메뉴 건너뛰기




Volumn 159, Issue 10, 1997, Pages 4700-4707

Inhibition of CTL Induction by Rapamycin: IL-2 Rescues Granzyme B and Perforin Expression but only Partially Restores Cytotoxic Activity

Author keywords

[No Author keywords available]

Indexed keywords

CD3 ANTIGEN; GRANZYME; GZMB PROTEIN, MOUSE; IMMUNOSUPPRESSIVE AGENT; INTERLEUKIN 2; MEMBRANE PROTEIN; MONOCLONAL ANTIBODY; PERFORIN; POLYENE; PORE FORMING CYTOTOXIC PROTEIN; RAPAMYCIN; RECOMBINANT PROTEIN; SERINE PROTEINASE;

EID: 0031573158     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (30)

References (60)
  • 1
    • 0016713286 scopus 로고
    • Rapamycin (AY-22, 989), a new anti-fungal antibiotic. II. Fermentation, isolation and characterization
    • Seghal, S. N., H. Baker, and C. Vezina. 1975. Rapamycin (AY-22, 989), a new anti-fungal antibiotic. II. Fermentation, isolation and characterization. J. Antibiot. (Tokyo) 28:727.
    • (1975) J. Antibiot. (Tokyo) , vol.28 , pp. 727
    • Seghal, S.N.1    Baker, H.2    Vezina, C.3
  • 2
    • 0029162384 scopus 로고
    • Rapamycin inhibits ribosomal protein synthesis and induces G1 prolongation in mitogen-activated T lymphocytes
    • Terada, N., K. Takase, P. Papst, A. C. Nairn, and E. W. Gelfand. 1995. Rapamycin inhibits ribosomal protein synthesis and induces G1 prolongation in mitogen-activated T lymphocytes. J. Immunol. 155:3418.
    • (1995) J. Immunol. , vol.155 , pp. 3418
    • Terada, N.1    Takase, K.2    Papst, P.3    Nairn, A.C.4    Gelfand, E.W.5
  • 3
    • 0025734876 scopus 로고
    • Inhibition of T and B lymphocyte proliferation by rapamycin
    • Kay, J. E., L. Kromwell, S. E. A. Doe, and M. Denyer. 1991. Inhibition of T and B lymphocyte proliferation by rapamycin. Immunology 72:544.
    • (1991) Immunology , vol.72 , pp. 544
    • Kay, J.E.1    Kromwell, L.2    Doe, S.E.A.3    Denyer, M.4
  • 5
    • 0025647885 scopus 로고
    • Two distinct signal transmission pathways in T lymphocytes are inhibited by complexes formed between an immunophilin and either FK506 or rapamycin
    • Bierer, B. E., P. S. Mattila, R. F. Standaert, L. A. Herzenberg, S. J. Burakoff, G. Crabtree, and S. L. Schreiber. 1990. Two distinct signal transmission pathways in T lymphocytes are inhibited by complexes formed between an immunophilin and either FK506 or rapamycin. Proc. Natl. Acad. Sci. USA 87:9231.
    • (1990) Proc. Natl. Acad. Sci. USA , vol.87 , pp. 9231
    • Bierer, B.E.1    Mattila, P.S.2    Standaert, R.F.3    Herzenberg, L.A.4    Burakoff, S.J.5    Crabtree, G.6    Schreiber, S.L.7
  • 8
    • 0029915031 scopus 로고    scopus 로고
    • p70 S6 kinase: An enigma with variations
    • Proud, C. G. 1996. p70 S6 kinase: an enigma with variations. Trends Biochem. Sci. 21:181.
    • (1996) Trends Biochem. Sci. , vol.21 , pp. 181
    • Proud, C.G.1
  • 9
    • 0023907493 scopus 로고
    • Interleukin-2: Inception, impact, and implications
    • Smith, K. A. 1988. Interleukin-2: inception, impact, and implications. Science 240:1169.
