Expression of insulin target genes in skeletal muscle and adipose tissue in adult patients with growth hormone deficiency: Effect of one year recombinant human growth hormone therapy

Journal of Endocrinology

Volumn 171, Issue 2, 2001, Pages 285-292

  Khalfallah, Y ^a   Sassolas, G ^a   Borson Chazot, F ^a   Vega, N ^a   Vidal, H ^a  

^a INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOSTEROID; GLUCOSE TRANSPORTER; GLYCOGEN SYNTHASE; HEXOKINASE; INSULIN; INSULIN RECEPTOR; LIPOPROTEIN LIPASE; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN P85; RECOMBINANT GROWTH HORMONE; SEX HORMONE; SOMATOMEDIN C; SOMATREM; THYROXINE; TRIACYLGLYCEROL LIPASE;

ABDOMEN; ADIPOSE TISSUE; ADULT; ARTICLE; BIOPSY; CLAMP; CLINICAL ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG EFFECT; FEMALE; GENE EXPRESSION REGULATION; GENE TARGETING; GROWTH HORMONE DEFICIENCY; HORMONAL THERAPY; HORMONE BLOOD LEVEL; HORMONE SENSITIVITY; HUMAN; HYPERINSULINEMIA; INSULIN SENSITIVITY; LIPID METABOLISM; MALE; OBESITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SKELETAL MUSCLE; SUBCUTANEOUS TISSUE;

EID: 0035149782     PISSN: 00220795     EISSN: None     Source Type: Journal    
DOI: 10.1677/joe.0.1710285     Document Type: Article

References (43)

1. Insulin sensitivity in growth hormone (GH)-deficient adults and effect of GH replacement therapy
2. Expression of the major insulin regulatable glucose transporter (GLUT4) in skeletal muscle of noninsulin-dependent diabetic patients and healthy subjects before and after insulin infusion
3. Defective regulation of phosphatidylinositol-3-kinase gene expression in skeletal muscle and adipose tissue of non-insulin-dependent diabetes mellitus patients
4. Regulation of gene expression during severe caloric restriction: Lack of induction of p85α phosphatidylinositol-3-kinase mRNA in skeletal muscle of patients with type II (non-insulin-dependent) diabetes mellitus
5. The use of the reverse transcription-competitive polymerase chain reaction to investigate the in vivo regulation of gene expression in small tissue samples
6. Tissue distribution and quantification of the expression of mRNAs of peroxisome proliferator-activated receptors and liver X receptor-alpha in humans: No alteration in adipose tissue of obese and NIDDM patients
7. The effects of short and long-term growth hormone replacement therapy in hypopituitary adults on lipid metabolism and carbohydrate tolerance
8. Effects of ketone bodies on basal and insulin-stimulated glucose utilization in man
9. Decrease in carotid intima-media thickness after one year growth hormone (GH) treatment in adults with GH deficiency
10. A low individualized GH dose in young patients with childhood onset GH deficiency normalized serum IGF-I without significant deterioration in glucose tolerance
11. Growth hormone deficiency in adulthood and the effects of growth hormone replacement: A review
12. Single step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
13. Defects of insulin action and skeletal muscle glucose metabolism in growth hormone-deficient adults persist after 24 months of recombinant human growth hormone therapy
14. Reduced glycogen synthase activity in skeletal muscle from obese patients with and without type 2 (non-insulin-dependent) diabetes mellitus
15. Glucose clamp technique: A method for quantifying insulin secretion and resistance
16. The theoretical bases of indirect calorimetry: A review
17. Effects of treatment with recombinant human growth hormone on insulin sensitivity and glucose metabolism in adults with growth hormone deficiency
18. A novel in vitro model for studying signal transduction and gene regulation via the growth hormone receptor
19. Lipoprotein lipase regulation by insulin and glucocorticoid in subcutaneous and omental adipose tissues of obese women and men
20. Insulin resistance in growth hormone-deficient adults: Defects in glucose utilization and glycogen synthase activity
21. Metabolic actions of growth hormone in man
22. Differential effects of prednisone and growth hormone on fuel metabolism and insulin antagonism in humans
23. Growth hormone (GH) replacement reduces total body fat and normalizes insulin sensitivity in GH-deficient adults: A report of one-year clinical experience
24. Insulin secretion and sensitivity in hyperthyroidism
25. Growth hormone versus placebo treatment for one year in growth hormone deficient adults: Increase in exercise capacity and normalization of body composition
26. Measurement of insulin-like growth factor I (IGF-I) in normal adults, patients with liver cirrhosis and acromegaly: Experience with a new competitive enzyme immunoassay
27. Glucose tolerance and hyperinsulinaemia in obese women: Role of adipose tissue distribution, muscle fibre characteristics and androgens
28. Acute regulation by insulin of phosphatidylinositol-3-kinase, Rad, Glut4, and lipoprotein lipase mRNA levels in human muscle
29. Depot-specific differences in adipose tissue gene expression in lean and obese subjects
30. The effect of 3 months of recombinant human growth hormone (GH) therapy on insulin and glucose-mediated glucose disposal and insulin secretion in GH-deficient adults: A minimal model analysis
31. Two weeks of daily injections and continuous infusion of recombinant human growth hormone (GH) in GH-deficient adults. II. Effects on serum lipoproteins and lipoprotein and hepatic lipase activity
32. GH but not IGF-I or insulin increases lipoprotein lipase activity in muscle tissues of hypophysectomised rats
33. Obesity associated insulin resistance occurs in hypopituitary subjects
34. Insulin-induced hexokinase II expression is reduced in obesity and NIDDM
35. Role of insulin resistance in human disease
36. Effect of growth hormone on adipose tissue and skeletal muscle lipoprotein lipase activity in humans
37. Growth hormone treatment of obese women for 5 wk: Effect on body composition and adipose tissue LPL activity
38. Premature mortality due to cardiovascular disease in hypopituitarism
39. Interactions of body fat and muscle mass with substrate concentrations and fasting insulin levels in adults with growth hormone deficiency
40. Effect of insulin on GLUT-4 mRNA and protein concentrations in skeletal muscle of patients with NIDDM and their first-degree relatives
41. Visceral fat accumulation in men is positively associated with insulin, glucose, and C-peptide levels, but negatively with testosterone levels
42. The expression of ob gene is not acutely regulated by insulin and fasting in human abdominal subcutaneous adipose tissue
43. The effect of low dose recombinant human growth hormone replacement on regional fat distribution, insulin sensitivity, and cardiovascular risk factors in hypopituitary adults