IL-18 not required for IRBP peptide-induced EAU: Studies in gene-deficient mice

Investigative Ophthalmology and Visual Science

Volumn 42, Issue 1, 2001, Pages 177-182

  Jiang, H R ^a   Wei, X Q ^a   Niedbala, W ^a   Lumsden, L ^a   Foo Yew Liew, ^a   Forrester, J V ^a  

^a UNIVERSITY OF ABERDEEN   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 18;

ANIMAL TISSUE; ARTICLE; AUTOIMMUNE DISEASE; AUTOIMMUNITY; KNOCKOUT MOUSE; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; TISSUE DISTRIBUTION; UVEITIS;

ANIMALS; AUTOIMMUNE DISEASES; CILIARY BODY; DNA PRIMERS; EYE PROTEINS; IMMUNOENZYME TECHNIQUES; INTERLEUKIN-18; IRIS; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED BALB C; MICE, INBRED DBA; MICE, KNOCKOUT; PEPTIDE FRAGMENTS; PIGMENT EPITHELIUM OF EYE; RETINA; RETINITIS; RETINOL-BINDING PROTEINS; T-LYMPHOCYTES; TH1 CELLS; UVEITIS;

EID: 0035174803     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. T cell lines mediating experimental autoimmune uveoretinitis (EAU) in the rat
2. Retinal specific antigens and immunopathogenic processes they provoke
3. A new model of autoimmune disease: Experimental autoimmune uveoretinitis induced in mice with two different retinal antigens
4. Pathology of experimental autoimmune uveoretinitis in mice
5. In vivo immunomudulation following intradermal injection with DNA encoding IL-18
6. IFN-γ-inducing factor up-regulates Fas ligand-mediated cytotoxic activity of murine natural killer cell clones
7. Cloning of a new cytokine that induces IFN-γ production by T cells
8. IFN-γ-inducing factor (IGIF) is a costimulatory factor on the activation of Th1 but not Th2 cells and exerts its effect independently of IL-12
9. A novel costimulatory factor for γ-interferon induction found in the livers of mice causes endotoxic shock
10. Regulation of interferon-γ production by IL-12 and IL-18
11. Interleukin 18, a cytokine which resembles IL-1 structurally and IL-12 functionally but exerts its effect independently of both
12. Defective NK cell activity and Th1 response in IL-18-deficient mice
13. The role of IL-18 in innate immunity
14. Current understanding of macrophage type 1 cytokine responses during intracellular infections
15. Marrow-derived activated macrophages are required during the effector phase of experimental autoimmune uveoretinitis in rats
16. Macrophages and dendritic cells in experimental autoimmune uveoretinitis in B1ORIII mice
17. Altered immune responses and susceptibility to Leishmania major and Staphylococcus aureus infection in IL-18-deficent mice
18. Active stage of autoimmune diabetes is associated with the expression of a novel cytokine, IGIF, which is located near Idd2
19. Immunomodulation of experimental autoimmune uveoretinitis: A model of tolerance induction with retinal antigens
20. Localisation and characterization of major histocompatibility complex class II-positive cells in the posterior segment of the eye: Implications for induction of autoimmune uveoretinitis
21. Interleukin 12 protects from a T helper type 1-mediated autoimmune disease, experimental autoimmune uveitis, through a mechanism involving interferon gamma, nitric oxide, and apoptosis
22. The blood-retinal barrier in experimental autoimmune uveitis (EAU): A review
23. A proinflammatory role for IL-18 in rheumatoid arthritis
24. (IFN-γ-inducing factor) regulates early cytokine production in, and promotes resolution of, bacterial infection in mice
25. Selective expression and functions of interleukin 18 receptor on T helper (Th) type 1 but not Th2 cells
26. IFN-γ-deficient mice develop experimental autoimmune uveitis in the context of a deviant effector response
27. IL-18 is a potent coinducer IL-13 in NK and T cells: A new potential role for IL-18 in modulating the immune response
28. Endogenous IL-12 is required for the induction and expression of experimental autoimmune uveitis
29. Differential production of IL-12 in BALB/c and DBA/2 mice controls IL-4 versus IFN-gamma synthesis in primed CD4 lymphocytes
30. Production of functional IL-18 by different subtypes of murine and human dendritic cells (DC): DC-derived IL-18 enhances IL-12-dependent Th1 development
31. Interferon-gamma-inducing factor enhances T helper 1 cytokine production by stimulated human T cells: Synergism with interleukin-12 for interferon-gamma production
32. Interleukin-18 (interferon-γ-inducing factor) is produced by osteoblasts and acts via granulocyte/macrophage colony-stimulating factor and not via interferon-γ to inhibit osteoclast formation