Electrostatics and the gating pore of Shaker potassium channels

Journal of General Physiology

Volumn 117, Issue 1, 2001, Pages 69-89

  Islas, Leon D ^a   Sigworth, Fred J ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Gating currents; Poisson Boltzmann equation; Voltage dependence

Indexed keywords

4 (2 HYDROXYETHYL) 1 PIPERAZINEETHANESULFONIC ACID; CALCIUM CHLORIDE; EGTAZIC ACID; MAGNESIUM CHLORIDE; POTASSIUM CHLORIDE; POTASSIUM ION; SODIUM ION; SUCROSE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CHANNEL GATING; ELECTROCHEMISTRY; IONIC STRENGTH; MATHEMATICAL COMPUTING; MEMBRANE POTENTIAL; NONHUMAN; POTASSIUM TRANSPORT; PROTEIN DOMAIN; VOLTAGE CLAMP; XENOPUS LAEVIS;

ANIMALS; ELECTROPHYSIOLOGY; ION CHANNEL GATING; MEMBRANE POTENTIALS; MODELS, THEORETICAL; OOCYTES; POTASSIUM CHANNELS; SHAKER SUPERFAMILY OF POTASSIUM CHANNELS; XENOPUS LAEVIS;

EID: 0035170817     PISSN: 00221295     EISSN: None     Source Type: Journal    
DOI: 10.1085/jgp.117.1.69     Document Type: Article

References (59)

1. + channel
2. Incorporating protein conformational flexibility into the calculation of pH-dependent protein properties
3. as in proteins
4. + channels
5. + channel gating
6. + channel
7. Solvent viscosity and protein dynamics
8. + channel activation correlated with the state dependence of calcium-binding to the pore
9. Altered sodium and gating current kinetics in frog skeletal muscle caused by low external pH
10. + channel with fluorescence
11. The effect of changing the internal solution on sodium inactivation and related phenomena in giant axons
12. Helix to helix packing in proteins
13. Quantal charge redistributions accompanying the structural transitions of sodium channels
14. Fluctuations in ion channel gating currents. Analysis of nonstationary shot noise
15. Asymmetric electrostatic effects on the gating of rat brain sodium channels in planar lipid membranes
16. + conduction and selectivity
17. + channels in open, closed, and inactivated conformations
18. High apparent dielectric constants in the interior of a protein reflect water penetration
19. Divalent cation effects on the Shaker K channel suggest a pentapeptide sequence as determinant of functional surface charge
20. The action of calcium on the electrical properties of squid axons
21. A structural vignette common to voltage sensors and conduction pores: Canaliculi
22. Tanford-Kirkwood electrostatics for protein modeling
23. + channel
24. Nonstationary noise analysis and application to patch clamp recordings
25. The effect of surface charge on the nerve membrane on the action of tetrodotoxin and saxitoxin in frog myelinated nerve
26. Negative surface charge near sodium channels of nerve: Divalent ions, monovalent ions, and pH
27. + channels
28. Biophysical and molecular mechanisms of Shaker potassium channel inactivation
29. External barium influences the gating charge movement of Shaker potassium channels
30. Voltage sensitivity and gating charge in Shaker and Shab family potassium channels
31. How electrolyte shielding influences the electrical potential in trans-membrane ion channels
32. Substituted-cysteine accessibility method
33. Focusing of electric fields in the active site of Cu-Zn superoxide dismutase: Effects of ionic strength and amino-acid modification
34. + channel S4
35. Direct physical measure of conformational rearrangement underlying potassium channel gating
36. Electrostatic contributions to the binding energy of the λcl repressor to DNA
37. Tests of continuum theories as models of ion channels. I. Poisson-Boltzmann theory versus Brownian dynamics
38. + channels
39. + channels
40. Internal cavities and buried waters in globular proteins
41. Voltage-sensitive and solvent-sensitive processes in ion channel gating. Kinetic effects of hyperosmolar media on activation and deactivation of sodium channels
42. Influence of the membrane potential on the free energy of an intrinsic protein
43. Ion transport in a model gramicidin channel. Structure and thermodynamics
44. The dielectric properties of water within model transbilayer pores
45. Activation of Shaker potassium channels. III. An activation gating model for wild-type and V2 mutant channels
46. + channel
47. Electrostatic aspects of protein-protein interactions
48. The variance of sodium current fluctuations at the node of Ranvier
49. Voltage gating of ion channels
50. Simulation of the packing of idealized transmembrane α-helix bundles
51. + channel
52. Unilateral exposure of Shaker B potassium channels to hyperosmolar solutions
53. A novel voltage clamp to record small, fast currents from ion channels expressed in Xenopus oocytes
54. Evidence for voltage-dependent S4 movement in sodium channels
55. Molecular basis of charge movement in voltage-gated sodium channels
56. How does the W434F mutation block current in Shaker potassium channels?
57. Shaker potassium channel gating. II: Transitions in the activation pathway
58. Solute inaccessible aqueous volume changes during opening of the potassium channel of the squid giant axon