    • (1988) Science , vol.240 , pp. 1169
    • Smith, K.A.1
  • 10
    • 0025190516 scopus 로고
    • Induction of perform and serine esterases in a mouse cytotoxic T lymphocyte clone
    • Lui, C.-C., S. V. Joag, B. S. Kwon, and J. Ding-E. Young. 1990. Induction of perform and serine esterases in a mouse cytotoxic T lymphocyte clone. J. Immunol. 144:1196.
    • (1990) J. Immunol. , vol.144 , pp. 1196
    • Lui, C.-C.1    Joag, S.V.2    Kwon, B.S.3    Young, J.D.-E.4
  • 12
    • 0028258577 scopus 로고
    • Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells
    • Heusel, J. W., R. L. Wesselschmidt, S. Shresta, J. H. Russell, and T. J. Ley. 1994. Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells. Cell 76:977.
    • (1994) Cell , vol.76 , pp. 977
    • Heusel, J.W.1    Wesselschmidt, R.L.2    Shresta, S.3    Russell, J.H.4    Ley, T.J.5
  • 15
    • 0028213824 scopus 로고
    • Heightened intragraft CTL gene expression in acutely rejecting renal allografts
    • Lipman, M. L., A. C. Stevens, and T. B. Strom. 1994. Heightened intragraft CTL gene expression in acutely rejecting renal allografts. J. Immunol. 152:5120.
    • (1994) J. Immunol. , vol.152 , pp. 5120
    • Lipman, M.L.1    Stevens, A.C.2    Strom, T.B.3
  • 16
    • 0029099845 scopus 로고
    • Activation of the apoptotic protease CPP32 by cytotoxic T-cell-derived granzyme B
    • Darmon, A. J., D. W. Nicholson, and R. C. Bleackley. 1995. Activation of the apoptotic protease CPP32 by cytotoxic T-cell-derived granzyme B. Nature 377: 446.
    • (1995) Nature , vol.377 , pp. 446
    • Darmon, A.J.1    Nicholson, D.W.2    Bleackley, R.C.3
  • 17
    • 0029022365 scopus 로고
    • Involvement of an ICE-like protease in fas-mediated apoptosis
    • Enari, M., H. Hug, and S. Nagata. 1995. Involvement of an ICE-like protease in fas-mediated apoptosis. Nature 375:78.
    • (1995) Nature , vol.375 , pp. 78
    • Enari, M.1    Hug, H.2    Nagata, S.3
  • 18
    • 0028174233 scopus 로고
    • Fas-based lymphocyte-mediated cytotoxicity against syngeneic activated lymphocytes: A regulatory pathway
    • Vignaux, F., and P. Golstein. 1994. Fas-based lymphocyte-mediated cytotoxicity against syngeneic activated lymphocytes: a regulatory pathway. Eur. J. Immunol. 24:923.
    • (1994) Eur. J. Immunol. , vol.24 , pp. 923
    • Vignaux, F.1    Golstein, P.2
  • 20
    • 0026072761 scopus 로고
    • Cellular mechanisms of allograft rejection
    • Hutchinson, I. 1991. Cellular mechanisms of allograft rejection. Curr. Opin. Immunol. 3:722.
    • (1991) Curr. Opin. Immunol. , vol.3 , pp. 722
    • Hutchinson, I.1
  • 21
    • 0026063950 scopus 로고
    • Use of rapamycin for the suppression of alloimmune reactions in vivo: Schedule dependence, tolerance induction, synergy with cyclosporin, and FK 506, and effect of host-versus-graft and graft-versus-host reactions
    • Morris, R. E., B. M. Meiser, J. Wu, R. Shorthouse, and J. Wang. 1991. Use of rapamycin for the suppression of alloimmune reactions in vivo: schedule dependence, tolerance induction, synergy with cyclosporin, and FK 506, and effect of host-versus-graft and graft-versus-host reactions. Transplant. Proc. 23:521.
