메뉴 건너뛰기




Volumn 15, Issue 8, 1996, Pages 1753-1765

Muscle wasting and dedifferentiation induced by oxidative stress in a murine model of cachexia is prevented by inhibitors of nitric oxide synthesis and antioxidants

Author keywords

AIDS; Cancer; Jun D; Myogenin; Myosin creatine phosphokinase

Indexed keywords

3 AMINO 1 (3 TRIFLUOROMETHYLPHENYL) 2 PYRAZOLINE; ALPHA TOCOPHEROL; ANTIOXIDANT; ANTISENSE OLIGONUCLEOTIDE; ARGININE DERIVATIVE; CREATINE KINASE; DITHIOTHREITOL; MYOGENIN; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NUCLEAR PROTEIN; PHORBOL ESTER; SUPEROXIDE; TUMOR NECROSIS FACTOR ALPHA;

EID: 0029921173     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1002/j.1460-2075.1996.tb00524.x     Document Type: Article
Times cited : (283)

References (73)
  • 1
    • 0025077481 scopus 로고
    • Redox regulation of Fos and Jun DNA-binding activity in vitro
    • Abate, C., Patel, L., Rauscher, F.J.,III and Curran, T. (1990) Redox regulation of Fos and Jun DNA-binding activity in vitro. Science, 249, 1157-1161
    • (1990) Science , vol.249 , pp. 1157-1161
    • Abate, C.1    Patel, L.2    Rauscher III, F.J.3    Curran, T.4
  • 2
    • 0025253851 scopus 로고
    • Biology of multifunctional cytokines: IL 6 and related molecules (IL 1 and TNF)
    • Akira, S., Hirano, T., Taga, T. and Kishimoto, T. (1990) Biology of multifunctional cytokines: IL 6 and related molecules (IL 1 and TNF). FASEB J., 4, 2860-2867.
    • (1990) FASEB J. , vol.4 , pp. 2860-2867
    • Akira, S.1    Hirano, T.2    Taga, T.3    Kishimoto, T.4
  • 5
    • 0022485610 scopus 로고
    • Cachectin and tumour necrosis factor as two sides of the same biological coin
    • Beutler, B. and Cerami, A. (1986) Cachectin and tumour necrosis factor as two sides of the same biological coin. Nature, 320, 584-588.
    • (1986) Nature , vol.320 , pp. 584-588
    • Beutler, B.1    Cerami, A.2
  • 6
    • 0025214499 scopus 로고
    • Myogenin resides in the nucleus and acquires high affinity for a conserved enhancer element on heterodimerization
    • Brennan, T. and Olson, E.N. (1990) Myogenin resides in the nucleus and acquires high affinity for a conserved enhancer element on heterodimerization. Genes Dev., 4, 582-595.
    • (1990) Genes Dev. , vol.4 , pp. 582-595
    • Brennan, T.1    Olson, E.N.2
  • 7
    • 0023637142 scopus 로고
    • Acetaldehyde increases collagen gene transcription in cultured human fibroblasts
    • Brenner, D.A. and Chojkier, M. (1987) Acetaldehyde increases collagen gene transcription in cultured human fibroblasts. J. Biol. Chem., 262, 17690-17695.
    • (1987) J. Biol. Chem. , vol.262 , pp. 17690-17695
    • Brenner, D.A.1    Chojkier, M.2
  • 8
    • 0024503589 scopus 로고
    • Prolonged activation of jun and collagenase genes by tumour necrosis factor α
    • Brenner, D.A., O'Hara, M., Angel, P., Chojkier, M. and Karin, M. (1989) Prolonged activation of jun and collagenase genes by tumour necrosis factor α. Nature, 337, 661-663.
    • (1989) Nature , vol.337 , pp. 661-663
    • Brenner, D.A.1    O'Hara, M.2    Angel, P.3    Chojkier, M.4    Karin, M.5
  • 9
    • 0025101235 scopus 로고
    • Tumor necrosis factor α inhibits albumin gene expression in a murine model of cachexia
    • Brenner, D.A., Buck, M., Feitelberg, S.P. and Chojkier, M. (1990) Tumor necrosis factor α inhibits albumin gene expression in a murine model of cachexia. J. Clin. Invest., 85, 248-255.
