The drug resistance proteins, multidrug resistance-associated protein and P-glycoprotein, do not confer resistance to Fas-induced cell death

Cytometry

Volumn 43, Issue 3, 2001, Pages 189-194

  Cullen, Karen ^b   Davey, Ross ^b   Davey, Mary ^a  

^a UNIVERSITY OF TECHNOLOGY SYDNEY   (Australia)

^b ROYAL NORTH SHORE HOSPITAL   (Australia)

Author keywords

Apoptosis; Caspase 3; Fas (CD95 APO 1); Multidrug resistance (MDR); Multidrug resistance associated protein (MRP); P glycoprotein

Indexed keywords

CASPASE 3; FAS ANTIGEN; GLYCOPROTEIN P; MULTIDRUG RESISTANCE PROTEIN; 7 AMINODACTINOMYCIN; 7-AMINOACTINOMYCIN D; ABC TRANSPORTER; CASP3 PROTEIN, HUMAN; CASPASE; DACTINOMYCIN; DRUG DERIVATIVE; FLUORESCENT DYE; MONOCLONAL ANTIBODY; VINBLASTINE;

CELL DEATH; CELL VIABILITY; CONFERENCE PAPER; ENZYME ACTIVATION; ENZYME ACTIVITY; FLOW CYTOMETRY; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; LEUKEMIA; PRIORITY JOURNAL; APOPTOSIS; ARTICLE; CELL CULTURE; CELL STRAIN K 562; GENETICS; METABOLISM; MULTIDRUG RESISTANCE; PHYSIOLOGY;

ANTIBODIES, MONOCLONAL; ANTIGENS, CD95; APOPTOSIS; ATP-BINDING CASSETTE TRANSPORTERS; CASPASE 3; CASPASES; CELL DEATH; DACTINOMYCIN; DRUG RESISTANCE, MULTIPLE; ENZYME ACTIVATION; FLOW CYTOMETRY; FLUORESCENT DYES; HUMANS; K562 CELLS; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; P-GLYCOPROTEIN; TUMOR CELLS, CULTURED; VINBLASTINE;

EID: 0035263363     PISSN: 01964763     EISSN: None     Source Type: Journal    
DOI: 10.1002/1097-0320(20010301)43:3<189::AID-CYTO1048>3.0.CO;2-W     Document Type: Conference Paper

References (33)

1. Overexpression of a transporter gene in a multidrug resistant human lung cancer cell line
2. The biochemistry of P-glycoprotein-mediated multidrug resistance
3. Pharmacological characterization of multidrug resistant MRP-transfected human tumor cells
4. The human multidrug resistance-associated protein MRP is a plasma membrane drug-efflux pump
5. Biochemistry of multidrug resistance mediated by the multidrug transporter
6. r 190,000 multidrug resistance protein (MRP): Evidence for cotransport with reduced glutathione
7. Multidrug resistance protein-mediated transport of chlorambucil and melphalan conjugated to glutathione
8. Transport of glutathione, glucuronate, and sulphate conjugates by MRP gene-encoded conjugate export pump
9. ATP-dependent 17β-estradiol 17-(β-D-glucuronide) transport by multidrug resistance protein (MRP)
10. The drug efflux protein, P-glycoprotein, additionally protects drug-resistant tumor cells from multiple forms of caspase-dependent apoptosis
11. Involvement of the CD95 (APO-Fas) receptor ligand system in drug-induced apoptosis in leukemia cells
12. The CD95 (APO-1/ Fas) system mediates drug-induced apoptosis in neuroblastoma cells
13. Comparison of apoptosis in wild-type and Fas-resistant cells: Chemotherapy-induced apoptosis is not dependent on Fas/Fas ligand interactions
14. Differential regulation and ATP requirement for caspase-8 and caspase-3 activation during CD95- and anticancer drug-induced apoptosis
15. P-glycoprotein: More than a drug pump?
16. Biochemical and molecular mechanisms regulating apoptosis
17. Programmed cell death and the caspases
18. Drug resistance results in alterations in expression of immune recognition molecules and failure to express Fas (CD95)
19. Selection for drug resistance results in resistance to Fas-mediated apoptosis
20. Expression of Fas antigen in acute myeloid leukemia is associated with therapeutic response to chemotherapy
21. Drug resistance mechanisms and MRP expression in response to epirubicin treatment in a human leukemia cell line
22. Altered surface membrane glycoprotein in Vinca alkaloid-resistant human leukemic lymphoblasts
23. Development of drug resistance is reduced with idarubicin relative to other anthracyclines
24. Differentiation and multidrug resistance in response to drug treatment in the K562 human leukemia cell line
25. The MTT cell viability assay for cytotoxicity testing in multidrug resistant human leukemic cells
26. Comparison of drug accumulation in P-glycoprotein-expressing and MRP-expressing human leukemia cells
27. Activation of the CD95 (APO-1/Fas) pathway in drug- and γ-irradiation-induced apoptosis of brain tumor cells
28. Cross-resistance of CD95- and drug-induced apoptosis as a consequence of deficient activation of caspases (ICE/Ced-3 proteases)
29. Chemosensitivity of solid tumor cells in vitro is related to activation of the CD95 system
30. The relationship between modulation of MDR and glutathione in MRP-overexpressing human leukemia cells
31. Anti-Fas/Apo1 monoclonal antibody CH-11 depletes glutathione and kills multidrug-resistant human leukemic cells
32. Amplification and expression of the ABC transporters ARA and MRP in a series of multidrug resistant leukemia cell sublines
33. Subcellular distribution and redistribution of Bcl-2 family proteins in human leukemia cells undergoing apoptosis