    • (1991) Transplant. Proc. , vol.23 , pp. 521
    • Morris, R.E.1    Meiser, B.M.2    Wu, J.3    Shorthouse, R.4    Wang, J.5
  • 22
    • 0026081972 scopus 로고
    • Synergistic interactions of cyclosporine and rapamycin to inhibit immune performances of normal human peripheral blood lymphocytes in vitro
    • Kahan, B. D., S. Gibbons, N. Tejpal, S. M. Stepkowski, and T.-C. Chou. 1991. Synergistic interactions of cyclosporine and rapamycin to inhibit immune performances of normal human peripheral blood lymphocytes in vitro. Transplantation 51:232.
    • (1991) Transplantation , vol.51 , pp. 232
    • Kahan, B.D.1    Gibbons, S.2    Tejpal, N.3    Stepkowski, S.M.4    Chou, T.-C.5
  • 24
    • 0001666108 scopus 로고
    • Monoclonal antibodies specific for murine CD2 reveal its presence on B as well as T cells
    • Yagita, H., T. Nakamura, H. Karasuyama, and K. Okumura. 1989. Monoclonal antibodies specific for murine CD2 reveal its presence on B as well as T cells. Proc. Natl. Acad. Sci. USA 86:645.
    • (1989) Proc. Natl. Acad. Sci. USA , vol.86 , pp. 645
    • Yagita, H.1    Nakamura, T.2    Karasuyama, H.3    Okumura, K.4
  • 25
    • 0015821893 scopus 로고
    • A rapid method for the isolation of functional thymus-derived murine lymphocytes
    • Julius, M. H., E. Simpson, and L. A. Herzenberg. 1973. A rapid method for the isolation of functional thymus-derived murine lymphocytes. Eur. J. Immunol. 3:645.
    • (1973) Eur. J. Immunol. , vol.3 , pp. 645
    • Julius, M.H.1    Simpson, E.2    Herzenberg, L.A.3
  • 26
    • 0028960092 scopus 로고
    • The antitumor effect of tumor-draining lymph node cells activated by both anti-CD3 antibody and activated B cells as costimulatory-signal-providing cells
    • Okamoto, T., M. Harada, Y. Shinomiya, G. Matsuzaki, and K. Nomoto. 1995. The antitumor effect of tumor-draining lymph node cells activated by both anti-CD3 antibody and activated B cells as costimulatory-signal-providing cells. Cancer Immunol. Immunother. 40:173.
    • (1995) Cancer Immunol. Immunother. , vol.40 , pp. 173
    • Okamoto, T.1    Harada, M.2    Shinomiya, Y.3    Matsuzaki, G.4    Nomoto, K.5
  • 27
    • 0029822896 scopus 로고    scopus 로고
    • Anti-CD3-activated killer T cells: Interferon-gamma and interleukin-10 cross-regulate granzyme B expression and the induction of major histocompatibility complex-unrestricted cytotoxicity
    • Fitzpatrick, L., A. P. Makrigiannis, M. Kaiser, and D. W. Hoskin. 1996. Anti-CD3-activated killer T cells: interferon-gamma and interleukin-10 cross-regulate granzyme B expression and the induction of major histocompatibility complex-unrestricted cytotoxicity. J. Interferon Cytokine Res. 16:537.
    • (1996) J. Interferon Cytokine Res. , vol.16 , pp. 537
    • Fitzpatrick, L.1    Makrigiannis, A.P.2    Kaiser, M.3    Hoskin, D.W.4
  • 28
    • 37049183447 scopus 로고
    • Novel serine proteases encoded by two cytotoxic T lymphocyte-specific genes
    • Lobe, C. G., B. B. Finlay, W. Paranchych, V. H. Paetkau, and R. C. Bleackley. 1986. Novel serine proteases encoded by two cytotoxic T lymphocyte-specific genes. Science 232:858.