    • (1990) J. Clin. Invest. , vol.85 , pp. 248-255
    • Brenner, D.A.1    Buck, M.2    Feitelberg, S.P.3    Chojkier, M.4
  • 10
    • 0028013216 scopus 로고
    • LAP (NF-IL6), a tissue-specific transcriptional activator, is an inhibitor of hepatoma cell proliferation
    • Buck, M , Turler, H. and Chojkier, M. (1994) LAP (NF-IL6), a tissue-specific transcriptional activator, is an inhibitor of hepatoma cell proliferation. EMBO J., 13, 851-860.
    • (1994) EMBO J. , vol.13 , pp. 851-860
    • Buck, M.1    Turler, H.2    Chojkier, M.3
  • 12
    • 0026770257 scopus 로고
    • Cachexia and graft-vs.-host-disease-type skin changes in keratin promoter-driven TNF-α transgenic mice
    • Cheng, J., Turksen, K., Yu, Q.C., Schreiber, H., Teng, M. and Fuchs, E. (1992) Cachexia and graft-vs.-host-disease-type skin changes in keratin promoter-driven TNF-α transgenic mice. Genes Dev., 6, 1444-1456.
    • (1992) Genes Dev. , vol.6 , pp. 1444-1456
    • Cheng, J.1    Turksen, K.2    Yu, Q.C.3    Schreiber, H.4    Teng, M.5    Fuchs, E.6
  • 13
    • 0024468325 scopus 로고
    • Stimulation of collagen gene expression by ascorbic acid in cultured human fibroblasts. A role for lipid peroxidation?
    • Chojkier, M., Houglum, K., Solis-Herruzo, J.A. and Brenner, D.A. (1989) Stimulation of collagen gene expression by ascorbic acid in cultured human fibroblasts. A role for lipid peroxidation? J. Biol. Chem., 264, 16957-16962.
    • (1989) J. Biol. Chem. , vol.264 , pp. 16957-16962
    • Chojkier, M.1    Houglum, K.2    Solis-Herruzo, J.A.3    Brenner, D.A.4
  • 15
    • 0025062982 scopus 로고
    • LAP, a novel member of the C/EBP gene family, encodes a liver-enriched transcriptional activator protein
    • Descombes, P., Chojkier, M., Lichtsteiner, S., Falvey, E. and Schibler, U. (1990) LAP, a novel member of the C/EBP gene family, encodes a liver-enriched transcriptional activator protein. Genes, Dev., 4, 1541-1551.
    • (1990) Genes, Dev. , vol.4 , pp. 1541-1551
    • Descombes, P.1    Chojkier, M.2    Lichtsteiner, S.3    Falvey, E.4    Schibler, U.5
  • 17
    • 0024547167 scopus 로고
    • Infusion of tumor necrosis/cachectin promotes muscle catabolism in the rat: A synergistic effect with interleukin 1
    • Flores, E.A., Bistran, B.R., Pompselli, J.J., Dinarello, C.A , Blackburn, G.L. and Istfan, N.W (1989) Infusion of tumor necrosis/cachectin promotes muscle catabolism in the rat: a synergistic effect with interleukin 1. J. Clin. Invest., 83, 1614-1622.
    • (1989) J. Clin. Invest. , vol.83 , pp. 1614-1622
    • Flores, E.A.1    Bistran, B.R.2    Pompselli, J.J.3    Dinarello, C.A.4    Blackburn, G.L.5    Istfan, N.W.6
  • 18
    • 0000498853 scopus 로고
    • Cachectin/TNF or IL-1 α induces cachexia with redistribution of body proteins
    • Fong, Y. et al. (1989) Cachectin/TNF or IL-1 α induces cachexia with redistribution of body proteins. Am. J. Physiol., 256, R659-R665.
    • (1989) Am. J. Physiol. , vol.256
    • Fong, Y.1
  • 21
    • 0027258162 scopus 로고
    • Muscle deficiency and neonatal death in mice with a targeted mutation in the myogenin gene
    • Hasty, P., Bradley, A., Morris, J.H., Edmondson, D.G., Venuti, J.M., Olson, E.N. and Klein, W.H. (1993) Muscle deficiency and neonatal death in mice with a targeted mutation in the myogenin gene. Nature, 364, 501-506.
