1H-NMR and circular dichroism spectroscopic studies on changes in secondary structures of the sodium channel inactivation gate peptides as caused by the pentapeptide KIFMK

Biophysical Journal

Volumn 77, Issue 3, 1999, Pages 1363-1373

  Kurpda, Yoshihiro ^a,b   Maeda, Yoshitaka ^a   Miyamoto, Kazuhide ^a   Tanaka, Kazufumi ^a   Kanaori, Kenji ^b   Otaka, Akira ^a   Fujii, Nobutaka ^a   Nakagawa, Terumichi ^a  

^a KYOTO UNIVERSITY   (Japan)

^b KYOTO INSTITUTE OF TECHNOLOGY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

PENTAPEPTIDE; PEPTIDE; SODIUM CHANNEL; SODIUM CHANNEL AFFECTING AGENT; OLIGOPEPTIDE; SODIUM CHANNEL BLOCKING AGENT;

ALPHA HELIX; ARTICLE; CIRCULAR DICHROISM; PROTEIN CONFORMATION; PROTEIN PROTEIN INTERACTION; PROTEIN SECONDARY STRUCTURE; PROTEIN STABILITY; PROTON NUCLEAR MAGNETIC RESONANCE; AMINO ACID SEQUENCE; ANIMAL; BRAIN; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECT; METHODOLOGY; MOLECULAR GENETICS; NUCLEAR MAGNETIC RESONANCE; PHYSIOLOGY; RAT;

AMINO ACID SEQUENCE; ANIMALS; BRAIN; CIRCULAR DICHROISM; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; OLIGOPEPTIDES; PEPTIDES; PROTEIN STRUCTURE, SECONDARY; RATS; SODIUM CHANNEL BLOCKERS; SODIUM CHANNELS;

EID: 0032589271     PISSN: 00063495     EISSN: None     Source Type: Journal    
DOI: 10.1016/s0006-3495(99)76985-7     Document Type: Article

References (40)

