Vascular endothelial growth factor enhances the expression of urokinase receptor in human endothelial cells via protein kinase C activation

Thrombosis and Haemostasis

Volumn 85, Issue 2, 2001, Pages 296-302

  Kroon, M E ^a   Koolwijk, P ^a   Vermeer, M A ^a   Van Der Vecht, B ^a   Van Hinsbergh, V W M ^a  

^a TNO   (Netherlands)

Author keywords

Human endothelial cells; PKC; u PAR; VEGF

Indexed keywords

2 [1 (3 AMIDINOTHIOPROPYL) 1H INDOL 3 YL] 3 (1 METHYL 1H INDOL 3 YL)MALEIMIDE; 2 [1 (3 DIMETHYLAMINOPROPYL) 3 INDOLYL] 3 (3 INDOLYL)MALEIMIDE; FIBROBLAST GROWTH FACTOR 2; PLASMIN; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROTEIN KINASE C; PROTEIN KINASE C INHIBITOR; TISSUE PLASMINOGEN ACTIVATOR; TYROSINE; UROKINASE RECEPTOR; VASCULOTROPIN; VASCULOTROPIN RECEPTOR;

ANTIGEN EXPRESSION; AORTA; ARTICLE; CELL CULTURE; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; MICROVASCULATURE; MITOSIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; RECEPTOR BINDING; SIGNAL TRANSDUCTION; UMBILICAL VEIN;

EID: 0035121593     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0037-1615683     Document Type: Article

References (48)

1. The role of alphav integrins during angiogenesis: Insights into potential mechanisms of action and clinical development
2. Upregulation of urokinase receptor expression on migrating endothelial cells
3. In vivo patterns of expression of urokinase and its inhibitor PAI-1 suggest a concerted role in regulating physiological angiogenesis
4. Membrane and matrix localization of proteinases: A common theme in tumor cell invasion and angiogenesis
5. Urokinase receptor antagonists inhibit angiogenesis and primary tumor growth in syngeneic mice
6. Cooperative effect of TNFalpha, bFGF, and VEGF on the formation of tubular structures of human microvascular endothelial cells in a fibrin matrix. Role of urokinase activity
7. Ultrastructural localization of plasma membrane-associated urokinase-type plasminogen activator at focal contacts
8. A slice of PAI
9. Plasminogen activation by receptor-bound urokinase - A kinetic study with both cell-associated and isolated receptor
10. Recycling of the urokinase receptor upon internalization of the uPA: Serpin complexes
11. Vascular endothelial growth factor increases urokinase receptor expression in vascular endothelial cells
12. Expression of the urokinase receptor in vascular endothelial cells is stimulated by basis fibroblast growth factor
13. Isolation and characterization of a vascular endothelial cell mitogen produced by pituitary-derived folliculo stellate cells
14. The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor
15. Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor
16. Treatment of diabetic retinopathy
17. Vascular endothelial growth factor in patients with rheumatoid arthritis
18. Levels of endothelial cell stimulating angiogenesis factor and vascular endothelial growth factor are elevated in psoriasis
19. Role of vascular endothelial growth factor in the regulation of angiogenesis
20. Tumor-secreted vascular permeability factor increases cytosolic Ca2+ and Vonwillebrand factor release in human endothelial cells
21. Different signal transduction properties of KDR and Flt1, two receptors for vascular endothelial growth factor
22. Functional upregulation of the vascular endothelial growth factor receptor KDR by hypoxia
23. The vascular endothelial growth factor receptor KDR activates multiple signal transduction pathways in porcine aortic endothelial cells
24. Characterization of vascular endothelial growth factor's effect on the activation of protein kinase C, its isoforms, and endothelial cell growth
25. Utilization of distinct signaling pathways by receptors for vascular endothelial cell growth factor and other mitogens in the induction of endothelial cell proliferation
26. Role and localization of urokinase receptor in the formation of new microvascular structures in fibrin matrices
27. Urokinase plasminogen activator receptor, beta2-integrins, and Src-kinases within a single receptor complex of human monocytes
28. Production of plasminogen activators and inhibitor by serially propagated endothelial cells from adult human blood vessels
29. Effect of thrombin on the production of plasminogen activators and PA inhibitor-1 by human foreskin microvascular endothelial cells
30. Differential distribution and modulation of expression of alpha 1/beta 1 integrin on human endothelial cells
31. Single-step method of RNA isolation by acid guanidinium thiocyanate- phenol-chloroform extraction
32. Effect of steroid hormones and retinoids on the formation of capillary-like tubular structures of human microvascular endothelial cells in fibrin matrices is related to urokinase expression
33. Receptor-mediated internalization and degradation of urokinase is caused by its specific inhibitor Pai-1
34. Protein kinase-C and the stimulation of tissue plasminogen activator release from human endothelial cells-dependence on the elevation of messenger RNA
35. Potent synergism between vascular endothelial growth factor and basic fibroblast growth factor in the induction of angiogenesis invitro
36. Lymphatic endothelium and Kaposi's sarcoma spindle cells detected by antibodies against the vascular endothelial growth factor receptor-3
37. Expression of the fms-like tyrosine kinase 4 gene becomes restricted to lymphatic endothelium during development
38. Differential expression of the two VEGF receptors Flt and Kdr in placenta and vascular endothelial cells
39. Migration of human monocytes in response to vascular endothelial growth factor (VEGF) is mediated via the VEGF receptor flt-1
40. VEGF activates protein kinase c-dependent, but ras-independent raf-MEK-MAP kinase pathway for DNA synthesis in primary endothelial cells
41. VEGF stimulates MAPK through a pathway that is unique for receptor tyrosine kinases
42. Vascular endothelial growth factor governs endothelial nitric-oxide synthase expression via a KDR/Flk-1 receptor and a protein kinase C signaling pathway
43. Tranilast inhibits protein kinase C-dependent signalling pathway linked to angiogenic activities and gene expression of retinal microcapillary endothelial cells
44. Protein kinase G mediates vascular endothelial growth factor-induced Raf-1 activation and proliferation in human endothelial cells
45. Protein kinase C lies on the signaling pathway for vascular endothelial growth factor-mediated tumor development and angiogenesis
46. Blockade of vascular endothelial cell growth factor receptor signaling is sufficient to completely prevent retinal neovascularization
47. Contribution of Src and Ras pathways in FGF-2 induced endothelial cell differentiation
48. Adenovirus-mediated delivery of a uPA/uPAR antagonist suppresses angiogenesis-dependent tumor growth and dissemination in mice