stimulator of osteoclast-like multinucleated cell formation to the same extent as PTH in mouse marrow cultures. Endocrinology 125:20-27.
22. Akatsu T, Takahashi N, Debari K, Morita I, Murota S, Nagata N, Takatani O, Suda T 1989 Prostaglandins promote osteoclast-like cell formation by a mechanism involving cyclic adenosine 3′,5′-monophosphate in mouse bone marrow cell cultures. J Bone Miner Res 4:29-35.
23. Akatsu T, Takahashi N, Udagawa N, Imamura K, Yamaguchi A, Sato K, Nagata N, Suda T 1991 Role of prostaglandins in interleukin-1-induced bone resorption in mice in vitro. J Bone Miner Res 6:183-190.
24. Takahashi N, Akatsu T, Udagawa N, Sasaki T, Yamaguchi A, Moseley JM, Martin TJ, Suda T 1988 Osteoblastic cells are involved in osteoclast formation. Endocrinology 123:2600-2602.
25. Tamura T, Takahashi N, Akatsu T, Sasaki T, Udagawa N, Tanaka S, Suda T 1993 New resorption assay with mouse osteoclast-like multinucleated cells formed in vitro. J Bone Miner Res 8:953-960.
26. Mosmann T 1983 Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. J Immunol Meth 65:55-63.
27. Abe E, Ishimi Y, Takahashi N, Akatsu T, Ozawa H, Yamana H, Yoshiki S, Suda T 1988 A differentiation-inducing factor produced by the osteoblastic cell line MC3T3-E1, stimulates bone resorption by promoting osteoclast formation. J Bone Miner Res 3:635-645.
28. Tamura T, Udagawa N, Takahashi N, Miyaura C, Tanaka S, Yamada Y, Koishihara Y, Ohsugi Y, Kumaki K, Taga T, Kishimoto T, Suda T 1993 Soluble interleukin-6 receptor triggers osteoclast formation by interleukin 6. Proc Natl Acad Sci USA 90:11924-11928.
29. Athanasou NA, Wells CA, Quinn J, Ferguson DP, Heryet A, McGee JOD 1989 The origin and nature of stromal osteoclast-like multinucleated giant cells in breast carcinoma: Implications for tumour osteolysis and macrophage biology. Br J Cancer 59:491-498.
30. El-Naggar AK, Gaber K, Ordonez NG 1993 Renal carcinoma with osteoclast-like giant cells. Virchows Archiv A Pathol Anat 422:427-431.
31. Pettinato G, Manivel JC, Petrella G, Insabato L 1989 Alveolar variant of infiltrating lobular carcinoma of the breast with stromal osteoclast-like giant cells. Path Res Pract 185:388-394.
32. Nakai M, Mundy GR, Williams PJ, Boyce B, Yoneda T 1992 A synthetic antagonist to laminin inhibits the formation of osteolytic metastases by human melanoma cells in nude mice. Cancer Res 52:5395-5399.
33. Nemoto R, Uchida K, Tsutsumi M, Koiso K, Satoh T 1988 Bone resorption induced by transplanted bladder tumor (MBT-2) in mice. J Urol 139:650-652.
34. Shinar DM, Rodan GA 1990 Biphasic effects of transforming growth factor-β on the production of osteoclast-like cells in mouse bone marrow cultures: The role of prostaglandins in the generation of these cells. Endocrinology 126:3153-3158.
35. Kanatani M, Sugimoto T, Kaji H, Kobayashi T, Nishiyama K, Fukase M, Kumegawa M, Chihara K 1995 Stimulatory effect of bone morphogenetic protein-2 on osteoclast-like cell formation and bone-resorbing activity. J Bone Miner Res 10:1681-1690.
36. Mochizuki H, Hakeda Y, Wakatsuki N, Usui N, Akashi S, Sato T, Tanaka K, Kumegawa M 1992 Insulin-like growth factor-I supports formation and activation of osteoclasts. Endocrinology 131:1075-1080.
37. Gearing DP 1993 The leukemia inhibitory factor and its receptor. Adv Immunol 53:31-58.
38. Ishimi Y, Abe E, Jin CH, Miyaura C, Hong MH, Oshida M, Kurosawa H, Yamaguchi Y, Tomida M, Hozumi M, Suda T 1992 Leukemia inhibitory factor/differentiation-stimulating factor (LIF/d-factor): Regulation of its production and possible roles in bone metabolism. J Cell Physiol 152:71-78.
39. Kamohara H. Sakamoto K. Ishiko T, Mita S, Masuda Y, Abe T, Ogawa M 1994 Human carcinoma cell lines produce biologically active leukemia inhibitory factor (LIE). Res Commun Mol Pathol Pharmacol 85:131-140.
40. Ishimi Y, Miyaura C, Jin CH, Akatsu T, Abe E, Nakamura Y, Yamaguchi A, Yoshiki S, Matsuda T, Hirano T, Kishimoto T, Suda T 1990 IL-6 is produced by osteoblasts and induces bone resorption. J Immunol 145:3297-3303.
41. 3 of osteoclast differentiation and bone resorption in neonatal mouse parietal bones. Calcif Tissue Int 55:114-119.
42. Udagawa N, Takahashi N, Akatsu T, Sasaki T, Yamaguchi A, Kodama H, Martin TJ, Suda T 1989 The bone marrow-derived stromal cell lines MC3T3-G2, PA6, and ST2 support osteoclast-like cell differentiation in cocultures with mouse spleen cells. Endocrinology 125:1805-1813.
43. Taylor LM, Turksen K, Aubin JE, Heersche JNM 1993 Osteoclast differentiation in cocultures of a clonal chondrogenic cell line and mouse bone marrow cells. Endocrinology 133:2292-2300.
44. Hughes DE, MacDonald BR, Russell RGG, Gowen M 1989 Inhibition of osteoclast-like cell formation by bisphosphonates in long-term cultures of human bone marrow. J Clin Invest 83:1930-1935.
45. Takahashi N, Mundy GR, Roodman GD 1986 Recombinant human interferon γ inhibits formation of human osteoclast-like cells. J Immunol 137:3544-3549.
46. Nishikawa M, Akatsu T, Katayama Y, Yasutomo Y, Kado S, Kugai N, Yamamoto M, Nagata N 1996 Bisphosphonaates act on osteoblastic cells and inhibit osteoclast formation in mouse marrow cultures. Bone 18:9-14.
47. Hortobagyi GN, Theriault RL, Porter L, Blayney D, Lipton A, Sinoff C, Wheeler H, Simeone JF, Pharm JS, Knight RD, Heffenan M, Reitsma DJ 1996 Efficacy of pamidronate in reducing skeletal complications in patients with breast cancer and lytic bone metastases. N Engl J Med 335:1785-1791.
48. Bruce AG, Hoggatt IH, Rose TM 1992 Oncostatin M is a differentiation factor for myeloid leukemia cells. J Immunol 149:1271-1275.