    • (1986) Science , vol.232 , pp. 858
    • Lobe, C.G.1    Finlay, B.B.2    Paranchych, W.3    Paetkau, V.H.4    Bleackley, R.C.5
  • 29
    • 0028021823 scopus 로고
    • Immunotherapy with anti-CD3 monoclonal antibodies and recombinant interleukin 2: Stimulation of molecular programs of cytotoxic killer cells and induction of tumor regression
    • Nakajima, F., A. Khanna, G. Xu, M. Lagman, R. Haschemeyer, J. Mouradian, J. C. Wang, K. H. Stenzel, A. L. Rubin, and M. Suthanthiran. 1994. Immunotherapy with anti-CD3 monoclonal antibodies and recombinant interleukin 2: stimulation of molecular programs of cytotoxic killer cells and induction of tumor regression. Proc. Natl. Acad. Sci. USA 91:7889.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 7889
    • Nakajima, F.1    Khanna, A.2    Xu, G.3    Lagman, M.4    Haschemeyer, R.5    Mouradian, J.6    Wang, J.C.7    Stenzel, K.H.8    Rubin, A.L.9    Suthanthiran, M.10
  • 30
    • 0028962125 scopus 로고
    • Fas-mediated cytotoxicity by freshly isolated natural killer cells
    • Arase, H., N. Arase, and T. Saito. 1995. Fas-mediated cytotoxicity by freshly isolated natural killer cells. J. Exp. Med. 181:1235.
    • (1995) J. Exp. Med. , vol.181 , pp. 1235
    • Arase, H.1    Arase, N.2    Saito, T.3
  • 31
    • 0028223847 scopus 로고
    • Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand
    • Takahashi, T., M. Tanaka, C. I. Brannan, N. A. Jenkins, N. G. Copeland, T. Suda, and S. Nagata. 1994. Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand. Cell 76:969.
    • (1994) Cell , vol.76 , pp. 969
    • Takahashi, T.1    Tanaka, M.2    Brannan, C.I.3    Jenkins, N.A.4    Copeland, N.G.5    Suda, T.6    Nagata, S.7
  • 33
    • 0025261191 scopus 로고
    • Measurement by quantitative PCR of changes in HPRT, PGK-1, PGK-2, APRT, Mtase and Zfy gene transcripts during mouse spermatogenesis
    • Singer-Sam, J., M. O. Robinson, A. R. Bellvè, M. I. Simon, and A. P. Riggs. 1990. Measurement by quantitative PCR of changes in HPRT, PGK-1, PGK-2, APRT, Mtase and Zfy gene transcripts during mouse spermatogenesis. Nucleic Acids Res. 18:1255.
    • (1990) Nucleic Acids Res. , vol.18 , pp. 1255
    • Singer-Sam, J.1    Robinson, M.O.2    Bellvè, A.R.3    Simon, M.I.4    Riggs, A.P.5
  • 34
    • 0025962661 scopus 로고
    • Human cytotoxic lymphocyte granzyme B: Its purification from granules and the characterization of substrate and inhibitor specificity
    • Poe, M., J. T. Blake, D. A. Boulton, M. Gammon, N. H. Sigal, J. K. Wu, and H. J. Zweerink. 1991. Human cytotoxic lymphocyte granzyme B: its purification from granules and the characterization of substrate and inhibitor specificity. J. Biol. Chem. 266:98.
    • (1991) J. Biol. Chem. , vol.266 , pp. 98
    • Poe, M.1    Blake, J.T.2    Boulton, D.A.3    Gammon, M.4    Sigal, N.H.5    Wu, J.K.6    Zweerink, H.J.7
  • 35
    • 0026556224 scopus 로고
    • Expression and utilization of chymotrypsin-like but not trypsin-like serine protease enzymes by nonspecific T killer cells activated by anti-CD3 monoclonal antibody
    • Kaiser, M., and D. W. Hoskin. 1992. Expression and utilization of chymotrypsin-like but not trypsin-like serine protease enzymes by nonspecific T killer cells activated by anti-CD3 monoclonal antibody. Cell. Immunol. 141:84.
