Divalent cation effects on the shaker K channel suggest a pentapeptide sequence as determinant of functional surface charge density

Journal of Membrane Biology

Volumn 165, Issue 2, 1998, Pages 183-189

  Elinder, F ^a   Liu, Y ^a   Arhem P ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Shaker K channel; Surface charges; Voltage clamp; Xenopus oocytes

Indexed keywords

ION CHANNEL; MAGNESIUM; POTASSIUM CHANNEL;

ARTICLE; CALCULATION; DATA ANALYSIS; GENE SEQUENCE; HYPOTHESIS; OOCYTE DEVELOPMENT; VOLTAGE CLAMP; XENOPUS;

ANIMALS; CATIONS; ELECTROPHYSIOLOGY; ELECTROSTATICS; OLIGOPEPTIDES; OOCYTES; POTASSIUM CHANNELS; STRUCTURE-ACTIVITY RELATIONSHIP; XENOPUS;

EID: 0032530716     PISSN: 00222631     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002329900432     Document Type: Article

References (23)

1. Århem, P. 1980. Effects of some heavy metal ions on the ionic currents of myelinated fibres from Xenopus laevis. J. Physiol. 306:219-231
2. Baumann, A., Grape, A., Ackermann, A., Pongs, O. 1988. Structure of the voltage-dependent potassium channel is highly conserved from Drosophila to vertebrate central nervous systems. EMBO J. 7:2457-2463
3. Chandler, W.K., Hodgkin, A.L., Meves, H. 1965. The effect of changing the internal solution on sodium inactivation and related phenomena in giant axons. J. Physiol. 180:821-836
4. Cukierman, S., Krueger, B. K. 1990. Modulation of sodium channel gating by external divalent cation: differential effects on opening and closing rates. Pfluegers Arch. 416:360-367
5. Elinder, F., Århem, P. 1994. Effects of gadolinium on ion channels in the myelinated axon of Xenopus laevis: four sites of action. Biophys. J. 67:71-83
6. Elinder, F., Århem, P. 1997. Effective surface charges on Shaker K channels are located on the S5-P loop. Biophys. J. 72:A31
7. Elinder, F., Århem, P. 1998. The functional surface charge density of a fast K channel in the myelinated axon of Xenopus laevis. J. Membrane Biol. 165:175-181
8. Elinder, F., Madeja, M., Århem, P. 1996. Surface charges of K channels. Effects of strontium on five cloned channels expressed in Xenopus oocytes. J. Gen. Physiol. 108:325-332
9. Frech, G. C., VanDongen, A.M.J., Schuster, G., Brown, A.M., Joho, R.H. 1989. A novel potassium channel with delayed rectifier properties isolated from rat brain by expression cloning. Nature 340:642-645
10. Goldin, A.L. 1992. Maintenance of Xenopus laevis and oocyte injection. In: Ion Channels. B. Rudy and L.E. Iversen, editors, pp. 266-279. Academic Press, San Diego, CA
11. Grahame, D.C. 1947. The electrical double layer and the theory of electrocapillarity. Chem. Rev. 41:441-501
12. Green, W.N., Andersen, O.S. 1991. Surface charges and ion channel function. Annu. Rev. Physiol. 53:341-359
13. Grape, A., Schröter, K.H., Ruppersber, J.P., Stocker, M., Drewes, T., Beckh, S., Pongs, O. 1990. Cloning and expression of a human voltage-gated potassium channel. A novel member of the RCK potassium channel family. EMBO J. 9:1749-1756
14. Hille, B. 1992. Ionic channels of excitable membranes, pp. 612. Sinauer, Sunderland, MA
15. Hille, B., Woodhull, A.M., Shapiro, B.I. 1975. Negative surface charge near sodium channels of nerve: divalent ions, monovalent ions and pH. Phil. Trans. R. Soc. Lond. B270:301-318
16. Li, M., Unwin, N., Stauffer, K.A., Jan, Y.N., Jan, L.Y. 1994. Images of purified Shaker potassium channels. Curr. Biol. 4:110-115
17. McLaughlin, S. 1989. The electrostatic properties of membranes. Ann. Rev. Biophys. Chem. 18:113-136
18. Peitzsch, R.M., Eisenberg, M., Sharp, K.A., McLaughlin, S. 1995. Calculation of the electrostatic potential adjacent to model phospholipid bilayers. Biophys. J. 68:729-738
19. Ribera, A.B., Nguyen, D.A. 1993. Primary sensory neurons express a Shaker-like potassium channel gene. J. Neurosci. 13:4988-4996
20. Schröter, K.H., Ruppersberg, J.P., Wunder, F., Rettig, J., Stocker, M., Pongs, O. 1991. Cloning and functional expression of a TEA-sensitive A-type potassium channel from rat brain. FEBS Lett. 278:211-216
21. Schwarz, T.L., Tempel, B.L., Papazian, D.M., Jan, Y.N., Jan, L.Y. 1988. Multiple potassium-channel components are produced by alternative splicing at the Shaker locus in Drosophila. Nature 331:137-142
22. Swanson, R., Marshall, J., Smith, J.S., Williams, J.B., Boyle, M.B., Folander, K., Luneau, C.J., Antanavage, J., Oliva, C., Buhrow, S.A., Bennett, C., Sein, R.B., Kaczmarek, L.K. 1990. Cloning and expression of cDNA and genomic clones encoding three delayed rectifier potassium channels in rat brain. Neuron 4:929-939
23. Zagotta, W.N., Aldrich, R.W. 1990. Voltage-dependent gating of Shaker A-type potassium channels in Drosophila muscle. J. Gen. Physiol. 95:29-60