Longitudinal analysis of T-cell receptor gene use by CD8+ T cells in early human immunodeficiency virus infection in patients receiving highly active antiretroviral therapy

Blood

Volumn 97, Issue 1, 2001, Pages 214-220

  Schito, Anna M ^a   Vittinghoff, Eric ^a   Hecht, Frederick M ^a   Elkins, Mary K ^a   Kahn, James O ^a   Levy, Jay A ^a   Oksenberg, Jorge R ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRUS AGENT; T LYMPHOCYTE RECEPTOR;

ADULT; ANTIVIRAL ACTIVITY; ARTICLE; CLINICAL ARTICLE; CLINICAL PROTOCOL; FEMALE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE RESPONSE; MALE; PRIORITY JOURNAL; T LYMPHOCYTE;

EID: 0035161241     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.V97.1.214     Document Type: Article

References (32)

1. Immunopathogenesis of HIV infection
2. Quantitation of HIV-1-specific cytotoxic T lymphocytes and plasma load of viral RNA
3. Longitudinal analysis of T cell receptor gene usage by HIV envelope-specific cytotoxic T lymphocyte clones reveals a limited TCR repertoire
4. Major expansion of CD8+ T cells with predominant V beta usage during primary immune response to HIV
5. Oligoclonal expansions of CDS+ T cells in chronic HIV infection are antigen specific
6. Biased TCR repertoire in HIV-1-infected patients due to clonal expansion of HIV-1-reverse transcriptase-specific CTL clones
7. HIV infection leads to differential expression of T cell receptor V beta genes in CD4+ and CD8+ T cells
8. Antiviral pressure exerted by HIV-1-specific cytotoxic T lymphocytes (CTLs) during primary infection demonstrated by rapid selection of CTL escape virus
9. Perturbation of CD4+ and CD8+ T-cell repertoires during progression to AIDS and regulation of the CD4+ repertoire during antiviral therapy
10. Weak anti-HIV CD8+ T-cell effector activity in HIV primary infection
11. Viral load and burden modification following early antiretroviral therapy of primary HIV-1 infection
12. Diversity of the T-cell receptor BV repertoire in HIV-1-infected patients reflects the biphasic CD4+ T-cell repopulation kinetics during highly active antiretroviral therapy
13. Factors influencing T-cell turnover in HIV-1-seropositive patients
14. New testing strategy to detect early HIV-1 infection for use in incidence estimates and for clinical and prevention purposes
15. Generation of TCR spectratypes by multiplex PCR for T cell repertoire analysis
16. Transient T cell receptor beta chain variable region-specific expansions of CD4+ and CD8+ T cells during the early phase of pediatric HIV infection: Characterization of expanded cell populations by T cell receptor phenotyping
17. Unbalanced repeated-measures models with structured covariance matrices
18. Selecting and maintaining a diverse T-cell repertoire
19. A direct estimate of the human alpha/beta T cell receptor diversity
20. A controlled trial of two nucleoside analogues plus indinavir in persons with human immunodeficiency virus infection and CD4 cell counts of 200 per cubic millimeter or less
21. Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection
22. Selective depletion in HIV infection of T cells that bear specific T cell receptor Vβ sequences
23. HIV induces deletion of T cell receptor variable gene product-specific T cells
24. Massive activation of immune cells with an intact T cell repertoire in acute human immunodeficiency virus syndrome
25. HIV-1-specific CD4+ T cells are detectable in most individuals with active HIV-1 infection, but decline with prolonged viral suppression
26. Human immunodeficiency virus type 1- and cytomegalovirus specific cytotoxic T lymphocytes can persist at high frequency for prolong periods in the absence of circulating peripheral CD4+ T cells
27. Vigorous HIV-1-specific CD4+ T cell responses associated with control of viremia
28. Determination of antigen-specific memory/effector CD4+ T cell frequencies by flow cytometry
29. Evidence for rapid disappearance of initially expanded HIV specific CD8+ T cell clones during primary HIV infection
30. Initiation of antiretroviral therapy during primary HIV-1 infection induces rapid stabilization of the T-cell receptor b chain repertoire and reduces the level of T-cell clonality
31. Early highly active antiretroviral therapy for acute HIV-1 infection preserves immune function of CD8+ and CD4+ T lymphocytes