Apoptotic killing of CD4+ T lymphocytes in HIV-1-infected PHA- stimulated PBL cultures is mediated by CD8+ LAK cells

Virology

Volumn 241, Issue 2, 1998, Pages 169-180

  Wang, Liqiang ^b   Klimpel, Gary R ^a   Planas, Josè M ^a   Li, Hongbo ^a   Cloyd, Miles W ^a  

^a UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

^b NONE

Author keywords

Apoptosis; CD4; CD8; HIV; LAK; Necrosis; PBL

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; INTERLEUKIN 2; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; PHYTOHEMAGGLUTININ;

APOPTOSIS; ARTICLE; CELL DEATH; CELL KILLING; CONTROLLED STUDY; CYTOPATHOGENIC EFFECT; EFFECTOR CELL; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; LYMPHOCYTE ACTIVATION; LYMPHOCYTE CULTURE; LYMPHOKINE ACTIVATED KILLER CELL; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; T LYMPHOCYTE SUBPOPULATION; VIRUS REPLICATION;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; RNA VIRUSES;

EID: 0032519892     PISSN: 00426822     EISSN: None     Source Type: Journal    
DOI: 10.1006/viro.1997.8979     Document Type: Article

References (49)

1. Baier M., Werner A., Bannert N., Metzner K., Kurth R. HIV suppression by interleukin-16. Nature. 378:1995;563.
2. Banda N. K., Bernier J., Kurahara D. K., Kurrle R., Haigwood N., Sekaly R.-P., Finkel T. H. Crosslinking CD4 by human immunodeficiency virus gp120 primes T cells for activation-induced apoptosis. J. Exp. Med. 176:1992;1099-1106.
3. +. J. Immunol. 156:1996;4476-4483.
4. Bergeron L., Sodroski J. Dissociation of unintegrated viral DNA accumulation from single-cell lysis induced by human immunodeficiency virus type 1. J. Virol. 66:1992;5777-5787.
5. Brenner B. G. Role of antibody-dependent cellular cytotoxicity and lymphokine-activated killer cells in AIDS and related diseases. J. Leukocyte Biol. 50:1991;628.
6. Brenner B. G., Gornitsky M., Wainberg M. A. Interleukin-2-inducible natural immune (lymphokine-activated killer cell) responses as a functional correlate of progression to AIDS. Clin. Diag. Lab. Immunol. 1:1994;538-544.
7. Brenner B. G., Gryllis C., Gornitsky M., Wainberg M. A. Changes in natural immunity during the course of HIV-1 infection. Clin. Exp. Immunol. 93:1993;142-148.
8. ++. J. Immunol. 144:1990;2961-2966.
9. Cheng-Mayer C., Weiss C., Seto D., Levy J. A. Isolates of human immunodeficiency virus type 1 from the brain may constitute a special group of the AIDS virus. Proc. Natl. Acad. Sci. USA. 86:1989;8575-8579.
10. Chernomordik L., Chanturiya A. N., Suss-Toby E., Nora E., Zimmerberg J. An amphipathic peptide from the C-terminal region of the human immunodeficiency virus envelope glycoprotein causes pore formation in membranes. J. Virol. 68:1994;7115-7123.
11. Cloyd M. W., Moore B. E. Spectrum of biological properties of human immunodifiency virus (HIV-1) isolates. Virology. 174:1990;103-116.
12. Cloyd M. W., Lynn W. S. Perturbation of host-cell membrane is a primary mechanism of HIV cytopathology. Virology. 181:1991;500-511.
13. +. Science. 270:1995;1811-1815.
14. Embretson J., Zupancic M., Ribas J. L., Burke A., Racz P., Tener-Racz K., Haase A. T. Massive covert infection of helper T lymphocytes and macrophages by HIV during the incubation period of AIDS. Nature. 362:1993;359-362.
15. Evans L. A., Moreau J., Odehouri K., Legg H., Barboza A., Cheng-Mayer C., Levy J. A. Characterization of a noncytopathic HIV-2 strain with unusual effects on CD4 expression. Science. 240:1988;1522-1525.
16. Fermin C. D., Garry R. F. Membrane alterations linked to early interactions of HIV with the cell surface. Virology. 191:1992;941-946.
17. Finkel T. H., Tudor-Williams G., Banda N. K., Cotton M. F., Curiel T., Monks C., Baba T. W., Ruprecht R. M., Kupfer A. Apoptosis occurs predominantly in bystander cells and not in productively infected cells of HIV- and SIV-infected lymph nodes [see comments]. Nat. Med. 1:1995;129-134.
18. +. J. Immunol. 142:1989;773-780.
19. Gryllis C., Wainberb M. A., Bentwich Z., Gornitsky M., Brenner B. G. Increased LAK activity against HIV-infected cell lines in HIV-1+ individuals. Clin. Exp. Immunol. 89:1992;356-361.
20. +in vitro. J. Virol. 64:1990;3399-3406.
21. Klimpel G. R., Asuncion M., Fons M., Norton J. D., Albrecht T., Klimpel K. D., Stien M. D. Interleukin-2 induced non-MHC-restricted killing of herpes simplex virus type 1 (HSV-1) infected allogeneic and autologous lymphoblasts. J. Clin. Lab. Immunol. 29:1989;1-7.
