Structural study of the sodium channel inactivation gate peptide including an isoleucine-phenylalanine-methionine motif and its analogous peptide (phenylalanine/glutamine) in trifluoroethanol solutions and SDS micelles

Journal of Peptide Research

Volumn 56, Issue 3, 2000, Pages 172-184

  Kuroda, Y ^a   Miyamoto, K ^a   Matsumoto, M ^a   Maeda, Y ^a   Otaka, A ^a   Fujii, N ^a   Nakagawa, T ^a   Kanaori, K ^b  

^a KYOTO UNIVERSITY   (Japan)

^b KYOTO INSTITUTE OF TECHNOLOGY   (Japan)

Author keywords

1H NMR; Circular dichroism; Inactivation gate peptide; Sodium channel

Indexed keywords

DODECYL SULFATE SODIUM; GLUTAMINE; ISOLEUCYLMETHIONYLPHENYLALANINE; PHENYLALANINE; SODIUM CHANNEL; SYNTHETIC PEPTIDE; TRIFLUOROETHANOL; UNCLASSIFIED DRUG;

ARTICLE; CHANNEL GATING; CIRCULAR DICHROISM; CONFORMATIONAL TRANSITION; HYDROGEN BOND; HYDROPHOBICITY; MICELLE; MOLECULAR DYNAMICS; NUCLEAR OVERHAUSER EFFECT; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; PROTEIN STRUCTURE; PROTON NUCLEAR MAGNETIC RESONANCE;

AMINO ACID MOTIFS; CIRCULAR DICHROISM; ION CHANNEL GATING; ISOLEUCINE; METHIONINE; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; OLIGOPEPTIDES; PEPTIDE FRAGMENTS; PHENYLALANINE; SODIUM CHANNEL BLOCKERS; SODIUM DODECYL SULFATE; TRIFLUOROETHANOL;

EID: 0033831716     PISSN: 1397002X     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1399-3011.2000.00745.x     Document Type: Article

References (28)

1. Classical biophysics of the squid giant axon
2. Cellular and molecular biology of voltage-gated sodium channels
3. Sodium channels and gating currents
4. Structural parts involved in activation and inactivation of the sodium channel
5. Identification of an intracellular peptide segment involved in sodium channel inactivation
6. Inhibition of inactivation of single sodium channels by a site-directed antibody
7. +-channel inactivation: Charge neutralizations and deletions in the III-IV linker
8. +-channel inactivation
9. A thermodynamic scale for the helix-forming tendencies of the commonly occurring amino acids
10. Structural basis of amino acid α helix propensity
11. Existence of distinct sodium channel messenger RNAs in rat brain
12. Solution structure of the sodium channel inactivation gate
13. Ordered conformation of polypeptides and proteins in acidic dodecyl sulfate solution
14. Experimental techniques of two-dimensional correlated spectroscopy
15. Selection of coherence-transfer pathways in NMR pulse experiments
16. MLEV-17-based two-dimensional homonuclear magnetization transfer spectroscopy
17. 1H spin system identification in macromolecules
18. NMRPipe: A multidimensional spectral processing system based on UNIX pipes
19. Solvent-accessible surfaces of proteins and nucleic acids
20. Effect of trifluoroethanol on protein secondary structure: An NMR and CD study using a synthetic actin peptide
21. Mechanisms of stabilization of helical conformations of polypeptides by water containing trifluoroethanol
22. Calculation of protein conformation from circular dichroism
23. Circular dichroism studies of helical oligopeptides
24. 10-helix
25. The chemical shift index: A fast and simple method for the assignment of protein secondary structure through NMR spectroscopy
26. Single-channel analysis of inactivation- defective rat skeletal muscle sodium channels containing the F1304Q mutation
27. + channels