Partial activation and induction of apoptosis in CD4+ and CD8+ T lymphocytes by conformationally authentic noninfectious human immunodeficiency virus type 1

Journal of Virology

Volumn 75, Issue 3, 2001, Pages 1152-1164

  Esser, M T ^a   Bess J W , Jr ^a   Suryanarayana, K ^a   Chertova, E ^a   Marti, D ^a   Carrington, M ^a   Arthur, L O ^a   Lifson, J D ^a  

^a SAIC FREDERICK INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CXCR4; FAS ANTIGEN; FAS LIGAND; GLYCOPROTEIN GP 120; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; RECOMBINANT PROTEIN; VIRUS PROTEIN;

ANTIGEN EXPRESSION; APOPTOSIS; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MONONUCLEAR CELL; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; VIRION; VIRUS INFECTIVITY; VIRUS PATHOGENESIS; VIRUS REPLICATION;

APOPTOSIS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; HISTOCOMPATIBILITY ANTIGENS CLASS II; HIV ENVELOPE PROTEIN GP120; HIV-1; HUMANS; LYMPHOCYTE ACTIVATION; RECEPTORS, CXCR4; VIRION; VIRUS REPLICATION;

EID: 0035152177     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.75.3.1152-1164.2001     Document Type: Article

References (77)

