Relationship between V3 genotype, biologic phenotype, tropism, and coreceptor use for primary isolates of human immunodeficiency virus type 1

Journal of Human Virology

Volumn 4, Issue 4, 2001, Pages 179-187

  McDonald, R A ^a   Chang, G ^a   Michael, N L ^a  

^a WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

Author keywords

Biologic phenotype; Coreceptor; DNA sequencing; V3 loop

Indexed keywords

CHEMOKINE RECEPTOR; CHEMOKINE RECEPTOR CCR5; COMPLEMENTARY DNA; DNA; RNA;

AMINO ACID SUBSTITUTION; ARTICLE; DNA SEQUENCE; GENOTYPE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MACROPHAGE; MONOCYTE; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN ANALYSIS; VIRUS INFECTION; VIRUS ISOLATION;

AMINO ACID SEQUENCE; GENOTYPE; GIANT CELLS; HIV ENVELOPE PROTEIN GP120; HIV INFECTIONS; HIV-1; HUMANS; MACROPHAGES; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; PHENOTYPE; PREDICTIVE VALUE OF TESTS; RECEPTORS, HIV; SEQUENCE ANALYSIS, DNA; T-LYMPHOCYTES;

EID: 0035169553     PISSN: 10909508     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. Distinct replicative and cytopathic characteristics of human immunodeficiency virus isolation
2. Association between biological properties of human immunodeficiency virus variants and risk for AIDS and AIDS mortality
3. A dual-tropic primary HIV-1 isolate that uses fusin and the beta-chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion cofactors
4. A new classification for HIV-1
5. Change in coreceptor use correlates with disease progression in HIV-1 infected individuals
6. HIV-1 tropism and co-receptor use
7. Mapping of independent V3 envelope determinants of human immunodeficiency virus type 1 macrophage tropism and syncytium formation in lymphocytes
8. Macrophage tropism of human immunodeficiency virus type 1 and utilization of the CC-CKR5 coreceptor
9. CCR5 signal transduction in macrophages by human immunodeficiency virus and simian immunodeficiency virus envelopes
10. HIV-1 tropism for mononuclear phagocytes can be determined by regions of gp120 outside the CD4-binding domain
11. Antibodies that inhibit fusion of human immunodeficiency virus-infected cells bind a 24-amino acid sequence of the viral envelope, gp120
12. Macrophage and T cell-line tropisms of HIV-1 are determined by specific regions of the envelope gp120 gene
13. Identification of envelope V3 loop as the major determinant of CD4 neutralization sensitivity of HIV-1
14. The V3 domain of the HIV-1 gp120 envelope glycoprotein is critical for chemokine-mediated blockade of infection
15. Minimal requirements for the human immunodeficiency virus type 1 V3 domain to support the syncytium-inducing phenotype: Analysis by single amino acid substitution
16. Macrophage-tropic human immunodeficiency virus isolates from different patients exhibit unusual V3 envelope sequence homogeneity in comparison with T-cell-tropic isolates: Definition of critical amino acids involved in cell tropism
17. Positioning of positively charged residues in the V3 loop correlates with HIV type 1 syncytium-inducing phenotype
18. Phenotype-associated sequence variation in the third variable domain of the human immunodeficiency virus type 1 gp120 molecule
19. Evolutionary variants of the human immunodeficiency virus type 1 V3 region characterized by using a heteroduplex tracking assay
20. Dideoxynucleoside resistance emerges with prolonged zidovudine monotherapy
21. Evolution of human immunodeficiency virus type 1 env sequence variation in patients with diverse rates of disease progression and T-cell function
22. Rapid disease progression without seroconversion following primary human immunodeficiency virus type 1 infection: Evidence for highly susceptible human hosts
23. Exclusive and persistent use of the entry coreceptor CXCR4 by human immunodeficiency virus type 1 from a subject homozygous for CCR5 delta32
24. Human immunodeficiency virus type 1 evolution in vivo tracked by DNA heteroduplex mobility assays
25. HIV population dynamics in vivo: Implications for genetic variation, pathogenesis, and therapy
26. Characterization of HIV type 1 from Romanian children: Lack of correlation between V3 loop amino acid sequence and syncytium formation in MT-2 cells
27. Molecular analyses of human immunodeficiency virus type 1 V3 region quasispecies derived from plasma and peripheral blood mononuclear cells of the first long-term-nonprogressing mother and child pair
28. Determinants for the syncytium-inducing phenotype of HIV-1 subtype F isolates are located in the V3 region
29. V3 loop sequence analysis of seven HIV type 1 group O isolates phenotyped in peripheral blood mononuclear cells and MT-2 cells
30. HIV type 1 infection of CD4+ T cells depends critically on basic amino acid residues in the V3 domain of envelope glycoprotein 120
31. A group of V3 sequences from human immunodeficiency virus type 1 subtype E non-syncytium-inducing, CCR5-using variants are resistant to positive selection pressure
32. Evolutionary variants of the human immunodeficiency virus type 1 V3 region characterized by using a heteroduplex tracking assay
33. Expression and function of CCR5 and CXCR4 on human Langerhans cells and macrophages: Implications for HIV primary infection
34. Fusion of monocytes and macrophages with HIV-1 correlates with biochemical properties of CXCR4 and CCR5
35. Consistent viral evolutionary changes associated with the progression of human immunodeficiency virus type 1 infection
36. Construction and biological characterization of infectious molecular clones of HIV-1 subtypes B and E (CRF01_AE) generated by the polymerase chain reaction