    • (1993) Nature , vol.364 , pp. 501-506
    • Hasty, P.1    Bradley, A.2    Morris, J.H.3    Edmondson, D.G.4    Venuti, J.M.5    Olson, E.N.6    Klein, W.H.7
  • 22
    • 0027176524 scopus 로고
    • Rapid proteolysis of IκB-α is necessary for activation of transcription factor NF-κB
    • Henkel, T., Machleidt, T , Alkalay, I , Kronke, M., Ben-Neriah, Y. and Baeuerle, P.A. (1993) Rapid proteolysis of IκB-α is necessary for activation of transcription factor NF-κB. Nature, 365, 182-185.
    • (1993) Nature , vol.365 , pp. 182-185
    • Henkel, T.1    Machleidt, T.2    Alkalay, I.3    Kronke, M.4    Ben-Neriah, Y.5    Baeuerle, P.A.6
  • 23
    • 0029017015 scopus 로고
    • Malondialdehyde-modified low density lipoproteins in patients with atherosclerotic disease
    • Holvoet, P., Perez, G., Zhao, Z., Brouwers, E., Bernar, H. and Collen, D. (1995) Malondialdehyde-modified low density lipoproteins in patients with atherosclerotic disease. J. Clin. Invest., 95, 2611-2619.
    • (1995) J. Clin. Invest. , vol.95 , pp. 2611-2619
    • Holvoet, P.1    Perez, G.2    Zhao, Z.3    Brouwers, E.4    Bernar, H.5    Collen, D.6
  • 24
    • 0025600464 scopus 로고
    • Malondialdehyde and 4-hydroxynonenal protein adducts in plasma and liver of rats with iron overload
    • Houglum, K., Filip, M., Witztum, J. and Chojkier, M. (1990) Malondialdehyde and 4-hydroxynonenal protein adducts in plasma and liver of rats with iron overload. J. Clin. Invest , 86, 1991-1998.
    • (1990) J. Clin. Invest , vol.86 , pp. 1991-1998
    • Houglum, K.1    Filip, M.2    Witztum, J.3    Chojkier, M.4
  • 25
    • 0025998187 scopus 로고
    • 1(I) gene expression in cultured human fibroblast: Modulation of constitutive collagen gene expression by lipid peroxidation
    • 1(I) gene expression in cultured human fibroblast: modulation of constitutive collagen gene expression by lipid peroxidation. J. Clin. Invest., 87, 2230-2235.
    • (1991) J. Clin. Invest. , vol.87 , pp. 2230-2235
    • Houglum, K.1    Brenner, D.A.2    Chojkier, M.3
  • 26
    • 0028047014 scopus 로고
    • Activation of the myogenic lineage by MEF2A, a factor that induces and cooperates with MyoD
    • Kaushal, S., Schneider, J.W., Nadal-Ginard, B. and Mahdavi, V. (1994) Activation of the myogenic lineage by MEF2A, a factor that induces and cooperates with MyoD. Science, 266, 1236-1240.
    • (1994) Science , vol.266 , pp. 1236-1240
    • Kaushal, S.1    Schneider, J.W.2    Nadal-Ginard, B.3    Mahdavi, V.4
  • 27
    • 0025195627 scopus 로고
    • N-Methy-L-arginine inhibits tumor necrosis factor-induced hypotension: Implications for the involvement of nitric oxide
    • Kilbourn, R.G., Gross, S.S., Jurban, A., Adams, J., Griffith, O.W., Levi, R. and Lodato, R.F. (1990) N-Methy-L-arginine inhibits tumor necrosis factor-induced hypotension: implications for the involvement of nitric oxide. Proc. Natl Acad. Sci. USA, 87, 3629-3632.
    • (1990) Proc. Natl Acad. Sci. USA , vol.87 , pp. 3629-3632
    • Kilbourn, R.G.1    Gross, S.S.2    Jurban, A.3    Adams, J.4    Griffith, O.W.5    Levi, R.6    Lodato, R.F.7
  • 28
    • 0242279855 scopus 로고
    • Excitation and contraction of skeletal muscle
    • West, J.B. (ed.), Williams & Wilkins, Baltimore, MD
    • Kirchberger, M. (1991) Excitation and contraction of skeletal muscle. In West, J.B. (ed.), Physiological Basis of Medical Practice. Williams & Wilkins, Baltimore, MD, pp. 62-102.