1. Detection of the cellular membrane proteins on human T cell leukemia virus type I
2. Intracellular transport of class I MHC molecules in antigen processing mutant cell lines
3. + T cells from HIV-infected patients increases with disease progression
4. Chemical inactivation of retroviral infectivity by targeting nucleocapsid protein zinc fingers: A candidate SIV vaccine
5. Cellular proteins bound to immunodeficiency viruses: Implications for pathogenesis and vaccines
6. Could Nef and Vpr proteins contribute to disease progression by promoting depletion of bystander cells and prolonged survival of HIV-infected cells?
7. Incorporation of HLA antigens into the envelope of RNA tumor viruses grown in human cells
8. Upregulation of Fas ligand expression by human immunodeficiency virus in human macrophages mediates apoptosis of uninfected T lymphocytes
9. Production of doughnut-shaped, protease-defective particles from a human T cell clone carrying a provirus with specific mutations in the env, pol, vpr, and nef genes
10. Crosslinking CD4 by human immunodeficiency virus gp120 primes T cells for activation-induced apoptosis
11. Microvesicles are a source of contaminating cellular proteins found in purified HIV-1 preparations
12. Activation of the CD95 system increases with disease progression in human immunodeficiency virus type 1-infected children and adolescents
13. Selective incorporation of H-2 antigenic determinants into Friend virus particles
14. The presence of host-derived HLA-DR1 on human immunodeficiency virus type 1 increases viral infectivity
15. Induction of lymphomonocyte activation by HIV-1 glycoprotein gp120: Possible role in AIDS pathogenesis
16. Typing of HLA-DQA1 and DQB1 using DNA single-strand conformation polymorphism
17. The human immunodeficiency virus type 1 gp120 V2 domain mediates gp41-independent intersubunit contacts
18. + cell numbers and clinical staging
19. HIV's evasion of the cellular immune response
20. Simian immunodeficiency virus from African green monkeys
21. Quantitation of human immunodeficiency virus type 1 infection kinetics
22. + T cell count, and HIV plasma viral copy number
23. + T cell subset phenotyping independently predict survival time in patients infected with human immunodeficiency virus
24. + T cells responding to a bacterial superantigen
25. Apoptosis occurs predominantly in bystander cells and not in productively infected cells of HIV- and SIV-infected lymph nodes
26. + T cells by a Fas-independent mechanism
27. Cell membrane vesicles are a major contaminant of gradient-enriched human immunodeficiency virus type-1 preparations
28. Apoptosis induced by HIV infection in H9 T cells is blocked by ICE-family protease inhibition but not by a Fas (CD95) antagonist
29. Programmed cell death in peripheral lymphocytes from HIV-infected persons: Increased susceptibility to apoptosis of CD4 and CD8 T cells correlates with lymphocyte activation and with disease progression
30. Programmed cell death as a mechanism of CD4 and CD8 T cell deletion in AIDS: Molecular control and effect of highly active anti-retroviral therapy
31. Tissue-specific expression of porphobilinogen deaminase. Two isoenzymes from a single gene
32. The human interleukin-2 receptor
33. + T cells is mediated by macrophages through interaction of HIV gp120 with chemokine receptor CXCR4
34. Selective depletion in HIV infection of T cells that bear specific T cell receptor V beta sequences
35. + T cells in vivo by the induction of apoptosis?
36. Protease-defective, gp120-containing human immunodeficiency virus type 1 particles induce apoptosis more efficiently than does wild-type virus or recombinant gp120 protein in healthy-donor-derived peripheral blood T cells
37. + killer cells in a small subset, leading to induction of apoptosis in bystander cells
38. Interleukin-1 beta converting enzyme-like protease involvement in Fas-induced and activation-induced peripheral blood T cell apoptosis in HIV infection: TNF-related apoptosis-inducing ligand can mediate activation-induced T cell death in HIV infection
39. Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome
40. Determinants of CD4 independence for a human immunodeficiency virus type 1 variant map outside regions required for coreceptor specificity
41. Incorporation of HLA-DR into the envelope of human immunodeficiency virus type 1 in vivo: Correlation with stage of disease and presence of opportunistic infection
42. Cellular compartments of human immunodeficiency virus type 1 replication in vivo: Determination by presence of virion-associated host proteins and impact of opportunistic infection
43. + T cells from HIV-infected persons
44. AIDS retrovirus induced cytopathology: Giant cell formation and involvement of CD4 antigen
45. Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: Inhibition by overexpression of Bcl-2 and Abl
46. Immunophenotypic analysis of peripheral blood mononuclear cells undergoing in vitro apoptosis after isolation from human immunodeficiency virus-infected children
47. Programmed death of T cells in HIV-1 infection
48. + T cells in vitro and in vivo: Association with Fas-mediated apoptosis and modulation by aurintricarboxylic acid
49. Soluble MHC II-peptide complexes induce antigen-specific apoptosis in T cells
50. Deceptive imprinting: Insights into mechanisms of immune evasion and vaccine development
51. Antibody recognition of an immunogenic influenza hemagglutinin-human leukocyte antigen class II complex
52. Noninfectious doughnut-shaped human immunodeficiency virus type 1 can induce syncytia mediated by fusion of the particles with CD4-positive cells
53. HLA-DR typing by PCR amplification with sequence-specific primers (PCR-SSP) in 2 hours: An alternative to serological DR typing in clinical practice including donor-recipient matching in cadaveric transplantation
54. Association of host cell surface adhesion receptors and other membrane proteins with HIV and SIV
55. The majority of cells are superinfected in a cloned cell line that produces high levels of human immunodeficiency virus type 1 strain MN
56. + T lymphocytes by inhibiting interleukin 2 mRNA
57. Accelerated apoptosis in peripheral blood mononuclear cells (PBMCs) from human immunodeficiency virus type-1 infected patients and in CD4 cross-linked PBMCs from normal individuals
58. + T-cell counts, spontaneous apoptosis, and Fas expression in peripheral blood mononuclear cells obtained from human immunodeficiency virus type 1-infected subjects
59. High levels of HIV-1 in plasma during all stages of infection determined by competitive PCR
60. The downregulation of CD4 and MHC-I by primate lentiviruses: A paradigm for the modulation of cell surface receptors
61. Viral strategies of immune evasion
62. Efficient incorporation of HLA class II onto human immunodeficiency virus type 1 requires envelope glycoprotein packaging
63. Detection, isolation, and continuous production of cytopathic retroviruses (HTLV-III) from patients with AIDS and pre-AIDS
64. +) T lymphocytes
65. Transport and intracellular distribution of MHC class II molecules and associated invariant chain in normal and antigen-processing mutant cell lines
66. HLA class II on HIV particles is functional in superantigen presentation to human T cells: Implications for HIV pathogenesis
67. Inactivation of human immunodeficiency virus type 1 infectivity with preservation of conformational and functional integrity of virion surface proteins
68. HIV-I Tat: A polypeptide for all seasons
69. Impaired assembly and transport of HLA-A and -B antigens in a mutant TxB cell hybrid
70. JAK3 activation and rescue of T cells from HIV gp120-induced unresponsiveness
71. + lymphopenia
72. Plasma SIV RNA viral load determination by real-time quantification of product generation in reverse transcriptase-polymerase chain reaction
73. T cell activation via Leu-23 (CD69)
74. The acquisition of host-encoded proteins by nascent HIV-1
75. Fas ligand-mediated depletion of CD4 and CD8 lymphocytes by monomeric HIV-1-gp120
76. + LAK cells
77. + lymphocytes and cells infected by human immunodeficiency virus