Immunomodulation of experimental colitis: The role of NK1.1 liver lymphocytes and surrogate antigens - Bystander effect

Journal of Pathology

Volumn 195, Issue 4, 2001, Pages 498-507

  Shlomai, Amir ^a   Trop, Shivti ^a   Gotsman, Israel ^a   Jurim, Oded ^a   Diment, Judith ^a   Alper, Ruslana ^a   Rabbani, Elazar ^b   Engelhardt, Dean ^b   Ilan, Yaron ^a  

^a HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^b Enzon Incorporated   (United States)

Author keywords

Experimental colitis; NKT cells; Oral tolerance

Indexed keywords

ALPHA INTERFERON; ANTIGEN; CELL PROTEIN; INTERLEUKIN 10; LYMPHOCYTE SURFACE MARKER; TRINITROBENZENESULFONIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD LEVEL; CELL SUBPOPULATION; COLITIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOTOXICITY; DIARRHEA; DOWN REGULATION; EDEMA; ENTERITIS; ENZYME LINKED IMMUNOSORBENT ASSAY; EXTRACTION; FEEDING; IMMUNE RESPONSE; IMMUNOGENICITY; IMMUNOLOGICAL TOLERANCE; IMMUNOMODULATION; INFLAMMATION; INTESTINE ULCER; INTESTINE WALL; LIVER; LYMPHOCYTE; MOUSE; MOUSE STRAIN; NONHUMAN; PARAMETER; PATHOGENESIS; PRIORITY JOURNAL; SCORING SYSTEM; TH1 CELL; TH2 CELL;

ANIMALS; ANTIGENS; ANTIGENS, SURFACE; CELL SEPARATION; COLITIS; CYTOTOXICITY TESTS, IMMUNOLOGIC; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; HUMANS; IMMUNE TOLERANCE; INTERFERON TYPE II; INTERLEUKIN-10; LECTINS, C-TYPE; LYMPHOCYTES; MALE; MICE; MICE, INBRED C57BL; PROTEINS; RABBITS; RATS;

EID: 0035170489     PISSN: 00223417     EISSN: None     Source Type: Journal    
DOI: 10.1002/path.974     Document Type: Article

References (55)

1. Pathogenesis and immunotherapy of autoimmune diseases
2. Cytokine imbalance and autoantibody production in T cell receptor-α mutant mice with inflammatory bowel disease
3. Reciprocal IFN-γ and TGF β responses regulate the occurrence of mucosal inflammation
4. Experimental granulomatous colitis in mice is abrogated by induction of TGFβ-mediated oral tolerance
5. Interleukin 10 prevents cytokine-induced disruption of T84 barrier integrity and limits chloride secretion
6. Multiple doses of intravenous interleukin 10 in steroid refractory Crohn's disease
7. Oral tolerance: Immune mechanisms and treatment of autoimmune diseases
8. Suppressor. T cells generated by oral tolerance to myelin basic protein suppress both in vitro and in vivo immune responses by the release of TGFβ following antigen specific triggering
9. Double blind pilot trial of oral tolerization with myelin antigen in multiple sclerosis
10. Oral insulin treatment suppresses virus-induced antigen-specific destruction of β cells and prevents autoimmune diabetes in transgenic mice
11. Treatment of autoimmune diseases by oral tolerance to autoantigens
12. Oral tolerization to adenoviral antigens permits long term gene expression using recombinant adenoviral vectors
13. Oral tolerization to adenoviral proteins permits repeated adenovirus-mediated gene therapy in rats with pre-existing immunity to adenovirus
14. Induction of tolerance to recombinant adenoviruses by injection into newborn rats: Long term amelioration of hyperbilirubinemia in Gunn rats
15. Transient immunosuppression with FK506 permits long term expression of therapeutic genes introduced into the liver using recombinant adenoviruses
16. Insertion of the adenoviral E3 region into a recombinant viral vector prevents antiviral humoral and cellular immune responses and permits long term gene expression
17. Induction of central tolerance by intrathymic inoculation of adenoviral antigens into the host thymus permits long term gene therapy in Gunn rats
18. Immune response to dietary antigens: Oral tolerance
19. Treatment of experimental colitis through induction of oral tolerance towards colitis extracted proteins
20. Strange brew: T cells in the liver
21. Critical role of the liver in inducing oral tolerance to adenoviral vectors for long term gene therapy
22. The effect of portacaval shunt on delayed-hypersensitivity responses following antigen feeding
23. Permanent acceptance of liver allografts by intraportal injection of donor spleen cells in rats
24. Portal vein administration of donor cells promotes peripheral allospecific hyporesponsiveness and graft tolerance
25. Detection of cell adhesion molecules on human liver associated lymphocytes
26. NK1.1 + T cells: New clues to their origin, specificity and function
27. Mouse NK1.1 + T cells
28. Liver associated lymphocytes expressing NK1.1 are essential for oral tolerance induction in a murine model
29. Antibodies to IL-12 abrogate established experimental colitis in mice
30. The NK1.1-mouse: A model to study differentiation of murine NK cells
31. Inflammatory bowel disease
32. Circulating antibodies to the surface antigens on colon epithelial cells in ulcerative colitis
33. A shared and unique epitope(s) on human colon, skin and biliary epithelium detected by a monoclonal antibody
34. Circulating immunoglobulin G1 in patients with ulcerative colitis against the colonic epithelial protein detected by a novel monoclonal antibody
35. Isolation and characterization of a colonic autoantigen specifically recognized by colon tissue-bound immunoglobulin G from idiopathic ulcerative colitis
36. Autoantibodies specific for villin found in patients with colon cancer and other colitides
37. The C-X-O chemokine ENA-78 is preferentially expressed in intestinal epithelium in inflammatory bowel disease
38. Bystander suppression induced by oral tolerance
39. Oral tolerization as a treatment of rheumatoid arthritis
40. Suppression of adjuvant arthritis in Lewis rats by oral administration of type II collagen
41. Effects of oral administration of type II collagen on rheumatoid arthritis
42. Inhibition of relapsing experimental autoimmune encephalomyelitis in SLJ mice by feeding the immunodominant PLP139-151 peptide
43. Antibystander suppression after oral administration of antigens
44. Oral tolerization leads to active suppression and bystander tolerance in adult rats while energy dominates in young rats
45. A peptide derived from an autoantibody can stimulate T cells in the (NZB × NZW) F1 mouse model of systemic lupus erythematosus
46. Epitopes of myelin basic protein that trigger TGF-beta release after oral tolerization are distinct from encephalitogeneic epitopes and mediate epitope-driven bystander suppression
47. Indirect effects of oral tolerance cannot be ascribed to bystander suppression
48. Induction of autoimmune diabetes by oral administration of autoantigen
49. Class I-restricted cross-presentation of exogenous self-antigens leads to deletion of autoreactive CD8 + T cells
50. Induction of a CD8 + cytotoxic T lymphocyte response by cross-priming requires cognate CD4 + T cell help
51. Chemical denaturation of ovalbumin abrogates the induction of oral tolerance of specific IgG antibody and DTH response in mice
52. Mouse liver T cells: Their change with aging and in comparison with peripheral T cells
53. RAG1, RAG2 and pre-T cell receptor α chain expression by adult human hepatic T cells: Evidence for extrathymic T cell maturation
54. Distinct cytotoxic lymphocyte subsets suggest a role for the liver in immune homeostasis
55. Expression of Fas/FasL and bcl2 in normal human liver derived leukocytes