    • (1991) Physiological Basis of Medical Practice , pp. 62-102
    • Kirchberger, M.1
  • 30
    • 0024448304 scopus 로고
    • MyoD is a sequence-specific DNA binding protein requiring a region of myc homology to bind to the muscle creatine kinase enhancer
    • Lassar, A.B., Buskin, D.L., Davis, R.L. and Apone, S. (1989) MyoD is a sequence-specific DNA binding protein requiring a region of myc homology to bind to the muscle creatine kinase enhancer. Cell, 58, 823-831.
    • (1989) Cell , vol.58 , pp. 823-831
    • Lassar, A.B.1    Buskin, D.L.2    Davis, R.L.3    Apone, S.4
  • 31
    • 0025128787 scopus 로고
    • Different members of the jun family exhibit distinct patterns of expression in response to type β transforming growth factor
    • Li, L., Hu, J S. and Olson, E.N. (1990) Different members of the jun family exhibit distinct patterns of expression in response to type β transforming growth factor. J. Biol. Chem., 265, 1556-1562
    • (1990) J. Biol. Chem. , vol.265 , pp. 1556-1562
    • Li, L.1    Hu, J.S.2    Olson, E.N.3
  • 32
    • 0027049533 scopus 로고
    • FGF inactivates myogenic helix-loop-helix proteins through phosphorylation of a conserved protein kinase C site in their DNA-binding domains
    • Li, L., Zhou, J., James, G., Heller-Harrison, R., Czech, M.P. and Olson, E N. (1992a) FGF inactivates myogenic helix-loop-helix proteins through phosphorylation of a conserved protein kinase C site in their DNA-binding domains. Cell, 71, 1181-1194.
    • (1992) Cell , vol.71 , pp. 1181-1194
    • Li, L.1    Zhou, J.2    James, G.3    Heller-Harrison, R.4    Czech, M.P.5    Olson, E.N.6
  • 33
    • 0026606084 scopus 로고
    • Fos and jun repress transcriptional activation by myogenin and MyoD: The amino terminus of Jun can mediate repression
    • Li, L., Chambard, J.-C., Karin, M. and Olson, E.N. (1992b) Fos and jun repress transcriptional activation by myogenin and MyoD: the amino terminus of Jun can mediate repression. Genes Dev., 6, 676-689.
    • (1992) Genes Dev. , vol.6 , pp. 676-689
    • Li, L.1    Chambard, J.-C.2    Karin, M.3    Olson, E.N.4
  • 34
    • 0027194540 scopus 로고
    • A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds
    • Lipton, S.A , Choi, Y.-B., Pan, Z.-H., Lei, S.Z., Chen, H.-S.V., Sucher, N.J., Loscalzo, J., Singel, D.J. and Stamler, J.S. (1993) A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds. Nature, 364, 626-632
    • (1993) Nature , vol.364 , pp. 626-632
    • Lipton, S.A.1    Choi, Y.-B.2    Pan, Z.-H.3    Lei, S.Z.4    Chen, H.-S.V.5    Sucher, N.J.6    Loscalzo, J.7    Singel, D.J.8    Stamler, J.S.9
  • 35
    • 0026322388 scopus 로고
    • The reductive half-reaction of xanthine oxidase
    • McWhirter, R.B. and Hille, R. (1991) The reductive half-reaction of xanthine oxidase J. Biol. Chem., 35, 23724-23731.
    • (1991) J. Biol. Chem. , vol.35 , pp. 23724-23731
    • McWhirter, R.B.1    Hille, R.2
  • 36
    • 0024425516 scopus 로고
    • Human fibroblasts release reactive oxygen species in response to interleukin-1 or tumor necrosis factor-α
    • Meier, B., Radeke, H.H , Selle, S. Younes, M., Sies, H., Resch, K and Habermehl, G.G. (1989) Human fibroblasts release reactive oxygen species in response to interleukin-1 or tumor necrosis factor-α. Biochem J., 263, 539-545.
