Transrepression of lck gene expression by human T-cell leukemia virus type 1-encoded p40(tax)

Journal of Virology

Volumn 71, Issue 3, 1997, Pages 1975-1983

  Lemasson, Isabelle ^a   Robert Hebmann, Véronique ^a   Hamaia, Samir ^b   Duc Dodon, Madeleine ^b   Gazzolo, Louis ^b   Devaux, Christian ^a,c  

^a INSERM   (France)

^b UNIVERSITÉ LYON 1   (France)

^c Centre National de la Recherche Scientifique   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CADMIUM; CHLORAMPHENICOL ACETYLTRANSFERASE; MESSENGER RNA; REX PROTEIN; TAX PROTEIN;

ARTICLE; CONTROLLED STUDY; GENE EXPRESSION REGULATION; GENE REPRESSION; HUMAN; HUMAN CELL; HUMAN T CELL LEUKEMIA VIRUS 1; LEUKEMIA CELL LINE; OPEN READING FRAME; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; VIRUS GENOME;

EID: 0031041649     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.71.3.1975-1983.1997     Document Type: Article

References (59)

1. Alexandre, C., P. Charnay, and B. Verrier. 1991. Transactivation of Krox-20 and Krox-24 promoters by the HTLV-I Tax protein through common regulatory elements. Oncogene 6:1852-1857.
2. Alexandre, C., and B. Verrier. 1991. Four regulatory elements in the human c-fos promoter mediate trans-activation by HTLV-1 Tax protein. Oncogene 6:543-551.
3. Altman, R., D. Harrich, J. A. Garcia, and R. B. Gaynor. 1988. Human T-cell leukemia virus types I and II exhibit different DNase I protection patterns. J. Virol. 62:1339-1346.
4. Ballard, D. W., E. Böhnlein, J. W. Lowenthal, Y. Wano, B. R. Franza, and W. C. Greene. 1988. HTLV-I Tax induces cellular proteins that activate the kB element in the IL-2 receptor a gene. Science 241:1652-1655.
5. Beimling, P., and K. Moelling. 1992. Direct interaction of CREB protein with 21 bp Tax-response elements of HTLV-I LTR. Oncogene 7:257-262.
6. Benkirane, M., P. Corbeau, V. Housset, and C. Devaux. 1993. An antibody that binds the immunoglobulin CDR3-like region of the CD4 molecule inhibits provirus transcription in HIV-infected T cells. EMBO J. 12:4909-4921.
7. Benkirane, M., K.-T. Jeang, and C. Devaux. 1994. The cytoplasmic domain of CD4 plays a critical role during the early stages of HIV infection in T-cells. EMBO J. 13:5559-5569.
8. Bhat, N. K., Y. Adachi, K. P. Samuel, and D. Derse. 1993. HTLV-1 gene expression by defective proviruses in an infected T-cell line. Virology 196: 15-24.
9. Böhnlein, E., M. Siekevitz, D. W. Ballard, J. W. Lowenthal, L. Rimsky, H. Bogerd, J. Hoffman, Y. Wano, B. R. Franza, and W. C. Greene. 1989. Stimulation of the human immunodeficiency virus type 1 enhancer by the human T-cell leukemia virus type I tax gene product involves the action of inducible cellular proteins. J. Virol. 63:1578-1586.
10. Cann, A. J., J. D. Rosenblatt, W. Wachsman, N. P. Shaw, and I. S. Y. Chen. 1985. Identification of the gene responsible for human T-cell leukaemia virus transcriptional regulation. Nature 318:571-574.
11. Corbeau, P., M. Benkirane, R. Weil, C. David, S. Emiliani, D. Olive, C. Mawas, A. Serre, and C. Devaux. 1993. Ig CDR3-like region of the CD4 molecule is involved in HIV-induced syncytia formation but not viral entry. J. Immunol. 150:290-301.
12. Dang, C. V., C. Dolde, M. L. Gillison, and G. J. Kato. 1992. Discrimination between related DNA sites by a single amino acid residue of Myc-related basic-helix-loop-helix proteins. Proc. Natl. Acad. Sci. USA 89:599-602.
13. Feigenbaum, L., K. Fujita, F. S. Collins, and G. Jay. 1996. Repression of the NF1 gene by Tax may explain the development of neurofibromas in human T-lymphotropic virus type 1 transgenic mice. J. Virol. 70:3280-3285.
14. Felber, B. K., H. Paskalis, C. Kleinman-Ewing, F. Wong-Staal, and G. N. Pavlakis. 1985. The pX protein of HTLV-1 is a transcriptional activator of its long terminal repeats. Science 229:675-679.
15. + ATPase. J. Virol. 67:7701-7704.
16. Franklin, A. A., M. F. Kubik, M. N. Uittenbogaard, A. Brauweiler, P. Utaisincharoen, M. A. H. Matthews, W. S. Dynan, J. P. Hoeffler, and J. K. Nyborg. 1993. Transactivation by the human T-cell leukemia virus tax protein is mediated through enhanced binding of activating transcription factor-2 (ATF-2), ATF-2 response and cAMP response element-binding protein (CREB). J. Biol. Chem. 28:21225-21231.
