Expression of transcripts of interleukin-6 and related cytokines by human breast tumors, breast cancer cells, and adipose stromal cells

Molecular and Cellular Endocrinology

Volumn 118, Issue 1-2, 1996, Pages 215-220

  Crichton, Miranda B ^a   Nichols, John E ^a   Zhao, Ying ^a   Bulun, Serdar E ^a   Simpson, Evan R ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Adipose; Aromatase; Breast cancer; Cytokines

Indexed keywords

CYTOKINE; ESTRADIOL; INTERLEUKIN 11; INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR; LEUKEMIA INHIBITORY FACTOR; MESSENGER RNA; ONCOSTATIN M;

ADIPOSE TISSUE; ARTICLE; BREAST TUMOR; CANCER CELL CULTURE; CONTROLLED STUDY; FEMALE; GENE INDUCTION; GENETIC TRANSCRIPTION; HORMONAL REGULATION; HUMAN; HUMAN CELL; HUMAN TISSUE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STROMA CELL;

EID: 0029867613     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/0303-7207(96)03761-6     Document Type: Article

References (41)

1. Grodin, J.M., Siiteri, P.K. and MacDonald, P.C. (1973) Source of estrogen production in postmenopausal women. J. Clin. Endocrinol. Metab. 36, 207-214.
2. McNatty, K.P., Baird, D.T., Bolton, A., Chambers, P., Corker, C.S. and MacLean, H. (1976) Concentrations of oestrogens androgens in human ovarian venous plasma and follicular fluid throughout the menstrual cycle. J. Endocrinol. 71, 77-85.
3. Doody, K., Lorence, M.C., Mason, J.I. and Simpson, E.R. (1990) Expression of mRNA species encoding steroidogenic enzymes in human follicles and corpora lutea throughout the menstrual cycle. J. Clin. Endocrinol. Metab. 70, 1041-1045.
4. Tsai-Morris, C.H., Aquilana, D.R. and Dufau, M.L. (1985) Gonadotropic regulation of aromatase activity in the adult rat testis. Endocrinology 116, 31-37.
5. Naftolin, F., Ryan, K.J., Davies, V.V. Reddy, F., Flores, Z., Petro, M., Kuhn, R.I., White, Y. and Takaoka, L. (1975) The formation of estrogens by central neuroendocrine tissues. Rec. Prog. Horm. Res. 31, 295-319.
6. Roselli, C.E., Horton, L.E. and Resko, J.A. (1985) Distribution and regulation of aromatase activity in the rat hypothalamus and limbic system. Endocrinology 117, 2471-2474.
7. Hemsell, D.L., Grodin, J.M., Brenner, P.F., Siiteri, P.K. and MacDonald, P.C. (1974) Plasma precursors of estrogen. II. Correlation of the extent of conversion of plasma androstenedione to estrone with age. J. Clin. Endocrinol. Metab. 38, 476-479.
8. Edman, C.D. and MacDonald, P.C. (1978) Effect of obesity on conversion of plasma androstenedione to estrone in ovulatory and anovulatory young women. Am. J. Obstet. Gynecol. 130, 456-461.
9. Edman, C.D., MacDonald, P.C. and Combes. B. (1975) Extraglandular production of estrogen in subjects with liver disease. Gastroenterology 69, 819 (abstract).
10. Gordon, G.G., Olivo, J., Rafil, F. and Southren, A.L. (1975) Conversion of androgens to estrogens in cirrhosis of the liver. J. Clin. Endocrinol. Metab. 40, 1018.
11. O'Neill, J.S., Elton, R.A. and Miller, W.R. (1988) Aromatase activity in adipose tissue from breast quadrants: a link with tumor site. Br. Med. J. 296, 741-743.
