Lipoprotein metabolism in Japanese centenarians: Effects of apolipoprotein E polymorphism and nutritional status

Journal of the American Geriatrics Society

Volumn 49, Issue 11, 2001, Pages 1434-1441

  Arai, Yasumichi ^a   Hirose, Nobuyoshi ^a   Nakazawa, Susumu ^a   Yamamura, Ken ^a   Shimizu, Ken Ichirou ^a   Takayama, Michiyo ^a   Ebihara, Yoshinori ^a   Osono, Yasunori ^a   Homma, Satoki ^b  

^a KEIO UNIVERSITY   (Japan)

^b Showa University Karasuyama Hospital   (Japan)

Author keywords

Apo E polymorphism; Centenarians; Interleukin 6; Lipoprotein; Nutrition

Indexed keywords

APOLIPOPROTEIN E; C REACTIVE PROTEIN; CHOLESTEROL ESTER TRANSFER PROTEIN; INTERLEUKIN 6; PREALBUMIN; SERUM ALBUMIN; TRANSFERRIN;

AGED; AGING; ARTICLE; ATHEROSCLEROSIS; CULTURAL FACTOR; DAILY LIFE ACTIVITY; DIETARY INTAKE; ENVIRONMENTAL FACTOR; FEMALE; GENETIC POLYMORPHISM; HUMAN; JAPAN; LIPID BLOOD LEVEL; LIPOPROTEIN BLOOD LEVEL; LIPOPROTEIN METABOLISM; LONGEVITY; MAJOR CLINICAL STUDY; MALE; NUTRITIONAL STATUS; RECEPTOR DENSITY; RISK FACTOR;

ACTIVITIES OF DAILY LIVING; AGED; AGED, 80 AND OVER; APOLIPOPROTEINS E; BODY MASS INDEX; CARRIER PROTEINS; CHOLESTEROL ESTER TRANSFER PROTEINS; CHOLESTEROL, HDL; CROSS-SECTIONAL STUDIES; FEMALE; GERIATRIC ASSESSMENT; GLYCOPROTEINS; HUMANS; INFLAMMATION MEDIATORS; JAPAN; LIPIDS; LIPOPROTEINS; MALE; MIDDLE AGED; NEUROPSYCHOLOGICAL TESTS; NUTRITIONAL STATUS; PHENOTYPE; POLYMORPHISM, GENETIC;

EID: 0035156337     PISSN: 00028614     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1532-5415.2001.4911234.x     Document Type: Article

References (57)

