The cyclin-dependent kinase inhibitor Roughex is involved in mitotic exit in Drosophila

Current Biology

Volumn 11, Issue 3, 2001, Pages 151-160

  Foley, Edan ^a   Sprenger, Frank ^a  

^a UNIVERSITY OF COLOGNE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALIA; DROSOPHILA; EUKARYOTA; HEXAPODA; SACCHAROMYCETALES;

EID: 0035129716     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(01)00050-1     Document Type: Article

References (33)

1. Universal control mechanism regulating onset of M-phase
2. Cancer cell cycles
3. Mitotic treasures in the nucleolus
4. P40SDB25, a putative CDK inhibitor, has a role in the M/G1 transition in Saccharomyces cerevisiae
5. Exit from mitosis is triggered by Tem1-dependent release of the protein phosphatase Cdc14 from nucleolar RENT complex
6. The phosphatase Cdc14 triggers mitotic exit by reversal of Cdk-dependent phosphorylation
7. Control of cyclin ubiquitination by CDK-regulated binding of Hct1 to the anaphase promoting complex
8. Inhibitory phosphorylation of the APC regulator Hct1 is controlled by the kinase Cdc28 and the phosphatase Cdc14
9. The role of phosphorylation and the CDC28 protein kinase in cell cycle-regulated nuclear import of the S. cerevisiae transcription factor SWI5
10. The transcription factor Swi5 regulates expression of the cyclin kinase inhibitor p40SIC1
11. A complex of Cdc4p, Skp1p, and Cdc53p/cullin catalyzes ubiquitination of the phosphorylated CDK inhibitor Sic1p
12. Cyclin is degraded by the ubiquitin pathway
13. Exit from mitosis is regulated by Drosophila fizzy and the sequential destruction of cyclins A, B and B3
14. Rux is a cyclin-dependent kinase inhibitor (CKI) specific for mitotic cyclin-Cdk complexes
15. Roughex is a dose-dependent regulator of the second meiotic division during Drosophila spermatogenesis
16. Cell cycle progression in the developing Drosophila eye: Roughex encodes a novel protein required for the establishment of G1
17. Roughex down-regulates G2 cyclins in G1
18. S-phase function of Drosophila cyclin A and its downregulation in G1 phase
19. Studies of nuclear and cytoplasmic behaviour during the five mitotic cycles that precede gastrulation in Drosophila embryogenesis
20. Distinct molecular mechanism regulate cell cycle timing at successive stages of Drosophila embryogenesis
21. Mitotic domains reveal early commitment of cells in Drosophila embryos
22. The three postblastoderm cell cycles of Drosophila embryogenesis are regulated in G2 by string
23. A His2AvDGFP fusion gene complements a lethal His2AvD mutant allele and provides an in vivo marker for Drosophila chromosome behavior
24. Closing the cell cycle circle in yeast: G2 cyclin proteolysis initiated at mitosis persists until the activation of G1 cyclins in the next cycle
25. Drosophila fizzy-related down-regulates mitotic cyclins and is required for cell proliferation arrest and entry into endocycles
26. The cdk inhibitors p25(rum1) and p40(SlC1) are functional homologues that play similar roles in the regulation of the cell cycle in fission and budding yeast
27. The Drosophila maternal-effect mutation grapes causes a metaphase arrest at nuclear cycle 13
28. Mad2 binding by phosphorylated kinetochores links error detection and checkpoint action in mitosis
29. Activating the DNA damage checkpoint in a developmental context
30. Expression and function of Drosophila cyclin A during embryonic cell cycle progression
31. The cyclin-dependent kinase inhibitory domain of the yeast Sic1 protein is contained within the C-terminal 70 amino acids
32. Roughex mediates G1 arrest through a physical association with cyclin A
33. The roles of Drosophila cyclins A and B in mitotic control