T cell activation induces human osteoclast formation via receptor activator of nuclear factor κB ligand-dependent and -independent mechanisms

Journal of Bone and Mineral Research

Volumn 16, Issue 2, 2001, Pages 328-337

  Weitzmann, M Neale ^a   Cenci, Simone ^a   Rifas, Leonard ^a   Haug, Jeffrey ^a   Dipersio, John ^a   Pacifici, Roberto ^a  

^a BARNES JEWISH HOSPITAL   (United States)

Author keywords

Macrophage colony stimulating factor; Osteoclast; Osteoprotegerin; Receptor activator of nuclear factor B ligand; T cell

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; COLONY STIMULATING FACTOR 1; OSTEOCLAST DIFFERENTIATION FACTOR;

ARTICLE; BONE ATROPHY; CELL MATURATION; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG MECHANISM; HUMAN; HUMAN CELL; INFLAMMATION; MACROPHAGE; MONONUCLEAR PHAGOCYTE; OSTEOCLAST; PROTEIN DETERMINATION; STROMA CELL; T LYMPHOCYTE ACTIVATION;

BASE SEQUENCE; CARRIER PROTEINS; DNA PRIMERS; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; LIGANDS; LYMPHOCYTE ACTIVATION; MACROPHAGE COLONY-STIMULATING FACTOR; MEMBRANE GLYCOPROTEINS; NF-KAPPA B; OSTEOCLASTS; RANK LIGAND; RECEPTOR ACTIVATOR OF NUCLEAR FACTOR-KAPPA B; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; T-LYMPHOCYTES;

EID: 0035139583     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/jbmr.2001.16.2.328     Document Type: Article

References (31)

1. Immunological function in osteoporosis
2. Malignant osteoporosis and defective immunoregulation
3. T lymphocyte subsets in osteoporosis. Effect of 1-alpha hydroxyvitamin D3
4. Effects of T cell adoptive transfer into nude mice on alveolar bone resorption induced by endotoxin
5. Histopathological study of the role of CD4- and CD8-positive T cells on bone resorption induced by Escherichia coli endotoxin
6. + T lymphocytes in osteoclast differentiation in vitro
7. Effects of phytohemagglutinin-P (PHA-P) on bone of the growing rat
8. Effect of dichloromethylene diphosphonate (C12-MDP) on bone resorption induced by PHA-stimulated human mononuclear cells in organ culture
9. Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand
10. Activated T lymphocytes support osteoclast formation in vitro
11. A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function
12. Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL
13. Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation
14. TRANCE (tumor necrosis factor [TNF]-related activation-induced cytokine), a new TNF family member predominantly expressed in T cells, is a dendritic cell-specific survival factor
15. Osteoclast markers accumulate on cells developing from human peripheral blood mononuclear precursors
16. Human blood-mobilized hematopoietic precursors differentiate into osteoclasts in the absence of stromal cells
17. Cell staining
18. Evidence for a role of a tumor necrosis factor-alpha (TNF-alpha)-converting enzyme-like protease in shedding of TRANCE, a TNF family member involved in osteoclastogenesis and dendritic cell survival
19. A human homolog of the 150 kD avian osteoclast membrane antigen related to superoxide dismutase and essential for bone resorption is induced by developmental agents and opposed by estrogen in FLG 29.1 cells
20. TRANCE, a TNF family member, is differentially expressed on T cell subsets and induces cytokine production in dendritic cells
21. Human osteoclasts derive from CD 14-positive monocytes
22. Osteoclast function is activated by osteoblastic cells through a mechanism involving cell-to-cell contact
23. Tumor necrosis factor-alpha induces differentiation of and bone resorption by osteoclasts
24. Tumor necrosis factor alpha stimulates osteoclast differentiation by a mechanism independent of the ODF/RANKL-RANK interaction
25. Production of colony-stimulating factor 1 by T cells: Possible involvement in their interaction with antigen-presenting cells
26. Contributions of the CD2 and CD28 T lymphocyte activation pathways to the regulation of the expression of the colony-stimulating factor (CSF- 1) gene
27. Vascular endothelial growth factor can substitute for macrophage colony-stimulating factor in the support of osteoclastic bone resorption
28. Granulocyte/macrophage colony-stimulating factor and interleukin-3 correct osteopetrosis in mice with osteopetrosis mutation
29. Activin A is an essential cofactor for osteoclast induction
30. TGF-beta enhances osteoclast differentiation in hematopoietic cell cultures stimulated with RANKL and M-CSF
31. B lymphocytes inhibit human osteoclastogenesis by secretion of TGFbeta