Tranilast inhibits protein kinase C-dependent signalling pathway linked to angiogenic activities and gene expression of retinal microcapillary endothelial cells

British Journal of Pharmacology

Volumn 127, Issue 2, 1999, Pages 537-545

  Koyama, Shinji ^a   Takagi, Hitoshi ^a   Otani, Atsushi ^a   Suzuma, Kiyoshi ^a   Nishimura, Kazuo ^b   Honda, Yoshihito ^a  

^a KYOTO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b SANTEN PHARMACEUTICAL CO LTD   (Japan)

Author keywords

Angiogenesis; Retinal ischaemia; Tranilast; Vascular endothelial growth factor

Indexed keywords

BASIC FIBROBLAST GROWTH FACTOR; DNA; INTEGRIN; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN KINASE C; TRANILAST; VASCULOTROPIN;

ANGIOGENESIS; ANIMAL CELL; ARTICLE; CATTLE; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; DNA SYNTHESIS; ENZYME INHIBITION; GENE EXPRESSION; HYPOXIA; MICROCIRCULATION; NONHUMAN; ONCOGENE C FOS; PRIORITY JOURNAL; RETINA BLOOD VESSEL; SIGNAL TRANSDUCTION; VASCULAR ENDOTHELIUM;

ANIMALS; ANTHRANILIC ACIDS; ANTI-ALLERGIC AGENTS; CAPILLARIES; CAPILLARY PERMEABILITY; CATTLE; CELL DIVISION; CELL HYPOXIA; CELLS, CULTURED; DNA; ENDOTHELIAL GROWTH FACTORS; ENDOTHELIUM, VASCULAR; ENZYME INHIBITORS; GENE EXPRESSION REGULATION; LYMPHOKINES; NEOVASCULARIZATION, PHYSIOLOGIC; PHOSPHORYLATION; PROTEIN KINASE C; RETINAL VESSELS; SIGNAL TRANSDUCTION; TETRADECANOYLPHORBOL ACETATE; TYROSINE; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS;

EID: 0032986959     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0702564     Document Type: Article

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