17. Franklin, A. A., and J. K. Nyborg. 1995. Mechanism of Tax regulation of human T cell leukemia virus type I gene expression. J. Biomed. Sci. 2:17-29.
18. Fujii, M., P. Sassone-Corsi, and I. M. Verma. 1988. c-fos promoter transactivation by the taxi protein of human T-cell leukemia virus type I. Proc. Natl. Acad. Sci. USA 85:8526-8530.
19. SRF causes the aberrant induction of cellular immediate early genes through CArG boxes. Genes Dev. 6:2066-2076.
20. Fujisawa, J., M. Seiki, M. Sato, and M. Yoshida. 1986. A transcriptional enhancer sequence of HTLV-I is responsible for transactivation mediated by p40x of HTLV-I. EMBO J. 5:713-718.
21. Garvin, A. M., S. Pawar, J. D. Marth, and R. M. Perlmutter. 1988. Structure of the murine lck gene and its rearrangement in a murine lymphoma cell line. Mol. Cell. Biol. 8:3058-3064.
22. Girerd, Y., H. Casse, M. Duc Dodon, and L. Gazzolo. 1995. Human T cell leukaemia virus type I env gene-transfected HeLa cells display a decrease in cell fusion ability. J. Gen. Virol. 76:1021-1024.
23. Haffner, R., and M. Oren. 1995. Biochemical properties and biological effects of p53. Curr. Opin. Genet. Dev. 5:84-90.
24. Hasegawa, H., Y. Utsunomiya, K. Kishimoto, K. Yanagisawa, and S. Fujita. 1996. SFA-1, a novel cellular gene induced by human T-cell leukemia virus type 1, is a member of the transmembrane 4 superfamily. J. Virol. 70:3258-3263.
25. lck: identification of novel intermolecular association. Science 252:1523-1528.
26. Jeang, K.-T., S. G. Widen, O. J. Semmes IV, and S. H. Wilson. 1990. HTLV-I trans-activator protein, Tax, is a transrepressor of the human β polymerase gene. Science 247:1082-1084.
27. Kadesch, T. 1992. Helix-loop-helix proteins in the regulation of immunoglobulin gene transcription. Immunol. Today 13:31-36.
28. Kamps, M. P., C. Murre, X. H. Sun, and D. Baltimore. 1990. A new homeobox gene contributes the DNA binding domain of the t(1;19) translocation protein in pre-B ALL. Cell 60:547-555.
29. Koga, Y., N. Oh-Hori, H. Sato, N. Yamamoto, G. Kimura, and K. Nomoto. 1989. Absence of transcription of lck (lymphocyte specific protein tyrosine kinase) message in IL-2-independcnt, HTLV-I-transformed T cell lines. J. Immunol. 142:4493-4499.
30. + -ATPase 16 kDa subunit protein. J. Gen. Virol. 76:1909-1916.
31. Lemasson, I., L. Briant, B. Hague, N. Coudronnière, L. Heron, C. David, C. Rebouissou, T. Kindt, and C. Devaux. 1996. An antibody that binds domain 1 of CD4 inhibits replication of HIV-1 but not HTLV-I in a CD4 positive/ p56lck negative HTLV-I transformed cell line. J. Immunol. 156:859-865.
32. Lilienbaum, A., M. Duc Dodon, C. Alexandre, L. Gazzolo, and D. Paulin. 1990. Effect of human T-cell leukemia virus type I Tax protein on activation of the human vimentin gene. J. Virol. 64:256-263.
33. Migone, T. S., J. X. Lin, A. Cereseto, J. C. Mulloy, J. J. O'Shea, G. Franchini, and W. J. Leonard. 1995. Constitutively activated Jak-STAT pathway in T cells transformed with HTLV-I. Science 269:79-83.
34. Mills, G. B., N. Arima, C. May, M. Hill, R. Schmandt, J. Li, N. G. Miyamoto, and W. C. Greene. 1992. Neither the lck nor the fyn kinases are obligatory for IL-2-mediated signal transduction in HTLV-I-infected human T cells. Int. Immunol. 4:1233-1243.
35. x protein activate the mouse granulocyte-macrophage colony-stimulating factor gene through a common DNA element. Mol. Cell. Biol. 8:5581-5587.
36. Murre, C., P. C. McCaw, H. Vaessin, M. Caudy, L. Y. Jan, Y. N. Jan, C. V. Cabrera, J. N. Buskin, S. D. Hauschka, A. B. Lassar, H. Weintraub, and D. Baltimore. 1989. Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence. Cell 58:537-544.
37. tax protein in the human T-cell line. Jurkat. J. Virol. 63:3220-3226.
38. - T-cells. Int. J. Cancer 48:789-793.
39. Neumann, J. R., C. A. Morency, and K. O. Russian. 1987. A novel rapid assay for chloramphenicol acetyltransferase gene expression. BioTechniques 5:444-447.
