Indirect effects of oral tolerance cannot be ascribed to bystander suppression

Scandinavian Journal of Immunology

Volumn 45, Issue 3, 1997, Pages 276-281

  Carvalho, C R ^a   Verdolin, B A ^a   Vaz, N M ^a  

^a FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; OVALBUMIN;

ANIMAL EXPERIMENT; ANTIBODY RESPONSE; ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; IMMUNIZATION; IMMUNOLOGICAL TOLERANCE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

EID: 0031042880     PISSN: 03009475     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-3083.1997.d01-394.x     Document Type: Article

References (46)

1. Hanson DG, Vaz NM, Maia LCS, Hornbrook MM, Lynch JL, Roy CA. Inhibition of specific immune responses by feeding protein antigens. Int Arch Allergy 1977;55:526-32.
2. Faria AMC, Garcia G, Rios MJC, Michalaros CL, Vaz NM. Decrease in susceptibility to oral tolerance induction and the occurrence of oral immunization to ovalbumin in 20-38 week-old mice. The effect of interval between oral exposures and rate of antigen intake in oral immunization. Immunol 1993;78:147-51.
3. Mowat AM. The regulation of immune responses to dietary proteins antigens. Immunol Today 1987;8:93-8.
4. Strobel S, Ferguson A. Immune responses to fed protein antigens in mice. III. Systemic tolerance or priming is related to age at which antigen is first encountered. Pediat Res 1984;18:588-94.
5. Weiner HL, Mackin GA, Matsui M et al. Double-blind pilot trial of oral tolerization with myelin antigens in multiple sclerosis. Science 1993;259:1321-4.
6. Weiner HL, Friedman A, Miller A et al. Oral tolerance: immunologic mechanisms and treatment of animal and human organ-specific autoimmune diseases by oral administration of autoantigens. Ann Rev Immunol 1994;12:809-37.
7. Yoon CK. MS study yields mixed results. Science 1993;259:1263.
8. Nagler-Anderson C, Bober LA, Robinson ME, Siskind GW, Throbecke JG. Suppression of type II collagen-induced arthritis by intragastric administration of soluble type II collagen. Proc Natl Acad Sci USA 1986;83:7443-6.
9. Zhang ZJ, Lee CSY, Lider O, Weiner HL. Suppression of adjuvant arthritis in Lewis rats by oral administration of type II collagen. J Immunol 1990;145:2489-93.
10. Trentham DE, Dynesius-Trentham RA, Orav EJ et al. Effects of oral administration of type II collagen on rheumatoid arthritis. Science 1993;261:1727-9.
11. Zhang ZJ, Davidson L, Eisenbarth G, Weiner HL. Suppression of diabetes in the NOD mouse by oral administration of porcine insulin. Proc Natl Acad Sci USA 1991;88:10252-6.
12. Gregerson DS, Obritsch WF, Donoso LA. Oral tolerance in experimental autoimmune uveoretinitis. Distinct mechanisms of resistance are induced by low dose versus high dose feeding protocols. J Immunol 1993;151:5751-61.
13. Rizzo LV, Miller-Rivero NE, Chan CC, Wiggert B, Nussenblatt RB, Caspi RR. Interleukin-2 treatment potentiates induction of oral tolerance in a murine model of autoimmunity. J Clin Invest 1994;94:1668-72.
14. Guimaraes VC, Quintans J, Fisfalen ME, Straus FH, Wilhelm K, Medeiros-Neto A, DeGroot LJ. Suppression of development of experimental autoimmune thyroiditis by oral administration of thyroglobulin. Endocrinology 1995;136:3353-9.
15. Lider O, Santos LMB, Lee CSY, Higgins PW, Weiner HL. Suppression of autoimmune encephalomyelitis by oral administration of myelin basic protein. J Immunol 1989;142:748-52.
16. Whitacre CC, Gienapp IE, Orosz CG, Bitar DM. Oral tolerance in experimental autoimmune encephalomyelitis. III Evidence for clonal anergy. J Immunol 1991;147:2155-63.
17. Stephen H, Thompson G, Staines NA. Could specific oral tolerance be a therapy for autoimmune disorders? Immunol Today 1990;11:396-9.
18. Qin YF, Sun DM, Goto M, Meyermann R, Wekerle H. Resistance to experimental autoimmune encephalomyelitis induced by neonatal tolerization to myelin basic protein: clonal elimination versus regulation of autoaggressive lymphocytes. Eur J Immunol 1989;19:373-80.
19. Chen Y, Inobe JI, Marks R, Gonella P, Kuchroo VK, Weiner HL. Peripheral deletion of antigen-reactive T cells in oral tolerance. Nature 1995;376:177-80.
20. Friedman A, Weiner HL. Induction of anergy or active suppression following oral tolerance is determined by antigen dosage. Proc Natl Acad Sci USA 1994;91:6688-92.
21. Melamed D, Friedman A. In vivo tolerization of Th1 lymphocytes following a single feeding with ovalbumin: anergy in the absence of suppression. Eur J Immunol 1994;24:1974-81.