    • (1989) Biochem J. , vol.263 , pp. 539-545
    • Meier, B.1    Radeke, H.H.2    Selle, S.3    Younes, M.4    Sies, H.5    Resch, K.6    Habermehl, G.G.7
  • 37
    • 0023620504 scopus 로고
    • Interleukin 1 and tumor necrosis factor do not regulate protein balance in skeletal muscle
    • Moldawer, L.L., Svaninger, G., Gelin, J. and Lundholm, K.G. (1987) Interleukin 1 and tumor necrosis factor do not regulate protein balance in skeletal muscle. Am. J Physiol., 253, C766-C773.
    • (1987) Am. J Physiol. , vol.253
    • Moldawer, L.L.1    Svaninger, G.2    Gelin, J.3    Lundholm, K.G.4
  • 38
    • 0024554495 scopus 로고
    • A new DNA binding motif in immunoglobulin enhancer binding, daughterless, myoD and myc proteins
    • Murre, C., McCaw, PS and Baltimore, D. (1989) A new DNA binding motif in immunoglobulin enhancer binding, daughterless, myoD and myc proteins. Cell, 56, 777-783.
    • (1989) Cell , vol.56 , pp. 777-783
    • Murre, C.1    McCaw, P.S.2    Baltimore, D.3
  • 39
    • 0027297310 scopus 로고
    • Myogenin gene disruption results in perinatal lethality because of severe muscle defect
    • Nabeshima, Y., Hanaoka, K , Hayasaka, M , Esumi, E., Shaowei, L., Nonaka, I. and Nabeshima, Y.-I. (1993) Myogenin gene disruption results in perinatal lethality because of severe muscle defect. Nature, 364, 532-535.
    • (1993) Nature , vol.364 , pp. 532-535
    • Nabeshima, Y.1    Hanaoka, K.2    Hayasaka, M.3    Esumi, E.4    Shaowei, L.5    Nonaka, I.6    Nabeshima, Y.-I.7
  • 40
    • 0024276585 scopus 로고
    • DNA binding activities of three murine Jun proteins, stimulation by fos
    • Nakabeppu, Y., Ryder, K. and Nathans, D. (1988) DNA binding activities of three murine Jun proteins, stimulation by fos Cell, 55, 907-915.
    • (1988) Cell , vol.55 , pp. 907-915
    • Nakabeppu, Y.1    Ryder, K.2    Nathans, D.3
  • 42
    • 0027980321 scopus 로고
    • The ubiquitin-proteasome pathway is required for processing the NF-κB1 precursor protein and the activation of NF-κB
    • Palombella, V.J., Rando, O.J., Goldberg, A.L. and Maniatis, T. (1994) The ubiquitin-proteasome pathway is required for processing the NF-κB1 precursor protein and the activation of NF-κB. Cell, 78, 773-785
    • (1994) Cell , vol.78 , pp. 773-785
    • Palombella, V.J.1    Rando, O.J.2    Goldberg, A.L.3    Maniatis, T.4
  • 43
    • 0028325891 scopus 로고
    • Mouse Jun-D negatively regulates fibroblast growth and antagonizes transformation by ras
    • Pfarr, C., Mechta, F., Spyrou, G., Lallemand, D., Carillo, S. and Yaniv, M. (1994) Mouse Jun-D negatively regulates fibroblast growth and antagonizes transformation by ras. Cell, 76, 747-760.
    • (1994) Cell , vol.76 , pp. 747-760
    • Pfarr, C.1    Mechta, F.2    Spyrou, G.3    Lallemand, D.4    Carillo, S.5    Yaniv, M.6
  • 45
    • 0025829599 scopus 로고
    • c-Jun, Jun B and Jun D differ in their binding affinities to AP-1 and CRE consensus sequences: Effect of FOS proteins
    • Ryseck, R.-P. and Bravo, R. (1991) c-Jun, Jun B and Jun D differ in their binding affinities to AP-1 and CRE consensus sequences: effect of FOS proteins. Oncogene, 6, 533-542.
