Pharmacokinetics and tissue distribution of a dna-methyltransferase antisense (MT-AS) oligonucleotide and its catabolites in tumor-bearing nude mice

Journal of Pharmacology and Experimental Therapeutics

Volumn 282, Issue 2, 1997, Pages 663-670

  Qian, Mingxin ^a   Chen, Shu Hui ^a,b   Von Hofe, Eric ^a,c   Gallo, James M ^a  

^a FOX CHASE CANCER CENTER   (United States)

^b NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^c HYBRIDON INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGODEOXYNUCLEOTIDE; DNA METHYLTRANSFERASE; OLIGODEOXYNUCLEOTIDE PHOSPHOROTHIOATE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DNA METHYLATION; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG PROTEIN BINDING; DRUG TISSUE LEVEL; INTRAVENOUS DRUG ADMINISTRATION; LUNG CARCINOMA; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; AREA UNDER CURVE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, ION EXCHANGE; DNA MODIFICATION METHYLASES; ELECTROPHORESIS, CAPILLARY; FEMALE; HALF-LIFE; HUMANS; LUNG NEOPLASMS; MICE; MICE, NUDE; NEOPLASM TRANSPLANTATION; OLIGONUCLEOTIDES, ANTISENSE; TISSUE DISTRIBUTION;

EID: 0030806944     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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