22. Chen Y, Kuchroo VK, Inobe J, Haffler DA, Weiner HL. Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis. Science 1994;265:1237-40.
23. Fishman-Lobell J, Friedman A, Weiner HL. Different kinetic patterns of cytokine gene expression in vivo in orally tolerant mice. Eur J Immunol 1994;24:2720-4.
24. Miller SD, Hanson DG. Inhibition of specific immune responses by feeding protein antigens. V. Evidence for tolerance and specific active suppression of cell-mediated immune responses to ovalbumin. J Immunol 1979;123:2344-50.
25. Richman LK, Chiler JM, Brown WR, Hanson DG, Vaz NM. Enterically induced immunological tolerance - I. Induction of suppressor T lymphocytes by intragastric administration of soluble protein antigens. J Immunol 1978;121:2429-34.
26. Wannemuehler MJ, Michalek SM, McGhee JR. Immune regulation of suppression in offspring of orally tolerized mice. Ann NY Acad Sci 1983;492:888-9.
27. Vaz NM, Hanson DG, Maia LCS, Lynch JL. Cross-suppression of specific immune responses after oral tolerance. Mem Inst Oswaldo Cruz 1981;76:83-91.
28. Carvalho CR, Verdolin BA, Souza AV, Vaz NM. Indirect effects of oral tolerance in mice. Scand J Immunol 1994;39:533-8.
29. Vaz NM, Carvalho CR. Assimilation, tolerance and the end of innocence. Ciência e Cultura 1994;47:351-7.
30. Carvalho CR, Vaz NM. Indirect effects are independent of the way of tolerance induction. Scand J Immunol 1996;43:613-8.
31. Ovary Z, Benacerraf B. Immunological specificity of the secondary response with dinitrophenylated proteins. Proc Soc Exp Biol Med 1963;124:72-6.
32. Vaz NM, Rios MJC, Lopes LM et al. Genetics of susceptibility to oral tolerance to ovalbumin. Braz J Med Biol Res 1987;20:785-90.
33. Titus RG, Chiller JM. Orally induced tolerance. Definition at the cellular level. Int Arch Allergy 1981;65:323-38.
34. Miller A, Lider O, Weiner HL. Antigen driven bystander suppression after oral administration of antigen. J Exp Med 1991;174:791-8.
35. Dahlman-Hoglund A, Dahlgren U, Ajhlstedt S, Hanson LA, Telemo E. Bystander suppression of the immune response to human serum albumin in rats fed ovalbumin. Immunol 1995;86:128-33.
36. Wildner G, Thurau SR. Orally induced bystander suppression in experimental autoimmune uveoretinitis occurs only in periphery and not in the eye. Eur J Immunol 1995;25:1292-7.
37. Melamed D, Friedman A. Modification of the immune response by oral tolerance: antigen requirements and interaction with immunogenic stimuli. Cell Immunol 1993;146:412-20.
38. Miller A, Lider O, Roberts AB, Sporn MB, Weiner HL. Suppressor T cells generated by oral tolerization to myelin basic protein suppress both in vitro and in vivo immune responses by the release of transforming growth factor beta after antigen-specific triggering. Proc Natl Acad Sci USA 1992;89:421-5.
39. Al-Sabbagh A, Miller A, Santos LMB, Weiner HL. Antigen-driven tissue-specific suppression following oral tolerance: orally administered myelin basic protein suppresses proteolipid protein-induced experimental autoimmune encephalitis in the SJL mouse. Eur J Immunol 1994;24:2104-9.
40. Vaz NM. The molecular and cellular correlates of immunological phenomena. Contrasting two explanatory pathways. Braz J Med Biol Res 1996;29:445-54.
41. Mouthon L, Nóbrega A, Nicolas N et al. Invariance and restriction toward a limited set of self-antigens characterize neonatal IgM antibody repertoires and prevail in autoreactive repertoire of healthy adults. Proc Natl Acad Sci USA 1995;92:3839-43.
42. Mouthon L, Haury M, Lacroix-Desmazes S, Barreau C, Coutinho M, Kazatchkine M. Analysis of the human natural IgG antibody repertoire. Evidence that IgG autoantibodies of healthy adults recognize a limited and conserved set of protein antigens in homologous tissues. J Immunol 1995;154:5768-78.
43. Coutinho A, Kazatchkine MD, Avrameas S. Natural antibodies. Curr Op Immunol 1995;7:812-8.
44. Malanchère E, Haury M, Rosado M, Nóbrega A, Coutinho A. Maternal determination of serum IgM repertoire in the adult progeny. J Exp Med 1996;in press.
45. Ebling FM, Tsao BP, Singh RR, Sercarz E, Hahn BH. A peptide derived from an autoantibody can stimulate T cells in the (NZB x NZW) F1 mouse model of systemic lupus erythematosus. Arthritis Rheum 1993;36:355-64.
46. Segel LA, Jager E, Elias D, Cohen I. A quantitative model of autoimmune disease: does more mean less? Immunol Today 1995;16:80-4.