1. Ahmed, C. M. L, D. H. Ware, S. C. Lee, C. D. Patten, A. V. Ferrer-Montiel, A. F. Schinder, J. D. McPherson, C. B. Wagner-McPherson, J. J. Wasmuth, G. A. Evans, and M. Montai. 1992. Primary structure, chromosomal localization, and functional expression of a voltage-gated sodium channel from human brain. Proc. Natl. Acad. Sei. USA. 89: 8220-8224.
2. Bax, A., and D. G. Davis. 1985a. MLEV-17-based two-dimensional homonuclear magnetization transfer sepctroscopy. J. Magn. Reson. 65: 355-360.
3. Bax, A., and D. G. Davis. 1985b. Practical aspects of two-dimensional transverse NOE spectroscopy. J. Magn. Reson. 63:207-213.
4. Buckingham, A. D. 1960. Chemical shifts in the nuclear magnetic resonance spectra of molecules containing polar groups. Can. J. Chem. 38:300-307.
5. Catterall, W. A. 1992. Cellular and molecular biology of voltage-gated sodium channels. Physiol. Rev. 72:S15-S48.
6. Daggett, V. D., P. A. Kollman, and I. D. Kuntz. 1989. Free energy perturbation calculations of charge interactions with the helix dipole. C/i/m. Scripta. 29A:205-215.
7. Delaglio, F., S. Gfzesiek, G.'W. Vuister, G. Zhu, J. Pfeifer, and A. Bax. 1995. NMRPipe: a multidimensional spectral processing system based on UNIX pipes. J. Biomol. NMR. 6:277-293.
8. Eaholtz, G., T. Scheuer, and W. A. Catterall. 1994. Restoration of inactivation and block of open sodium channels by an inactivation gate peptide. Neuron. 12:1041-1048.
9. Eaholtz, G., W. N. Zagotta, and W. A. Catterall. 1998. Kinetic analysis of block of open sodium channels by a peptide containing the isdleucine, phenylalanine, and methionine (IFM) motif from the inactivation gate. J. Gen. Physiol. 111:75-82.
10. Gellens, M. E., A. L. George, Jr., L. Chen, M. Chahine, R. Horn, R. L. Barchi, and R. G. Kallen. 1992. Primary structure and functional expression of the human cardiac tetrodotoxin-insensitive voltage-dependent sodium channel. Proc. Nail. Acad. Sei. USA. 89:554-558.
11. George, A. L., Jr., J. Komisarof, R. G. Kallen, and R. L. Barchi. 1992. Primary structure of the adult human skeletal muscle voltage-dependent sodium channel. Ann. Neural. 31:131-137.
12. Ghatpande, A. S., and S. K. Sikdar. 1997. Competition for binding between veratridine and KIFMK: an open channel blocking peptide of the RIIA sodium channel. J. Membr. Biol. 160:177-182.
13. Groebke, K., P. Renold, K. Y. Tsang, T. J. Alien, K. F. McClure, and D. S. Kemp. 1996. Template-nucleated alanine-Iysine helices are stabilized by position-dependent interactions between the lysine side chain and the helix barrel. Proc. Nail. Acad. Sei. USA. 93:4025-4029.
14. Hille, B. 1992. Ionic Channels of Excitable Membranes, 2nd Ed. Sinauer Associates, Sunderland, MA.
15. Israelachvili, J. N. 1992. Intermolecular and Surface Forces, 2nd Ed. Academic Press, New York. 31-47.
16. Joseph, D., G. A. Petsko, and M. Karplus. 1990. Anatomy of a conformational change: hinged "lid" motion of the triosephosphate isomerase loop. Science. 249:1425-1428.
17. + channels. J. Gen. Physiol. 109:607-617.
18. + channels. J. Gen. Physiol. 109:589-605.
19. Lawrence, J. H., D. W. Orias, J. R. Baiser, H. B. NUSS, G. F. Tomaselli, B. O'Rourke, and E. Marban. 1996. Single-channel analysis of inactivation-defective rat skeletal muscle sodium channels containing the F1304Q mutation. Biophys. J. 71:1285-1294.
20. + channel probed by cysteine mutagenesis. J. Physiol. (Loud.). 505.2:345-352.
21. + salt bridges in short peptides of de novo design. Proc. Natl. Acad Sei. USA. 84:8898-8902.
22. McPhee, J. C., D. S. Ragsdale, T. Scheuer, and W. A. Catterall. 1994. A mutation in segment IVS6 disrupts fast inactivation of sodium channels. Proc. Natl. Acad. Sei. USA. 91:12346-12350.
23. McPhee, J. C., D. S. Ragsdale, T. Scheuer, and W. A. Catterall. 1995. A critical role for transmembrane segment IVS6 of the sodium channel a subunit in fast inactivation. J. Biol. Cliem. 270:12025-12034.
24. McPhee, J. C., D. S. Ragsdale, T. Scheuer, and W. A. Catterall. 1998. A critical role for the S4-S5 intracellular loop in domain IV of the sodium channel a-subunit in fast inactivation. J. Biol. Chem. 273:1121-1129.
25. 1H chemical shifts obtained as a function of temperature and trifluoroethanol concentration for the peptide series GGXGG. /. Biomol. NMR. 5:14-24.
26. Nagayama, K., A. Kumar, K. Wiithrich, and R. R. Ernst. 1980. Experimental techniques of two-dimensional correlated spectroscopy. J. Magn. Reson. 40:321-334.
27. Noda, M., T. Ikeda, T. Kayano, H. Suzuki, H. Takeshima, M. Kurasaki, H. Takahashi, and S. Numa. 1986. Existence of distinct sodium channel messenger RNAs in rat brain. Nature. 320:188-192.
28. Patton, D. E., J. W. West, W. A. Catterall, and A. L. Goldin. 1992. Amino acid residues required for fast Na+-channel inactivation: charge neutralizations and deletions in the III-IV linker. Proc. Natl. Acad. Sei. USA. 89:10905-10909.
29. Pople, J. A., W. G. Schneider, and H. J. Berstein. 1959. High-resolution Nuclear Magnetic Resonance. McGraw-Hill, New York. 165-183 and 400-421.
30. Smith, M. R., and A. L. Goldin. 1997. Interaction between the sodium channel inactivation linker and domain III S4-S5. Biophys. J. 73: 1885-1895.
31. Strichartz, G. R., and J. M. Ritchie. 1987. The action of local anesthetics on ion channels of excitable tissues. In Local Anesthetics. G. R. Strichartz, editor. Springer-Verlag, New York. 21-52.
32. Tang, L., R. G. Kallen, and R. Horn. 1996. Role of an S4-S5 linker in sodium channel inactivation probed by mutagenesis and a peptide blocker. J. Gen. Physiol. 108:89-104.
33. Vila, J. A., D. R. Ripoli, M. E. Villegas, Y. N. Vorobjev, and H. A. Scheraga. 1998. Role of hydrophobicity and solvent-mediated chargecharge interactions in stabilizing a-helices. Biophys. J. 75:2637-2646.
34. +-channel inactivation. Proc. Natl. Acad. Sei. USA. 89: 10910-10914.
35. Williamson, M. P., T. Asakura, E. Nakamura, and M. Demura. 1992. A method for the calculation of protein a-CH chemical shifts. J. Biomol. NMR. 2:83-98.
36. Wishart, D. S., and B. D. Sykes. 1994. Chemical shifts as a tool for structure determination. Methods Enzymol. 239:363-392.
37. Wishart, D. S., B. D. Sykes, and F. M. Richards. 1991. Relationship between nuclear magnetic resonance chemical shift and protein secondary structure. J. Mol. Biol. 222:311-333.
38. Wishart, D. S., B. D. Sykes, and F. M. Richards. 1992. The chemical shift index: a fast and simple method for the assignment of protein secondary structure through NMR spectroscopy. Biochemistry. 31:1647-1651.
39. Wu, C.-S. C., K. Ikeda, and J. T. Yang. 1981. Ordered conformation of polypeptides and proteins in acidic dodecyl sulfate solution. Biochemistry. 20:566-570.
40. Wüthrich, K. 1986. NMR of Proteins and Nucleic Acids. John Wiley and Sons, New York. 130-161.