    • (1991) Oncogene , vol.6 , pp. 533-542
    • Ryseck, R.-P.1    Bravo, R.2
  • 46
    • 0024956317 scopus 로고
    • Expression of two myogenic regulatory factors myogenin and MyoD1 during mouse embryogenesis
    • Sassoon, D., Lyons, G., Wright, W.E., Lin, V., Lassar, A., Weintraub, H and Buckingham, M. (1989) Expression of two myogenic regulatory factors myogenin and MyoD1 during mouse embryogenesis. Nature, 341, 303-307.
    • (1989) Nature , vol.341 , pp. 303-307
    • Sassoon, D.1    Lyons, G.2    Wright, W.E.3    Lin, V.4    Lassar, A.5    Weintraub, H.6    Buckingham, M.7
  • 48
    • 0025739254 scopus 로고
    • Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-κB transcription factor and HIV-1
    • Schreck, R., Rieber, P. and Baeuerle, P. (1991) Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-κB transcription factor and HIV-1. EMBO J., 10, 2247-2258.
    • (1991) EMBO J. , vol.10 , pp. 2247-2258
    • Schreck, R.1    Rieber, P.2    Baeuerle, P.3
  • 49
    • 0027328056 scopus 로고
    • Depletion of the mitochondrial electron transport abrogates the cytotoxic and gene-inductive effects of TNF
    • Schulze-Osthoff, K., Beyaert, R., Vandevoorde, V., Haegeman, G. and Fiers, W. (1993) Depletion of the mitochondrial electron transport abrogates the cytotoxic and gene-inductive effects of TNF. EMBO J., 12, 3095-3104
    • (1993) EMBO J. , vol.12 , pp. 3095-3104
    • Schulze-Osthoff, K.1    Beyaert, R.2    Vandevoorde, V.3    Haegeman, G.4    Fiers, W.5
  • 52
    • 0028928036 scopus 로고
    • Inhibition of myogenic differentiation in proliferating myoblasts by cyclin D1-dependent kinase
    • Skapek, S.X., Rhee, J., Spicer, D.B. and Lassar, A.B. (1995) Inhibition of myogenic differentiation in proliferating myoblasts by cyclin D1-dependent kinase. Science, 267, 1022-1024.
    • (1995) Science , vol.267 , pp. 1022-1024
    • Skapek, S.X.1    Rhee, J.2    Spicer, D.B.3    Lassar, A.B.4
  • 53
    • 0027324558 scopus 로고
    • Through thick and thin: Wasting, obesity and TNFα
    • Spiegelman, B.M. and Hotamisligil, G.S. (1993) Through thick and thin: wasting, obesity and TNFα Cell, 73, 625-627.
    • (1993) Cell , vol.73 , pp. 625-627
    • Spiegelman, B.M.1    Hotamisligil, G.S.2
  • 54
    • 0028132836 scopus 로고
    • Redox signaling: Nitrosylation and related interactions of nitric oxide
    • Stalmer, J.S. (1994) Redox signaling: nitrosylation and related interactions of nitric oxide. Cell, 78, 931-936
    • (1994) Cell , vol.78 , pp. 931-936
    • Stalmer, J.S.1
  • 56
    • 0026689535 scopus 로고
    • Evidence for the involvement of interleukin 6 in experimental cancer cachexia
    • Strassmann, G., Fong, M., Kenney, J.S. and Jacob, C.O. (1992) Evidence for the involvement of interleukin 6 in experimental cancer cachexia. J. Clin. Invest., 89, 1681-1684.
    • (1992) J. Clin. Invest. , vol.89 , pp. 1681-1684
    • Strassmann, G.1    Fong, M.2    Kenney, J.S.3    Jacob, C.O.4
  • 57
    • 0027414452 scopus 로고
    • Deficiency in rhabdomyosarcomas of a factor required for myoD activity and myogenesis
    • Tapscott, S.J., Thayer, M.J. and Weintraub, H. (1993) Deficiency in rhabdomyosarcomas of a factor required for myoD activity and myogenesis. Science, 259, 1450-1453.
    • (1993) Science , vol.259 , pp. 1450-1453
    • Tapscott, S.J.1    Thayer, M.J.2    Weintraub, H.3
  • 58
    • 0002461840 scopus 로고
    • The acute and chronic pathophysiologic effects of TNF: Mediation of septic shock and wasting (cachexia)
    • Butler, B. (ed), Raven Press, New York
    • Tracey, K.J. (1992) The acute and chronic pathophysiologic effects of TNF: mediation of septic shock and wasting (cachexia). In Butler, B. (ed), Turner Necrosis Factors: The Molecules and Their Emerging Role in Medicine. Raven Press, New York, pp. 255-273.