    • (1992) Cell. Immunol. , vol.141 , pp. 84
    • Kaiser, M.1    Hoskin, D.W.2
  • 36
    • 0027378246 scopus 로고
    • Cytotoxic cell proteinase gene expression and cytolytic activity by anti-CD3-activated cytotoxic T lymphocytes is sensitive to cyclosporin A but is not dependent on interleukin-2 synthesis
    • Kaiser, M., J. Brooks-Kaiser, L. Filzpatrick, R. C. Bleackley, and D. W. Hoskin. 1993. Cytotoxic cell proteinase gene expression and cytolytic activity by anti-CD3-activated cytotoxic T lymphocytes is sensitive to cyclosporin A but is not dependent on interleukin-2 synthesis. J. Leukocyte Biol. 54:458.
    • (1993) J. Leukocyte Biol. , vol.54 , pp. 458
    • Kaiser, M.1    Brooks-Kaiser, J.2    Filzpatrick, L.3    Bleackley, R.C.4    Hoskin, D.W.5
  • 37
    • 0025294203 scopus 로고
    • Generation of cytolytic activity with anti-CD3 monoclonal antibodies involves both IL-2-independent and -dependent components
    • Stohl, W., Z. Tovar, and N. Talal. 1990. Generation of cytolytic activity with anti-CD3 monoclonal antibodies involves both IL-2-independent and -dependent components. J. Immunol. 144:3718.
    • (1990) J. Immunol. , vol.144 , pp. 3718
    • Stohl, W.1    Tovar, Z.2    Talal, N.3
  • 38
    • 0025364691 scopus 로고
    • Evidence for tumor necrosis factor-α involvement in the optimal induction of class I allospecitic cytotoxic T cells
    • Robinet, E., D. Branellec, A. M. Termijtelen, J. Y. Blay, F. Gay, and S. Chouaib. 1990. Evidence for tumor necrosis factor-α involvement in the optimal induction of class I allospecitic cytotoxic T cells. J. Immunol. 144:4555.
    • (1990) J. Immunol. , vol.144 , pp. 4555
    • Robinet, E.1    Branellec, D.2    Termijtelen, A.M.3    Blay, J.Y.4    Gay, F.5    Chouaib, S.6
  • 39
    • 0028032355 scopus 로고
    • Rapamycin selectively inhibits translation of mRNAs encoding elongation factors and ribosomal proteins
    • Terada, N., H. R. Patel, K. Takase, K. Kohno, A. C. Nairn, and E. W. Gelfand. 1994. Rapamycin selectively inhibits translation of mRNAs encoding elongation factors and ribosomal proteins. Proc. Natl. Acad. Sci. USA 91:11477.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 11477
    • Terada, N.1    Patel, H.R.2    Takase, K.3    Kohno, K.4    Nairn, A.C.5    Gelfand, E.W.6
  • 40
    • 0031008982 scopus 로고    scopus 로고
    • Inhibition of protein tyrosine kinases or protein kinase C prevents nonspecific killer T lymphocyte-mediated tumoricidal activity
    • Stewart, B. H., and D. W. Hoskin. 1997. Inhibition of protein tyrosine kinases or protein kinase C prevents nonspecific killer T lymphocyte-mediated tumoricidal activity. Biochim. Biophys. Acta 1356:331.
    • (1997) Biochim. Biophys. Acta , vol.1356 , pp. 331
    • Stewart, B.H.1    Hoskin, D.W.2
  • 41
    • 0030064475 scopus 로고    scopus 로고
    • Effect of rapamycin on the expression of the IL-2 receptor (CD25)
    • Woerly, G., N. Brooks, and B. Ryffel. 1996. Effect of rapamycin on the expression of the IL-2 receptor (CD25). Clin. Exp. Immunol. 103:322.
    • (1996) Clin. Exp. Immunol. , vol.103 , pp. 322
    • Woerly, G.1    Brooks, N.2    Ryffel, B.3
  • 43
    • 0029014107 scopus 로고
    • Rapamycin graft pretreatment in small bowel and kidney transplantation in the rat
    • Chen, H., D. Xu, S. Qi, J. Wu, H. Luo, and P. Daloze. 1995. Rapamycin graft pretreatment in small bowel and kidney transplantation in the rat. Transplantation 59:1084.
