Analysis of p53 inactivation in a human T-cell leukemia virus type 1 Tax transgenic mouse model

Journal of Virology

Volumn 75, Issue 5, 2001, Pages 2185-2193

  Portis, T ^a   Grossman, W J ^a   Harding, J C ^a   Hess, J L ^a   Ratner, L ^a  

^a WASHINGTON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P53; TAX PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DEATH; CONTROLLED STUDY; GENE INACTIVATION; HUMAN T CELL LEUKEMIA VIRUS 1; LYMPHOMA; MALIGNANT TRANSFORMATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SINGLE STRAND CONFORMATION POLYMORPHISM; T CELL LEUKEMIA; TRANSGENIC MOUSE; VIRUS CARCINOGENESIS; VIRUS CELL TRANSFORMATION;

ANIMALS; APOPTOSIS; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; GENE PRODUCTS, TAX; GENES, P53; GENES, PX; HUMAN T-LYMPHOTROPIC VIRUS 1; HUMANS; LEUKEMIA-LYMPHOMA, T-CELL, ACUTE, HTLV-I-ASSOCIATED; MICE; MICE, TRANSGENIC; MUTATION; NEOPLASMS; POLYMERASE CHAIN REACTION; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL; TRANS-ACTIVATION (GENETICS); TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0035124758     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.75.5.2185-2193.2001     Document Type: Article

References (48)

1. Human T-cell leukemia virus type I Tax induces expression of the Rel-related family of kappa B enhancer-binding proteins: Evidence for a pretranslational component of regulation
2. p53 mutations in C57BL/6J murine thymic lymphomas induced by gamma-irradiation and N-methylnitrosourea
3. Repression of Bax gene expression by the HTLV-I Tax protein: Implications for suppression of apoptosis in virally infected cells
4. Identification of the gene responsible for human T-cell leukemia virus transcriptional regulation
5. p53 functional impairment and high p21 (waf1/cip1) expression in human T-cell lymphotropic/leukemia virus type I-transformed T cells
6. Structural and functional analysis of oncogenes and tumor suppressor genes in adult T-cell leukemia/lymphoma shows frequent p53 mutations
7. High-efficiency transformation of mammalian cells by plasmid DNA
8. Crystal structure of a p53 tumor suppressor-DNA complex: Understanding tumorigenic mutations
9. Transforming growth factor beta induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism
10. Molecular mechanisms of human T-cell leukemia/lymphotropic virus type I infection
11. HTLV-I Tax induces expression of various immediate early serum responsive genes
12. The complexity of p53 modulation: Emerging patterns from divergent signals
13. Anchoring of CREB binding protein to the human T-cell leukemia virus type I promoter: A molecular mechanism of Tax transactivation
14. Development of leukemia in mice transgenic for the tax gene of human T-cell leukemia virus type I
15. Cytokine expression and tumorigenicity of large granular lymphocytic leukemia cells from mice transgenic for the tax gene of human T-cell leukemia virus type I
16. Database of p53 gene somatic mutations in human tumors and cell lines
17. Human T-cell leukemia virus type I Tax protein abrogates interleukin-2 dependence in a mouse T-cell line
18. Tumor spectrum analysis in p53-mutant mice
19. Herpes simplex virus inhibits apoptosis through the action of two genes, Us5 and Us3
20. Absence of p53 in a mouse mammary tumor model promotes tumor cell proliferation without affecting apoptosis
21. Disruption of nulceotide excision repair by the human T-cell leukemia virus type 1 Tax protein
22. Resistance to Fas-mediated apoptosis of peripheral T cells in human T lymphocyte virus type 1 (HTLV-1) transgenic mice with autoimmune arthropathy
23. Transrepression of lck gene expression by human T-cell leukemia virus type I-encoded p40 (tax)
24. p53, the cellular gatekeeper for growth and division
25. Human papillo-mavirus-induced carcinogenesis with p53 deficiency in mouse: Hover lymphomagenesis in HPV E6E7 transgenic mice mimicking p53 defect
26. Novel interactions between human T-cell leukemia virus Tax and activating transcription factor 3 at a cyclic AMP-responsive element
27. Human T-cell leukemia virus type I Tax releases cell cycle arrest induced by p16 (INK4a)
28. Trans-activator Tax of human T-cell leukemia virus type 1 enhances mutation frequency of the cellular genome
29. Human T-cell leukemia virus type I Tax and cell cycle progression: Role of cyclin D-cdk and p110Rb
30. Mutations in the p53 gene occur in diverse human tumor types
31. Inhibition of p53 transactivation function by the human T-cell lymphotropic virus type I Tax protein
32. Phosphorylation of p53: A novel pathway for p53 inactivation in human T-cell lymphotropic virus type 1-transformed cells
33. A lymphoproliferative disorder caused by human T-lymphotrophic virus type I: Demonstration of a continuum between acute and chronic adult T-cell leukemia-lymphoma
34. Stabilization of wild-type p53 in human T-lymphocytes transformed by HTLV-I
35. Human T-cell leukemia virus type I Tax transactivates the human proliferating cell nuclear antigen promoter
36. The polyproline region of p53 is required to activate apoptosis but not growth arrest
37. Transcriptional up-regulation of the cyclin D2 gene and acquisition of new cyclin-dependent kinase partners in human T-cell leukemia virus type I-infected cells
38. Adenovirus E1B-58kd tumor antigen and SV40 targe tumor antigen are physically associated with the same 54 kd cellular protein in transformed cells
39. 1- to S-phase transition in human lymphocytes by the human T-cell leukemia/lymphotropic virus type I Tax protein
40. Control of cell cycle entry and apoptosis in B lymphocytes infected by Epstein-Barr Virus
41. HTLV-I Tax protein interacts with cyclin-dependent kinase inhibitor p16 (INK4a) and counteracts its inhibitory activity towards CDK4
42. Down-regulation of the INK4 family of cyclin-dependent kinase inhibitors by tax protein of HTLV-I through two distinct mechanisms
43. Mutation of Tp53 contributes to the malignant phenotype of Abelson virus-transformed lymphoid cells
44. Induction of Bcl-xl expression by human T-cell leukemia virus type I through NF-κB in apoptosis-resistant T-cell transfectants with Tax
45. p53 mediates apoptotic crisis in primary Abelson virus-transformed pre-B cells
46. Retention of wild-type p53 in tumors from p53 heterozygous mice: Reduction of p53 dosage can promote cancer formation
47. Association of human papillomavirus types 16 and 18 E6 proteins with p53
48. Loss of p53 in F-MuLV induced-erythroleukemias accelerates the acquisition of mutational events that confers immortality and growth factor independence