    • (1992) Turner Necrosis Factors: The Molecules and Their Emerging Role in Medicine , pp. 255-273
    • Tracey, K.J.1
  • 59
    • 0027333425 scopus 로고
    • Tumor necrosis factor, other cytokines and disease
    • Tracey, K.J. and Cerami, A (1993) Tumor necrosis factor, other cytokines and disease. Annu. Rev. Cell Biol., 9, 317-343.
    • (1993) Annu. Rev. Cell Biol. , vol.9 , pp. 317-343
    • Tracey, K.J.1    Cerami, A.2
  • 60
    • 0023916786 scopus 로고
    • Cachectin/tumor necrosis factor induces cachexia, anemia and inflammation
    • Tracey, K.J. et al (1988) Cachectin/tumor necrosis factor induces cachexia, anemia and inflammation J. Exp. Med., 167, 1211-1227.
    • (1988) J. Exp. Med. , vol.167 , pp. 1211-1227
    • Tracey, K.J.1
  • 62
    • 0028148227 scopus 로고
    • A proteasome inhibitor prevents activation of NF-κB and stabilizes a newly phosphorylated form of IκB-α that is still bound to NF-κB
    • Traenckner, E.B.-M., Wilk, S. and Baeuerle, P.A. (1994) A proteasome inhibitor prevents activation of NF-κB and stabilizes a newly phosphorylated form of IκB-α that is still bound to NF-κB. EMBO J., 13, 5433-5441.
    • (1994) EMBO J. , vol.13 , pp. 5433-5441
    • Traenckner, E.B.-M.1    Wilk, S.2    Baeuerle, P.A.3
  • 63
    • 0027186357 scopus 로고
    • Transactivation by NF-IL6/LAP is enhanced by phosphorylation of its activation domain
    • Trautwein, C., Caelles, C., van der Geer, P., Hunter, T., Karin, M. and Chojkier, M. (1993) Transactivation by NF-IL6/LAP is enhanced by phosphorylation of its activation domain. Nature, 364, 544-547.
    • (1993) Nature , vol.364 , pp. 544-547
    • Trautwein, C.1    Caelles, C.2    Van Der Geer, P.3    Hunter, T.4    Karin, M.5    Chojkier, M.6
  • 64
    • 0028362082 scopus 로고
    • Protein kinase A and C site-specific phosphorylations of LAP (NF-IL6) modulate its binding affinity to DNA-recognition elements
    • Trautwein, C., van der Geer, P., Karin, M., Hunter, T. and Chojkier, M. (1994) Protein kinase A and C site-specific phosphorylations of LAP (NF-IL6) modulate its binding affinity to DNA-recognition elements. J. Clin. Invest , 93, 2554-2561
    • (1994) J. Clin. Invest , vol.93 , pp. 2554-2561
    • Trautwein, C.1    Van Der Geer, P.2    Karin, M.3    Hunter, T.4    Chojkier, M.5
  • 65
    • 0027964873 scopus 로고
    • Getting a grip on myosin
    • Vale, R.D. (1994) Getting a grip on myosin. Cell, 78, 733-737.
    • (1994) Cell , vol.78 , pp. 733-737
    • Vale, R.D.1
  • 66
    • 0025171934 scopus 로고
    • Differential gene expression of IFN-α and tumor necrosis factor-α in peripheral blood mononuclear cells from patients with AIDS related complex and AIDS
    • Voth, R., Rossol, S., Klein, K., Hess, G., Schutt, K H., Schroder, H.C., Buschenfelde, K.-H.M.Z. and Müller, W.E.G. (1990) Differential gene expression of IFN-α and tumor necrosis factor-α in peripheral blood mononuclear cells from patients with AIDS related complex and AIDS. J. Immunol , 144, 970-975.