1. The familial component in longevity - A study of offspring of nonagenarians: III Intrafamilial studies
2. The effect of genetic factors for longevity: A comparison of identical and fraternal twins in the Swedish twin registry
3. The heritability of human longevity: A population-based study of 2872 Danish twin pairs born 1870-1900
4. Influence of major histocompatibility complex region genes on human longevity among Okinawan-Japanese centenarians and nonagenarians
5. Genetic association with human longevity at the apo E and ACE loci
6. Aging and genetic variation of plasma apolipoproteins. Relative loss of the apolipoprotein E4 phenotype in centenarians
7. Tokyo centenarian study 4. Apolipoprotein E phenotype in Japanese centenarians living in the Tokyo metropolitan area
8. Prevalence of dementia and distribution of apo E alleles in Japanese centenarians: An almost-complete survey in Yamanashi prefecture, Japan
9. Apolipoprotein E and B polymorphism-longevity factors assessed in nonagenarians
10. Gene polymorphisms predicting high plasma levels of coagulation and fibrinolysis proteins. A study in centenarians
11. Cardiovascular risk factors in the elderly
12. Is the relationship between serum cholesterol and risk of premature death from coronary heart disease continuous and graded? Findings in 356,222 primary screeners of the Multiple Risk Factor lnterventional Trial (MRFIT)
13. Plasma lipids and lipoproteins and the incidence of cardiovascular disease in the very elderly. The Bronx Aging study
14. Cholesterol-lowering therapy in woman and elderly patients with myocardial infarction or angina pectoris: Findings from the Scandinavian Simvastatin Survival study (4S)
15. Prevalence of coronary heart disease and associated risk factors among elderly Finnish men in the Seven Countries study
16. Lack of association between cholesterol and coronary heart disease mortality and morbidity and all-cause mortality in persons older than 70 years
17. Total cholesterol and risk of mortality in the oldest old
18. Lowering cholesterol concentrations and mortality: A review of primary prevention trials
19. Lipid and lipoprotein profile of Japanese centenarians - High prevalence of hypobetalipoproteinemia
20. Lipoprotein profile and highdensity lipoproteins: Subfracrion distributions in centenarians
21. In search of a biological pattern for human longevity: Impact of apo A-IV genetic polymorphisms on lipoproreins and the hyper-Lp(a) in centenarians
22. Lipoprotein (a) and lipoprotein profile in healthy centenarians: A reappraisal of vascular risk factors
23. Elevated lipoprotein (a) levels and small apo (a) isoforms are compatible with longevity: Evidence from a large population of French centenarians
24. Hypocholesterolemia as a predictor of death: A prospective study of 224 nursing home residents
25. Tokyo Centenarian Study 5. Nutritional status of Japanese centenarians
26. Amyloidgenic role of cytokine TGFbeta 1 in transgenic mice and Alzheimer's disease
27. Cytokine RNA levels in transiliac bone biopsies from healthy early postmenopausal women
28. Interleukin 6 receptor antibody inhibits muscle atrophy and modulates proteolytic systems in interleukin 6 transgenic mice
29. Serum IL-6 levels and the development of disability in older persons
30. Evidence for inflammation as a cause of hypocholesterolemia
31. Leisure time exercise and lipid and lipoprotein levels in an older population
32. The distribution and chemical composition of ultracentrifugally separated lipoprotein in human serum
33. Enzyme immunoassay for cholesteryl ester transfer protein in human serum
34. Apolipoprotein E phenotypes in Finnish youths: A cross-sectional and 6-year follow-up study
35. Evaluation of interleukin 6 (IL-6) measurement by highly sensitive chemiluminescent enzyme immunoassay
36. A new clinical scale for the staging of dementia
37. Association of apo E polymorphism with plasma lipid levels in a multiethnic population
38. Acute inflammation, acute phase serum amyloid A and cholesterol metabolism in the mouse
39. Relation of serum cytokine concentrations to cardiovascular risk factors and coronary heart disease
40. The prognostic value of serum albumin in healthy older persons with low and high serum interleukin-6 (IL-6) levels
41. A high plasma concentration of TNF-α is associated with dementia in centenarians
42. Mental aging and its medicopsychosocial background in the very old Japanese
43. Lack of association of apolipoprotein E allele epsilon 4 with late-onset Alzheimer's disease among Finnish centenarians
44. High-density lipoprotein cholesterol subfractions in older people
45. Relationship of high-density lipoprotein subfractions and cholesteryl ester transfer protein in plasma to carotid artery wall thickness
46. Plasma concentrations of cholesteryl ester transfer protein in hyperlipoproteinemia: Relation to cholesteryl ester transfer protein activities and other lipoprotein variables
47. Relation between cholesterol ester transfer protein activities and lipoprotein cholesterol in patients with hypercholesterolemia and combined hyperlipidemia
48. Determinants of plasma HDL-cholesterol in hypertriglyceridemic patients: Role of cholesterol-ester transfer protein and lecithin cholesteryl acyl transferase
49. Heterogeneity at the CETP gene locus: Influence on plasma CETP concentration and HDL cholesterol levels
50. Increased high-density lipoprotein levels caused by a common cholesteryl ester transfer protein gene mutation
51. Increased catabolic rate of low density lipoproteins in humans with cholesteryl ester transfer protein deficiency
52. Dietary calorie restriction in the Emory mouse: Effects on lifespan, eye lens cataract prevalence and progression, levels of ascorbate, glutathione, glucose, and glycohemoglobin, tail collagen break time, DNA and RNA oxidation, skin integrity, fecundity, and cancer
53. Protein oxidation associated with aging is reduced by dietary restriction of protein or calories
54. The cholesterol facts. A summary of the evidence relating dietary fats, serum cholesterol, and coronary heart disease: A joint statement by the American Heart Association and the National Heart, Lung, and Blood Institute
55. Dietary lipids and blood cholesterol: Quantitative meta-analysis of metabolic ward studies
56. Dietary associations of serum total, LDL, and HDL cholesterol and triglycerides in patients with coronary heart disease
57. Gene-nutrient interactions: Dietary, behaviour associated with high coronary heart disease risk particular affects serum LDL cholesterol in apolipoprotein E ε4- carrying free-living individuals