A kinase in the life of the β cell

Journal of Clinical Investigation

Volumn 108, Issue 11, 2001, Pages 1575-1576

  Accili, D ^a  

^a Columbia University ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHOTRANSFERASE;

CELL CYCLE; CELL FUNCTION; CELL PROLIFERATION; CELL SIZE; ENZYME ACTIVATION; ENZYME SUBSTRATE; INSULIN RELEASE; INSULIN SYNTHESIS; NOTE; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

EID: 0035213887     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI14454     Document Type: Note

References (21)

1. Banting lecture 1995. A lesson in metabolic regulation inspired by the glucokinase glucose sensor paradigm
2. Glucose homeostasis: Lessons from knock-out mice
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4. Regeneration of pancreatic tissue from the transplanted pancreatic duct in the dog
5. Intercellular signals regulating pancreas development and function
6. Evidence for a circulating islet cell growth factor in insulin-resistant states
7. IGF-I and GH post-receptor signaling mechanisms for pancreatic beta-cell replication
8. Islet β cell expression of constitutively active Akt1/PKBα induces striking hypertrophy, hyperplasia, and hyperinsulinemia
9. Regulation of pancreatic β-cell growth and survival by the serine/threonine kinase AKt1/PKB
10. Disruption of IRS-2 causes type 2 diabetes in mice
11. Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia
12. Hypoinsulinaemia, glucose intolerance and diminished beta-cell size in S6K1-deficient mice
13. Tissue-specific knock-out of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes
14. Altered function of insulin receptor substrate-1-deficient mouse islets and cultured beta-cell lines
15. Selective insulin signaling through A and B insulin receptors regulates transcription of insulin and glucokinase genes in pancreatic beta cells
16. Insulin regulation of gene expression through the forkhead transcription factor Foxo 1 (Fkhr) requires kinases distinct from Akt
17. Translational control is required for the unfolded protein response and in vivo glucose homeostasis
18. Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survival
19. Beta cell proliferation and growth factors
20. Association between islets of Langerhans and pancrearic ductal system in adult rat. Where endocrine and exocrine meer together?
21. Characterization of immunoreactive components of insulin and somatostatin in canine pancreatic juice