In vitro effect of leptin on LH release by anterior pituitary glands from female rats at the time of spontaneous and steroid-induced LH surge

European Journal of Endocrinology

Volumn 145, Issue 5, 2001, Pages 659-665

  De Biasi, S N ^a   Apfelbaum, L I ^a   Apfelbaum, M E ^a  

^a UNIVERSIDAD NACIONAL DE CÓRDOBA   (Argentina)

Author keywords

[No Author keywords available]

Indexed keywords

ESTRADIOL; GONADORELIN; LEPTIN; LUTEINIZING HORMONE; N(G) METHYLARGININE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; PROGESTERONE; STEROID HORMONE;

ADENOHYPOPHYSIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CULTURE MEDIUM; DEATH; DIESTRUS; DOSE RESPONSE; DRUG POTENCY; ESTRUS; ESTRUS CYCLE; FEMALE; HORMONAL REGULATION; IN VITRO STUDY; INCUBATION TIME; LUTEINIZING HORMONE RELEASE; NONHUMAN; OVARIECTOMY; PRIORITY JOURNAL; PROESTRUS; RAT; TIME;

EID: 0035167662     PISSN: 08044643     EISSN: None     Source Type: Journal    
DOI: 10.1530/eje.0.1450659     Document Type: Article

References (46)

1. Positional cloning of the mouse obese gene and its human homologue
2. Leptin: A molecule integrating somatic energy stores, energy expediture and fertility
3. Human leptin: From an adipocyte hormone to an endocrine mediator
4. Early onset of reproductive function in normal female mice treated with leptin
5. Leptin is a metabolic gate for the onset of puberty in the female rat
6. Leptin is a metabolic signal to the reproductive system
7. Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin
8. Role of leptin in the neuroendocrine response to fasting
9. 116-130 stimulates prolactin and luteinizing hormone secretion in fasted adult male rats
10. Evidence for GnRH regulation by leptin: Leptin administration prevents reduced pulsatile LH secretion during fasting
11. The stimulatory effect of leptin on the neuroendocrine reproductive axis of the monkey
12. Role of leptin in hypothalamic-pituitary function
13. Influence of the endogenous leptin tone on the oestrus cycle and luteinizing hormone pulsatility in female rats
14. Identification of targets of leptin action in the rat hypothalamus
15. Localization of leptin receptor mRNA and the long form splice variant (OB-Rb) in mouse hypothalamus and adjacent brain regions by in situ hybridization
16. Leptin activates neurons in ventrobasal hypothalamus and brainstem
17. Leptin and leptin receptor expression in rat and mouse pituitary cells
18. Nitric oxide metiates leptin-induced luteinizing hormone-releasing hormone (LHRH) and LHRH and leptin-induced LH release from the pituitary gland
19. Leptin inhibits testosterone secretion from adult rat testis in vitro
20. The adipose obese gene product, leptin: Evidence of a direct inhibitory role in ovarian function
21. In vitro pituitary and testicular effects of the leptin-related synthetic peptide leptin(116-130) amide involve actions both similar to and distinct from those of the native leptin molecule in the adult rat
22. Regulation of serum leptin levels by gonadal function in rats
23. Evidence for a physiological role of nitric oxide in the regulation of the LH surge: Effect of central administration of antisense oligonucleotides to nitric oxide synthase
24. Basal and GnRH-induced release and synthesis of LH and FSH from incubated pituitary glands throughout the 4-day estrous cycle of the rat
25. Upregulation of leptin receptor gene expression in the anterior pituitary of human growth hormone-releasing hormone transgenic mice
26. Leptin gene expression in the brain and pituitary gland
27. Estrogen increases in vivo leptin production in rats and human subjects
28. Leptin in human pregnancy: The relationship with gestational hormones
29. Regulation of leptin by steroid hormones in rat adipose tissue
30. Circulating leptin in normal children and during the dynamic phase of juvenile obesity. Relation to body fatness, energy metabolism, caloric intake, and sexual dimorphism
31. Leptin secretion and action: An update
32. Differential expression and regulation of leptin receptor isoforms in the rat brain: Effects of fasting and oestrogen
33. The leptin receptor
34. The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors
35. OB protein binds specifically to the choroid plexus of mice and rats
36. The role of nitric oxide in reproduction
37. Gaseous transmitters and neuroendocrine regulation
38. The L-arginine-nitric oxide pathway
39. Histochemical locatization of nitric oxide neurons in the hypothalamus: Association with gonadotropin-releasing hormone neurons and colocalization with N-methyl-D-aspartate receptors
40. Nitric oxide synthase and cGMP in the anterior pituitary gland: Effect of a GnRH antagonist and nitric oxide donors
41. Evidence that nitric oxide may mediate the ovarian steroid-induced luteinizing hormone surge: Involvement of excitatory amino acids
42. Evidence in support of nitric oxide (NO) involvement in the cyclic release of prolactin and LH surges
43. Evidence that neuronal nitric oxide synthase but not heme oxygenase increases in the hypothalamus on proestrus afternoon
44. Role of nitric oxide in the control of luteinizing hormone-releasing hormone release in vivo and in vitro
45. Nitric oxide (NO) stimulates gonadotropin secretion in vitro through a calcium-dependent, cGMP-independent mechanism
46. New concepts on the neuroendocrine regulation of gonadotropin surges in rats