    • (1990) J. Immunol , vol.144 , pp. 970-975
    • Voth, R.1    Rossol, S.2    Klein, K.3    Hess, G.4    Schutt, K.H.5    Schroder, H.C.6    Buschenfelde, K.-H.M.Z.7    Müller, W.E.G.8
  • 67
    • 0023094408 scopus 로고
    • Association between tumour necrosis factor in serum and fatal outcome in patients with meningococcal disease
    • Waage, A., Halstensen, A. and Espevik, T. (1987) Association between tumour necrosis factor in serum and fatal outcome in patients with meningococcal disease Lancet, i, 355-357.
    • (1987) Lancet , vol.1 , pp. 355-357
    • Waage, A.1    Halstensen, A.2    Espevik, T.3
  • 68
    • 0025292850 scopus 로고
    • MyoD binds cooperatively to two sites in a target enhancer sequence: Occupancy of two sites is required for activation
    • Weintraub, H., Davis, R., Lockshon, D. and Lassar, A. (1990) MyoD binds cooperatively to two sites in a target enhancer sequence: occupancy of two sites is required for activation. Proc. Natl Acad. Sci. USA, 87, 5623-5627.
    • (1990) Proc. Natl Acad. Sci. USA , vol.87 , pp. 5623-5627
    • Weintraub, H.1    Davis, R.2    Lockshon, D.3    Lassar, A.4
  • 69
    • 0027460118 scopus 로고
    • Glucocorticoids activate the ATP-ubiquitin-dependent proteolytic system in skeletal muscle during fasting
    • Wing, S.S. and Goldberg, A L. (1993) Glucocorticoids activate the ATP-ubiquitin-dependent proteolytic system in skeletal muscle during fasting. Am. J. Physiol., 264, E668-E676.
    • (1993) Am. J. Physiol. , vol.264
    • Wing, S.S.1    Goldberg, A.L.2
  • 70
    • 0024428198 scopus 로고
    • Manganous superoxide dismutase is essential for cellular resistance to cytotoxicity of tumor necrosis factor
    • Wong, GH.W , Elwell, J.H., Oberley, L.W. and Goeddel, D.V. (1989) Manganous superoxide dismutase is essential for cellular resistance to cytotoxicity of tumor necrosis factor. Cell, 58, 923-931
    • (1989) Cell , vol.58 , pp. 923-931
    • Wong, G.H.W.1    Elwell, J.H.2    Oberley, L.W.3    Goeddel, D.V.4
  • 71
    • 0026583944 scopus 로고
    • Identification and characterization of Ref-1, a nuclear protein that facilitates AP-1 DNA-binding activity
    • Xanthoudakis, S. and Curran, T. (1992) Identification and characterization of Ref-1, a nuclear protein that facilitates AP-1 DNA-binding activity EMBO J., 11, 653-665
    • (1992) EMBO J. , vol.11 , pp. 653-665
    • Xanthoudakis, S.1    Curran, T.2
  • 72
    • 0026714672 scopus 로고
    • Redox activation of Fos-Jun DNA binding activity is mediated by a DNA repair enzyme
    • Xanthoudakis, S., Miao, G., Wang, F., Pan, Y.C.E. and Curran, T. (1992) Redox activation of Fos-Jun DNA binding activity is mediated by a DNA repair enzyme EMBO J., 11, 3323-3335.
    • (1992) EMBO J. , vol.11 , pp. 3323-3335
    • Xanthoudakis, S.1    Miao, G.2    Wang, F.3    Pan, Y.C.E.4    Curran, T.5
  • 73
    • 0025906749 scopus 로고
    • Evidence that tumor necrosis factor plays a pathogenetic role in the paraneoplastic syndromes of cachexia, hypercalcemia and leukocytosis in a human tumor in nude mice
    • Yoneda, T., Alsina, M.A., Chavez, J.B., Bonewald, L., Nishimura, R. and Mundy, G.R. (1991) Evidence that tumor necrosis factor plays a pathogenetic role in the paraneoplastic syndromes of cachexia, hypercalcemia and leukocytosis in a human tumor in nude mice. J. Clin. Invest., 87, 977-985
    • (1991) J. Clin. Invest. , vol.87 , pp. 977-985
    • Yoneda, T.1    Alsina, M.A.2    Chavez, J.B.3    Bonewald, L.4    Nishimura, R.5    Mundy, G.R.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.