40. Nourse, J., J. D. Mellentin, N. Gulili, J. Wilkinson, E. Stanbridge, S. D. Smith, and M. L. Cleary. 1990. Chromosomal translocation t(1;19) results in synthesis of a homeobox fusion mRNA that codes for a potential chimeric transcription factor. Cell 60:535-545.
41. Nyborg, J. K., W. S. Dynan, I. S. Y. Chen, and W. Wachsman. 1988. Binding of host-cell factors to DNA sequences in the long terminal repeat of human T-cell leukemia virus type 1: implication for viral gene expression. Proc. Natl. Acad. Sci. USA 85:1457-1461.
42. Poiesz, B. J., F. W. Ruscetti, A. F. Gazdar, P. A. Bunn, J. D. Minna, and R. C. Gallo. 1980. Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma. Proc. Natl. Acad. Sci. USA 77:7415-7419.
43. Reid, R. L., P. F. Lindholm, A. Mireskandari, J. Dittmer, and J. N. Brady. 1993. Stabilization of wild-type p53 in human T-lymphocytes transformed by HTLV-I. Oncogene 8:3029-3036.
44. Ruben, S., H. Poteat, T. H. Tan, K. Kawakami, R. Roeder, W. Haseltine, and C. A. Rosen. 1988. Cellular transcription factors and regulation of IL-2 receptor gene expression by HTLV-1 tax gene product. Science 241:89-92.
45. Rudd, C. E., J. M. Trevillyan, J. D. Dasgupta, L. L. Wong, and S. F. Schlossman. 1988. The preceptor is complexed in detergent lysates to a protein-tyrosine kinase from human T lymphocytes. Proc. Natl. Acad. Sci. USA 85:5190-5194.
46. Salahuddin, S. Z., P. D. Markham, S. G. Linder, J. Gootenberg, M. Popovic, H. Hemmi, P. S. Sarin, and R. Gallo. 1984. Lymphokine production by cultured human T-cells transformed by human T-cell leukemia lymphoma virus I. Science 223:703-707.
47. Seiki, M., J. Inoue, T. Takeda, and M. Yoshida. 1986. Direct evidence that p40x of human T-cell leukemia virus type I is a trans-acting transcriptional activator. EMBO J. 5:561-565.
48. Siekevitz, M., M. B. Feinberg, N. Holbrook, F. Wong-Staal, and W. C. Green. 1987. Activation of interleukin 2 and interleukin 2 receptor (Tac) promoter expression by the trans-activator (Tat) gene product of human T-cell leukemia virus type I. Proc. Natl. Acad. Sci. USA 84:5389-5393.
49. Sodroski, J. G., C. A. Rosen, and W. A. Haseltine. 1984. Trans-acting transcrfitional activation of the long terminal repeat of human T lymphotropic viruses in infected cells. Science 225:381-385.
50. Takadera, T., S. Leung, A. Gernone, Y. Koga, Y. Takihara, N. G. Miyamoto, and T. W. Mak. 1989. Structure of the two promoters of the human lck gene: differential accumulation of two classes of lck transcripts in T cells. Mol. Cell. Biol. 9:2173-2180.
51. tax. Mol. Cell. Biol. 12:3784-3795.
52. Uittenbogaard, M. N., A. P. Armstrong, A. Chiaramello, and J. K. Nyborg. 1994. Human T-cell leukemia virus type I tax protein represses gene expression through the basic helix-loop-helix family of transcription factors. J. Biol. Chem. 269:22466-22469.
53. Uittenbogaard, M. N., H. A. Giebler, D. Reisman, and J. K. Nyborg. 1995. Transcritional repression of p53 by human T-cell leukemia virus type I Tax protein. J. Biol. Chem. 270:28503-28506.
54. lck. Cell 55:301-308.
55. Wildin, R. S., A. M. Garvin, S. Pawar, D. B. Lewis, K. M. Abraham, K. A. Forbush, S. F. Ziegler, J. M. Allen, and R. M. Perlmutter. 1991. Developmental regulation of lck gene expression in T lymphocytes. J. Exp. Med. 173:383-393.
56. Yoshida, M. 1995. HTLV-I oncoprotein Tax deregulates transcription of cellular genes through multiple mechanisms. J. Cancer Res. Clin. Oncol. 121:521-528.
57. Yoshida, M., I. Miyoshi, and Y. Hinuma. 1982. Isolation and characterization of retrovirus from cell lines of human adult T-cell leukemia and its implication in the disease. Proc. Natl. Acad. Sci. USA 79:2031-2035.
58. Yoshimura, T., J. I. Fujisawa, and Y. Yoshida. 1990. Multiple cDNA clones encoding nuclear proteins that bind to the tax-dependent enhancer of HTLV-I: all contain a leucine zipper and a basic amino and domain. EMBO J. 9:2537-2542.
59. Zololukhin A. S., J. B. Harford, and B. K. Felber. 1994. Rev of human immunodeficiency virus and Rex of the human T-cell leukemia virus type I can counteract an mRNA downregulatory element of the transferrin receptor mRNA. Nucleic Acids. Res. 22:4725-4732.