12. Reed, M.J., Topping, L., Coldham, N.G., Purohit, A., Ghilchik, M.W. and James, V.H.T. (1993) Control of aromatase activity in breast cancer cells: the role of cytokines and growth factors. J. Steroid Biochem. Mol. Biol. 44, 589-596.
13. Harada, N., Utsume, T. and Takagi, Y. (1993) Tissue-specific expression of the human aromatase cytochrome P450 gene by alternative use of multiple exons 1 and promoters, and switching of tissue-specific exons 1 in carcinogenesis. Proc. Natl. Acad. Sci. USA 90, 11312-11316.
14. Bulun, S.E., Price, T.M., Mahendroo, M.S, Aitken, J. and Simpson, E.R. (1993) A link between breast cancer and local estrogen biosynthesis suggested by quantification of breast adipose tissue aromatase cytochrome P450 transcripts using competitive polymerase chain reaction after reverse transcription. J. Clin. Endocrinol. Metab. 77, 1622-1628.
15. arom) gene expression in breast adipose tissue and breast cancer. TEM 5, 113-120.
16. Bulun, S.E. and Simpson, E.R. (1994) Regulation of aromatase expression in human tissues. Breast Cancer Res. Treat. 30, 19-29.
17. Thijssen, J.H.H., Blankenstein, M.A., Donker, G.H. and Daroszewski, J. (1991) Endogenous steroid hormones and local aromatase activity in the breast. J. Steroid Biochem. Mol. Biol. 39, 799-804.
18. Simpson, E.R., Mahendroo, M.S., Means, G.D., Kilgore, M.W., Hinshelwood, M.M., Graham-Lorence. S., Amarneh, B., Ito, Y., Fisher, C.R., Michael, M.D. et al. (1994) Aromatase cytochrome P450, the enzyme responsible for estrogen biosynthesis. Endocr. Rev. 15, 342-355.
19. Purohit, A., Ghilchik, M.W., Duncan, L., Wang, D.Y., Singh, A., Walker, M.M. and Reed, M.J. (1995) Aromatase activity and interleukin-6 production by normal and malignant breast tissues. J. Clin. Endocrinol. Metab. 80, 3052-3058.
20. Ackerman, G.E., Smith, M.E., Mendelson, C.R., MacDonald, P.C. and Simpson, E.R. (1981) Aromatization of androstenedione by human adipose tissue stromal cells in monolayer culture. J. Clin. Endocrinol. Metab. 53, 412-417.
21. Means, G.D., Mahendroo, M., Corbin, C.J., Mathis, J.M., Powell, F.E., Mendelson, C.R. and Simpson, E.R. (1989) Structural analysis of the gene encoding human aromatase cytochrome P-450, the enzyme responsible for estrogen biosynthesis. J. Biol. Chem. 264, 19385-19391.
22. Means, G.D., Kilgore, M.W., Mahendroo, M.S., Mendelson, C.R. and Simpson, E.R. (1991) Tissue-specific promoters regulate aromatase cytochrome P450 gene expression in human ovary and fetal tissues. Mol. Endocrinol. 5, 2005-2013.
23. arom: the promoter responsible for expression in adipose is different from that utilized in placenta. J. Biol. Chem. 266, 11276-11281.
24. Harsda, N., Yamada, K., Saito, K., Kibe, N., Dohmae, S. and Takagi, Y. (1990) Structural characterization of the human estrogen synthetase (aromatase) gene. Biochem. Biophys. Res. Commun. 166, 365-372.
25. Harda, N., Utsumi, T. and Takagi, Y. (1993) Tissue-specific expression of the human aromatase cytochrome P450 gene by alternative use of multiple exons I and promoters, and switching of tissue-specific exons I in carcinogenesis. Proc. Natl. Acad. Sci. USA 90, 11312-11316.
26. Mahendroo, M.S., Mendclson, C.R. and Simpson, E.R. (1993) Tissue-specific and hormonally-controlled alternative promoters regulate aromatase cytochrome P450 gene expression in human adipose tissue. J. Biol. Chem. 268, 19463-19470.