    • (1995) Transplantation , vol.59 , pp. 1084
    • Chen, H.1    Xu, D.2    Qi, S.3    Wu, J.4    Luo, H.5    Daloze, P.6
  • 44
    • 0028048353 scopus 로고
    • T cell receptor-induced Fas ligand expression in cytotoxic T lymphocyte clones is blocked by protein tyrosine kinase inhibitors and cyclosporin A
    • Anel, A., M. Buferne, C. Boyer, A.-M. Schmitt-Verhulst, and P. Golstein. 1994. T cell receptor-induced Fas ligand expression in cytotoxic T lymphocyte clones is blocked by protein tyrosine kinase inhibitors and cyclosporin A. Eur. J. Immunol. 24:2469.
    • (1994) Eur. J. Immunol. , vol.24 , pp. 2469
    • Anel, A.1    Buferne, M.2    Boyer, C.3    Schmitt-Verhulst, A.-M.4    Golstein, P.5
  • 46
    • 0029161921 scopus 로고
    • Fas-mediated cytotoxicity: An immunoeffector or immunoregulatory pathway in T cell-mediated immune responses?
    • Larsen, C. P., D. Z. Alexander, R. Hendrix, S. Ritchie, and T. C. Pearson. 1995. Fas-mediated cytotoxicity: an immunoeffector or immunoregulatory pathway in T cell-mediated immune responses? Transplantation 60:221.
    • (1995) Transplantation , vol.60 , pp. 221
    • Larsen, C.P.1    Alexander, D.Z.2    Hendrix, R.3    Ritchie, S.4    Pearson, T.C.5
  • 49
    • 0026749324 scopus 로고
    • IL-2 and EGF receptors stimulate the hematopoietic cell cycle via different signalling pathways: Demonstration of a novel role for c-myc
    • Shibuya, H., M. Yoneyama, J. Ninomiya-Tsuji, K. Matsumoto, and T. Taniguchi. 1992. IL-2 and EGF receptors stimulate the hematopoietic cell cycle via different signalling pathways: demonstration of a novel role for c-myc. Cell 70:57.
    • (1992) Cell , vol.70 , pp. 57
    • Shibuya, H.1    Yoneyama, M.2    Ninomiya-Tsuji, J.3    Matsumoto, K.4    Taniguchi, T.5
  • 50
    • 0029060110 scopus 로고
    • Interleukin 2 and erythropoietin activate STAT5/MGF via distinct pathways
    • Wakao, H., N. Harada, T. Kitamura, A. L.-F. Mui, and A. Miyajima. 1995. Interleukin 2 and erythropoietin activate STAT5/MGF via distinct pathways. EMBO J. 14:2527.
    • (1995) EMBO J. , vol.14 , pp. 2527
    • Wakao, H.1    Harada, N.2    Kitamura, T.3    Mui, A.L.-F.4    Miyajima, A.5
  • 51
    • 0027983480 scopus 로고
    • Positive regulation of the cAMP-responsive activator CREM by the p70 S6 kinase: An alternative route to mitogen-induced gene expression
    • de Groot, R. P., L. M. Ballou, and P. Sassone-Corsi. 1994. Positive regulation of the cAMP-responsive activator CREM by the p70 S6 kinase: an alternative route to mitogen-induced gene expression. Cell 79:81.
    • (1994) Cell , vol.79 , pp. 81
    • De Groot, R.P.1    Ballou, L.M.2    Sassone-Corsi, P.3
  • 52
    • 0028861545 scopus 로고
    • Regulation of cAMP-responsive enhancer binding proteins during cell cycle progression in T lymphocytes stimulated by IL-2
    • Feuerstein, N., D. Huang, S. H. Hinrichs, D. J. Orten, N. Aiyar, and M. B. Prystowsky. 1995. Regulation of cAMP-responsive enhancer binding proteins during cell cycle progression in T lymphocytes stimulated by IL-2. J. Immunol. 154:68.