22. Knight C. R., Rees R. C., Platts A., Johnson T., Griffin M. Interleukin-2-activated human effector lymphocytes mediate cytotoxicity by inducing apoptosis in human leukemia and solid tumor target cells. Immunology. 79:1993;535-541.
23. Kong L. I., Lee S.-W., Kappes J. C., Parkin J. S., Decker D., Hoxie J. A., Hahn B. H., Shaw G. M. West African HIV-2-related human retrovirus with attenuated cytopathicity. Science. 240:1988;1525-1529.
24. +. J. Immunol. 153:1994;4826-4833.
25. Laurent-Crawford A. G., Krust B., Muller S., Riviere Y., Rey-Cuille M. A., Bechet J. M., Montagnier L., Hovanessian A. G. The cytopathic effect of HIV is associated with apoptosis. Virology. 185:1991;829-839.
26. Li X.-D., Moore B., Cloyd M. W. Gradual shutdown of virus production resulting in latency is the norm during the chronic phase of human immunodeficiency virus replication and differential rates and mechanisms of shutdown are determined by viral sequences. Virology. 225:1996;196-212.
27. Liegler T. J., Stites D. P. HIV-1 gp120 and anti-gp120 induce reversible unresponsiveness in peripheral CD4 T lymphocytes. J. AIDS. 7:1994;340-348.
28. Lifson J. D., Reyes G. R., McGrath M. S., Stein B. S., Engelman E. G. AIDS retrovirus induced cytopathology: giant cell formation and involvement of CD4 antigen. Science. 232:1986;1123-1127.
29. +. AIDS Res. Hum. Retroviruses. 8:1992;1039-1050.
30. +. AIDS Res. Hum. Retroviruses. 6:1990;1451-1457.
31. +in vitro: J. of Immunol. 152:1994;330-342.
32. Miller M. A., Cloyd M. W., Liebmann J., Rinaldo C. R. Jr., Islam K. R., Wang S. Z., Mietzner T. A., Montelaro R. C. Alterations in cell membrane permeability by the lentivirus lytic peptide (LLP-1) of HIV-1 transmembrane protein. Virology. 196:1993a;89-100.
33. Miller M. A., Mietzner T. A., Cloyd M. W., Robey W. G., Montelaro R. C. Identification of a calmodulin-binding and inhibitory peptide domain in the HIV-1 transmembrane glycoprotein. AIDS Res. Hum. Retroviruses. 9:1993b;1057-1066.
34. Muro-Cacho C. A., Pantaleo G., Fauci A. S. Analysis of apoptosis in lymph nodes of HIV-infected persons: Intensity of apoptosis correlates with the general state of activation of the lymphoid tissue and not with stage of disease or viral burden. J. Immunol. 154:1995;5555-5566.
35. Nuovo G. J., Becker J., Burk M. W., Margiotta M., Fuhrer J., Steigbigel R. T. In situ. J. AIDS. 7:1994;916-923.
36. Ochoa A. C., Hasz D. E., Rezonzew R., Anderson P. M., Bach F. H. Lymphokine-activated killer activity in long-term cultures with anti-CD3 plus interleukin 2: Identification and isolation of effector subsets. Cancer Res. 49:1989;963-968.
37. Oyaizu N., McCloskey T. W., Coronesi M., Chirmule N., Kalyanaraman V. S., Pahwa S. Accelerated apoptosis in peripheral blood mononuclear cells (PBMCs) from human immunodeficiency virus type-1 infected patients and in CD4 cross-linked PBMCs from normal individuals. Blood. 82:1993;3392-3400.
38. Pantaleo G., Fauci A. S. The immunopathogenesis of human immunodeficiency virus infection. N. Engl. J. Med. 328:1993;327-335.
39. Popovic M., Sarngadharam M. G., Read E., Gallo R. C. Detection, isolation and continuous production of cytopathic retroviruses (HTLV-III) from patients with AIDS and pre-AIDS. Science. 224:1984;497-500.
40. +. AIDS Res. Hum. Retroviruses. 13:1997;79-85.
41. +--. Clin. Exp. Immunol. 82:1990;416-421.
42. +. Pro. Natl. Acad. Sci. USA. 87:1990;6058-6062.
43. Stevenson M., Stanwick T. L., Dempsey M. P., Lanonica C. A. HIV-1 replication is controlled at the level of T cell activation and proviral integration. EMBO J. 9:1990;1551-1560.
44. Terai C., Kornbluth R. S., Pauza C. D., Richman D. D., Carson D. A. Apoptosis as a mechanism of cell death in cultured T lymphoblasts acutely infected with HIV-1. J. Clin. Invest. 87:1991;1710-1715.
45. +. J. Virol. 65:1991a;5921-5927.
46. Walker C. M., Levy J. A. A diffusible lymphokine produced by CD8+ T lymphocytes suppresses HIV replication. Immunology. 66:1989;628-630.
47. +. Science. 234:1986;1563-1566.
48. +. Cell. Immunol. 137:1991b;420-428.
49. Williams L. M., Cloyd M. W. Polymorphic human gene(s) determines differential susceptibility of CD4 lymphocytes to infection by certain HIV-1 isolates. Virology. 184:1991;723-728.