27. arom) mRNA formed by alternative use of tissue specific exons I in human skin fibroblasts. Biochem. Biophys. Res. Commun. 189, 1001-1007.
28. Zhao, Y., Mendelson, C.R. and Simpson, E.R. (1995) Characterization of the sequences of the human CYP19 (aromatase) gene that mediate regulation by glucocorticoids in adipose stromal cells and fetal hepatocytes. Mol. Endocrinol 9, 340-349.
29. Simpson, E.R., Ackerman, G.E., Smith, M.E. and Mendelson, C.R. (1981) Estrogen formation in stromal cells of adipose tissue of women: induction by glucocorticosteroids. Proc. Natl. Acad. Sci. USA 78, 5690-5694.
30. Nichols, J.E., Bulun, S.E. and Simpson, E.R. (1995) Effects of conditioned medium from different cultured cell types on aromatase expression in adipose stromal cells. J. Soc. Gynecol. Invest 2, 45-50.
31. Schmidt, M. and Loffler, G. (1994) The human breast cancer cell line MDA-MB 231 produces an aromatase stimulating activity. Eur. J. Cell. Biol. 63, 96-101.
32. Zhao, Y., Nichols, J.E., Bulun, S.E., Mendelson, C.R. and Simpson, E.R. (1995) Aromatase P450 gene expression in human adipose tissue: role of a Jak/STAT pathway in regulation of the adipose-specific promoter. J. Biol. Chem. 270, 16449-16457.
33. Chirgwin, J.M., Przybyla, A.E., MacDonald, R.J. and Rutter, W.J. (1979) Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry 18, 5294-5299.
34. Wei, J., Xu, H., Davies, J.L. and Hemmings, G.P. (1992) Increase of plasma IL-6 concentration with age in healthy subjects. Life Sci. 51, 1953-1956.
35. Daynes, R.A., Araneo, B.A., Ershler, W.B., Maloney, C., Li, G.Z. and Ryu, S.Y. (1993) Altered regulation of IL-6 production with normal aging. J. Immunol. 150, 5219-5230.
36. Bulun, S.E. and Simpson, E.R. (1994) Competitive RT-CR analysis indicates levels of aromatase cytochrome P450 transcripts in adipose tissue of buttocks, thighs, and abdomen of women increase with advancing age. J. Clin. Endocrinol. Metab. 78, 428-432.
37. Kawashima, I., Ohsumi, J., Mita-Honjo, K., Shimoda-Takano, K., Ishikawa, H., Sakakibara, S., Miyadai, K. and Takiguchi, Y. (1991) Molecular cloning of cDNA encoding adipogenesis inhibitory factor and identity with interleukin-11. FEBS Lett. 283, 199-202.
38. Yasukawa, K., Hirano, T., Wanatabe, Y., Muratani, K., Matsuda, T., Nakai, S. and Kishimoto, T. (1987) Structure and expression of human B cell stimulatory factor-2 (BSF-2/IL-6) gene. EMBO J. 6, 2939-2945.
39. Yamasaki, K., Taga, T., Hirata, Y., Yawata, H., Kawanishi, Y., Seed, B., Taniguchi, T., Hirano, T. and Kishimoto, T. (1988) Cloning and expression of the human interleukin-6 (BSF-2/ IFNβ2) receptor. Science 241, 825-828.
40. Stahl, J., Gearing, D.P., Wilson, T.A., Brown, M.A., King, J.A. and Gough, N.M. (1990) Sturctural organization of the genes for murine and human leukemia inhibitory factor: evolutionary conservation of coding and non-coding regions. J. Biol. Chem. 265, 8833-8841.
41. Moreau, J.F., Donaldson, D.D., Bennett, F., Witek-Giannotti, J., Clark, S.C. and Wong, G.G. (1988) Leukaemia inhibitor factor is identical to the myeloid growth actor human interleukin for DA cells. Nature 336, 690-692.