    • (1995) J. Immunol. , vol.154 , pp. 68
    • Feuerstein, N.1    Huang, D.2    Hinrichs, S.H.3    Orten, D.J.4    Aiyar, N.5    Prystowsky, M.B.6
  • 54
    • 0025778274 scopus 로고
    • Structure of the mouse pore-forming protein (perform) gene: Analysis of transcription initiation site, 5′ flanking sequence, and alternative splicing of 5′ untranslated regions
    • Youn, B.-S., C.-C. Liu, K.-K. Kim, J. D.-E. Young, M. H. Kwon, and B. Kwon, 1991. Structure of the mouse pore-forming protein (perform) gene: analysis of transcription initiation site, 5′ flanking sequence, and alternative splicing of 5′ untranslated regions. J. Exp. Med. 173:813.
    • (1991) J. Exp. Med. , vol.173 , pp. 813
    • Youn, B.-S.1    Liu, C.-C.2    Kim, K.-K.3    Young, J.D.-E.4    Kwon, M.H.5    Kwon, B.6
  • 55
    • 0027518159 scopus 로고
    • Consensus AP-1 and CRE motifs upstream from the human cytotoxic serine protease B (CSP-B/CGL-1) gene synersize to activate transcription
    • Hanson, R. D., J. L. Grisolano, and T. J. Ley. 1993. Consensus AP-1 and CRE motifs upstream from the human cytotoxic serine protease B (CSP-B/CGL-1) gene synersize to activate transcription. Blood 82:2749.
    • (1993) Blood , vol.82 , pp. 2749
    • Hanson, R.D.1    Grisolano, J.L.2    Ley, T.J.3
  • 56
    • 0029789643 scopus 로고    scopus 로고
    • Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase
    • Xing, J., D. D. Ginty, and M. E. Greenberg. 1996. Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase. Science 273:959.
    • (1996) Science , vol.273 , pp. 959
    • Xing, J.1    Ginty, D.D.2    Greenberg, M.E.3
  • 57
    • 0027231244 scopus 로고
    • Failure of rapamycin to block proliferation once resting cells have entered the cell cycle despite inactivation of p70 S6 kinase
    • Terada, N., R. A. Franklin, J. J. Lucas, J. Blenis, and G. W. Gelfand. 1993. Failure of rapamycin to block proliferation once resting cells have entered the cell cycle despite inactivation of p70 S6 kinase. J. Biol. Chem. 268:12062.
    • (1993) J. Biol. Chem. , vol.268 , pp. 12062
    • Terada, N.1    Franklin, R.A.2    Lucas, J.J.3    Blenis, J.4    Gelfand, G.W.5
  • 58
    • 0027403270 scopus 로고
    • A promoter element of the human serine esterase granzyme B gene controls specific transcription in activated T cells
    • Haddad, P., A. Wargnier, J.-F. Bourge, M. Sasportes, and P. Paul. 1993. A promoter element of the human serine esterase granzyme B gene controls specific transcription in activated T cells. Eur. J. Immunol. 23:625.
    • (1993) Eur. J. Immunol. , vol.23 , pp. 625
    • Haddad, P.1    Wargnier, A.2    Bourge, J.-F.3    Sasportes, M.4    Paul, P.5
  • 59
    • 0029936611 scopus 로고    scopus 로고
    • Interleukin-2 activation of STAT5 requires the convergent action of tyrosine kinases and a serine/threonine kinase pathway distinct from the Raf1/ERK2 MAP kinase pathway
    • Beadling, C., J. Ng, J. W. Babbage, and D. A. Cantrell. 1996. Interleukin-2 activation of STAT5 requires the convergent action of tyrosine kinases and a serine/threonine kinase pathway distinct from the Raf1/ERK2 MAP kinase pathway. EMBO J. 15:1902.
    • (1996) EMBO J. , vol.15 , pp. 1902
    • Beadling, C.1    Ng, J.2    Babbage, J.W.3    Cantrell, D.A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.