Helix-stabilizing effects of the pentapeptide KIFMK and its related peptides on the sodium channel inactivation gate peptides

Journal of Peptide Research

Volumn 58, Issue 5, 2001, Pages 413-423

  Maeda, Y ^a   Nakagawa, T ^a   Kuroda, Yoshihiro ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

helix; 1H NMR; Circular dichroism; Inactivation gate; KIFMK; Sodium channel

Indexed keywords

GLUTAMINE; LYSINE; LYSYLISOLEUCYLPHENYLALANYLMETHIONYLLYSINE; METHIONINE; OLIGOPEPTIDE; PENTAPEPTIDE; PHENYLALANINE; SODIUM CHANNEL; SODIUM CHANNEL AFFECTING AGENT; THREONINE; TRIFLUOROETHANOL; UNCLASSIFIED DRUG;

ALPHA HELIX; AMINO ACID SUBSTITUTION; ARTICLE; HYDROPHOBICITY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CONFORMATION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANIMALS; CIRCULAR DICHROISM; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR SEQUENCE DATA; OLIGOPEPTIDES; PEPTIDES; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; RATS; SEQUENCE HOMOLOGY, AMINO ACID; SODIUM CHANNEL BLOCKERS; SODIUM CHANNELS; WATER;

EID: 0035188509     PISSN: 1397002X     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1399-3011.2001.00939.x     Document Type: Article

References (52)

1. Prion diseases and the BSE crisis
2. Structural basis of amino acid α helix propensity
3. Determination of α-helix propensity within the context of a folded protein. Sites 44 and 131 in bacteriophage T4 lysozyme
4. A thermodynamic scale for the helix-forming tendencies of the commonly occurring amino acids
5. Helix capping propensities in peptides parallel those in proteins
6. Determination of free energies of N-capping in α-helices by modification of the Lifson-Roig helix coil theory to include N- and C-capping
7. Helix signals in proteins
8. Helix propagation and N-cap propensities of the amino acids measured in alanine-based peptides in 40 volume trifluoroethanol
9. Capping and α-helix stability
10. Charged histidine affects α-helix stability at all positions in the helix by interacting with the backbone charges
11. Enhanced protein thermostability from designed mutations that interact with α-helix dipoles
12. Nature of the charged-group effect on the stability of the C-peptide helix
13. Tests of the helix dipole model for stabilization of α-helices
14. The role of the α-helix dipole in protein function and structure
15. + salt bridges in short peptides of de novo design
16. The energies of ion-pair and hydrogen-bonding interactions in a helical peptide
17. Measuring the strength of side-chain hydrogen bonds in peptide helices: The Gln-Asp (i, i+4) interaction
18. Hydrogen bonding interactions between glutamine and asparagine in α-helical peptides
19. Interactions between hydrophobic side chains within α-helices
20. The stabilization of the α-helix in aqueous solution by hydrophobic side-chain interaction
21. Helix-stabilizing interaction between tyrosine and leucine or valine when the spacing is i, i+4
22. 1H NMR and CD studies in alanine-lysine peptides
23. Side-chain interactions between sulfur-containing amino acids and phenylalanine in α-helices
24. 1H-NMR and circular dichroism spectroscopic studies on changes in secondary structures of the sodium channel inactivation gate peptides as caused by the pentapeptide KIFMK
25. +-channel inactivation
26. Restoration of inactivation and block of open sodium channels by an inactivation gate peptide
27. Kinetic analysis of block of open sodium channels by a peptide containing the isoleucine, phenylalanine, and methionine (IFM) motif from the inactivation gate
28. Experimental techniques of two-dimensional correlated spectroscopy
29. MLEV-17-based two-dimensional homonuclear magnetization transfer spectroscopy
30. Selection of coherence-transfer pathways in NMR pulse experiments
31. NMRPipe: A multidimensional spectral processing system based on UNIX pipes
32. Ordered conformation of polypeptides and proteins in acidic dodecyl sulfate solution
33. Relationship between nuclear magnetic resonance chemical shift and protein secondary structure
34. The chemical shift index: A fast and simple method for the assignment of protein secondary structure through NMR spectroscopy
35. Chemical shifts as a tool for structure determination
36. Identifying nonpolar transbilayer helices in amino acid sequences of membrane proteins
37. α-Helix stabilization by natural and unnatural amino acids with alkyl side chains
38. Structural study of the sodium channel inactivation gate peptide including an isoleucine-phenylalanine-methionine motif and its analogous peptide (phenylalanine/glutamine) in trifluoroethanol solutions and SDS micelles
39. Solution structures of the inactivation gate particle peptides of rat brain type-IIA human heart sodium channels in SDS micelles
40. The helix-destabilizing propensity scale of D-amino acids: The influence of side chain steric effects
41. A noncovalent peptide complex as a model for an early folding intermediate of cytochrome c
42. Side chain contributions to the stability of alpha-helical structure in peptides
43. Energetic contribution of solvent-exposed ion pairs to alpha-helix structure
44. 5
45. 5 linker in sodium channel inactivation probed by mutagenesis and a peptide blocker
46. - channel probed by cysteine mutagenesis
47. 5 intracellular loop in domain IV of the sodium channel α-subunit in fast inactivation
48. 4-5 region of the SkM1 sodium channel
49. 4 affects channel block by the pentapeptide KIFMK
50. Block of brain sodium channels by peptide mimetics of the isoleucine, phenylalanine, and methionine (IFM) motif from the inactivation gate
51. Oligopeptide-mediated stabilization of the α-helix of a prion protein peptide